266 Whitney Ave.

        New Haven, CT 06520

                 email: paul.dalhaimer@yale.edu

          phone: 203-432-3194

 Research Synopsis 

Biochemistry and biophysics of cytoskeletal proteins and their interactions with exogenous objects.  Fission yeast S. pombe as a model genetic system and source of eukaryotic proteins.  Adaptable drug delivery geometries from synthetic and natural amphiphiles.  Statistical mechanics and simulation.

Education 

B.S., Chemical Engineering (1998)
University of Pennsylvania

Research Support
 
NIH – Ruth Kirschstein NRSA (2005-present)
NSF – GAANN (2001-2003)

·        Nucleotide-mediated conformational changes of monomeric actin studied by molecular dynamics simulations.  P. Dalhaimer^†, B.J. Nolen^†, & T.D. Pollard.  (to be submitted).

·        Long circulating cylindrical micelles demonstrate the strong effects of morphology on biological transport and interaction. Y. Geng^†, P. Dalhaimer^†, P.J. Photos, B.W. Fyfe, M. Tewari, & D.E. Discher. (in review).

·        Phases, elasticity, and soft-modes of actin networks with varied filament length and crosslinking. P. Dalhaimer, D.E. Discher, & T.C. Lubensky. Nature Physics (to appear).

·        Dynamics of wormlike micelles in elongational flows. P.A. Stone, S.D. Hudson, P. Dalhaimer, D.E. Discher, E.J. Amis, & K.B. Migler. Macromolecules 39, 7144-7148 (2006).

·        Polymeric worm micelles as nano-carriers for drug delivery. Y.H. Kim, P. Dalhaimer, D. Christian, & D.E. Discher. Nanotechnology 16, 484-491 (2005).

·        Flexibility and loop conformations in irreversible polymer adsorption. P. Dalhaimer, O. Wagner, J.-F. Leterrier, P.A. Janmey, H. Aranda-Espinoza, & D.E. Discher. Journal of Polymer Science B: Polymer Physics 43, 280-286 (2005).

·        Targeted worm micelles. P. Dalhaimer, A.J. Engler, R. Parthasarathy, F.S. Bates, & D.E. Discher. Biomacromolecules 5, 1714-1719 (2004).

·        Direct visualization of polymers in nematic liquid crystals. Dogic, J. Zhang, A.W.C. Lau, H. Aranda-Espinoza, P. Dalhaimer, D.E. Discher, P.A. Janmey, T.C. Lubensky, & A.G. Yodh. Physical Review Letters 92, 125503 (2004).

·        Biopolymer mimicry with polymeric worm-like micelles: MW-scaled flexibility, locked-in curvature, and coexisting microphases. P. Dalhaimer, H. Bermudez, & D.E. Discher. Journal of Polymer Science B: Polymer Physics 4, 168-176 (2003).

·        Single molecule visualization of stiffness-tunable, flow-conforming worm micelles. P. Dalhaimer, F.S. Bates, & D.E. Discher. Macromolecules 36, 6873-6877 (2003).

·        Synthetic cell elements from block copolymers – hydrodynamic aspects.  P. Dalhaimer, F.S. Bates, H. Aranda-Espinoza, & D.E. Discher. Comptes Rendus – Physique 4, 251-258 (2003).

·        Cooperativity in forced unfolding of tandem spectrin repeats. R. Law, P. Carl, S. Harper, P. Dalhaimer, D.W. Speicher, & D.E. Discher. Biophysical Journal 84, 533-544 (2003).

·        Actin protofilament orientation in deformation of the erythrocyte membrane skeleton. C. Picart, P. Dalhaimer, & D.E. Discher. Biophysical Journal 79, 2987-3000 (2000).

² Nucleotide-mediated conformational changes of monomeric actin.

American Society for Cell Biology.

¹ Worm micelles as synthetic phages.

American Institute of Chemical Engineers Annual Conference.

San Francisco, CA. 2003.

² Biopolymer mimicry with polymeric worm-like micelles: MW-scaled flexibility, locked-in curvature, and coexisting microphases.

GRC: Chemistry of Supramolecular Assemblies. 

¹ Self-assembly and phase behavior of membrane skeletons.

American Society of Mechanical Engineers Bioengineering Conference.

Key Biscayne, FL. 2003.

¹ Single molecule visualization of stiffness- and curvature-tunable worm micelles with applications for micro and nano delivery.

American Physical Society Annual Meeting.

Austin, TX. 2003.

² Flexibility transitions and loop conformations in irreversible polymer adsorption.
Biophysical Society Annual Meeting.

¹ Phase behavior of spectrin-actin skeletons by simulation.

Biophysical Society Annual Meeting.

San Francisco, CA. 2002.

² Phase behavior of 2D nematic elastomer skeletons.

Principles of Soft Matter. 

Sante Fe, NM. 2001.

Block copolymer worm micelles for drug delivery and imaging

D.E. Discher and P. Dalhaimer

U.S. Copyright

Protein Unfolding Analysis Software (PUAS)

P. Carl and P. Dalhaimer

T.A.:   Process Design (9/00-12/00)

Biotechnology and Gene Engineering Laboratory (1/01-5/01).

 High Tech Charter High School of Philadelphia

Instructor: Computer Programming (Fall semester 2002).

 
Professional Experience

Engineer: Designed sales and engineering ActiveX software developed with MS VC++ and MFC for WinNT. (11/98-8/99).

Programmer: Developed DataMap^TM a MFC ActiveX control using MS VC++ 6.0 for Microsoft Excel. (6/00-9/00).

Last Updated: January 25, 2007