Jimin Wang, PhD.
Research Scientist


Welcome!

Please visit Jimin Wang's new page

Department of Molecular Biophysics and Biochemistry


You are the th visitor at the local time: (This line is created using the Count-Man)

Here is my rayshade colletion of RB69 DNA polymerase (also known as gp43):


gp43 in sunrise. gp43 in a wineglass. DNA and gp43 in aineglass. gp43 in a wineglass.
And many other variations ( Rb69 replisome model , rb69.cell , C , and D ,).

BioSketch

Born in Zhejiang, PR China
B.Sc. Chemistry, Peking University, Beijing, China, 1982;
Ph.D. Chemistry, University of California, San Diego, 1988;
Postdoctoral Associate, Yale University, New Haven, 1988-1991;
Associate Research Scientist, Yale University, New Haven, 1991-1996;
Research Scientist, Yale University, New Haven, 1996-1998.

Research Interest

To understand mechanisms of the information processing apparatuses, ie, from DNA to DNA, DNA to RNA, RNA to polypeptide, and polypeptide to folded, functional protein, and finally to its destruction, at atomic level by x-ray crystallography. Each apparatus or machinery comprises of many protein components and is assembled into a large size in a so called "molecular organelle", making its study very chanllenging and more interesting. My point is exactly: the larger the machinery size, the more interesting the structure. Who says the size does not matter!

Selected Publications

( Also see Medline Entrez search results for Dr. Jimin Wang)

Insights into editing from the structure of ile-tRNA synthetase with tRNA(ile) and mupirocin.
L.F. Silvian, J. Wang, & T.A. Steitz (1999), Science, 285, 1074-1077 .

New insights into the ATP-dependent Clp protease: E. coli and beyond.
J. Porankiewicz, J. Wang, & A.K. Clarke (1999), Molecular Microbiology, 32, 449-458.

Crystal Structure Determination of Escherichia coli ClpP Starting from an EM-Derived Mask.
J. Wang, J.A. Hartling, & J.M. Flanagan (1998), J. Struct. Biol. 124, 151-163.

The structure of ClpP at 2.3 Angstroms resolution suggests a model for ATP-dependent proteolysis.
J. Wang, J.A. Hartling, & J.M. Flanagan (1997). Cell, 91, 447-456.

Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
J. Wang, A.K.M.A Satter, C.C. Wang, J.D. Karam, W.H. Konigsberg, & T.A. Steitz (1997),
Cell, 89,1087-1099.

The structure of Taq polymerase with DNA at the polymerase active site.
S.H. Eom, J. Wang, & T.A. Steitz (1996) Nature, 382, 278-281.

The crystal structure of elongation factor G complex with GDP at 2.7 Angstroms.
J. Czworkowski, J. Wang, T.A. Steitz, & P.B. Moore (1994) EMBO J, 13, 3661-3668.

Crystal structure at 3.5 Angstroms resolution of HIV-1 reverse transcriptase with an inhibitor.
L.A. Kohlstaedt, J. Wang, J.M. Friedman, P.A. Rice, & T.A. Steitz (1992) Science, 256, 1783-1790.

X-ray structure of recombinant yeast cytochrome c peroxidase and three cleft mutants prepared by site-directed mutagenesis.
J.M. Wang, J.M. Mauro, S.L. Edwards, S.T. Oatley, L.A. Fishel, V.A. Ashford, Ng.-H. Xuong, & J. Kraut (1990), Biochemistry , 29, 7160-7173.


Here are some online Journals.

Other Interest

I also enjoy figure skating, ballet dance, and photography.
Einstein was also thinking about figure skating, wasn't he?

Here are some of my photo albums from the 1995 New Haven Ballet's Nutcracker with guest star dancers from New York City Ballet (Reheasals: swan dive, uplift, shoulder lift, pirouette, prince and pricess, and pas de duex ). Can you find where I am?



Jimin Wang, PhD
Dept. Molecular Biophysics and Biochemistry, Bass Center, Room 415
266 Whitney Ave., New Haven CT 06520-8114
Phones: (203) 432-5625 or 432-5611; FAX: (203) 432-3282.
E-mail: wang {at} csb.yale.edu
Last update: Nov 18, 1998