Curriculum vitae

Frank Slack

Associate Professor
Department of Molecular, Cellular and Developmental Biology
Yale University

Mailing Address:
Department of Molecular, Cellular and Developmental Biology,
Yale University, KBT 716
PO Box 208103, 266 Whitney Ave
New Haven, CT 06520.
Phone (203) 432 3492; Fax (203) 432 6161;
e-mail: frank.slack@yale.edu

Citizenship: USA

Education:

1984-1986: B.Sc., The University of Cape Town (Microbiology, Biochemistry);
1987: B.Sc.(Hons), The University of Cape Town (Molecular Genetics);
1988-1993: Ph.D., Tufts University School of Medicine (Molecular Biology);
1990: Microbial Diversity Course, Marine Biological Laboratory, Woods Hole, MA;
1993-1994: Postdoctoral Fellow, Stanford University School of Medicine (Biochemistry);
1994-1999: Postdoctoral Fellow, Harvard Medical School (Genetics)/MGH (Molecular Biology)

Research experience:

1987: B. Sc. (Honours) Thesis in the laboratory of Dr. Frank Robb, Department of Microbiology, University of Cape Town. "Mutagenic analysis of the Vibrio alginolyticus glnA gene promoter, and sequencing of these mutations".

1993: Ph.D. Thesis in the laboratory of Dr. Linc Sonenshein, Department of Molecular Biology and Microbiology, Tufts University School of Medicine. "Function and regulation of dciA, the Bacillus subtilis dipeptide transport operon".

1993-1994: Postdoctoral research in the laboratory of Dr. Dale Kaiser, Department of Biochemistry, Stanford University School of Medicine. Signal transduction by C-factor during development of Myxococcus xanthus.

1994-1999: Postdoctoral research in the laboratory of Dr. Gary Ruvkun. Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital. Temporal pattern formation by heterochronic genes in C. elegans.

2000- 2005: Assistant Professor, Department of MCDB, Yale University. Developmental timing by microRNAs and heterochronic genes.

2005- present: Associate Professor, Department of MCDB, Yale University. Developmental timing by microRNAs and heterochronic genes.

2007- present: Associate Professor with tenure, Department of MCDB, Yale University. MicroRNAs in development and disease.

Research Interests:

The role of microRNAs and their targets in development and disease.

Honors, fellowships and service:

