Technologies Available for Licensing

Welcome to the Yale OCR's searchable Technologies Database.

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Allosteric Ribozyme by Ron Breaker, Henry Ford II Professor of Molecular, Cellular and Developmental Biology (MCDB), HHMI Investigator

A proposed mechanism for allosteric inhibition of an ATP-sensitive hammerhead ribozyme. Depicted are five superimposed orientations for an ATP-binding RNA aptamer that represent a series of conjoined aptamer/ribozyme constructs. The aptamer's protruding hairpin generates a procession of spatial orientations arrayed around the helical screw axis of a central connective stem as the number of base pairs comprising this stem is varied.