Strobel lab

Publications [PubMed List]

2013

146. M. A. Griffin, J. H. Davis, and S. A. Strobel. Bacterial toxin RelE: A highly efficient ribonuclease with exquisite substrate specificity using atypical catalytic residues. Biochemistry. 52, 8633-8642 (2013) [PubMed].

145. S. A. Strobel. Biochemistry: Metal ghosts in the splicing machine. Nature. 503, 201-202 (2013) [PubMed].

144. S. Li, K. D. Smith, J. H. Davis, P. B. Gordon, R. R. Breaker, and S. A. Strobel. Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins. Proc Natl Acad Sci U S A. 110, 19018-19023 (2013) [PubMed].

143. E. G. Baraban, J. B. Morin, G. M. Phillips, A. J. Phillips, S. A. Strobel, and J. Handelsman. Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis. Tetrahedron Lett. 54, 4058-4060 (2013) [PubMed].

142. C. A. Shanahan, B. L. Gaffney, R. A. Jones, and S. A. Strobel. Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase. Biochemistry. 52, 365-377 (2013) [PubMed].

2012

141. D. I. Hanauer, J. Frederick, B. Fotinakes, and S. A. Strobel. Linguistic analysis of project ownership for undergraduate research experiences. CBE Life Sci. Educ. 11, 378-385 (2012) [PubMed].

140. C. A. Bascom-Slack, A. E. Arnold, and S. A. Strobel. IBI series winner. Student-directed discovery of the plant microbiome and its products. Science. 338, 485-486 (2012) [PubMed].

139. C. A. Shanahan and S. A. Strobel. The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs. Org. Biomol. Chem. 10, 9113-9129 (2012) [PubMed].

138. T. A. Gianoulis, M. A. Griffin, D. J. Spakowicz, B. F. Dunican, C. J. Alpha, A. Sboner, A. M. Sismour, C. Kodira, M. Egholm, G. M. Church, M. B. Gerstein, and S. A. Strobel. Genomic analysis of the hydrocarbon-producing, cellulolytic, endophytic fungus Ascocoryne sarcoides. PLoS Genet. 8, e1002558 (2012) [PubMed].

137. K. D. Smith, S. V. Lipchock and S. A. Strobel. Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry. 51, 425-432 (2012) [PubMed].

136. D. A. Kingery and S. A. Strobel. Analysis of enzymatic transacylase Brønsted studies with application to the ribosome. Acc. Chem. Res. 45, 495-503 (2012) [PubMed].

2011

135. W. A. Anderson, R.M. Amasino, M. Jr Ares, U. Banerjee, B. Bartel, V. G. Corces, C. L. Drennan, S. C. Elgin, I. R. Epstein, E. Fanning, L. J. Jr Guillette, J. Handelsman, G. F. Hatfull, R. R. Hoy, D. Kelley, L. A. Leinwand, R. Losick, Y. Lu, D. G. Lynn, C. Neuhauser, D. K. O'Dowd, T. Olivera, P. Pevzner, R. R. Richards-Kortum, J. Rine, R. L. Sah, S. A. Strobel, G. C. Walker, D. R. Walt, I. M. Warner, S. Wessler, H. F. Willard, R. N. Zare. Competencies: a cure for pre-med curriculum. Science. 334, 760-761 (2011) [PubMed].

134. N. Carrasco, D. A. Hiller and S. A. Strobel. Minimal transition state charge stabilization of the oxyanion during peptide bond formation by the ribosome. Biochemistry. 50, 10491-10498 (2011) [PubMed].

133. D. A. Hiller and S. A. Strobel. The chemical versatility of RNA. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 366, 2929-2935 (2011) [PubMed].

132. C. A. Shanahan, B. L. Gaffney, R. A. Jones and S. A. Strobel. Differential analogue binding by two classes of c-di-GMP riboswitches. J. Am. Chem. Soc. 133, 15578-15592 (2011) [PubMed].

131. J. H. Davis, B. F. Dunican and S. A. Strobel. glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality. Biochemistry. 50, 7236-7242 (2011) [PubMed].

130. D. A. Hiller, V. Singh, M. Zhong, S. A. Strobel. A two-step chemical mechanism for ribosome-catalysed peptide bond formation. Nature 476, 236-239 (2011). [PubMed].

