Papers from the Slack Lab

Babar, I A., F. J. Slack, J. B. Weidhaas microRNA modulation of the cellular stress response. Future Oncology. 4:289-298.

A. Esquela-Kerscher, J. Weidhaas, and F. J. Slack. MicroRNA detection and profiling. Invited review for Methods in Molecular Biology by Humana Press, USA. In press.

Niwa, R. F. Zhou, C. Li and F. J. Slack. (2008) C. elegans Alzheimer APP-like is regulated by developmental timing microRNAs and their targets. Dev Biol. Jan 8; [Epub ahead of print]

Weidhaas, J., I. Babar, S. Naller, S. Roush, M. Boehm, and F. J. Slack. (2007) MicroRNAs as Potential Agents to Alter Resistance to Cytotoxic anti-Cancer Therapy. Cancer Res.67:11111-11116.

Chan, S-P., and F. J. Slack. (2007) And now introducing mammalian mirtrons. Dev. Cell. 13:605-607.

Chin, L. and F. J. Slack. (2007) MicroRNA mediated regulation of gene expression. Invited review for RNA and the regulation of Gene Expression (Horizon Scientific Press). In press.

Kato, M. and F. J. Slack. (2007) microRNAs: small molecules with a big role in biology and disease. Invited review for Biology of the Cell. 100:71-81.

Johnson, C., Esquela-Kerscher, A., Stefani, G., Byrom, M., Kelnar, K., Ovcharenko, D., Wilson, M., Wang, X., Shelton, J., Shingara, J., Brown, D., and F.J. Slack. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 67:7713-7722.

Nolde, M., N. Saka, K. Reinert and F. J. Slack. (2007) The C. elegans Pumilio homologue, PUF-9 is required for 3' UTR mediated regulation of the let-7 microRNA target, hbl-1. Dev. Biol. Mar 3 Epub ahead of print.

Niwa, R. and F. J. Slack. (2007) Evolution of microRNA function. Curr Opin Genet Dev. 17:145-50. Epub 2007 Feb 20.

Babar, I., and F.J. Slack (2007) MicroRNAs in Cancer. Am. Soc. Clin. Oncol. Ed Book. p716-719

Mona Nolde and F. J. Slack. MicroRNAs in C. elegans. In Regulation of Gene Expression by Small RNAs (CRC Press). In press.

Chan, S-P and F. J. Slack. (2006) microRNA-mediated silencing inside P-bodies. RNA Biol. 3:97-100.

Stefani, G and F. J. Slack. (2006) MicroRNAs in search of targets. Invited review for CSHL Quantitative Symposium. Available online.

Niwa, R. and F. J. Slack. Ins and outs of RNAi analysis. Invited review for Molec. Cell. In press.

Niwa, R. and F. J. Slack. Evolution of microRNA function. Invited review for Current Opinion in Genetics and Development. In press.

Boehm, M. and F. J. Slack. (2006) microRNA control of lifespan and metabolism. Cell Cycle. Vol: 5 Issue: 8 16 April 2006 pp e1-e4.

Roush, S. and F. J. Slack. (2006) Micromanagement: microRNAs stabilize mRNAs. ACS Chem. Biol. 1 (3), 132-134

Esquela-Kerscher, A. and F. J. Slack.(2006) Oncomirs - microRNAs with a role in cancer. Nature Reviews Cancer. 6:259-269. (Featured and cover article)

Slack, F. J. and J. B. Weidhaas. (2006) MicroRNAs as a potential magic bullet in cancer. Future Oncology. 2:73-82.

Boehm, M., and F. J. Slack. (2005). A developmental timing microRNA and its target regulate life span in C. elegans. Science. 310:1954-1957.

Schulman, B., A. Esquela-Kerscher, and F. J. Slack. (2005) Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev. Dyn. 234:1046-1054.

Esquela-Kerscher, A., S. M. Johnson, L. Bai, K. Saito, J. Partridge, K. Reinert and F. J. Slack. (2005) Post-embryonic expression of C. elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and reproductive system. Dev Dyn. 234:868-877.

Vella, M and F. J. Slack. (2005) C. elegans microRNAs. WormBook, ed. The C. elegans Research Community, WormBook,doi/10.1895/wormbook.1.26.1, http://www.wormbook.org.

Johnson, S., H. Grosshans, J. Shingar, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K. L. Reinert, D. Brown, and F. J. Slack. (2005) RAS is regulated by the let-7 microRNA family. Cell. 120:635-647.

Grosshans, H., T. Johnson, M. K. Reinert, Gerstein and F. J. Slack. (2005) The temporal patterning microRNA let-7 controls several transcription factors during the larval to adult transition in C. elegans. Dev. Cell. 8:321-330.

Banerjee, D., A. Kwok, S.-Y. Lin, and F. .J. Slack. (2005) Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev. Cell. 8:287-295.

Banerjee, D. and F.J. Slack. (2005) Temporal and spatial patterning of an organ by a single transcription factor. Genome Biol. 6:205-208.

Esquela-Kerscher, A. and F. J. Slack (2004) The age of high-throughput microRNA profiling. Nature Methods. 1:106-107.

