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  3.     Our research focus is a tiny cell surface organelle called the cilium. The cilium is present on diverse cell types in vertebrates. Some cilia beat to generate fluid flow or propel sperm movement. The cilium also functions as an antenna for the cell. It detects and transduces environmental signals to regulate diverse cellular responses. Consistent with the wide distribution and functional importance of cilia, defects in this organelle have been linked to  a growing list of human diseases, coined as ‘ciliopathies’, ranging from laterality defects, retinal degeneration, polycystic kidney disease (PKD) to obesity and diabetes. We are using zebrafish as a model system to study the role of the cilium in development and disease, particularly kidney development and PKD.

  1. Sun laboratory

  2. Department of Genetics

  3. Yale University School of Medicine

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