Computational Biology: Post-doctoral positions
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Computational Biologist


Research Area:  non-coding RNAs, RNA-seq, Ribosome profiling, Par-Clip, Gene expression analysis


Description of project: Several postdoctoral position in computational biology are available to study:

  1. -The regulatory motifs and the RNA binding proteins that control translation, transcription and mRNA decay during development.


  1. -Small RNAs and other non-coding small RNAs by combining high throughput sequencing and genetics in vertebrate model systems.


The Giraldez laboratory provides an integrated environment for computational biologists and experimental biologists to develop these projects.

Applicants require a strong background in Bioinformatics, sequence analysis, statistics and perl programming.  There are two other computational biologists in the Giraldez laboratory.


Application:

Please e-mail CV, summary and relevance of your current research (500 word max), why you are interested in the giraldez lab (200 word max) and names of three references to: giraldezlab@gmail.com

Include “Computational Biology 2012” in the subject of the email


These are some of the papers recently published by the laboratory:

  1. 1.Bazzini AA, Lee MT, Giraldez AJ‡. Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish. Science 13 April 2012: 233-237.

  2. 2.Staton AA, Knaut H and Giraldez AJ‡. miRNA regulation of SDF1 chemokine signaling provides genetic robustness to germ cell migration. Nature Genetics. 2011 Mar;43(3):204-11. Epub 2011 Jan 23

  3. 3.Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson N, Wolfe S, Giraldez AJ‡. A novel miRNA processing pathway independent of Dicer requires Argonaute2. Science. 2010, Jun 25;328(5986):1694-8. Epub 2010 May 6

  4. 4.Mishima Y, Abreu-Goodger C, Staton AA, Stahlhut C, Shou C, Cheng C, Gerstein M, Enright AJ and Giraldez AJ. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Genes & Development. 2009 Mar 1;23(5):619-32. Epub 2009 Feb 24. PMID: 19240126

  5. 5.Choi WY, Giraldez AJ‡, Schier AF‡. Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430. Science. 2007. Oct 12;318(5848):271-4. ‡Corresponding authors.

  6. 6.Giraldez AJ‡, Mishima Y, Rihel J, Grocock R, van Dongen S, Inoue, K, Enright A, and Schier AF‡. Zebrafish miR-430 promotes deadenylation and clearance of maternal mRNAs. Science. 2006 Apr 7;312(5770):75-9.

Thanks for checking out our postings for positions:

We are a lab of scientists who are passionate about what we do, with interests and expertise spanning Development, Biochemistry, Genomics, and Computational biology. Our projects are focused on collaborative, integrative science to study the earliest steps of vertebrate development. We are looking for scientists who share our passion for science and would like to work in a friendly, multidisciplinary and multicultural environment.