Jacobs-Wagner Lab

Publications

Campos M, Surovtsev IV, Kato S, Paintdakhi A, Beltran B, Ebmeier SE, Jacobs-Wagner C (2014). A constant size extension drives bacterial cell size homeostasis. Cell 159:1433-46.
PubMed

Chou S, Daugherty MD, Peterson SB, Biboy J, Yang Y, Jutras BL, Fritz-Laylin LK, Ferrin MA, Harding BN, Jacobs-Wagner C, Yang XF, Vollmer W, Malik HS, Mougous JD (in press). Transferred interbacterial antagonism genes augment eukaryotic innate immune function. Nature doi: 10.1038/nature13965.
PubMed

Alpha CJ, Campos M, Jacobs-Wagner C, Strobel SA (in press). Mycofumigation by the volatile organic compound producing fungus Muscodor albus induces bacterial cell death through DNA damage. Appl Environ Microbiol pii: AEM.03294-14.
PubMed

Lim HC, Surovtsev IV, Beltran BG, Huang F, Bewersdorf J, Jacobs-Wagner C (2014). Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation. Elife 3:e02758.
PubMed

Deghelt M, Mullier C, Sternon JF, Francis N, Laloux G, Dotreppe D, Van der Henst C, Jacobs-Wagner C, Letesson JJ, De Bolle X (2014). G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus. Nat Commun 5:4366.
PubMed

Parry BR, Surovtsev IV, Cabeen MT, O'Hern CS, Dufresne ER, Jacobs-Wagner C (2014) The bacterial cytoplasm has glass-like properties and is fluidized by metabolic activity. Cell 156:183-94.
PubMed

Laloux G, Jacobs-Wagner C (2014) How do bacteria localize proteins to the cell pole? J Cell Sci 127:11-9.
PubMed

Ko JH, Montero Llopis PM, Heinritz J, Jacobs-Waner C, Soll D (2013). Suppression of amber codons in Caulobacter crescentus by the orthogonal Escherichia coli Histidyl-tRNA synthetase/tRNAHis pair. PloS One 8:e83630.
PubMed

Fang G, Passalacqua K, Hocking J, Montero Llopis P, Gerstein M, Bergman NH, and Jacobs-Wagner C (2013) Transcriptomic and phylogenetic analysis of a bacterial cell cycle reveals strong associations between gene co-expression and evolution. BMC Genomics 14:450.
PubMed

Laloux G and Jacobs-Wagner C. (2013) Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization. J Cell Biol 201:827-41. PubMed

Takacs CN, Hocking J, Cabeen MT, Bui NK, Poggio S, Vollmer W, and Jacobs-Wagner C. (2013) Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus. PloS One 8(2):e57579.
PubMed

Campos M and Jacobs-Wagner C. (2013) Cellular organization of the transfer of genetic information. Curr Opin Microbiol 16:171-6.
PubMed

Montero Llopis P, Sliusarenko O, Heinritz J, and Jacobs-Wagner C. (2012) In vivo biochemistry in bacterial cells using FRAP: insight into the translation cycle. Biophys J 103: 1848-59.
PubMed

Anwari K, Webb CT, Poggi S, Perry AJ, Bousoff M, Celik N, Ramm G, Lovering A, Sockett RE, Smit J, Jacobs-Wagner C, Lithgow T. (2012) The evolution of new lipoprotein subunits of the bacterial outer membrane BAM complex. Mol Microbiol 84:832-44.
PubMed

Hocking J, Priyadarshini R, Takacs NC,Costa T, Dye N, Vollmer W, and Jacobs-Wagner C. (2012) Osmolarity-dependent relocation of penicillin-binding protein PBP2 to the division machinery in Caulobacter crescentus. J Bacteriol 194:3116-27.
PubMed

Charbon G, Wang J, Brustad E, Schultz PG, Horwich , Jacobs-Wagner C, Chapman E. (2011) Localization of GroEL determined by in vivo incorporation of fluorescent amino acid. Bioorg Med Chem Lett 211:6067-70.
PubMed

Charbon G, Brustad E, Scott KA, Wang J, Løbner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E. (2011) Subcellular protein localization by using a genetically encoded fluorescent amino Acid. Chembiochem 12:1818-21.
PubMed

Sliusarenko O, Heinritz J, Emonet T, Jacobs-Wagner C. (2011) High-throughput, subpixel precision analysis of bacterial morphogenesis and intracellular spatio-temporal dynamics. Mol Microbiol; 80:612-27.
PubMed

Cabeen MT, Herrmann H, Jacobs-Wagner C. (2011) The domain organization of the bacterial intermediate filament-like protein crescentin is important for assembly and function. Cytoskeleton (Hoboken); 68:205-19.
PubMed

Cabeen MT, Jacobs-Wagner C. (2010) The bacterial cytoskeleton. Annu Rev Genet; 44:365-92.
PubMed

Schofield WB, Lim HC, Jacobs-Wagner C. (2010) Cell cycle coordination and regulation of bacterial chromosome segregation dynamics by polarly localized proteins. EMBO J; 29:3068-81.
PubMed

Cabeen MT, Jacobs-Wagner C. (2010) A metabolic assembly line in bacteria. Nat Cell Biol; 12:731-3.
PubMed

Montero Llopis PM, Jackson AF, Sliusarenko O, Surovtsev I, Heinritz J, Emonet T, Jacobs-Wagner C. (2010) Spatial organization of the flow of genetic information in bacteria. Nature; 466: 77-81.
PubMed

Poggio S, Takacs CN, Vollmer W, Jacobs-Wagner C. (2010) A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains. Mol Microbiol; 77:74-89
PubMed