129. J. R. Russell, J. Huang, P. Anand, K. Kucera, A. G. Sandoval, K. W. Dantzler, D. Hickman, J. Jee, F. M. Kimovec, D. Koppstein, D. H. Marks, P. A. Mittermiller, S. J. Núñez, M. Santiago, M. A. Townes, M. Vishnevetsky, N. E. Williams, M. P. Vargas, L. A. Boulanger, C. Bascom-Slack and S. A. Strobel. Biodegradation of polyester polyurethane by endophytic fungi. Appl. Environ. Microbiol. 77, 6076-6084 (2011). [PubMed].

128. H. S. Zaher, J. J. Shaw, S. A. Strobel, R. Green. The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC. EMBO J. 30, 2445-2453 (2011). [PubMed].

127. E. B. Butler, Y. Xiong, J. Wang and S. A. Strobel. Structural basis of cooperative ligand binding by the glycine riboswitch. Chem Biol. 18, 293-298 (2011) [PubMed].

126. K. D. Smith and S. A. Strobel. Interactions of the c-di-GMP riboswitch with its second messenger ligand. Biochem Soc Trans. 39, 647-651 (2011) [PubMed].

125. W. A. Anderson, C. L. Drennan, U. Banerjee, S. C. R Elgin, I. R Epstein, J. Handelsman, G. F. Hatfull, R. Losick, D. K. O’Dowd, B. M. Olivera, S. A. Strobel, G. C. Walker, I. M. Warner. Changing the culture of science education at research universities. Science 331, 152-153 (2011) [PubMed].

124. T.N. Vu and S. A. Strobel. Identification of a tertiary interaction important for cooperative ligand binding by the glycine riboswitch. RNA 17, 74-84 (2011) [PubMed].

2010

123. G. A. Strobel, A. Tomsheck, B. Geary, D. Spakowicz, S. A. Strobel, S. Mattner and R. Mann. Endophyte strain NRRL 50072 producing volatile organics is a species of Ascocoryne. Mycology 1, 187–194 (2010) [Abstract].

122. M. A. Griffin, D. J. Spakowicz and S. A. Strobel. Volatile organic compound production by organisms in the Ascocoryne genus and a reevaluation of myco-diesel production by NRRL 50072. Microbiology 156, 3814-3829(2010) [PubMed].

121. K. D. Smith, S. V. Lipchock, A. L. Livingston, C. A. Shanahan and S. A. Strobel. Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch. Biochemistry 49, 7351-7359 (2010) [PubMed].

120. I. Suydam, S. Levandowski and S. A. Strobel. Catalytic importance of a protonated adenosine in the hairpin ribozyme active site. Biochemistry 49, 3723-3732 (2010) [PubMed].

119. D. A. Hiller, M. Zhong, V. Singh and S. A. Strobel. Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects. Biochemistry 49, 3868-78 (2010) [PubMed].

118. A. H. Antonioli, J. C. Cochrane, S. V. Lipchock, and S. A. Strobel. Plasticity of the RNA kink turn structural motif. RNA 16, 762-768 (2010) [PubMed].

2009

117. K. D. Smith, S. V. Lipchock, T. D. Ames, J. Wang , R. R. Breaker, and S. A. Strobel. Structural basis of ligand binding by a c-di-GMP riboswitch. Nat. Struct. Mol. Biol. 16, 1218-23 (2009) [PubMed].

116. Lee S. J., G. A. Strobel, K. Eisenman, B. Geary, P. N. Vargas, S. A. Strobel. Aurosphaeria, a novel coelomycetous genus. Mycotaxon 107, 463–472 (2009).

115. C. A. Bascom-Slack, C. Ma, E. Moore, B. Babbs, K. Fenn, J. S. Greene, B. D. Hann, J. Keehner, E. G. Kelley-Swift, V. Kembaiyan, S. J. Lee, P. Li, D. Y. Light, E. H. Lin, M. A. Schorn, D. Vekhter, L. A. Boulanger, W. M. Hess, P. N. Vargas, G. A. Strobel, S. A. Strobel. Multiple, Novel Biologically Active Endophytic Actinomycetes Isolated from Upper Amazonian Rainforests. Microb Ecol. 58, 374-383 (2009) [PubMed].

114. J. C. Cochrane, S. V. Lipchock, K. D Smith, and S. A. Strobel. Structural and Chemical Basis for Glucosamine 6-Phosphate Binding and Activation of the glmS Ribozyme. Biochemistry 48, 3239-3246 (2009) [PubMed].

