Dr. Christopher Jurgenson

 

Education:

 

Cornell University                                                                                             2008

Ph.D. in Biophysical Chemistry

Seton Hall University                                                                                        2002

M.S. in Physical Chemistry

Indiana University – Bloomington                                                                   1998

B.S. in Biochemistry

                                   

Research Positions:

 

Yale University – Dept. of Molecular, Cellular and Developmental        2008-

Biology

 

Cornell University – Dept. of Chemistry and Chemical Biology              2003-2008

 

Merck and Co., Inc. – Process Research Dept.                                          1998-2003

 

Seton Hall University – Dept. of Chemistry                                                1999-2002

 

Indiana University – Dept. of Chemistry                                                   1997-1998

 

Awards/Affiliations:

 

 

Presentations:

 

“Structural Insights into the Role of Thiazole Synthase in Saccharomyces cerevesiae” 2006 Meeting of the American Crystallographic Association

 

“Crystal Structure of a Sulfur Carrying Protein Complex found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis” 2007 NIH Chemistry and Chemical Biology Interface Summit

 

“Structure Based Enzymology of the Formation of Several Intermediates from the Thiamin Biosynthetic Enzyme Thi4 in Saccharomyces cerevisiae” 2008 Meeting of the American Crystallographic Association

 

Posters:

 

“Crystal Structure of a Sulfur Carrying Protein Complex found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis” 2007 Chemistry and Chemical Biology Interface Summit and 2007 Meeting of the American Crystallographic Association

 

“Structure Based Enzymology of the Formation of Several Intermediates from the Thiamin Biosynthetic Enzyme Thi4 in Saccharomyces cerevisiae” 2008 CHESS Users Meeting

 

Publications:

 

  1. Jurgenson CT, Chatterjee A, Begley TP and Ealick SE. Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae. Biochemistry 45:11061-11070 (2006).
  2. Jurgenson CT, Burns KE, Begley TP, Ealick SE. Crystal Structure of a Sulfur Carrying Protein Complex found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis. Accepted
  3. Jurgenson CT, Xu Q, Deacon A, Ealick SE. Crystal Structure of a Purine Nucleoside Phosphorylase (Tm1596) from Thermotoga maritima at 2.01 Å Resolution. In preparation           
  4. Jurgenson CT, Ealick SE, Begley TP. The Structural and Biochemical Foundations of Thiamin Biosynthesis. In preparation (review)
  5. Jurgenson CT, Ealick SE, Begley TP. Biosynthesis of Thiamin. Escherichia coli and Salmonella: Cellular and Molecular Biology, Vol. III, Chapter 3.6.3.7. Accepted
  6. Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, and Begley TP. Thiamin Biosynthesis in Eukaryotes: Characterization of the Enzyme-Bound Product of Thiazole Synthase from Saccharomyces cerevisiae and Its Implications in Thiazole Biosynthesis. J. Am. Chem. Soc. 128:7158-7159 (2006).
  7. Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, Begley TP. Biosynthesis of the Thiamin Thiazole in Eukaryotes: The Conversion of NAD to and Advanced Intermediate. J. Am. Chem. Soc. 129:126-134 (2007).
  8. Chatterjee A, Schroeder FC., Jurgenson CT, Ealick SE, Begley TP. Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Novel Thiazole Tautomer Intermediate. J. Am. Chem. Soc. In Press
  9. O’Leary SE, Jurgenson CT, Ealick SE, Begley TP. O-Phospho-L-serine and the Thiocarboxylated Sulfur Carrier Protein CysO-COSH are Substrates for CysM, a Cysteine Synthase from Mycobacterium tuberculosis. Submitted