Scientific Program

ZOMES-IV

The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3

- at the Interface between Signaling & Proteolysis

June 18-21, 2006

Yale University Campus, New Haven, Connecticut

Organizing committee:

Ning Wei, Yale University,

Dieter A. Wolf, Harvard School of Public Health

Daniel Chamovitz, Tel Aviv University

Sunday, June 18, 2006

2:00 pm -10:30 pm Conference registration at Swing Residential Hall

6:00 pm -7:30 pm Dinner, Commons Dinning Hall

7:40 pm Welcoming note

7:45 pm Session-A: The ZOMES complexes

Moderator, Ning Wei

Xing Wang Deng, Yale University

The COP gene clusters in Arabidopsis light responses, a genetic perspective

Daniel Finley, Harvard Medical School

Regulation of proteasome activity by Hul5 and Ubp6

John Hershey, University of California at Davis

Structure and Regulation of Human eIF3

9:20 pm- 10:20 pm Reception: Wine and Beer at Swing Residential Hall

Monday, June 19, 2006

7:15 am - 8:30 am Breakfast at Commons

8:30 am -12:25 Session-B: Cullin and Nedd8/Rub1

Moderators, Dieter Wolf and Ning Zheng

Ning Zheng, University of Washington.

Structure, Function, and Regulation of Cullin-RING E3 Machineries

Zhen-Qiang Pan, Mount Sinai School of Medicine, NYC

A novel insight into regulation of SCF activity by Nedd8

Judy Callis, University of California at Davis

Roles of the RUB pathway revealed through alterations in expression of pathway components in Arabidopsis thaliana

Yaru Chan, Institute of Molecular Biology, Academia Sinica, Taiwan

Characterizing the function of Drosophila DEN 1

Daniel Kornitzer, Rappaport Institute, Technion, Israel

Role of neddylation and of CAND1 in morphogenesis of the dimorphic yeast Candida Albicans.

Break

Dieter A. Wolf, Harvard School of Public Health

Control of CRLs by the CSN

Ning Wei, Yale University

Cullin neddylation and functions of CSN1 and CSN8

Elisabetta Bianchi, Institut Pasteur, France

Role of the human COP9 signalosome in cell cycle regulation

L. Pintard, Samuel Lunenfeld Research Institute, Canada

The COP9/Signalosome contains seven subunits in C. elegans and regulates MEI-1/Katanin degradation by counteracting the autocatalytic instability of MEL-26

12:30 pm Lunch, Commons Dinning Hall

1:30 pm – 3:10 pm Poster Session at Commons

3:15 pm - 6:10 pm Session-C: Proteasome

Moderators, Alfred Goldberg and Michael Glickman

Alfred Goldberg, Harvard Medical School.

Multiple Roles of ATP in Proteasome Function

Mark Hochstrasser, Yale University,

20S proteasome assembly in yeast

Eric Chang, Baylor College of Medicine

Cell signaling and proteolysis control

Break

Michael Glickman, The Technion, Israel.

A checkpoint on access of ubiquitin-like domains to the proteasome

Colin Gordon, MRC, UK

Characterisation of the fission yeast mts mutants

Peter Jackson, Stanford University School of Medicine & Genentech

Organizing Ubiquitination and the Proteasome on the Microtubule Cytoskeleton: Lessons from the Mitotic Spindle and the Primary Cilium

6:15 pm - 7:30 pm Dinner at Commons

7:45 pm - 9:45 pm Session-D: PCI / MPN domains and eIF3

Moderator, Kay Hoffman

Kay Hofmann, Miltenyi Biotec GmbH, Germany.

The Evolution of PCI-based complexes and their components

Albrecht von Arnim, University of Tennessee,

Functions of the MPN domain protein, eIF3h, in mRNA sequence-specific initiation of translation

Moshe Dessau, Tel-Aviv University, Israel

Biochemical and structural analysis of CSN7 – a model PCI protein

Ganes C. Sen, Lerner Research Institute, Cleveland Clinic Foundation.

Modulation of eIF3 functions by the P56 family of viral stress-inducible proteins

Robert Gemmill, Univ of Colorado at Denver and Health Sci. Center

The TRC8 hereditary kidney cancer gene is a sterol-regulated E3 ubiquitin ligase that links protein translation and growth control to sterol and lipid status.