2008

113. I. T. Suydam and S. A. Strobel. Fluorine substituted adenosines as probes of nucleobase protonation in functional RNAs. J. Am. Chem. Soc. 130, 13639-13648 (2008) [PubMed].

112. S. A. Smith, D. C. Tank, L. A. Boulanger, C. A. Bascom-Slack, K. Eisenman, D. Kingery, B. Babbs, K. Fenn, J. S. Greene, B. D. Hann, J. Keehner, E. G. Kelley-Swift, V. Kembaiyan, S. J. Lee , P. Li, D. Y. Light, E. H. Lin, C. Ma, E. Moore, M. A. Schorn, D. Vekhter, P. V. Nunez, G. A. Strobel, M. J. Donoghue, S. A. Strobel. Bioactive endophytes warrant intensified exploration and conservation. PLoS ONE. 3, e3052 (2008) [PubMed].

111. K. S. Huang, N. Carrasco, E. Pfund, and S. A. Strobel. Transition State Chirality and Role of the Vicinal Hydroxyl in the Ribosomal Peptidyl Transferase Reaction. Biochemistry 47, 8822-8827(2008) [PubMed].

110. J. C. Cochrane and S. A. Strobel. Catalytic Strategies of Self-Cleaving Ribozymes. Acc Chem Res. (2008) [PubMed].

109. D. A. Kingery, E. Pfund, R. M. Voorhees, K. Okuda, I. Wohlgemuth, D. E. Kitchen, M. V. Rodnina, and S. A. Strobel. An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction. Chem. Biol.15, 493-500 41, 1027-1035 (2008) [PubMed].

108. J. C. Cochrane and S. A. Strobel. Riboswitch effectors as protein enzyme cofactors. RNA 14, 993-1002 ( 2008) [PubMed].

107. S. V. Lipchock and S. A. Strobel. A relaxed active site after exon ligation by the group I intron. Proc. Natl. Acad. Sci. 105, 5699-5704 (2008) [PubMed].

106. M. Zhong and S. A. Strobel. Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction. J. Org. Chem. 73, 603-611 (2008) [PubMed].

105. M. Kwon and S. A. Strobel. Chemical basis of glycine riboswitch cooperativity. RNA 14, 25-34 (2008) [PubMed].

2007

104. S. A. Strobel and J. C. Cochrane. RNA catalysis: ribozymes, ribosomes and riboswitches. Curr. Opin. Chem. Biol. 11, 636-643 (2007) [PubMed].

103. S. A. Strobel and G. A. Strobel, Plant endophytes as a platform for discovery-based undergraduate science education, Nature Chem. Biol. 3, 356-359 (2007) [PubMed].

102. M. R. Stahley, P. L. Adams, J. Wang, and S. A. Strobel. Structural metals in the group I intron: a ribozyme with a multiple metal ion core. J. Mol. Biol. 372, 89-102 (2007) [PubMed].

101. R. M. Anderson, M. Kwon, and S. A. Strobel. Toward ribosomal RNA catalytic activity in the absence of protein. J. Mol. Evo. 64, 472-483 (2007) [PubMed].

100. J. C. Cochrane, S. V. Lipchock, and S. A. Strobel. Structural investigation of the GlmS ribozyme bound to its catalytic cofactor. Chemistry & Biology. 14, 97-105 (2007) [PubMed].

99. J. S. Weinger and S. A. Strobel. Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics. Blood, Cells, Molecules & Diseases. 38, 110-116 (2007) [PubMed].

2006

98. S. A. Strobel. Book Review. Present at the Flood: How Structural Molecular Biology Came About by Richard E. Dickerson. Structure 14, 809-810 (2006).

97. S. A. Strobel. A general two-metal mechanism for RNA and protein catalysts. The Biochemist. 28, 21-24 (2006).

96. M. L. Gill, S. A. Strobel, and J. P. Loria. Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex. Nucleic Acids Research. 34, 4506-4514 (2006) [PubMed].

95. M. R. Stahley and S. A. Strobel. RNA splicing: group I intron crystal structures reveal the basis of splice site selection and metal ion catalysis. Curr. Opin. Struct. Biol. 16, 319-326 (2006) [PubMed].

94. J. S. Weinger and S. A. Strobel. Participation of the tRNA A76 hydroxyl groups throughout translation. Biochemistry. 16, 5939-5948 (2006) [PubMed].

