Small Molecule Discovery Center

The Yale Small Molecule Discovery Center helps researchers discover small molecules with precise, valuable activities. Specifically, we work with you to design, optimize and perform small molecule screens to modify the activities of biological systems of interest. In the Center, Yale researchers have performed a variety of biochemical and cell-based assays to identify small molecules with specific activities for target molecules, cells or organisms including: enzymatic inhibitors, inhibitors of protein-protein interactions, modifiers of protein polymerization states, inducers and repressors of gene expression, toxic responses and developmental modifiers in model organisms.

Janie Merkel, Ph.D.
Director, Small Molecule Discovery Center
Yale University
203-432-5930
janie.merkel@yale.edu