Cabeen MT, Murolo MA, Briegel A, Bui NK, Vollmer W, Ausmees N, Jensen GJ, Jacobs-Wagner C. (2010) Mutations in the Lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus. J Bacteriol;192: 3368-78.
PubMed

Sliusarenko O, Cabeen MT, Wolgemuth CW, Jacobs-Wagner C, Emonet T. (2010) Processivity of peptidoglycan synthesis provides a built-in mechanism for the robustness of straight-rod cell morphology. Proc Natl Acad Sci U S A;107: 10086-91.
PubMed

Anwari K, Poggio S, Perry A, Gatsos X, Ramarathinam SH, Williamson NA, Noinaj N, Buchanan S, Gabriel K, Purcell AW, Jacobs-Wagner C, Lithgow T. (2010) A modular BAM complex in the outer membrane of the alpha-proteobacterium Caulobacter crescentus. PLoS One 5, e8619.
PubMed

Takacs CN, Poggio S, Charbon G, Pucheault M, Vollmer W, Jacobs-Wagner C. (2010) MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall.
J Bacteriol. 192, 1671-84.
PubMed

Angelastro PS, Sliusarenko O, Jacobs-Wagner C. (2010) Polar localization of the CckA histidine kinase and cell cycle periodicity of the essential master regulator CtrA in Caulobacter crescentus. J Bacteriol. 192, 539-52.
PubMed

Clements A, Bursac D, Gatsos X, Perry AJ, Civciristov S, Celik N, Likic VA, Poggio S, Jacobs-Wagner C, Strugnell RA, Lithgow T. (2009) The reducible complexity of a mitochondrial molecular machine. Proc Natl Acad Sci U S A. 106, 15791-5.
PubMed  PDF

Cabeen MT, Charbon G, Vollmer W, Born P, Ausmees A, Weibel, D and Jacobs-Wagner C. (2009) Bacterial cell curvature via mechanical control of cell growth. EMBO J 28, 1208-1219.
PubMed  PDF  EMBO J Commentary

Charbon G, Cabeen MT and Jacobs-Wagner C. (2009) Bacterial intermediate filaments: In vivo assembly, organization and dynamics of crescentin. Genes & Dev 23, 1131-44.
PubMed  PDF  Supplemental

Alyahya S.A, Alexander A, Costa T, Henriques AO, Emonet T, Jacobs-Wagner C. (2009) RodZ, a component of the bacterial core morphogenic apparatus. Proc Natl Acad Sci USA 106:1239-44.
PubMed  PDF  Supplemental

Costa T, Priyadarshini R, Jacobs-Wagner C. (2008) Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain. Mol Microbiol. 70:634-651.
PubMed  PDF  Supplemental

Ebersbach G, Briegel A, Jensen GJ, Jacobs-Wagner C. (2008) A self-associating protein critical for chromosome attachment, division, and polar organization in Caulobacter. Cell 134:956-68.
PubMed  PDF  Supplemental  Cell Preview  

Obuchowski PL, Jacobs-Wagner C. (2008) PflI, a protein involved in flagellar positioning in Caulobacter crescentus.
J Bacteriol. 190:1718-29.
PubMed  PDF

Cabeen MT, Jacobs-Wagner C. (2007) Skin and bones: the bacterial cytoskeleton, cell wall, and cell morphogenesis.
J Cell Biol. 179:381-7.
PubMed  PDF

Aaron M, Charbon G, Lam H, Schwarz H, Vollmer W, Jacobs-Wagner C. (2007) The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus. Mol Microbiol. 64:938-52.
PubMed  PDF  Supplemental  Molecular Microbiology Commentary  

Hallez R, Mignolet J, Van Mullem V, Wery M, Vandenhaute J, Letesson JJ, Jacobs-Wagner C, De Bolle X. (2007) The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus. EMBO J. 26:1444-55.
PubMed  PDF

Ebersbach G, Jacobs-Wagner C. (2007) Exploration into the spatial and temporal mechanisms of bacterial polarity. Trends Microbiol. 15:101-8.
PubMed  PDF

Lam H., Schofield W.B. and Jacobs-Wagner, C. (2006) A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell. Cell 124:1011-23.
PubMed  PDF  Supplemental  Cell Preview

Cabeen, M.T. and Jacobs-Wagner, C. (2005) Bacterial cell shape. Nat Rev Microbiol. 3:601-10
PubMed  PDF

Matroule J.Y., Lam H., Burnette D.T., and Jacobs-Wagner C. (2004) Cytokinesis monitoring during development: Rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter. Cell 118: 579-90.
PubMed  PDF  Nature Micro Review

Jacobs-Wagner, C. (2004) Regulatory proteins with a sense of direction: Cell cycle signaling network in Caulobacter. Mol Microbiol. 51:7-13.
PubMed  PDF

Ausmees, N., Kuhn, J. R., and Jacobs-Wagner, C. (2003) The Bacterial cytoskeleton: An Intermediate Filament-like Function in Cell Shape. Cell 115:705-13.
PubMed  PDF  Science News  Nature Micro Review  Cell Preview  Current Biology Dispatch

Ausmees, N. and Jacobs-Wagner, C. (2003) Spatial and temporal control of differentiation and cell cycle progression in Caulobacter crescentus. Annu Rev Microbiol. 57, 225-247.
PubMed  PDF

Lam, H., Matroule, J.-Y., and Jacobs-Wagner, C. (2003) The asymmetric spatial distribution of bacterial signal transduction proteins coordinates cell cycle events. Dev Cell 5, 149-159.
PubMed  PDF

Jacobs C, Ausmees N, Cordwell SJ, Shapiro L, Laub MT. (2003) Functions of the CckA histidine kinase in Caulobacter cell cycle control. Mol Microbiol. 47:1279-90.
PubMed  PDF