Recent publications (full list on PubMed)

A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase

Deng, Y., Couch, B. A., Koleske, A. J., Turk, B. E.

ChemBioChem 13, 2510-2512 (2012)

Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress

Lee, Y. J., Jeschke, G. R., Roelants, F. M., Thorner, J., Turk B. E.

Mol. Cell. Biol. 32, 4705-4717 (2012)

Cyclic-GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase

Wong, A., Zhang, Y.-W., Jeschke, G. R., Turk, B. E., Rudnick, G.

J. Biol. Chem. 287, 36051-36058 (2012)

The type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

Ha, B. Davis, M. J., Chen, C., Lou, H. J., Gao, J., Zhang, R., Krauthammer, M., Halaban, R., Schlessinger, J., Turk, B. E., Boggon, T. J.

Proc. Natl. Acad. Sci. USA 109, 16107-16112 (2012)

Identification of exosite-targeting inhibitors of anthrax lethal factor by high throughput screening

Bannwarth, L., Goldberg, A. B., Chen, C., Turk, B. E.

Chem. Biol. 19, 875-882 (2012)

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

Shehata, S. E., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E., Sakamoto, K.

Cell. Signal., published online July 13, 2012.

Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking

Strochlic, T. I., Concilio, S., Viaud, J., Eberwine, R., Wong, L. E., Minden, A., Turk, B. E., Plomann, M., Peterson, J. R.

Proc. Natl. Acad. Sci. USA 109, 4116-4121 (2012)

Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps

Yip, K. Y., Utz, L., Sitwell, S., Hu, X., Sidhu, S. S., Turk, B. E., Gerstein, M. B., Kim, P. M.

BMC Biol. 9, 53 (2011)

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-Homologous Kinase (CHK) and Identification of β-synuclein as a potential CHK physiological substrate

Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H. J., Catimel, B. L., Turk, B. E., Cheng, H. C.

Biochemistry 50, 6667-6677 (2011)

Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation

Kikani, C. K., Antonysamy, S. A., Bonanno, J. B., Romero, R., Zhang, F. F., Russell, M., Gheyi, T., Iizuka, M., Emtage, S., Sauder, J. M., Turk, B. E., Burley, S. K., and Rutter, J.

J. Biol. Chem. 285, 41034-41043 (2010)

The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover

Sirichandra, C., Davanture, M., Turk, B. E., Zivy, M., Valot, B., Leung, J., and Merlot, S.

PLoS One 5, e13935 (2010)

Phosphorylation of immunity-related GTPases by a parasite secretory kinase promotes macrophage survival and virulence

Fentress, S. J., Behnke, M. S., Dunay, I. R., Mashayekhi, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Taylor, G. A., Turk, B. E., Lichti, C. F., Townsend, R. R., Qiu, W., Hui, R., Beatty, W. L. and Sibley, L. D.

Cell Host Microbe 8, 484-495 (2010)

MOTIPS: Automated motif analysis for predicting targets of modular protein domains

Lam, H. Y. K., Kim, P. M., Mok, J., Tonikian, R., Sidhu, S. S., Turk, B. E., Snyder, M., and Gerstein, M. B.

BMC Bioinformatics 11, 243 (2010)

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

Mok, J., Kim, P. M., Lam, H. Y. K., Piccirillo, S., Zhou, X., Jeschke, G. R., Sheridan, D. L., Parker, S. A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J. N., Sheu, Y., Sassi, H. E., Sopko, R., Chan, C. S. M., De Virgilio, C., Hollingsworth, N. M., Lim, W. A., Stern, D. F., Stillman, B., Andrews, B. J., Gerstein, M. B., Snyder, M. and Turk, B. E.

Sci. Signal., 3, ra12 (2010)

Analysis of protein kinase specificity using arrayed positional scanning peptide libraries

Chen, C. and Turk, B. E.

Curr. Protoc. Mol. Biol. Unit 18.14 (2010)

Active site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

Caescu, C. I., Jeschke, G. R. and Turk, B. E.

Biochem. J., 424, 79-88 (2009)

Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases

Davis, T. L., Walker, J. R., Allali-Hassani, A., Parker, S. A., Turk, B. E., and Dhe-Paganon, S. 

FEBS J., 276, 4395-4404 (2009)

Mixture-based peptide libraries for identifying protease cleavage motifs 

Turk, B. E.

