Section of Critical Care Medicine
- Clifford W. Bogue, M.D., Associate Research Scientist
Special Interests: Developmental Biology, Mouse genetics, organogenesis, homeobox genes
Non-Faculty members (technical, clerical)
- Christine Wilson, Research Associate
- Hema Vasavada, Research Associate
Fellows and other trainees
- Rong Cong, Ph.D., Post-Doctoral Associate
- Haifa Hallaq, Ph.D., Post-Doctoral Fellow
Current Grant Support
|Name ||Title ||Funding Agency ||Dates|
|Clifford Bogue|| Hex – a Homeobox Gene Essential for Liver Development ||NIDDK/NIH ||9/01 – 8/06|
|Clifford Bogue|| The Ontogeny of Lymphocyte Development ||Charles H. Hood Foundation ||7/02 – 6/03|
Publications for 2001 and 2002:
Bogue CW, Zhang P.-X., McGrath J, Jacobs HC and Fuleihan RL. Impaired B cell development in mice with a targeted disruption of the homeobox gene Hex. Proc Natl Acad Sci, USA. 2003 Jan 21;100(2):556-61.
Reviews and Chapters:
Bogue CW. Genetic models of respiratory tract development – from invertebrates to vertebrates, in Genetic Models in Cardiorespiratory Biology. Haddad GG and Xu T, ed. Marcel Dekker, New York, pp. 59 – 89, 2001.
Bogue CW. Genetic and molecular basis of airway and lung development, in Basic Mechanisms of Pediatric Respiratory Disease. Haddad GG, Abman SH and Chernick V, ed. B. C. Decker, Hamilton, Ontario. pp. 9 – 23, 2002.
The primary interest of my laboratory is to understand at the molecular level the events leading to the establishment of the mammalian body plan and how growth and differentiation of various tissues and organs are regulated during embryogenesis. In particular, I am studying the expression, regulation and function of homeobox transcription factors in murine development. Current projects include: 1) the molecular events responsible for specification of the early gut endoderm into hepatoblasts and the subsequent development of the liver; 2) the role of both the foregut endoderm and endocardium in cardiac morphogenesis; and 3) the development of early hematopoietic precursors into B cells. In all these projects, we are examining the role that the divergent homeobox gene Hhex plays in these important developmental events. By studying mice and cells with both null and conditional mutations of Hhex, we are gaining important insight into basic mechanisms of organ development and cell-type specification.