1986: B.Sc. With Distinction; Microbiology (First-in-Class Medal); Industrial Microbiology (First-in-Class Medal);
1987: CSIR Honours Fellowship;
1987: B.Sc. (Hons) With Distinction (First-in-Class Medal);
1988: FRD Masters Fellowship (gratefully declined);
1990: Marine Biological Laboratory Scholarship;
1992: Alla Korjagin Fellowship (Tufts University);
1992- 1995: Referee, Journal of Bacteriology;
1993- 1994: Dean's Postdoctoral Fellowship (Stanford University);
1996- 1997: Fund for Medical Discovery Postdoctoral Fellowship (MGH);
1997-1999: NIH NRSA Individual Fellowship
2000: Referee, Genetics
2000: Chair of session - East Coast C. elegans Meeting, Emory University
2001: Chair of session - International C. elegans Meeting, UCLA
2001-02: Yale University Institutional Animal Care and Use Committee
2001- 05: Reviewer, National Science Foundation
2001- 03: Division Editor, Division of Developmental Biology, Journal of Experimental Zoology
2001: Rockefeller Brothers Fund (Culpeper Biomedical Pilot Initiative)
2001: Yale Core Center for Musculoskeletal Disorders (Pilot and Feasibility Grant)
2001: National Institutes of Health R01 from NIGMS
2002: Chair of session - East Coast C. elegans Meeting, Univ. of New Hampshire
2002: Referee, Developmental Biology; Developmental Dynamics, Biotechniques, Bioessays, Genes and Development.
2002: National Institutes of Health R01 from NIGMS
2003: Referee, Developmental Biology, Genome Biology; Bioessays, The Lancet
2003: Junior Faculty Fellowship (Yale University)
2003: Reviewer, Medical Research Council, UK
2003: National Institute of Health (NIDDK) study section
2003: Reviewer, Cancer Research UK
2003: Reviewer, Austrian Science Fund (FWF)
2004: Reviewer, Netherlands Organization for Scientific Research (NOW)
2004: National Science Foundation Grant
2004: The Robert Leet And Clara Guthrie Patterson Trust Award
2004: Co-organizer of the Developmental Biology Symposium, Yale University, CT
2004: Chair of session Keystone meeting on siRNAs and miRNAs, Keystone, CO
2004: Co-organizer of the East Coast Worm Meeting, Yale University, CT
2004- 05: Listed in Who's Who in Science and Engineering 8th Ed.
2004: Referee, Journal of Experimental Zoology; Nature Reviews Genetics; Science; PNAS; PLOS Biology; Genes and Development, Nature Methods, Biology Letters (The Royal Society), Drug Discovery Today: TARGETS; NAR; Gene.
2005: Chair of session - National Academy of Sciences' Frontiers of Science, Irvine, CA
2005/06: Keystone Symposia Molecular Biology Study Group
2005: Reviewer, Yale Core Center for Musculoskeletal Disorders
2005: Reviewer, Netherlands Organization for Scientific Research (NOW)
2005: Reviewer, Medical Research Council, UK
2005: Reviewer, AIRC (Italian Cancer Association)
2005: National Institute of Health (NCI) study section
2005: Referee, Cell; Nature; Genes and Development; Nature Cell Biology; Nature Genetics; Nature Methods; Molecular Cell; PLOS Biology; Development; Chemistry and Biology; PNAS; Genome Biology; NAR.
2006: Referee, Nature; Cell; Science; Nature Genetics; Nature Cell Biology; Nature Reviews Cancer; Nature Reviews Neuroscience; PLOS Biology; Current Biology; Nature Methods; PNAS; Oncogene; RNA; Dev. Dyn.; Leukemia Research; International Journal of Cancer, Trends Mol. Med.
2006: Scientific organizing committee and chair of session - 4th International RNAi-2006, Boston, MA
2006: International Program Committee (IPC) for the IASTED International Conference on Computational and Systems Biology (CSB 2006)
2006: Reviewer, Wellcome Trust
2006: Reviewer, Austrian Science Fund (FWF)
2006: National Institute of Health (NCI) study section
2006: Reviewer, Dutch Cancer Society
2006: Reviewer, Singapore ASTAR
2007: Editorial Board, Developmental Dynamics. Referee, Nature; Cell; Science; Nature Genetics; Nature Structural and Molecular Biology; Molecular Cell; Cancer Cell, Nature Methods; Nature Reviews Cancer; PNAS; Oncogene; Genome Biology; PLOS Genetics; Developmental Dynamics; RNA; BMC Genomics; BMC Dev Biol.; NAR; Molecular Psychiatry; Pharmacogenomics.
2007: Chair of session - American Society of Clinical Oncology (ASCO), Chicago
2008: Chair of session – ASBMB 2008
2008: Scientific Advisory Committee, 2nd Annual World Congress of Gene-2008, Guangzhou, China
2008: International Program Committee (IPC) for the IASTED International Conference on Computational and Systems Biology (CSB 2008)
2008: ASBMB Program Planning Committee
2008: Editorial Board, Developmental Dynamics; Cell Cycle; Chromosoma. Guest Editor, PNAS.
2009: Main organizer of the Keystone Conference on MicroRNAs and Cancer, Keystone, CO