Meth. Mol. Biol. 539, 79-91 (2009)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation

Bullock, A. N., Das, S., Debreczeni, J. E., Rellos, P., Fedorov, O., Niesen, F., Guo, K., Papagrigoriou, E., Amos, A. L., Cho, S., Turk B. E., Ghosh, G. and Knapp, S.

Structure 17, 352-362 (2009)

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

Huang, X., Finerty, P., Walker, J. R., Butler-Cole, C., Vedadi, M., Shapira, M., Parker, S. A., Turk, B. E., Thompson, D. A., and Dhe-Paganon, S. 

J. Struct. Biol. 165, 88-96 (2009)

Structural coupling of Fes and Abl SH2-kinase domains links substrate recognition and kinase activation

Filippakopoulos, P., Kofler, M., Hantschel, O., Gish, G. D., Grebien, F., Salah, E., Neudecker, P., Kay, L. E., Turk, B. E., Pawson, T. and Knapp, S.

Cell 134, 793-803 (2008)

Linear motif atlas for phosphorylation-dependent signaling

Miller, M. L., Jensen, L. J., Diella, F., Jørgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S. A., Bordeaux, J., Sicheritz-Ponten, T., Knapp, S., Blom, N., Bork, P., Li, S., Cesareni, G., Pawson, T., Turk, B. E., Yaffe, M. B., Brunak, S. and Linding, R. 

Sci. Signal., 1, ra2 (2008)

Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs

Sheridan, D. L., Kong, Y., Parker, S. A., Dalby, K. N., and Turk, B. E.

J. Biol. Chem. 283, 19511-19520 (2008)

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk B. E. and Shaw, R. J.

Mol. Cell. 30, 214-226 (2008)

Understanding and exploiting substrate recognition by protein kinases

Turk, B. E.  

Curr. Opin. Chem. Biol. 12, 4-10 (2008)

Structure of the human protein kinase MPSK1 reveals a novel activation loop architecture

Eswaran, J., Bernad, A., Ligos, J. M., Guinea, B., Debreczeni, J. E., Sobott, F., Parker, S. A., Najmanovich, R., Turk, B. E. and Knapp, S.

Structure 16, 115-124 (2008)

Activation segment dimerization: a mechanism for kinase auto-phosphorylation of non-consensus sites

Pike, A. W., Rellos, P., Nielsen, F. H., Turnbull, A., Oliver, A. W., Parker, S. A., Turk, B. E., Pearl, L. H. and Knapp, S.

EMBO J. 27, 704-714 (2008)

Discovery and development of anthrax lethal factor metalloproteinase inhibitors

Turk, B. E.

Curr. Pharm. Biotechnol. 9, 24-33 (2008)

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites 

Rennefahrt, U. E. E., Deacon, S., Parker, S. A., Devarajan, K., Beeser, A., Chernoff, J., Knapp, S., Turk, B. E., and Peterson, J. R.

J. Biol. Chem. 282, 15667-15678 (2007)

Manipulation of host signaling pathways by anthrax toxins

Turk, B.E. 

Biochem. J. 402, 405-417 (2007)

Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase

Fu, Z., Larson, K.A., Chitta, R.K., Parker, S.A., Turk, B.E., Lawrence, M.W., Kaldis, P., Galaktionov, K., Cohn, S.M., Shabanowitz, J., Hunt, D.F. and Sturgill, T.W.

Mol. Cell. Biol. 26, 8639-8654 (2006)

Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates

Turk, B.E., Hutti, J.E. and Cantley, L.C.

Nat. Protocols 1, 375-379 (2006)

Structure and substrate specificity of the Pim-1 kinase

Bullock, A.N., Debreczeni, J., Knapp, S. and Turk, B.E.

J. Biol. Chem. 280, 41675-41682 (2005)

Measuring kinase activity:  finding needles in a haystack

Turk, B.E.

Nat. Methods 2, 251-252 (2005)

A rapid method for determining protein kinase phosphorylation specificity

Hutti, J.E., Jarrell, E.T., Chang, J.D., Abbott, D.W., Storz, P., Toker, A., Cantley, L.C. and Turk, B.E.

Nat. Methods 1, 27-29 (2004)

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

Turk, B.E., Wong, T.Y., Schwarzenbacher, R., Jarrell, E.T., Leppla, S.H., Collier, R.J., Liddington R.C. and Cantley, L.C.

Nat. Struct. Mol. Biol. 11, 60-66 (2004).