93. K. S. Huang, E. B. Butler and S. A. Strobel. Regiospecificity of the peptidyl tRNA ester within the ribosomal P site. J. Am. Chem. Soc. 15, 3108-3109 (2006) [PubMed].

92. M. Zhong and S. A. Strobel. Synthesis of the ribosomal P-site substrate CCA-pcb. Organic Letters. 8, 55-58 (2006) [PubMed].

2005

91. S. A. Strobel and T. W. Muir. Biopolymers. Exploring biological function through chemical manipulation of biopolymers. Current Opin. Chem. Biol. 9, 545-547 (2005) (Volume co-editor).

90. S. A. Strobel. Ribonucleic general acid. Nature Chem. Biol. 1, 5-6 (2005).

89. M. L. Gill, S. A. Strobel and J. P. Loria. 205Tl NMR methods for the characterization of monovalent cation binding to nucleic acid. J. Am. Chem. Soc. 127, 16723-16732 (2005) [PubMed].

88. T. M. Schmeing, K. S. Huang, S. A. Strobel and T. A. Steitz. Structural insights into the roles of water and the 2' hydroxyl of the P-site tRNA in the peptidyl transferase reaction. Molec. Cell. 20, 437-448 (2005) [PubMed].

87. T. M. Schmeing, K. S. Huang, S. A. Strobel and T. A. Steitz. Induced-fit mechanism for the peptidyl transferase reaction of the large ribosomal subunit. Nature. 438, 520-524 (2005) [PubMed].

86. M. R. Stahley and S. A. Strobel. Structural evidence for a two-metal-ion mechanism of group I intron splicing. Science. 309, 1587-1590 (2005) [PubMed].

85. L. B. Weinstein Szewczak, J. S. Gabrielsen, S. J. Degregario, S. A. Strobel and J. A. Steitz. Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein. RNA. 11, 1407-1419 (2005) [PubMed].

84. K. Okuda, A. C. Seila and S. A. Strobel. Uncovering the Enzymatic pKa of the Ribosomal Peptidyl Transferase Reaction Utilizing a Fluorinated Puromycin Derivative. Biochemistry. 44, 6675-6684 (2005) [PubMed].

83. A. C. Seila, K. Okuda, S. Nunez, A. F. Seila and S. A. Strobel. Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction. Biochemistry. 44, 4018-4027 (2005) [PubMed].

2004

82. S. A. Strobel, P. L. Adams, M. R. Stahley and J. Wang. RNA kink turns to the left and to the right. RNA. 10, 1852-1854 (2004) [PubMed].

81. P. L. Adams, M. R. Stahley, M. L. Gill, A. B. Kosek, J. Wang and S. A. Strobel. Crystal structure of a group I intron splicing intermediate. RNA. 10, 1867-1887 (2004) [PubMed].

80. K. Okuda, A. Seila, S. A. Strobel. Synthesis of isotopically labeled puromycin derivatives for kinetic isotope effect studies on ribosome catalyzed peptide bond formation. Tetrahedron. 60, 12101-12112 (2004).

79. J. S. Weinger, K. M. Parnell, S. Dorner, R. Green and S. A. Strobel. Substrate-assisted catalysis of peptide bond formation by the ribosome. Nature Struc. Molec. Biol. 11, 1101-1106 (2004) [PubMed].

78. A. Eversole-Hesslein, V. I. Katunin, M. Beringer, A. B. Kosek, M. V. Rodnina and S. A. Strobel. Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes. Nucleic Acids Res. 32, 3760-3770 (2004) [PubMed].

77. P. L. Adams, M. R. Stahley, A. B. Kosek, J. Wang and S. A. Strobel. Crystal structure of a self-splicing group I intron with both exons. Nature. 430, 45-50 (2004) [PudMed].

76. J. C. Cochrane and S. A. Strobel. Probing RNA structure and function by Nucleotide Analogue Interference Mapping. Curr. Protocols Nucleic Acid Chem. 6.9.1- 6.9.21 (2004).

75. J.S. Weinger, D Kitchen, SA Scaringe, SA Strobel and GW Muth. Solid phase synthesis and bindingaffinity of peptidyle transferase transition state mimics containing 2'-OH and P-site position A76. Nucleic Acids Res. 32, 1502-1511 (2004) [PubMed].

