1. Control of cell division and cell morphology in yeast

2. Characterization of proteomes

3. Analysis of regulatory circuits in yeast

4. Characterization of the human genome

5. Sex-specific gene expression in mammals

To better understand the molecular differences between adult males and females in mammals we have analyzed gene expression in kidney, liver, brain and reproductive tissues in mice and brain tissues in human.  We have found little sex specific gene expression in the hypothalamus, but significant differences in gene expression in the reproductive tissues (as expected).  We also found a number of differences in gene expression in male and female liver and kidney.  The majority of differentially expressed genes are involved in drug metabolism and osmotic regulation; the latter is important for controlling hypertension.  These results have important implications in understanding the different physiology of males and females and how they lead to different sex specific difference in human health and its control.