Recent publications from members of the Rhoades lab:
- DeWitt DC, Rhoades E. (2013) "α-Synuclein Can Inhibit SNARE-Mediated Vesicle Fusion through Direct Interactions with Lipid Bilayers." Biochemistry doi: 10.1021/bi4002369 »
- Nath A, Rhoades E. (2013) "A Flash in the Pan: Dissecting Dynamic Amyloid Intermediates Using Fluorescence." FEBS Lett. doi:10.1016/j.febslet.2013.02.044 »
- Ciubotaru M, Trexler A, Spiridon LN, Surleac MD, Rhoades E, Petrescu AJ, Schatz DG. (2013) "RAG and HMGB1 Create a Large Bend in the 23RSS in the V(D)J Recombination Synaptic Complexes." Nucleic Acids Res. doi:10.1093/nar/gks1294 »
- Nath A, Sammalkorpi M, DeWitt DC, Trexler A, Elbaum-Garfinkle S, O'Hern CS, Rhoades E. (2012) "The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations." Biophys. J. 103(9):1940-1949. »
- Trexler A, Rhoades E. (2012) "Function and Dysfunction of α-Synuclein: Probing Conformational Changes and Aggregation by Single Molecule Fluorescence." Mol. Neurobiol. doi:10.1007/s12035-012-8338-x »
- Smith WW, Schreck CF, Hashem N, Soltani S, Nath A, Rhoades E, O'Hern CS. (2012) "Molecular Simulations of the Fluctuating Conformational Dynamics of Intrinsically Disordered Proteins." Phys. Rev. E. 86:041910. »
- Ducas VC, Rhoades E. (2012) "Quantifying Interactions of β-Synuclein and γ-Synuclein with Model Membranes." J. Mol. Biol. 423(4):528-539. »
- Elbaum-Garfinkle S, Rhoades E. (2012) "Identification of an Aggregation-Prone Structure of Tau." J. Am. Chem. Soc. 134(40):16607-13. »
- Trexler AJ, Rhoades E. (2012) "N-terminal Acetylation is Critical for Forming α-helical Oligomer of α-Synuclein." Protein Sci. 21(5):601-605. »
- Braun AR, Sevcsik E, Chin P, Rhoades E, Tristram-Nagle S, Sachs JN. (2012) "α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in Membranes." J. Am. Chem. Soc. 134(5):2613-20. »
- Nath A, Miranker AD, Rhoades E. (2011) "A Membrane-bound Antiparallel Dimer of Rat Islet Amyloid Polypeptide." Angew. Chem. Intl. Ed. 50(46):10859-62. »
- Cao W, Coman MM, Ding S, Henn A, Middleton ER, Bradley M, Rhoades E, Hackney DD, Pyle AM, De La Cruz EM. (2011) "Mechanism of Mss116 ATPase Reveals Functional Diversity of DEAD-Box Proteins." J. Mol. Biol. 409(3):399-414. »
- Last N, Rhoades E, Miranker AD. (2011) "Islet Amyloid Polypeptide Demonstrates a Persistent Capacity to Disrupt Membrane Integrity." PNAS 108(23):9460-9465. »
- Sevcsik E, Trexler AJ, Dunn JM, Rhoades E. (2011) "Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally to Regulate Membrane Binding." J. Am. Chem. Soc. 133(18):7152-7158. »
- Foti RS, Honaker M, Nath A, Pearson JR, Buttrick B, Isoherranen N, Atkins WM. (2011) "Catalytic versus Inhibitory Promiscuity in Cytochrome P450s: Implications for Evolution of New Function." Biochemistry 50(13):2387-93. »
- Trexler AJ, Rhoades E. (2010) "Single Molecule Characterization of α-Synuclein in Aggregation-Prone States." Biophys J. 99(9):3048-55. »
- Middleton E, Rhoades E. (2010) "Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles." Biophys J. 99(7):2279-88. »
- Wolfe L.S.†, Calabrese M.F.†, Nath
A.†, Blaho D.V., Miranker A.D., Xiong Y. (2010) "
Protein-Induced Photophysical Changes to the Amyloid Indicator Dye Thioflavin T."
PNAS 107(39):1683-68. »
- Nath A.*,
Zientek M., Burke B., Jiang Y., Atkins W.M. (2010) "Specificity and
Promiscuity in Small-Molecule Inhibition of Cytochrome P450 Isoforms."
Drug Metab. Dispos. 38(12):2195-2203.
»
- Elbaum-Garfinkle S, Ramlal T, Rhoades E. (2010) "The Role of the Lipid Bilayer in Tau Aggregation." Biophys J. 98(11):2722-30.
»
- Hsiao HH, Nath A, Lin C-Y, Folta-Stogniew EJ, Rhoades E, Braddock DT. (2010) "Quantitative Characterization of the Interactions between c-myc Transcriptional Regulators FUSE, FBP and FIR." Biochemistry
49(22):4620-34. »
- Nath A, Trexler AJ, Koo P, Miranker AD, Atkins WM, Rhoades E. (2010) "Single-Molecule Fluorescence Spectroscopy Using Phospholipid Bilayer Nanodiscs." Methods in Enzymology 472:89-117 »
- Ilagan RP, Rhoades E, Gruber DF, Kao HT, Pieribone VA, Regan L. (2010) "A New Bright Green-Emitting Fluorescence Protein - Engineered Monomeric and Dimeric Forms." FEBS J. 277(8):1967-78 »
- Trexler A, Rhoades E. (2009) "α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix." Biochemistry 48(11):2304-6 »
- Nath A, Koo PK, Rhoades E, Atkins WM. (2008) "Allosteric Effects in Substrate Dissociation from Cytochrome P450 3A4 in Nanodiscs Observed by Ensemble and Single-Molecule Fluorescence Spectroscopy." J. Am. Chem. Soc. 130(47):15746 »
- Chen H, Rhoades E. (2008) "Fluorescence Characterization of Denatured Proteins." Curr. Opin. Struct. Biol. 18(4):516 »
- Sherman E, Itkin A, Kuttner YY, Rhoades E, Amir D, Haas E, Haran G. (2008) "Using Fluorescence Correlation Spectroscopy to Study Conformational Changes in Denatured Proteins." Biophys. J. 94(12):4819 »
- Park HY, Kim SA, Korlach J, Rhoades E, Kwok LW, Zipfel WR, Waxham MN, Webb WW, Pollack L. (2008) "Conformational Changes of Calmodulin upon Ca2+ Binding Studied with a Microfluidic Mixer." Proc. Natl. Acad. Sci. USA 105(2):542 »
Yale University, Molecular Biophysics & Biochemistry Department
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