2003

74. K. M. Parnell and S. A . Strobel. HIS & HERS, magic magnesium and the ballet of protein synthesis. Curr. Op. in Chem. Bio. 7 528-533 (2003) [PubMed].

73. J. Cochrane, R. Batey and S.A. Strobel. Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping. RNA. 10, 1282-1289 (2003) [PubMed].

72. H. D. Cho, A. K. Oyelere, S. A. Strobel and A. M. Weiner. Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection. RNA. 9, 970-981 (2003) [Pubmed].

71. F. D. Jones and S. A. Strobel. Ionization of a critical adenosine residue in the Neurospora Varkud Satellite ribozyme active site. Biochemistry. 42, 4265-4276 (2003) [PubMed].

2002

70. S. A. Strobel. Biochemical identification of A-minor motifs within RNA tertiary structure by interference analysis. Biochem. Soc. Trans. 30 1126-1131 (2002).

69. L. B. W. Szewczak, S. A. Strobel and J. A. Steitz. Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP. Chem. & Biol. 9, 1095-1107 (2002) [PubMed].

68. K. M. Parnell, A. C. Seila and S. A. Strobel. Evidence against stabilization of the transition state oxyanion by the peptidyl transferase center of the ribosome. Proc. Natl. Acad. Sci. U.S.A. 99, 11658-63 (2002) [PubMed].

67. J. K. Soukup, N. Minakawa, A. Matsuda, S. A. Strobel. Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping. Biochemistry. 41, 10426-38 (2002) [Pubmed].

66. V. I Katunin, G. W. Muth, S. A. Strobel, W. Wintermeyer and M. V. Rodina. Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. Molecular Cell. 10, 339-346 (2002) [PubMed].

65. T. M. Schmeing, A. C. Seila, J. L. Hansen, B. Freeborn, J. K. Soukup, S. A. Scaringe, S. A. Strobel, P. B. Moore and T. A. Steitz. A pre-translocation intermediate in peptide bond formation observed in crystals of enzymatically active subunits. Nature Struc. Biol. 9, 225-230 (2002) [PubMed].

64. S. P. Ryder and S. A. Strobel. Comparative analysis of hairpin ribozyme structures: summary and survey. Nucleic Acids Res. 30, 1287-91 (2002).

63. A. K. Oyelere, J. Kardon and S. A. Strobel. pKa perturbation in Hepatitis Delta Virus ribozyme catalysis evidenced by nucleotide analog interference mapping. Biochemistry. 41, 3667-75 (2002).

62. A. A. Szewczak, A. B. Kosek, J. A. Piccirilli and S. A. Strobel. Identification of an active site ligand for a group I ribozyme catalytic metal ion. Biochemistry. 41, 2516-25 (2002).

2001

61. S. A. Strobel, G. W. Muth and L. Chen. Exploring the mechanism of the peptidyl transferase reaction by chemical footprinting. Cold Spring Harbor Symp. Quant. Biol. 66, 109-117 (2001).

60. F. D. Jones, S. P. Ryder and S. A. Strobel. An efficient ligation reactionpromoted by a VS ribozyme with extended 5' and 3' termini. Nucleic Acids Res. 29, 5115-20 (2001).

59. G. W. Muth, L. Chen, A. B. Kosek and S. A. Strobel. pH dependent conformational flexibility within the ribosomal peptidyl transferase center. RNA. 7, 1403-1415 (2001).

58. S. P. Ryder, A. K. Oyelere, J. Podilla, D. Klostermeier, D. Millar and S. A. Strobel. Investigation of Adenosine Base Ionization in the Hairpin Ribozyme. RNA. 7, 1454-1463 (2001).

57. A. K. Oyelere and S. A. Strobel. Synthesis of 5'-O-Silyl-2'-O-orthoester Protected Phosphoramidite of 6-Azauridine and its Incorporation into the Genomic HDV Ribozyme. Nucleotides, Nucleosides and Nucleic Acids. 20, 1851-58 (2001).

56. S. A. Strobel. Chemical approaches to the structural and functional analysis of RNA. Methods. 23, 199-200 (2001).

55. S. A. Strobel. Biological Catalysis: Repopulating the RNA World. Nature. 411, 1003-1105 (2001).

54. S. A. Strobel and S. P. Ryder. Biological Catalysis: The Hairpin's Turn Nature. 410, 761-763 (2001).

53. S. A. Strobel. Editorial. Methods. 23, 199-200 (2001).

52. S. Basu and S. A. Strobel. Biochemical Detection of Monovalent Metal Ion Binding Sites in RNA. Methods. 23, 264-275 (2001).

