Recent publications (full list on PubMed)

Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex

Fisher, O. S., Deng, H., Liu, D., Zhang, Y., Wei, R., Deng, Y., Zhang, F., Louvi, A., Turk, B. E., Boggon, T. J., Su, B.

Nat. Commun. 6, 7937 (2015).

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Egan, D. F., Chun, M. G., Vamos, M., Zou, H., Rong, J., Miller, C. J., Lou, H. J., Raveendra-Panickar, D., Yang, C. C., Sheffler, D. J., Teriete, P., Asara, J. M., Turk, B. E., Cosford, N. D., Shaw, R. J.

Mol. Cell 59, 285-297 (2015)

Biochemical characterization of FIKK8 - A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans

Osman, K. T., Lou, H. J., Qiu, W., Brand, V., Edwards, A. M., Turk B. E., Hui R.

Mol. Biochem. Parasitol. 201, 85-89 (2015)

Signaling, regulation and specificity of the type II p21-activated kinases

Ha, B.H., Morse, E.M., Turk, B.E., and Boggon, T.J.

J. Biol. Chem. 290, 12975-12983 (2015)

Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

Howard, C., Hanson-Smith, V., Kennedy, K. J., Miller, C. J., Lou, H. J., Johnson, A. D., Turk, B. E.*, Holt, L. J.*

eLife 3, e04126 (2014)

Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays

Deng, Y., Alicea-Velázquez, N. L., Bannwarth, L., Lehtonen, S. I., Boggon, T. J., Cheng, H. C., Hytönen, V. P., Turk, B. E.

J. Proteome Res. 13, 4339-4346 (2014)

An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential

Goodwin, J. M., Svensson, R. U., Lou, H. J., Winslow, M. M., Turk,  B. E., Shaw, R. J.

Mol. Cell 55, 436-450 (2014)

Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho

Chen, C. D., Tung, T. Y., Liang, J., Zeldich, E., Tucker Zhou, T. B., Turk, B. E., Abraham, C. R.

Biochemistry 53, 5579-5587 (2014)

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3

Galan, J. A., Geraghty, K. M., Lavoie, G., Kanshin, E., Tcherkezian, J., Calabrese, V., Jeschke, G. R., Turk, B. E., Ballif, B. A., Blenis, J., Thibault, P., Roux, P. P.

Proc. Natl. Acad. Sci. USA 111, E2918-2927 (2014)

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice

Etheridge, R. D., Alaganan, A., Tang, K., Lou, H. J., Turk, B. E., Sibley, L. D.

Cell Host Microbe 15, 537-550 (2014)

Modulation of the chromatin phosphoproteome by the Haspin protein kinase

Maiolica, A., De Medina Redondo, M., Schoof E. M., Villa, F., Gatti, M., Jeganatgan, S., Lou, H. J., Novy, K., Hauri, S., Toprak, U. H., Herzog, F., Meraldi, P., Penengo, L., Turk, B. E., Knapp, S., Linding, R., Aebersold, R.

Mol. Cell. Proteomics 13, 1724-1740 (2014).

Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase

Papinski, D., Schuschnig, M., Reiter, W., Wilhelm, L., Barnes, C., Majolika, A., Pfaffenwimmer, T., Kijanska, M., Stoffel, I., Hansmann, I., Lou, H. J., Turk, B. E., Aebersold, R., Ammerer, G., Peter, M., Kraft, C.

Mol. Cell 53, 471-483 (2014)

Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity

Chen, C., Ha, B. H., Thévenin, A. F., Lou, H. J., Zhang, R., Yip, K. Y., Peterson, J. R., Gerstein, M., Kim, P. M., Filippakopoulos, P., Knapp, S., Boggon, T. J., Turk, B. E.

Mol. Cell 53, 140-147 (2014)

Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6

Gao, J., Ha, B. H., Lou, H. J., Morse, E. M., Zhang, R., Calderwood, D. A., Turk, B. E., Boggon, T. J.

PLoS One, 8, e77818 (2013)

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

Kang, S. A., Cervantes, C. L., Lim, D., Lou, H. J., Ottina, K., Gray, N. S., Turk, B. E., Yaffe, M. B., Sabatini, D. M.

