Recent publications from members of the Rhoades lab:
  1. Jülich D., Cobb G., Melo A. M., McMillen P., Lawton A., Mochrie S. G. J., Rhoades E., Holley S. A. (2015) “Cross-scale Integrin regulation organizes ECM and tissue topology” Dev. Cell, Accepted
  2. Metskas L. A., Rhoades E. (2015) “Folding upon phosphorylation: translational regulation by a disorder-to-order transition” Trends Biochem. Sci. 40(5): 243-244. »
  3. Kumar S., Schlamadinger D. E., Brown M. A., Dunn J. M., Mercado. B., Hebda J. A., Saraogi I., Rhoades E., Hamilton A. D., Miranker A. D. (2015) “Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics” Chem. Biol. 22(3): 369-378. »
  4. Liu Y., Cai Y., Liu W., Li X.-H., Rhoades E., Yan E. C. Y. (2015) “Triblock peptide–linker–lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors” Chem. Commun. 51(28): 6157-6160. »
  5. Esposito D. L. A., Nguyen J. B., DeWitt D. C., Rhoades E., Modis Y. (2015) “Physicochemical requirements and kinetics of membrane fusion of flavivirus-like particles” J. Gen. Virol. vir.0.000113 »
  6. LaRochelle J. R., Cobb G., Steinauer A., Rhoades E., Schepartz A. (2015) “Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides” J. Am. Chem. Soc., 137(7): 2536-2541. »
  7. Shi Z., Sachs J. N., Rhoades E., Baumgart T. (2015) “Biophysics of α-synuclein induced membrane remodelling” Phys. Chem. Chem. Phys. Advance Article. »
  8. Ciubotaru M., Surleac M. D., Metskas L. A., Koo P., Rhoades E., Petrescu A. J., Schatz D. G. (2015) “The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes” Nucleic Acids Res. 43(2): 917-931. »
  9. Braun A. R., Lacy M. M., Ducas V. C., Rhoades E., Sachs J. N. (2014) “α-Synuclein-Induced Membrane Remodeling Is Driven by Binding Affinity, Partition Depth, and Interleaflet Order Asymmetry” J. Am. Chem. Soc., 136(28): 9962-9972. »
  10. Elbaum-Garfinkle S., Cobb G., Compton J. T., Li X.-H., Rhoades E. (2014) “Tau mutants bind tubulin heterodimers with enhanced affinity” Proc. Natl. Acad. Sci. USA 111(17): 6311-6316. »
  11. Munro J. B., Nath A., Färber M., Datta S. A. K., Rein A., Rhoades E., Mothes W.(2014) “A conformational transition in HIV-1 Gag early during virus assembly” J. Virol., 88(6): 3577-3585. »
  12. Fribourgh J., Wolfe L., Nguyen H., DeWitt D. C., Rhoades E., Xiong Y. (2014) “CBFβ plays a critical role facilitating the assembly of the Vif-Cul5 E3 ubiquitin ligase” J. Virol., 88(6): 3309-3319 »
  13. Ducas V. C., Rhoades E. (2014) “Investigation of intramolecular dynamics and conformations of α-, β-, and γ-Synuclein” PLoS ONE, 9(1): e86983 »
  14. DeWitt D. C., Rhoades E. (2013) "α-Synuclein Can Inhibit SNARE-Mediated Vesicle Fusion through Direct Interactions with Lipid Bilayers." Biochemistry 52 (14):2385-2387.»
    *Highlighted on the Biochemistry homepage.
  15. Nath A., Rhoades E. (2013) "A Flash in the Pan: Dissecting Dynamic Amyloid Intermediates Using Fluorescence." FEBS Lett. 587 (8):1096-1105.»
  16. Capraro B. R., Shi Z., Dunn J. M., Wu T., Rhoades E., Baumgart T. (2013) “Kinetics of endophilin N-BAR domain dimerization and membrane interactions” J. Biol. Chem., 288(18): 12533-12543. »
  17. Ciubotaru M., Trexler A., Spiridon L. N., Surleac M. D., Rhoades E., Petrescu A. J., Schatz D. G. (2013) "RAG and HMGB1 Create a Large Bend in the 23RSS in the V(D)J Recombination Synaptic Complexes." Nucleic Acids Res. 41 (4):2437-2454. »
  18. Trexler A. J., Rhoades E. (2012) “Function and dysfunction of α-Synuclein: Probing conformational changes and aggregation by single molecule fluorescence” Mol. Neurobiol., 47(2): 622-631. »
  19. Smith W. W., Schreck C. F., Hashem N., Soltani S., Nath A., Rhoades E., O'Hern C. S. (2012) "Molecular Simulations of the Fluctuating Conformational Dynamics of Intrinsically Disordered Proteins." Phys. Rev. E. 86:041910. »
  20. Elbaum-Garfinkle S., Rhoades E. (2012) "Identification of an Aggregation-Prone Structure of Tau." J. Am. Chem. Soc. 134(40):16607-16613. »
    * Highlighted in C&E News, JACS Spotlights, and ASBMB Today.