2000

51. A. K. Oyelere and S. A. Strobel. Biochemical Detection of Cytidine Protonation within RNA. J. Amer. Chem. Soc. 42, 10259-10267 (2000).

50. J. Strauss-Soukup and S. A. Strobel. A Chemical Phylogeny of Group I Introns Base upon Interference Mapping of a Bacterial Ribozyme. J. Mol. Biol. 302, 339-358 (2000).

49. G. W. Muth, L. Ortoleva-Donnelly and S. A. Strobel. A Single Adenosine with a Neutral pKa in the Ribosomal Peptidyl Transferase Center. Science. 289, 947-50 (2000).

48. S. Basu, A. A. Szewczak and S. A. Strobel. Direct Detection of Monovalent Metal Ion Binding to a DNA G-quartet by 205Tl NMR. J. Amer. Chem. Soc. 122, 3240-41 (2000).

47. S. P. Ryder, L. Ortoleva-Donnelly, A. B. Kosek and S. A. Strobel. Nucleotide Analog Interference Mapping, Methods Enzymology. 317, 92-109 (2000).

1999

46. S. Basu and S. A. Strobel. Thiophilic Metal Ion Rescue of Phosphorothioate Interference within the Tetrahymena Ribozyme P4-P6 Domain. RNA. 5, 1399-1407 (1999).

45. A. A. Szewczak, L. Ortoleva-Donnelly, M. V. Zivarts, A. K. Oyelere, A. V. Kazantsev and S. A. Strobel. Defining a Network of Hydrogen Bonds that Mediates Substrate Binding and Helps Organize the Active Site of the Tetrahymena Group I Intron. Proc. Natl. Acad. Sci. USA 96, 11183-88 (1999).

44. S. A. Strobel. A Chemogenetic Approach to RNA Function/Structure Analysis. Curr. Op. Struc. Biol. 9, 346-352 (1999).

43. S. A. Strobel. Catalytic RNA/Ribozymes & Group I/Group II Introns. Encyclopedia of Molecular Biology, Ed. T. E. Creighton, John Wiley & Sons, Inc., New York (1999).

42. S. P. Ryder and S. A. Strobel. Nucleotide Analog Interference Mapping of the Hairpin Ribozyme: Implications for Secondary and Tertiary Structure Formation. J. Mol. Biol. 291, 295-311 (1999).

41. S. P. Ryder and S. A. Strobel. Nucleotide Analog Interference Mapping. Methods. 18, 38-50 (1999).

40. J. Strauss-Soukup and S. A. Strobel. Ribozyme Enzymology. In Comprehensive Natural Products Chemistry, vol. 6 Prebiotic Chemistry, Molecular Fossils, Nucleosides, and RNA; Vol. Ed.: D. Soll, S. Nishimura and P. B. Moore, Elsevier Science Press, Oxford, pp. 149-168 (1999).

39. L. Ortoleva-Donnelly and S. A. Strobel. A Hydrogen Bonding Triad Stabilizes the Tetrahymena Ribozyme Chemical Transition State. Chem. & Biol. 6, 153-165 (1999).

38. D. Siew, N. Zahler, A. G. Cassano, S. A. Strobel and M. Harris. Identification of Adenosine Functional Groups Involved in Substrate Binding by the Ribonuclease P Ribozyme. Biochemistry 38, 1873-1883 (1999).

1998

37. J. P. Rife, C. S. Chang, P. B. Moore and S. A. Strobel. The Synthesis of RNA Containing the Modified Nucleotides N2-methylguanosine and N6,N6-dimethyladenosine. Nucleosides & Nucleotides17, 2281-2288 (1998).

36. S. Basu, R. Rambo, J.K. Strauss-Soukup, J. H. Cate, A. R. Ferre-D’ Amare, S. A. Strobel and J. A. Doudna. A Specific Monovalent Metal Ion Integral to the A-A Platform of the RNA Tetraloop Receptor. Nature Struc. Biol. 5, 986-992 (1998).

35. A. A. Szewczak, L. Ortoleva-Donnelly, S. P. Ryder and S. A. Strobel. A Minor Groove Triple Helix within the catalytic core of a group I intron.Nature Struc. Biol. 5, 1037-1042 (1998).