Tuesday, June 20, 2006

7:15 am - 8:30 am Breakfast at Commons

8:30 am - 12:10 pm Session-E: CSN and Jab1

Moderators, Daniel Chamovitz and Jun-ya Kato

Jun-ya Kato, Nara Institute of Science and Technology, Japan

Control of mammalian stem cell proliferation by Jab1/CSN5

Ruggero Pardi, DIBIT-Scientific Institute San Raffaele, ITALY.

The mammalian CSN as a master regulator of cell cycle- and DNA damage Checkpoints

Jürgen Bernhagen, University Hospital RWTH Aachen, Germany.

Cytosolic trapping and inhibition of non-classical MIF secretion by JAB1/CSN5: implications for a regulatory role in the Akt survival pathway

Claus Schwechheimer, Universitaet Tuebingen, Germany

The role of the COP9 signalosome in plant development

Giuliana Gusmaroli, Yale University

Arabidopsis CSN5 and CSN6 subunits are essential to maintain COP9 signalosome integrity and stability, plant viability and to prevent degradation of CUL3

Break

Daniel Chamovitz, Tel Aviv University, Israel.

Genomic analysis of the CSN in Drosophila development

Wolfgang Dubiel, Humboldt University, Germany.

CSN-associated activities and super-complexes

Cheng-Ting Chien,

Institute of Molecular Biology, Academia Sinica, Taiwan

CUL3 downregulates Cubitus interruptus activity in high-level Hedgehog signaling

Avital Yahalom, Tel Aviv University, Israel

Increase in Arabidopsis eIF3e levels causes changes in protein turnover, translation and development

12:30 pm Lunch, Commons Dinning Hall

1:30 pm–3:00 pm Poster Session at Commons

3:20 pm-9:30 pm Social event to be announced and Banquet

Wednesday, June 21, 2006

7:15 am - 8:30 am Breakfast at Commons

8:30 am -12:05 pm Session-F Cul4, DDB1, COP1

Moderators: Antony Carr and Yue Xiong

Antony Carr, University of Sussex, UK.

The role of Cdt2 and the signalosome in regulating RNR

Vishva Dixit, Genentech, Inc.

COP1: an E3-ligase that Regulates p53

Elah Pick, Yale University

Human DET1 complexes regulate Cul4A ubiquitin ligase activity

Pradip Raychaudhuri, University of Illinois at Chicago

Regulation of the cell cycle checkpoints by the Cul4A-Signalosome complex

Vesna Rapic-Otrin, University of Pittsburgh, Hillman Cancer Center

The DDB1-CUL4A^DDB2 ubiquitin ligase targets histone H2A at UV-damaged DNA sites

Break

Yue Xiong, University of North Carolina at Chapel Hill

The Cullin-ROC family of E3 ligases

Hui Zhang, Yale University School of Medicine

Regulation of the Cell Cycle by the CUL4/CSN Complexes

Johannes Walter, Harvard Medical School

Cell cycle regulated proteolysis of Cdt1

Jianping Jin, Harvard Medical School

New Components in the Cullin-based ubiquitin ligase pathway

12:30 pm –1:30 pm Lunch, Commons Dinning Hall

1:30 pm – 3:40 pm Session-G: ZOMES in physiology and diseases

Moderator: Gerhard Braus

Gerhard Braus, Georg-August-Univers+ity, Germany.

Signalosome and Development in the filamentous fungus Aspergillus nidulans

Yi Liu, University of Texas Southwestern Medical Center.

The roles of COP9 signalosome in mediating protein degradation, circadian clock and light responses in Neurospora

Xuejun Wang, University of South Dakota School of Medicine

"The Ubiquitin-Proteasome System in Heart Failure"

Noriko Kato, Nara Institute of Science and Technology, Japan

Role of Cop9 signalosome subunit 3 in mammalian cell growth and tumorigenesis

David Mack, National Cancer Institute, National Institutes of Health

Expression of truncated INT6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis

3:40 pm – 3:45 pm Award announcement and closing