Invited lectures

December 1997: Progress in Molecular Genetics, Asilomar, California
June 1998: East Coast Worm Meeting, Boston University, Massachusetts
August 1998: Department of Applied Genomics, Bristol-Myers Squibb Pharmaceutical Research Institute
September 1998: Sixth Cold Spring Harbor Conference on Translational Control, CSHL, New York
January 1999: Department of Biochemistry and Biophysics, Texas A and M University
January 1999: Laboratory for Molecular Biology, University of Illinois at Chicago
February 1999: Department of Biology, Tufts University, Massachusetts
March 1999: Department of Molecular, Cellular and Developmental Biology, Yale University
April 1999: Department of Molecular genetics and Cell Biology, University of Chicago, Illinois
May 1999: Department of Biochemistry and Molecular Biophysics/Medicine, Columbia University College of Physicians and Surgeons, New York
June 1999: Stowers Institue for Medical Research, Kansas City
June 1999: 12th International C. elegans Meeting, Madison, Wisconsin
November 1999: Department of Cell Biology and Anatomy, Tufts University School of Medicine
March 2000: Development Symposium, Yale University
April 2000: Department of Biochemistry, Rutgers University
June 2000: East Coast Worm Meeting, Emory University, Georgia
July 2000: Gordon Conference on Biological Regulatory Mechanisms, Holderness, New Hampshire
Oct 2000: Department of Biology, University of Pennsylvania
April 2002: YCCMD Research Day, Yale University
June 2002: Gordon Conference on Nucleic Acids
October 2002: Program in Molecular Biology, University of Colorado Health Science Center
April 2003: American Society for Molecular Biology and Biochemistry, San Diego, CA
June 2003: Department of Biology, New York University
June 2003: Beyond Genome; Cambridge Healthtech Institute, San Diego, CA
June 2003: Division of Biological Sciences, University of California, San Diego, CA
September 2003: Department of Genetics, Yale University
October 2003: Sackler School of Biomedical Sciences, Tufts University School of Medicine
January 2004: School of Biosciences and Bioengineering, Indian Institute of Technology, Mumbai, India
February 2004: Department of Molecular Medicine and Biology, Jaslok Hospital and Research Centre, Mumbai, India
February 2004: Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa
March 2004: Department of Genetics, Dartmouth Medical School, NH
March 2004: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, NE
April 2004: Keystone Symposium on siRNAs and miRNAs, Keystone ,CO
June 2004: Gordon Conference on Nucleic Acids, Salve Regina College, RI
August 2004: Santa Cruz Conference on Developmental Biology, University of California, Santa Cruz, CA
September 2004: Department of Biology, University of Puerto Rico, Bayamón
September 2004: Department of Biology, University of Puerto Rico, Mayaguez
November 2004: GTCBio International Conference on Tumor Progression and Therapeutic Resistance, Philadelphia, PA
February 2005: New York Academy of Science, NY
March 2005: Neuroscience and Development Seminar Committee, Rockefeller University, NY
April 2005: Ambion Inc. Austin TX.
April 2005: Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, IL
July 2005: Keynote address, IBC's Annual International Conference on RNAi/siRNA, Boston, MA (cancelled).
July 2005: CABD, Sevilla, Spain.
August 2005 : Bio.com Webcast: Gene Silencing: Micro RNAs in Biology and the Laboratory
September 2005: National Institute on Aging, NIH, Bethesda, MD
September 2005: Washington Area Worm Meeting, Bethesda, MD
September 2005: Frontiers in Biology, Stanford University School of Medicine, Stanford, CA.
October 2005: National Academy of Sciences Frontiers of Science, Irvine, CA.
October 2005: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO.
November 2005: 3rd Annual Nucleic Acid World Summit 2005, Boston, MA
November 2005: Keynote address at GTCBio conference on RNAi, San Diego, CA
January 2006: Leading Edge Lecture; Beckman Research Inst. City of Hope, LA, CA.
January 2006: Keystone Symposium on RNAi and related pathways, Vancouver, British Columbia
March 2006: Graduate Association of Biological Sciences Symposium, Univ. of Maryland, Baltimore, MD.
March 2006: Department of Biochemistry, Univ. of Wisconsin, Madison, Madison, WI
March 2006: Ribogroup, Univ. of Wisconsin, Madison, Madison, WI
April 2006: Department of Genetics, University of Pennsylvania, PA.
April 2006: Department of Biochemistry and Molecular Biology, University of South Florida, FL.
May 2006: 4th International RNAi-2006, Boston, MA
May 2006: Yale Communication Speaker Series, New Haven, CT
May 2005: MicroRNA and cancer symposium; New York Academy of Science, NY