  21. Nath A., Sammalkorpi M., DeWitt D. C., Trexler A., Elbaum-Garfinkle S., O'Hern C. S., Rhoades E. (2012) "The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations." Biophys. J. 103(9):1940-1949. »
  22. Ducas V. C., Rhoades E. (2012) "Quantifying Interactions of β-Synuclein and γ-Synuclein with Model Membranes." J. Mol. Biol. 423(4):528-539. »
  23. Trexler A. J., Rhoades E. (2012) "N-terminal Acetylation is Critical for Forming α-helical Oligomer of α-Synuclein." Protein Sci. 21(5):601-605. »
    * Most cited paper in Protein Science 2012.
  24. Braun A. R., Sevcsik E., Chin P., Rhoades E., Tristram-Nagle S, Sachs JN. (2012) "α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in Membranes." J. Am. Chem. Soc. 134(5):2613-2620. »
  25. Tseng C.-H., Weinacht T. C., Rhoades E., Murray M., Pearson B. J. (2011) “Using shaped ultrafast laser pulses to detect enzyme binding” Opt. Express, 19(24): 24638-24646. »
  26. Nath A., Miranker A. D., Rhoades E. (2011) "A Membrane-bound Antiparallel Dimer of Rat Islet Amyloid Polypeptide." Angew. Chem. Intl. Ed. 50(46):10859-10862. »
  27. Last N., Rhoades E., Miranker A. D. (2011) "Islet Amyloid Polypeptide Demonstrates a Persistent Capacity to Disrupt Membrane Integrity."Proc. Natl. Acad. Sci. USA 108(23):9460-9465. »
  28. Sevcsik E., Trexler A. J., Dunn J. M., Rhoades E. (2011) "Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally to Regulate Membrane Binding." J. Am. Chem. Soc. 133(18):7152-7158. »
  29. Cao W., Coman M. M., Ding S., Henn A., Middleton E. R., Bradley M., Rhoades E., Hackney D. D., Pyle A. M., De La Cruz E. M. (2011) "Mechanism of Mss116 ATPase Reveals Functional Diversity of DEAD-Box Proteins." J. Mol. Biol. 409(3):399-414. »
  30. Trexler A. J., Rhoades E. (2010) "Single Molecule Characterization of α-Synuclein in Aggregation-Prone States." Biophys J. 99(9):3048-3055. »
    *Selected as a “Research Highlight” by Biophysical Journal
  31. Nath A., Trexler A. J., Koo P., Miranker A. D., Atkins W. M., Rhoades E. (2010) "Single-Molecule Fluorescence Spectroscopy Using Phospholipid Bilayer Nanodiscs." Methods in Enzymology 472:89-117. »
  32. Middleton E. R., Rhoades E. (2010) "Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles." Biophys J. 99(7):2279-2288. »
  33. Elbaum-Garfinkle S., Ramlal T., Rhoades E. (2010) "The Role of the Lipid Bilayer in Tau Aggregation." Biophys J. 98(11):2722-2730. »
  34. Ilagan R. P., Rhoades E., Gruber D. F., Kao H. T., Pieribone V. A., Regan L. (2010) "A New Bright Green-Emitting Fluorescence Protein - Engineered Monomeric and Dimeric Forms." FEBS J. 277(8):1967-1978 »
  35. Hsiao H. H., Nath A., Lin C.-Y., Folta-Stogniew E. J., Rhoades E., Braddock D. T. (2010) "Quantitative Characterization of the Interactions between c-myc Transcriptional Regulators FUSE, FBP and FIR." Biochemistry 49(22):4620-4634. »
  36. Trexler A. J., Rhoades E. (2009) "α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix." Biochemistry 48(11):2304-2306 »
    *One of Biochemistry’s “Most-Accessed Rapid Reports” in 2009
  37. E. Sherman, A. Itkin, Y.Y. Kutner, E. Rhoades, D. Amir, E. Haas, and G. Haran (2008) “Using fluorescence correlation spectroscopy to study conformational changes in denatured proteins” Biophys. J. 94(12): 4819-4827. »
  38. Nath A., Koo P. K., Rhoades E., Atkins WM. (2008) "Allosteric Effects in Substrate Dissociation from Cytochrome P450 3A4 in Nanodiscs Observed by Ensemble and Single-Molecule Fluorescence Spectroscopy." J. Am. Chem. Soc. 130(47):15746-15747 »
  39. Chen H., Rhoades E. (2008) "Fluorescence Characterization of Denatured Proteins." Curr. Opin. Struct. Biol. 18(4):516-524 »