34. L. Ortoleva-Donnelly, M. Kronman and S. A. Strobel. Identifying RNA Minor Groove Tertiary Contacts by Nucleotide Analog Interference Mapping with N2-Methylguanosine. Biochemistry 37, 12933-12942 (1998).

33. J. P. Rife, C. S. Chang, P. B. Moore and S. A. Strobel. N2-Methylguanosine is Iso-energetic with Guanosine in RNA Duplexes and a GNRA TetraloopNucleic Acids Res. 26, 3640-3644 (1998).

32. L. Ortoleva-Donnelly, A. A. Szewczak, R. R. Gutell and S. A. Strobel. The Chemical Basis of Adenosine Conservation throughout the Tetrahymena Ribozyme. RNA 4, 498-519 (1998).

31. S. A. Strobel, L. Ortoleva-Donnelly, S. Ryder, J. H. Cate and E. Moncoeur. Complementary Sets of Noncanonical Base Pairs Mediate RNA Helix Packing in the Group I Intron Active Site. Nature Struc. Biol. 5, 60-67 (1998).

30. S. A. Strobel. Ribozyme Chemogenetics, Biopolymers: Nucleic Acid Science 48, 65-81 (1998).

1997

29. S. A. Strobel and J. A. Doudna. RNA Seeing Double: Close Packing of Helices in RNA Tertiary Structure.TiBS22, 262-266 (1997).

28. S. A. Strobel and K. Shetty. Defining the Chemical Groups Essential for Tetrahymena Group I Intron Function by Nucleotide Analog Inteference Mapping. Proc. Natl. Acad. Sci. USA 94, 2903-2908 (1997).

1996

27. C. C. Query, S. A. Strobel, P. A. Sharp, Three Recognition Events at the Branch Site Adenine. EMBO J.15, 1392-1402 (1996).

26. S. A. Strobel and T. R. Cech. The Exocyclic Amine of the Conserved G·U Pair at the Cleavage Site of the Tetrahymena Ribozyme Contributes to 5’-Splice Site Selection and Transition State Stabilization. Biochemistry 35, 1201-1212 (1996).

1995

25. C. C. Query, S. A. Strobel, and P. A. Sharp. The Branch Site Adenosine is Recognized Differently for the Two Steps of Pre-mRNA Splicing. Nucleic Acids Symposium Series 33, 224-225 (1995).

24. S. A. Strobel and T. R. Cech. Minor Groove Recognition of the Conserved G·U Pair at the Tetrahymena Ribozyme Reaction Site. Science 267, 675-679 (1995).

1994

23. S. A. Strobel, T. R. Cech, N. Usman, L. Beigelman. The 2, 6-Diaminopurine Riboside·5-Methyl-Isocytidine Wobble Base Pair: An Isoenergetic Substitution for the Study of G·U Pairs in RNA. Biochemistry33, 13824-35 (1994).

22. A. M. Pyle, S. Moran, S. A. Strobel, T. Chapman, D. H. Turner, and T. R. Cech. Replacement of the Conserved G·U with a G-C Pair at the Cleavage Site of the Tetrahymena Ribozyme Decreases Binding, Reactivity, and Fidelity. Biochemistry33, 13856-63 (1994).

21. S. A. Strobel and T. R. Cech. Translocation of an RNA Duplex on a Ribozyme. Nature Struct. Biol. 1, 13-17 (1994).

1993

20. S. A. Strobel and T. R. Cech. Tertiary Interactions with the Internal Guide Sequence Mediate Docking of the P1 Helix into the Catalytic Core of the Tetrahymena Ribozyme. Biochemistry32, 13593-13604 (1993).

19. T. R. Cech, P. C. Bevilacqua, J. A. Doudna, T. S. McConnell, S. A. Strobel, and L. B. Weinstein. Mechanism and Structure of a Catalytic RNA Molecule. The Robert A. Welch Foundation Conferences on Chemical Research, Vol. XXXVII, pp. 91-110 (1993).

18. The Huntington's Disease Collaborative Research Group; A Novel Gene Containing a Trinucleotide Repeat That is Expanded and Unstable on Huntingon's Disease Chromosomes. Cell 72, 971-983 (1993).

1992

17. S. A. Strobel and T. R. Cech; Efficient Ligation of a Highly Structured RNA using T4 DNA Ligase. Comments 19, 89-91 (1992).