May 2006: Yale Cancer Center Grand Rounds
May 2006: Cold Spring Harbor Symposium on Quantitative Biology “Regulatory RNAs”. CSHL, NY
June 2006: Gordon Conference on Phosphorylation and G Protein Mediated Signaling Networks, ME
June 2006: Cambridge Healthtech Institute's 13th Annual "Nucleic Acid-Based Technologies" conference, Arlington, VA
June 2006: Beyond Genome 2006, San Francisco, CA
June 2006: University of Pittsburg Medical Center, PA
August 2006: Third Wave Technologies, Madison, WI
August 2006: CSHL C. elegans course, CSHL, NY
September 2006: Biology of Aging Interest Group, Yale University, CT
October 2006: Friedrich Miescher Institute, Basel, Switzerland
October 2006: Conference on “Molecules, Mechanisms, and Models in Embryogenesis and Organogenesis”. Freiburg, Germany
October 2006: UConn Health Science Center, Farmington, CT
October 2006: Department of Biology, McGill University, Canada
October 2006: Memorial Sloan- Kettering Cancer Center, New York, NY.
October 2006: Graduate Program in Genetics and Molecular Biology, Emory University, GA.
October 2006: TRTP conference, Baltimore, MD.
October 2006: Longevity Consortium Symposium, University of California, San Francisco, CA (student presenting, Michelle Boehm)
November 2006: Yale Undergraduate Society for Biological Science, Yale University, CT
December 2006: Department of Pathology, Harvard Medical School, Boston, MA
January 2007: Conference on “Molecular genetics and cell signaling in cancer and cancer metastasis”. University of Hong Kong, China
February 2006: AEK Symposium, Frankfurt, Germany
February 2006: Dept of Oncology-Pathology, Karolinska Institute, Sweeden
March 2007: Keystone Conference on Systems Biology and Regulatory Networks, Steamboat Springs, Co
March 2007: CHI's Third Annual microRNA in Human Disease and Development, Boston, MA. (postdoc presenting, Giovanni Stefani)
April 2007: College of Medicine, Ohio State University, Columbus, OH
April 2007: Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY
May 2007: Gordon Conference on The Red Cell, France
May 2007: 40th Annual Meeting of the Japanese Society of Developmental Biologists, Fukuoka, Japan. (postdoc presenting, Ryusuke Niwa).
June 2007: American Society of Clinical Oncology (ASCO), Chicago, IL
June 2007: Keystone Conference on MicroRNAs and Cancer, Keystone, CO
July 2007: Distinguished Speaker at the Ninth Annual Beckman Scholars Symposium (Invitation declined)
September 2007: Gordon Conference on Cell Signaling, Oxford, UK
September 2007: IRCC, Torino, Italy
October 2007: MicroRNA and Carcinogenesis Symposium @ the Environmental Mutagen Society Annual Meeting Atlanta, GA (invitation declined).
October 2007: American Association for Cancer Research-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics, San Francisco, CA
October 2007: American Society of Human Genetics, San Diego, CA
November 2007: AACR Conference The Role of Non-Coding RNAs in Cancer, Cambridge, MA
November 2007: Department of Molecular Genetics Albert Einstein College of Medicine, Yeshiva University, NY
February 2008: 2008 Nature Miami Winter Symposium, Miami, FL
March 2008: ASBMB Meeting, San Diego, CA
November 2007: NY Area Worm Meeting, Rockefeller, NY, NY
January 2008: Science Magazine Webinar, miRNAs in normal and diseased cell function, Washington DC.
January 2008: Department of Immunology, Yale University School of Medicine, CT
February 2008: 2008 Nature Miami Winter Symposium, Miami, FL
February 2008: Merck, Boston, MA
March 2008: “MiRNAs in biology and disease”, PMI, Cologne, Germany
March 2008: Department of Biological Sciences, Duquesne University, Pittsburgh, PA
April 2008: Dept of Biology, Virginia Tech, Blacksburg, VA
April 2008: ASBMB Meeting, San Diego, CA
April 2008: NYU Cancer Institute, NY, NY
May 2008: RNA symposium, Seoul National University, Seoul, Korea
May 2008: Annual Symposium of Korean Society of Biochemistry and Molecular Biology, Seoul, Korea
May 2008: Department of Molecular Biology, Dankook University, Korea
May 2008: Northwestern Basic Science Event. Northwestern Univ. Chicago IL
May 2008: Frontiers in Gene and Molecular Therapy Lecture Series, Stanford University, CA
June 2008: Keynote address, Children's Tumor Foundation Annual Neurofibromatosis Meeting, Naples, FL
July 2008: MD Anderson Cancer Center, Houston, TX
July 2008: Functional Genomics, Sigma Aldrich Corporation, St. Loius, MO
July 2008: Washington University, St Louis, MO
August 2008: Fidelity Foundation Conference, Bar Harbor, Maine
October 2008: Human Genetics Conference Committee, McGill University Montreal, Canada.
October 2008: NCRI, Birmingham, England
October 2008: Biogen Idec, Cambridge, MA