Science 341, 1236566 (2013)

Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity

Morell, M., Nguyen Duc, T., Willis, A. L., Syed, S., Lee, J., Deu, E., Deng, Y., Xiao, J., Turk, B. E., Jessen, J. R., Weiss, S. J., Bogyo, M.

J. Am. Chem. Soc. 135, 9139-9148 (2013)

Construction of human activity-based phosphorylation networks

Newman, R. H., Hu, J., Rho, H., Xie, Z., Woodard, C., Neiswinger, J., Cooper, C., Shirley, M., Clark, H. M., Hu, S., Hwang, W., Jeong, J. Wu, G., Lin, J., Gao, X., Ni, Q., Goel, R., Xia, S., Ji, H., Dalby, K. N., Birnbaum, M. J., Cole, P. A., Knapp, S., Ryazanov, A. G., Zack, D. J., Blackshaw, S., Pawson, T., Gingras, A. C., Desiderio, S., Pandey, A., Turk, B. E., Zhang, J., Zhu, H., Qian, J.

Mol. Syst. Biol. 9, 655 (2013)

Exploiting the unique ATP-binding pocket of Toxoplasma calcium-dependent protein kinase 1 to identify its substrates

Lourido, S., Jeschke, G. R., Turk, B. E., Sibley, L. D.

ACS Chem. Biol., in press (2013)

A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase

Deng, Y., Couch, B. A., Koleske, A. J., Turk, B. E.

ChemBioChem 13, 2510-2512 (2012)

Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress

Lee, Y. J., Jeschke, G. R., Roelants, F. M., Thorner, J., Turk B. E.

Mol. Cell. Biol. 32, 4705-4717 (2012)

Cyclic-GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase

Wong, A., Zhang, Y.-W., Jeschke, G. R., Turk, B. E., Rudnick, G.

J. Biol. Chem. 287, 36051-36058 (2012)

The type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

Ha, B. Davis, M. J., Chen, C., Lou, H. J., Gao, J., Zhang, R., Krauthammer, M., Halaban, R., Schlessinger, J., Turk, B. E., Boggon, T. J.

Proc. Natl. Acad. Sci. USA 109, 16107-16112 (2012)

Identification of exosite-targeting inhibitors of anthrax lethal factor by high throughput screening

Bannwarth, L., Goldberg, A. B., Chen, C., Turk, B. E.

Chem. Biol. 19, 875-882 (2012)

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

Shehata, S. E., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E., Sakamoto, K.

Cell. Signal. 24, 2085-94 (2012)

Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking

Strochlic, T. I., Concilio, S., Viaud, J., Eberwine, R., Wong, L. E., Minden, A., Turk, B. E., Plomann, M., Peterson, J. R.

Proc. Natl. Acad. Sci. USA 109, 4116-4121 (2012)

Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps

Yip, K. Y., Utz, L., Sitwell, S., Hu, X., Sidhu, S. S., Turk, B. E., Gerstein, M. B., Kim, P. M.

BMC Biol. 9, 53 (2011)

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-Homologous Kinase (CHK) and Identification of β-synuclein as a potential CHK physiological substrate

Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H. J., Catimel, B. L., Turk, B. E., Cheng, H. C.

Biochemistry 50, 6667-6677 (2011)

Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation

Kikani, C. K., Antonysamy, S. A., Bonanno, J. B., Romero, R., Zhang, F. F., Russell, M., Gheyi, T., Iizuka, M., Emtage, S., Sauder, J. M., Turk, B. E., Burley, S. K., and Rutter, J.

J. Biol. Chem. 285, 41034-41043 (2010)

The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover

Sirichandra, C., Davanture, M., Turk, B. E., Zivy, M., Valot, B., Leung, J., and Merlot, S.

PLoS One 5, e13935 (2010)

Phosphorylation of immunity-related GTPases by a parasite secretory kinase promotes macrophage survival and virulence

Fentress, S. J., Behnke, M. S., Dunay, I. R., Mashayekhi, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Taylor, G. A., Turk, B. E., Lichti, C. F., Townsend, R. R., Qiu, W., Hui, R., Beatty, W. L. and Sibley, L. D.

