Jacobs-Wagner Lab

Professional Address
	Dept. of Molecular, Cellular and Developmental Biology Yale University P.O. Box 208103 New Haven , CT 06520
Education
1986 - 1991 1991 - 1996 1996 - 2000	M.S. in Biochemistry University of Liège , Belgium PhD in Biochemistry University of Liège , Belgium Postdoc in Developmental Biology Stanford University , CA, USA
Current Position
2001- present	Maxine Singer Associate Professor Dept. of Molecular, Cellular and Developmental Biology Yale University
Honors
1991 - 1992 1992 - 1996 1993 1994 - 1995 1996 - 1998 1997 1997 1998 1998 2001 2003 - present 2004 - present	BAEF (Belgian American Educational Foundation) fellowship FNRS (Fonds National de la Recherche Scientifique) fellowship Short-term FNRS fellowship Short-term EMBO (European Molecular Biology Organization) fellowship Long-term EMBO fellowship Grand Prize Winner of the Young Scientist Award (formerly Amersham Pharmacia Biotech and Science Prize for Young Scientists) Marcel-Florkin Prize Award TOYP (The Young Outstanding Persons) in Medical Innovations from the Young Economic Chamber of Belgium A. Wetrems Prize in Natural Sciences E. Van Beneden Prize Pew Scholarship Award in the Biomedical Sciences Maxine Singer Associate Professor of Molecular, Cellular, and Developmental Biology, Yale University
Publications
Lam H., Schofield W.B. and Jacobs-Wagner, C. (2006) A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell. Cell 124:1011-23. Cabeen MT and Jacobs-Wagner C. (2005) Bacterial cell shape. Nat Rev Microbiol 3:601-10. Matroule JY, Lam H, Burnette DT,and Jacobs-Wagner C. (2004) Cytokinesis monitoring during development: Rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter. Cell 118: 579-90. Jacobs-Wagner C. (2004) Regulatory proteins with a sense of direction: Cell cycle signaling network in Caulobacter. Mol Microbiol 51:7-13. Ausmees N, Kuhn JR, and Jacobs-Wagner C. (2003) The Bacterial Cytoskeleton: An Intermediate Filament-like Function in Cell Shape. Cell 115:705-13. Featured on the cover. Ausmees N and Jacobs-Wagner C. (2003) Spatial and temporal control of differentiation and cell cycle progression in Caulobacter crescentus. Annu Rev Microbiol 57, 225-247. Lam H, Matroule J-Y, and Jacobs-Wagner C. (2003) The asymmetric spatial distribution of bacterial signal transduction proteins coordinates cell cycle events. Dev Cell 5, 149-159. Jacobs C, Ausmees N, Cordwell SJ, Shapiro L and Laub M. (2003) The bacterial CckA histidine kinase controls the global cell cycle functions of the CtrA response regulator. Mol Microbiol 47, 1279-1290. Jacobs C, Hung D, and Shapiro L. (2001) Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle. Proc Natl Acad Sci USA 98, 4095-4100. Jacobs C and Shapiro L. (1999) Bacterial cell division: A moveable feast. Proc Natl Acad Sci USA 96, 5891-5893. Jacobs C, Domian IJ, Maddock J, and Shapiro L. (1999) Cell cycle-dependent polar localization of an essential bacterial histidine kinase that controls DNA replication and cell division. Cell 97, 111-120. Jacobs C and Shapiro L. (1998) Microbial asymmetric cell division: localization of cell fate determinants. Curr Opin Genet & Dev 8, 386-391. Jacobs C. (1997) Life in the balance: Cell walls and antibiotic resistance. Science 278, 1731-1732. Jacobs C, Frère J-M, and Normark S. (1997) Cytosolic intermediates for cell wall biosynthesis and degradation control inducible ß-lactam resistance in Gram-negative bacteria. Cell 88, 823-832. Jacobs C, Joris B, Jamin M, Klarsov K, Van Beeumen J, Mengin-Lecreulx D, van Heijenoort J, Park JT, Normark S, and Frère J-M. (1995) AmpD, essential for both ß-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase. Mol Microbiol 15, 553-559. Jacobs C, Huang L-J, Bartowsky E, Normark S, and Park JT. (1994) Bacterial cell wall recycling provides cytosolic muropeptides as effectors for ß-lactamase induction. EMBO J 13, 4684-4694. Normark S, Bartowsky E, Erickson J, Jacobs C, Lindberg F, Lindquist S, Weston-Hafer K, and Wikström M. (1994) Mechanisms of chromosomal ß-lactamase induction in Gram-negative bacteria. In Ghuysen, J.-M. and Hakenbeck, R. (Eds.), Bacterial cell wall . Elsevier Science B.V., Amsterdam, 485-503. Dubus A, Monnaie D, Jacobs C, Normark S, and Frère J-M. (1993) A dramatic change in the rate-limiting step of ß-lactam hydrolysis results from the substitution of the active-site serine residue by a cysteine in the class C ß-lactamase of Enterobacter 908R. Biochem J 292, 537-543. Jacobs C, Dubus A, Monnaie D, Normark S, and Frère, J-M (1992) Mutation of serine 318 in the class C ß-lactamase of Enterobacter 908R. FEMS Microbiol Letters 92, 95-100.