Scheduled

Scientific organizations:

American Association for the Advancement of Science
Genetics Society of America
Yale Cancer Center
New York Academy of Science

Publications:

Mueller, J. P., C. Mathiopoulos, F. J. Slack, and A. L. Sonenshein. (1991) Identification of Bacillus subtilis adaptive response genes by subtractive differential hybridization. Res. in Microbiol. (Inst. Pasteur), 142: 805-813

Mathiopoulos, C., J. P. Mueller, F. J. Slack, C. G. Murphy, S. Patankar, G. Bukusoglu, and A. L. Sonenshein. (1991) A Bacillus subtilis dipeptide transport system expressed early during sporulation. Mol. Microbiol. 5: 1903-1913

Slack, F. J., J. P. Mueller, M. A. Strauch, C. Mathiopoulos, and A. L. Sonenshein. (1991) Transcriptional regulation of a Bacillus subtilis dipeptide transport operon. Mol. Microbiol. 5: 1915-1925

Slack, F. J., J. P. Mueller, and A. L. Sonenshein. (1993) Mutations that relieve nutritional repression of the Bacillus subtilis dipeptide permease operon. J. Bacteriol. 175:4605-4614

Slack, F. J., P. Serror, E. Joyce, and A. L. Sonenshein. (1995) A gene involved in nutritional repression of the Bacillus subtilis dipeptide permease operon. Mol. Microbiol. 15:689-702

Sogaard-Andersen* L., F. J. Slack,*, H. Kimsey, and D. Kaiser. (1996) Intercellular C-signaling in Myxococcus xanthus involves a branched signal transduction pathway. Genes Dev. 10:740-754
* contributed equally

Slack, F. J. and G. Ruvkun. (1997) Temporal pattern formation by heterochronic genes. Annu. Rev. Genet. 31:611-634.

Slack, F. J. and G. Ruvkun. (1998) A novel repeat domain that is often associated with RING finger and B box motifs. Trends Biochem. Sci. 23:474-475.

Slack, F. J. and G. Ruvkun. (1998) Heterochronic genes in development and evolution. Biol. Bulletin. 195:375-376.

