Glenn Schafe



Assistant Professor (Ph.D., 1997, University of Washington)

Personal Home Page

My lab studies the neurobiological substrates of learning and memory, with particular emphasis on Pavlovian fear conditioning. This type of associative learning has gained much attention from both basic and clinical neuroscientists over the last half decade, not only because of its simplicity and tractability as a neurobiological model of learning and memory, but also because of its potential relevance to various psychological disorders, including post-traumatic stress and panic disorders in which acquired fear appears to play a prominent role. Specifically, I am interested in the cellular and/or biochemical events that contribute to fear memory consolidation, or the process by which short-term fear memories are transformed in the brain, over time, into stable, long-term memories. Much of this work has focused on the amygdala, a temporal lobe structure that has been implicated in emotion and emotional learning for many years. Work in my lab utilizes a multidisciplinary approach to the study of fear memory formation in the amygdala and other relevant brain areas that includes behavioral, anatomical, electrophysiological, and biochemical techniques.

Schafe, G.E., Nader, K., Blair, H.T. & LeDoux, J.E. (2001). Memory consolidation of Pavlovian fear conditioning: A cellular and molecular perspective. Trends In Neurosciences, 24, 540 - 546.

Schafe, G.E., Atkins, C.M., Swank, M.W., Bauer, E.P., Sweatt, J.D., & LeDoux, J.E. (2000). Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning. The Journal of Neuroscience, 20, 8177 - 8187.

Schafe, G.E. & LeDoux, J.E. (2000). Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. The Journal of Neuroscience, 20, RC96, 1 - 5.

Nader, K., Schafe, G.E., & LeDoux, J.E. (2000). Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature, 406, 722 - 726.

Schafe, G.E., Nadel, N.V., Sullivan, G.M., Harris, A. & LeDoux, J.E. (1999). Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learning & Memory, 6, 97 - 110.