Welcome to the Rhoades lab! We use single-molecule fluorescence and other biophysical techniques to study protein conformations and dynamics, protein-protein interactions, and protein-membrane interactions. The biological focus of our research is on some of the proteins associated with amyloid formation and disease, including α-synuclein (Parkinson's disease), tau (Alzheimer's disease) and IAPP (Type II diabetes).
Single molecule fluorescence - applied to protein molecules that are either diffusing freely through solution (using confocal microscopy) or those localized to a surface (using total internal reflection microscopy) - is an elegant and powerful approach to studying biological molecules and processes. Please see our Research page for more details.