Miyabayashi, T., M. T. Palfreyman, A. Sluder, F. J. Slack, and P. Sengupta. (1999) Members of a divergent nuclear hormone receptor family are expressed in multiple cell types in C. elegans. Dev Biol. 15:314-331

Slack, F. J., M. Basson, Z. Liu, V. Ambros, R. Horvitz and G. Ruvkun. (2000) The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Molecular Cell 5:659-669

Reinhart, B.*, Slack, F. J.*, M. Basson, A. Pasquinelli, J. Bettinger, A. Rougvie, R. Horvitz, and G. Ruvkun. (2000) The 21 nucleotide let-7 RNA regulates C. elegans developmental timing. Nature 403:901-905
*Contributed equally

Pasquinelli, A. B. Reinhart, F. Slack, ..... and G. Ruvkun. (2000) Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408:86-89.

Banerjee, D. and F. J. Slack. (2002) Control of developmental timing by small temporal RNAs: a paradigm for RNA mediated regulation of gene expression. Bioessays 24:119-129.

Grosshans, H. and F. J. Slack. (2002) Micro-RNAs: small is plentiful. J. Cell Biol. 156:17-21.

Ramaswamy, G. and F. J. Slack. (2002) siRNAs: a guide to silencing. Chem Biol. 9:1053-1057.

Lin S.-Y., S. Johnson, M. Abraham, M. Vella, A. Pasquinelli, C. Gamberi, E. Gottlieb, and F. J. Slack. (2003) The C. elegans hunchback homologue, hbl-1, controls temporal patterning and is a probable microRNA target. Dev. Cell. 4:639-650

Johnson, S., S.-Y. Jin, and F. J. Slack. (2003) Temporal up-regulation of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in the let-7 promoter. Dev Biol.259:364-379

Vella M. C., E.-Y. Choi, S.-Y. Lin, K. Reinert, and F. J. Slack. (2004) The C. elegans microRNA let-7 binds to imperfect complementary sites from the lin-41 3’UTR. Genes Dev. 18:132-137.

Ramaswamy, G. and F. J. Slack (2004) The silent revolution. Review on the Book RNAi: A Guide to Gene Silencing edited by Gregory Hannon. Nature Cell Biol. 6:277.

Esquela-Kerscher, A. and F. J. Slack. (2004) The age of high-throughput microRNA profiling. Nature Methods. 1:106-107.

Vella, M.C., K. Reinert and F. J. Slack. (2004) Architecture of a validated microRNA::target interaction. Chem. Biol. 11:1619-1623.

Banerjee, D., A. Kwok, S.-Y. Lin, and F. J. Slack. (2005) Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev. Cell. 8:287-295.

Banerjee, D. and F. J. Slack. Temporal and spatial patterning of an organ by a single transcription factor. Genome Biol. 6:205-208.

Grosshans, H, T. Johnson, M. K. Reinert, Gerstein and F. J. Slack. (2005) The temporal patterning microRNA let-7 controls several transcription factors during the larval to adult transition in C. elegans. Dev. Cell. 8:321-330.

Johnson, S., H. Grosshans, J. Shingar, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K. L. Reinert, D. Brown, and F. J. Slack. (2005) RAS is regulated by the let-7 microRNA family. Cell. 120:635-647.

Vella, M and F. J. Slack. (2005) C. elegans microRNAs. WormBook, ed. The C. elegans Research Community, WormBook,doi/10.1895/wormbook.1.26.1, http://www.wormbook.org.

Esquela-Kerscher, A., S. M. Johnson, L. Bai, K. Saito, J. Partridge, K. Reinert and F. J. Slack. (2005) Post-embryonic expression of C. elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and reproductive system. Dev. Dyn. 234:868-877.

Schulman, B., A. Esquela-Kerscher, and F. J. Slack. (2005) Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev. Dyn. 234:1046-1054.

Boehm, M., and F. J. Slack. (2005). A developmental timing microRNA and its target regulate life span in C. elegans. Science. 310:1954-1957.

Slack, F. J. and J. B. Weidhaas. (2006) MicroRNAs as a potential magic bullet in cancer. Future Oncology. 2:73-82.