16. S. A. Strobel and P. B. Dervan; Triple Helix-Mediated Single-Site Enzymatic Cleavage of Megabase Genomic DNA. R. Wu (Ed.): Methods in Enzymology: Recombinant DNA, Part G, 216, 309-321 (1992) Academic Press, San Diego, CA.

15. T. J. Povsic, S. A. Strobel and P. B. Dervan; Sequence-Specific Double-Strand Alkylation and Cleavage of DNA Mediated by Triple-Helix Formation. J. Am. Chem. Soc. 114, 5934-41 (1992).

1991

14. S. A. Strobel, L. A. Doucette-Stamm, L. Riba, D. E. Housman and P. B. Dervan; Site Specific Enzymatic Cleavage of a Human Chromosome Mediated by Triple Helix Formation. Science 254, 1639-1642 (1991).

13. S. A. Strobel and P. B. Dervan; Single Site Enzymatic Cleavage of the Yeast Genome Mediated by Triple Helix Formation.Nature350, 172-174 (1991).

12. F. Sugawara, S. A. Strobel, G. A. Strobel, R. D. Larsen, D. Berglund, G. Gray, N. Takahashi, T. J. Stout and J. Clardy; The Structure and Biological Activity of Cercosporamide from Cecosporidium henningsii. J. Org. Chem. 56, 909-910 (1991).

1990

11. S. A. Strobel and P. B. Dervan; Site Specific Cleavage of a Yeast Chromosome by Oligonucleotide Directed Triple Helix Formation. Science 249, 73-75 (1990).

10. D. F. Wiemer, L. K. Wolfe, W. Fenical, S. A. Strobel, G. D. Van Duyne and J. Clardy; New Sesquiterpenoids from the Indian Ocean Telestacean Octocoral Coelogorgia palmosa. Tetrahedron Letters 31, 1973-1976 (1990)

9. V. Roussis, Z. Wu, W. Fenical, S. A. Strobel, G. D. Van Duyne and J. Clardy; New Antiinflammatory Pseudopterosins from the Marine Octocoral Pseudopterogorgia elisabethae. J. Org. Chem. 55, 4916-4922 (1990).

1989

8. S. A. Strobel and P. B. Dervan; Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA. J. Amer. Chem. Soc. 111, 7286-7287 (1989).

1988

7. S. A. Strobel, H. E. Moser and P. B. Dervanc; Double Strand Cleavage of Genomic DNA at a Single Site by Triple-Helix Formation.J. Amer. Chem. Soc. 110, 7927-7929 (1988).

6. D. M. Bedwell, S. A. Strobel, K. Yun, G. D. Jongeward and S. D. Emr; Sequence and Structural Requirements of a Mitochondrial Protein Import Signal Defined by Saturation Cassette Mutagenesis. Molec. Cell. Biol. 9, 1014-1025 (1988).

5. D. Kenfield, S. A. Strobel, F. Sugawara, D. Berglund and G. A. Strobel; Triticone A: A Novel Bioactive Lactam with Potential as a Molecular Probe. Biochem. Biophys. Res. Comm. 157, 174-182 (1988).

4. D. L. Berglund, S. A. Strobel, F. Sugawara and G. Strobel; Flow Cytometry as a Method for Assaying the Biological Activity of Phytotoxins. Plant Science 56, 183-188 (1988).

3. F. Sugawara, N. Takahashi, G. A. Strobel, S. A. Strobel, M. S. M. Lu and J. Clardy; Triticones A and B, Novel Phytotoxins from the Plant Pathogenic Fungus Drechslera tritici-repentis. J. Amer. Chem. Soc. 110, 4086 (1988).

1987

2. J. H. Cardellina, R. L. Hendickson, K. P. Manfredi, S. A. Strobel and J. Clardy; Bissetone, A Unique Antimicrobial Pyranone from the Gorganian Briareum polyanthes.Tetrahedron Letters 28, 727-730 (1987).

1986

1. J. S. Bradshaw, P. Huszthy, H. Koyama, S. G. Wood, S. A. Strobel, R. B. Davidson, R. M. Izatt, N. K. Dalley, J. D. Lamb and J. J. Christensen; Proton-Ionizable Crown Compounds. 8. Synthesis and Structural Studies of Macrocyclic Polyether Ligands Containing a 4-Thiopyridone Subcyclic Unit. J. Heterocyclic Chem. 23, 1837-1843 (1986).