Vella, M.C., K. Reinert and F. J. Slack. (2004) Architecture of a validated microRNA::target interaction. Chem. Biol. In press

Ramaswamy, G. and F. J. Slack (2004) The silent revolution. Review on the Book RNAi: A Guide to Gene Silencing edited by Gregory Hannon. Nature Cell Biol. 6:277.

Vella M. C., E.-Y. Choi, S.-Y. Lin, K. Reinert, and F. J. Slack. (2004) The C. elegans microRNA let-7 binds to imperfect complementary sites from the lin-41 3’UTR. Genes Dev. 18:132-137.

1:	Johnson SM, Lin SY, Slack FJ.	Related Articles, Links
	The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev Biol. 2003 Jul 15;259(2):364-79. PMID: 12871707 [PubMed - in process]

2:	Lin SY, Johnson SM, Abraham M, Vella MC, Pasquinelli A, Gamberi C, Gottlieb E, Slack FJ.	Related Articles, Links
	The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell. 2003 May;4(5):639-50. PMID: 12737800 [PubMed - indexed for MEDLINE]

3:	Ramaswamy G, Slack FJ.	Related Articles, Links
	siRNA. A guide for RNA silencing. Chem Biol. 2002 Oct;9(10):1053-5. PMID: 12401489 [PubMed - indexed for MEDLINE]

4:	Banerjee D, Slack F.	Related Articles, Links
	Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression. Bioessays. 2002 Feb;24(2):119-29. Review. PMID: 11835276 [PubMed - indexed for MEDLINE]

5:	Grosshans H, Slack FJ.	Related Articles, Links
	Micro-RNAs: small is plentiful. J Cell Biol. 2002 Jan 7;156(1):17-21. Epub 2002 Jan 07. Review. PMID: 11781331 [PubMed - indexed for MEDLINE]

6:	Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Muller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G.	Related Articles, Links
	Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000 Nov 2;408(6808):86-9. PMID: 11081512 [PubMed - indexed for MEDLINE]

7:	Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G.	Related Articles, Links
	The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000 Apr;5(4):659-69. PMID: 10882102 [PubMed - indexed for MEDLINE]

8:	Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G.	Related Articles, Links
	The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24;403(6772):901-6. PMID: 10706289 [PubMed - indexed for MEDLINE]

9:	Miyabayashi T, Palfreyman MT, Sluder AE, Slack F, Sengupta P.	Related Articles, Links
	Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Dev Biol. 1999 Nov 15;215(2):314-31. PMID: 10545240 [PubMed - indexed for MEDLINE]

10:	Slack F, Ruvkun G.	Related Articles, Links
	Heterochronic genes in development and evolution. Biol Bull. 1998 Dec;195(3):375-6. Review. No abstract available. PMID: 9924779 [PubMed - indexed for MEDLINE]

11:	Slack FJ, Ruvkun G.	Related Articles, Links
	A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998 Dec;23(12):474-5. No abstract available. PMID: 9868369 [PubMed - indexed for MEDLINE]

12:	Slack F, Ruvkun G.	Related Articles, Links
	Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1997;31:611-34. Review. PMID: 9442909 [PubMed - indexed for MEDLINE]

13:	Sogaard-Andersen L, Slack FJ, Kimsey H, Kaiser D.	Related Articles, Links
	Intercellular C-signaling in Myxococcus xanthus involves a branched signal transduction pathway. Genes Dev. 1996 Mar 15;10(6):740-54. PMID: 8598300 [PubMed - indexed for MEDLINE]

14:	Slack FJ, Serror P, Joyce E, Sonenshein AL.	Related Articles, Links
	A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon. Mol Microbiol. 1995 Feb;15(4):689-702. PMID: 7783641 [PubMed - indexed for MEDLINE]

15:	Slack FJ, Mueller JP, Sonenshein AL.	Related Articles, Links
	Mutations that relieve nutritional repression of the Bacillus subtilis dipeptide permease operon. J Bacteriol. 1993 Aug;175(15):4605-14. PMID: 8335620 [PubMed - indexed for MEDLINE]

16:	Mueller JP, Mathiopoulos C, Slack FJ, Sonenshein AL.	Related Articles, Links
	Identification of Bacillus subtilis adaptive response genes by subtractive differential hybridization. Res Microbiol. 1991 Sep-Oct;142(7-8):805-13. Review. PMID: 1784820 [PubMed - indexed for MEDLINE]

17:	Slack FJ, Mueller JP, Strauch MA, Mathiopoulos C, Sonenshein AL.	Related Articles, Links
	Transcriptional regulation of a Bacillus subtilis dipeptide transport operon. Mol Microbiol. 1991 Aug;5(8):1915-25. PMID: 1766371 [PubMed - indexed for MEDLINE]

18:	Mathiopoulos C, Mueller JP, Slack FJ, Murphy CG, Patankar S, Bukusoglu G, Sonenshein AL.	Related Articles, Links
	A Bacillus subtilis dipeptide transport system expressed early during sporulation. Mol Microbiol. 1991 Aug;5(8):1903-13. PMID: 1766370 [PubMed - indexed for MEDLINE]

Please send questions and comments to frank.slack@yale.edu.

Prepared and copyrighted (2000) by Frank Slack

Last modified on May 26th 2008