Esquela-Kerscher, A. and F. J. Slack. (2006) Oncomirs - microRNAs with a role in cancer. Nature Reviews Cancer. 6:259-269. (Featured and cover article)

Boehm, M. and F. J. Slack. (2006) microRNA control of lifespan and metabolism. Cell Cycle. Vol: 5 Issue: 8 16 April 2006 pp e1-e4.

Roush, S. and F. J. Slack. (2006) Micromanagement: microRNAs stabilize mRNAs. ACS Chem. Biol. 1 (3), 132-134

Chan, S-P and F. J. Slack. (2006) miRNAs and P-bodies. RNA Biol. 3:97-100.

Stefani, G and F. J. Slack. (2006) MicroRNAs in search of targets. Invited review for CSHL Quantitative Symposium. Available online.

F. J. Slack. Regulatory RNAs and the demise of 'junk' DNA. Meeting report of 71st CSHL Symposium on Quantitative Biology “Regulatory RNAs”. Genome Biol. 2006 Sep 28;7(9):328

Niwa, R. and F. J. Slack. (2007) Ins and outs of RNAi analysis. Invited review for Molec. Cell. In press.

Nolde, M., N. Saka, K. Reinert and F. J. Slack. (2007) The C. elegans Pumilio homologue, PUF-9 is required for 3' UTR mediated regulation of the let-7 microRNA target, hbl-1. Dev. Biol. Mar 3 Epub ahead of print.

Niwa, R. and F. J. Slack. (2007) Evolution of microRNA function. Curr Opin Genet Dev. 17:145-50. Epub 2007 Feb 20.

Babar, I., and F.J. Slack. (2007) MicroRNAs in Cancer. Am. Soc. Clin. Oncol. Ed Book. p716-719

Mona Nolde and F. J. Slack. MicroRNAs in C. elegans. In Regulation of Gene Expression by Small RNAs (CRC Press). In press.

Stahlhut, C., and F. J. Slack. MicroRNAs in cancer. Invited review for Yale Journal of Biology and Medicine. In press.

Johnson, C., Esquela-Kerscher, A., Stefani, G., Byrom, M., Kelnar, K., Ovcharenko, D., Wilson, M., Wang, X., Shelton, J., Shingara, J., Brown, D., and F.J. Slack. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 67:7713-7722.

Weidhaas, J., I. Babar, S. Naller, S. Roush, M. Boehm, and F. J. Slack. (2007) MicroRNAs as Potential Agents to Alter Resistance to Cytotoxic anti-Cancer Therapy. Cancer Res. 67:11111-11116.

Kato, M. and F. J. Slack. (2007) microRNAs: small molecules with a big role in biology and disease. Invited review for Biology of the Cell. 100:71-81.

Chan, S-P., and F. J. Slack. (2007) And now introducing mammalian mirtrons. Dev. Cell. 13:605-607.

Chin, L. and F. J. Slack. (2007) MicroRNA mediated regulation of gene expression. Chapter 6 of “RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity” (Horizon Scientific Press). In press.

Babar, I A., F. J. Slack, J. B. Weidhaas (2008). MicroRNA modulation of the cellular stress response. Future Oncology. 4:289-298.

Niwa, R. F. Zhou, C. Li and F. J. Slack. (2008) C. elegans Alzheimer APP-like is regulated by developmental timing microRNAs and their targets. Dev Biol. Jan 8; [Epub ahead of print]

Esquela-Kerscher, A., P. Trang, Cheng, A., Ford, L., Weidhaas, J, Brown, D. Bader, A, and F. J. Slack. (2008) The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle. 7:759-64

Stefani, G. and F. J. Slack. (2008) The role of small RNAs in animal development. Invited review for Nature Reviews Molecular Cell Biology. 9:219-30.

A. Esquela-Kerscher, J. Weidhaas, and F. J. Slack. (2008) MicroRNA detection and profiling. Invited review for Methods in Molecular Biology by Humana Press, USA. In press.