Cell Host Microbe 8, 484-495 (2010)

MOTIPS: Automated motif analysis for predicting targets of modular protein domains

Lam, H. Y. K., Kim, P. M., Mok, J., Tonikian, R., Sidhu, S. S., Turk, B. E., Snyder, M., and Gerstein, M. B.

BMC Bioinformatics 11, 243 (2010)

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

Mok, J., Kim, P. M., Lam, H. Y. K., Piccirillo, S., Zhou, X., Jeschke, G. R., Sheridan, D. L., Parker, S. A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J. N., Sheu, Y., Sassi, H. E., Sopko, R., Chan, C. S. M., De Virgilio, C., Hollingsworth, N. M., Lim, W. A., Stern, D. F., Stillman, B., Andrews, B. J., Gerstein, M. B., Snyder, M. and Turk, B. E.

Sci. Signal., 3, ra12 (2010)

Analysis of protein kinase specificity using arrayed positional scanning peptide libraries

Chen, C. and Turk, B. E.

Curr. Protoc. Mol. Biol. Unit 18.14 (2010)

Active site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

Caescu, C. I., Jeschke, G. R. and Turk, B. E.

Biochem. J., 424, 79-88 (2009)

Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases

Davis, T. L., Walker, J. R., Allali-Hassani, A., Parker, S. A., Turk, B. E., and Dhe-Paganon, S. 

FEBS J., 276, 4395-4404 (2009)

Mixture-based peptide libraries for identifying protease cleavage motifs 

Turk, B. E.

Meth. Mol. Biol. 539, 79-91 (2009)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation

Bullock, A. N., Das, S., Debreczeni, J. E., Rellos, P., Fedorov, O., Niesen, F., Guo, K., Papagrigoriou, E., Amos, A. L., Cho, S., Turk B. E., Ghosh, G. and Knapp, S.

Structure 17, 352-362 (2009)

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

Huang, X., Finerty, P., Walker, J. R., Butler-Cole, C., Vedadi, M., Shapira, M., Parker, S. A., Turk, B. E., Thompson, D. A., and Dhe-Paganon, S. 

J. Struct. Biol. 165, 88-96 (2009)

Structural coupling of Fes and Abl SH2-kinase domains links substrate recognition and kinase activation

Filippakopoulos, P., Kofler, M., Hantschel, O., Gish, G. D., Grebien, F., Salah, E., Neudecker, P., Kay, L. E., Turk, B. E., Pawson, T. and Knapp, S.

Cell 134, 793-803 (2008)

Linear motif atlas for phosphorylation-dependent signaling

Miller, M. L., Jensen, L. J., Diella, F., Jørgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S. A., Bordeaux, J., Sicheritz-Ponten, T., Knapp, S., Blom, N., Bork, P., Li, S., Cesareni, G., Pawson, T., Turk, B. E., Yaffe, M. B., Brunak, S. and Linding, R. 

Sci. Signal., 1, ra2 (2008)

Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs

Sheridan, D. L., Kong, Y., Parker, S. A., Dalby, K. N., and Turk, B. E.

J. Biol. Chem. 283, 19511-19520 (2008)

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk B. E. and Shaw, R. J.

Mol. Cell. 30, 214-226 (2008)

Understanding and exploiting substrate recognition by protein kinases

Turk, B. E.  

Curr. Opin. Chem. Biol. 12, 4-10 (2008)

Discovery and development of anthrax lethal factor metalloproteinase inhibitors

Turk, B. E.

Curr. Pharm. Biotechnol. 9, 24-33 (2008)

Manipulation of host signaling pathways by anthrax toxins

Turk, B.E. 

Biochem. J. 402, 405-417 (2007)

Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates

Turk, B.E., Hutti, J.E. and Cantley, L.C.

Nat. Protocols 1, 375-379 (2006)

Structure and substrate specificity of the Pim-1 kinase

Bullock, A.N., Debreczeni, J., Knapp, S. and Turk, B.E.

J. Biol. Chem. 280, 41675-41682 (2005)

A rapid method for determining protein kinase phosphorylation specificity

Hutti, J.E., Jarrell, E.T., Chang, J.D., Abbott, D.W., Storz, P., Toker, A., Cantley, L.C. and Turk, B.E.

Nat. Methods 1, 27-29 (2004)

TURK LAB Yale University