Chan, S-P., G.Ramaswamy, E.-Y.Choi, and F. J. Slack. (2008) Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans. RNA. Aug 21. [Epub ahead of print].

Ding, X., F. J. Slack* and H. Grosshans*. (2008) The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell Cycle. 7:3083-3090. *joint corresponding author

Lena J. Chin, L.J., S. Nallur, Y. Zhu, S. Leng, E. A. Burki, R. E. Crowell, E. Straka, E. Ratner, S. A. Belinsky,K. K. Kidd,R. Homer, F. J. Slack*and J. B. Weidhaas*. (2008) A SNP in a let-7 microRNA complementary site in the KRAS 3¢UTR Increases Lung Cancer Risk. Can. Res. In press. *joint corresponding author

Godshalk, S., G. Miller and F. J. Slack. De novo infection of human primary B-cells by the Epstein-Barr virus deregulates multiple oncogenic and tumor-suppressive microRNAs. Cell Cycle. In press.

Babar, I A., F. J. Slack, J. B. Weidhaas. (2008) MicroRNA modulation of the cellular stress response. Future Oncology. 4:289-298.

Ratner, E., A. Esquela-Kerscher, J. Weidhaas, and F. J. Slack. (2008) MicroRNA detection and profiling. Invited review for Methods in Molecular Biology by Humana Press, USA. In press.

Büssing I., F. J. Slack and H. Grosshans. (2008) “The role of the let-7 microRNA family: implications for human disease. Trends Mol Med. 4:400-409. Epub 2008 Jul 31.

Medina, P. and F. J. Slack. (2008) MicroRNAs and cancer, an overview. Cell Cycle. Aug17;7(16). [Epub ahead of print]

Roush, S. and F. J. Slack. (2008) The let-7 family of microRNAs. Trends Cell Biol. Sep 4. [Epub ahead of print].

Chin, L and F. J. Slack. (2008) Truth serum for cancer: microRNAs show potential as biomarkers of cancer. Cell Science. 18:983–984.

Pincus, Z., and F. J. Slack. Transcriptional (Dys)regulation and Aging in C. elegans. Genome Res. 9:233.

Prepared and copyrighted (2000) by Frank Slack
Please send queries to frank.slack@yale.edu.

Last modified on Oct 27th 2008

Go to the Slack Lab Homepage

November 2008: Department of Radiation Oncology Grand Rounds, Yale University School of Medicine, New Haven, CT

January 2009: Univ. of North Carolina, Chapel Hill, NC

January 2009: University of Texas M. D. Anderson Cancer Center and Baylor College of Medicine Conference on Development of Non-coding RNAs for Cancer Therapy.

February 2009: Moffitt Cancer Center Basic Grand Rounds, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

February 2009: MicroRNAs and Human Disease Conference, St Kitts.

February 2009: Molecular Medicine Tri-conference, San Francisco, California

March 2009: CHI’s Fifth Annual microRNA in human disease and development, Boston, MA

April 2009: AACR Annual meeting, Denver, CO

May 2009: NYAS conference on "RNA in Stress Response and Longevity Control", New York, NY

May 2009: American Thorasic Society Annual Meeting

May 2009: The Center for Integrative Genomics (CIG), University of Lausanne, Switzerland

May 2009: Symposium of the Cancer Epigenetics and Biology Program (PEBC), Barcelona, Spain

June 2009: U Penn Cancer Center

June 2009: Keystone Conference on MicroRNAs and Cancer, Keystone, CO

June 2009: Van Andel Institute Oncogene Conference, Grand Rapids, MI

July 2009: Aspen Cancer Conference, Aspen CO.

October 2009: MD Anderson

Curriculum vitae

Frank Slack

Associate Professor Department of Molecular, Cellular and Developmental Biology Yale University

Go to the Slack Lab Homepage

Associate Professor
Department of Molecular, Cellular and Developmental Biology
Yale University