Publications

2014 (Back to top)

"Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain."
Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD.
J Virol. 2013 Oct 30. [Epub ahead of print] PMID: 24173222. PDF

2013 (Back to top)

"Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain."
Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD.
J Virol. 2013 Oct 30. [Epub ahead of print] PMID: 24173222. PDF

"Aspartate Embedding Depth Affects pHLIP's Insertion pKa."
Fendos J, Barrera FN, Engelman DM.
Biochemistry. 2013;52(27):4595–4604 . PDF

"Family of pH (low) insertion peptides for tumor targeting."
Weerakkody D, Moshnikova A, Thakur MS, Moshnikova V, Daniels J, Engelman DM, Andreev OA, Reshetnyak YK.
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5834-9. PDF

"Peptide targeting and imaging of damaged lung tissue in influenza-infected mice."
Li N, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VT, Engelman DM, Engelward BP.
Future Microbiol. 2013 Feb;8(2):257-69. PDF

"pHLIP peptide targets nanogold particles to tumors."
Yao L, Danniels J, Moshnikova A, Kuznetsov S, Ahmed A, Engelman DM, Reshetnyak YK, Andreev OA.
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):465-70. PDF

2012 (Back to top)

"pH (low) insertion peptide (pHLIP) targets ischemic myocardium."
Sosunov EA, Anyukhovsky EP, Sosunov AA, Moshnikova A, Wijesinghe D, Engelman DM, Reshetnyak YK, Andreev OA.
Proc Natl Acad Sci USA (2012) Dec 17. [Epub ahead of print]. PDF

"In Vivo pH Imaging with (99m)Tc-pHLIP."
Macholl S, Morrison MS, Iveson P, Arbo BE, Andreev OA, Reshetnyak YK, Engelman DM, Johannesen E.
Mol Imaging Biol. 2012 Dec;14(6):725-34. PDF

"Membrane physical properties influence transmembrane helix formation."
Barrera FN, Fendos J, Engelman DM.
Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14422-7. Epub 2012 Aug 20. PDF

"Modulation of the pHLIP Transmembrane Helix Insertion Pathway ."
Karabadzhak AG, Weerakkody D, Wijesinghe D, Thakur MS, Engelman DM, Andreev OA, Markin VS, Reshetnyak YK.
Biophys J. 2012 Apr 18;102(8):1846-55. PDF

2011 (Back to top)

"Tuning a Polar Molecule for Selective Cytoplasmic Delivery by a pH (Low) Insertion Peptide."
Wijesinghe D, Engelman DM, Andreev OA, Reshetnyak YK..
Biochemistry. 2011 Nov 4. [Epub ahead of print]. PDF

"Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides."
Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM.
J Mol Biol. 2011 Aug 23. [Epub ahead of print]. PDF

"Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation"
Matthews EE, Thévenin D, Rogers JM, Gotow L, Lira PD, Reiter LA, Brissette WH, Engelman DM
FASEB J. 2011 Mar 14. [Epub ahead of print]. PDF

2010 (Back to top)

"Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP"
Reshetnyak YK, Yao L, Zheng S, Kuznetsov S, Engelman DM, Andreev OA
Mol Imaging Biol. 2010 Dec 23. PDF

"The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein"
Miyauchi K, Curran AR, Long Y, Kondo N, Iwamoto A, Engelman DM, Matsuda Z
Retrovirology. 2010 Nov 13;7:95. PDF - Show Abstract

"pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation"
An M, Wijesinghe D, Andreev OA, Reshetnyak YK, Engelman DM
Proc Natl Acad Sci USA (2010) Early Edition. PDF - Show Abstract

"pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents"
Andreev OA, Engelman DM, Reshetnyak YK
Molecular Membrane Biology, 2010; Early Online, 341–352. PDF - Show Abstract

"Analysis of membrane proteins in metagenomics: Networks of correlated environmental features and protein families"
Patel PV, Gianoulis TA, Bjornson RD, Yip KY, Engelman DM , Gerstein MB
Genemone Research (2010) Apr 29. PDF - Show Abstract

"pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path."
Andreev OA, Karabadzhak AG, Weerakkody D, Andreev GO, Engelman DM, Reshetnyak YK
Proc Natl Acad Sci USA (2010) March 2 107(9) 4081-4086. PDF - Show Abstract

"Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor"
Cammet TJ , Jun SJ, Cohen EB, Barrera FN, Engelman DM, DiMaio D
Proc Natl Acad Sci USA (2010) 107(8) 3447-3452. PDF - Show Abstract


2009 (Back to top)

"Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP)"
Segala J, Engelman DM, Reshetnyak YK, Andreev OA
Int. J. Mol. Sci (2009) 10, 3478-3487. PDF - Show Abstract

"Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP) "
Andreev OA, Engelman DM, Reshetnyak YK
Chim Oggi. (2009) Mar 1; 27(2): 34-37. PDF - Show Abstract

"Tuning the insertion properties of pHLIP "
Musical-Siwek M, Karabadzhak A, Andreev OA, Reshetnyak YK, Engelman DM
Biochim. Biophys. Acta (2009) ahead of print. PDF - Show Abstract

"Computational analysis of membrane proteins: the largest class of drug targets"
Arinaminpathy Y , Khurana E, Engelman DM, Mark B. Gerstein
Drug discovery Today. (2009) ahead of print. PDF - Show Abstract

"pHLIP-Mediated Translocation of Membrane-Impermeable Molecules into Cells"
Thévenin D, An M, Engelman DM
Chem. Biol. (2009) 16(7), 754-762. PDF - Show Abstract

"Artificial transmembrane oncoproteins smaller that the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor {beta} receptor "
Talbert-Slage K, Marlatt S, Barrera FN, Khurana E, Oates JE, Gerstein M, Engelman DM, Dixon A, Dimaio D
J Virol. (2009) 83, 9773-9785. PDF - Show Abstract

"Molecular dynamics studies of the transmembrane domain of Gp41 from HIV-1"
Kim J, Hartley TL, Curran AR, Engelman DM
Biochim Biophys Acta (2009) 1788, 1804-1812. PDF - Show Abstract

"Image analysis of soft-tissue in-growth and attachment into highly porous alumina ceramic foam metals"
Khalil A, Aponte C, Zhang R, Davisson T, Dickey I, Engelman D, Hawkins M, Mason M.
Medical Engineering & Physics (2009) 31, 775-783. PDF - Show Abstract

"A novel technology for the imaging of acidic prostate tumors by positron emission tomography"
Vavere AL, Biddlecombe GB, Spees WM, Garbow JR, Wijesinghe D, Andreev OA, Engelman DM, Reshetnyak YK, Lewis JS
Cancer Res (2009) 69(10), 4510-4516. PDF - Show Abstract


2008 (Back to top)

"Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane "
Reshetnyak YK, Andreev OA, Segala M, Markin VS, Engelman DM
Proc Natl Acad Sci USA (2008) 105(40), 15340-5. PDF - Show Abstract

"Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors."
Zoonens M, Reshetnyak YK, and Engelman DM
Biophysical Journal (2008) 95(1), 225-235. PDF - Show Abstract

"An integrated system for studying residue coevolution in proteins"
Yip KY, Patel P, Kim PM, Engelman DM, McDermott D and Gerstein M
Bioinformatics (2008) 24(2), 290-2. PDF - Show Abstract

"Bacteriorhodopsin/amphipol complexes: structural and functional properties"
Gohon Y, Dahmane T, Ruigrok RW, Schuck P, Charvolin D, Rappaport F, Timmins P, Engelman DM, Tribet C, Popot JL and Ebel C
Biophysical Journal (2008) 94(9), 3523-37. PDF - Show Abstract

"Protein area occupancy at the center of the red blood cell membrane"
Dupuy AD and Engelman DM
Proc Natl Acad Sci USA (2008) 105(8), 2848-52. PDF - Show Abstract


2007 (Back to top)

"A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers"
Reshetnyak YK, Segala M, Andreev OA and Engelman DM
Biophysical Journal (2007) 93(7), 2363-72. PDF - Show Abstract

"Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo"
Andreev OA, Dupuy AD, Segala M, Sandugu S, Serra DA, Chichester CO, Engelman DM and Reshetnyak YK
Proc Natl Acad Sci USA (2007) 104(19), 7893-8. PDF - Show Abstract


2006 (Back to top)

"Introduction to the membrane protein reviews: the interplay of structure, dynamics, and environment in membrane protein function"
Sachs JN and Engelman DM
Annu. Rev. Biochem. (2006) 75, 707-12. PDF - Show Abstract

"Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix"
Reshetnyak YK, Andreev OA, Lehnert U and Engelman DM
Proc Natl Acad Sci USA (2006) 103(17), 6460-5. PDF - Show Abstract

"Mutations of conserved glycine residues within the membrane-spanning domain of human immunodeficiency virus type 1 gp41 can inhibit membrane fusion and incorporation of Env onto virions"
Miyauchi K, Curran R, Matthews E, Komano J, Hoshino T, Engelman DM and Matsuda Z
Jpn J Infect Dis (2006) 59(2), 77-84. PDF - Show Abstract

"Dynamic helix interactions in transmembrane signaling"
Matthews EE, Zoonens M and Engelman DM
Cell (2006) 127(3), 447-50. PDF - Show Abstract

"The stability of transmembrane helix interactions measured in a biological membrane"
Finger C, Volkmer T, Prodöhl A, Otzen DE, Engelman DM and Schneider D
Journal of Molecular Biology (2006) 358(5), 1221-8. PDF - Show Abstract

"Invariant chain transmembrane domain trimerization: a step in MHC class II assembly"
Dixon AM, Stanley BJ, Matthews EE, Dawson JP and Engelman DM
Biochemistry (2006) 45(16), 5228-34. PDF - Show Abstract


2005 (Back to top)

"Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor"
Freeman-Cook L, Edwards AP, Dixon AM, Yates KE, Ely L, Engelman DM and DiMaio D
Journal of Molecular Biology (2005) 345(4), 907-21. PDF

"Membranes are more mosaic than fluid"
Engelman DM
Nature (2005) 438(7068), 578-80. PDF

"Transmembrane homodimerization of receptor-like protein tyrosine phosphatases"
Chin CN, Sachs JN and Engelman DM
FEBS Letters (2005) 579(17), 3855-8. PDF

"Normal modes for predicting protein motions: a comprehensive database assessment and associated Web tool"
Alexandrov V, Lehnert U, Echols N, Milburn D, Engelman D and Gerstein M
Protein Sci (2005) 14(3), 633-43. PDF


2004 (Back to top)

"Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions"
Schneider D and Engelman DM
Journal of Molecular Biology (2004) 343(4), 799-804. PDF

"Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins"
Schneider D and Engelman DM
J Biol Chem (2004) 279(11), 9840-6. PDF

"Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol"
Mitra K, Ubarretxena-Belandia I, Taguchi T, Warren G and Engelman DM
Proc Natl Acad Sci USA (2004) 101(12), 4083-8. PDF

"The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication"
Melnyk RA, Kim S, Curran AR, Engelman DM, Bowie J and Deber CM
J Biol Chem (2004) 279(16), 16591-7. PDF

"Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism"
Liu Y, Gerstein M and Engelman DM
Proc Natl Acad Sci USA (2004) 101(10), 3495-7. PDF

"Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions"
Lehnert U, Xia Y, Royce TE, Goh CS, Liu Y, Senes A, Yu H, Zhang ZL, Engelman DM and Gerstein M
Q Rev Biophys (2004) 37(2), 121-46. PDF

"Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor beta receptor"
Freeman-Cook L, Dixon AM, Frank JB, Xia Y, Ely L, Gerstein M, Engelman DM and DiMaio D
Journal of Molecular Biology (2004) 338(5), 907-20. PDF

"Molecular Dynamics Simulations of Micelle Formation around Dimeric Glycophorin A Transmembrane Helices"
Braun R, Engelman DM and Schulten K
Biophysical Journal (2004) 87(2), 754-63. PDF

2003 (Back to top)

"GALLEX, a measurement of heterologous association of transmembrane helices in a biological membrane"
Schneider D and Engelman DM
J Biol Chem (2003) 278(5), 3105-11. PDF

"Amphipols: polymeric surfactants for membrane biology research"
Popot JL, Berry EA, Charvolin D, Creuzenet C, Ebel C, Engelman DM, Flötenmeyer M, Giusti F, Gohon Y, Hong Q, Lakey JH, Leonard K, Shuman HA, Timmins P, Warschawski DE, Zito F, Zoonens M, Pucci B and Tribet C
Cell Mol Life Sci (2003) 60(8), 1559-74. PDF

"Effect of detergents on the association of the glycophorin a transmembrane helix"
Fisher LE, Engelman DM and Sturgis JN
Biophysical Journal (2003) 85(5), 3097-105. PDF

"Membrane protein folding: beyond the two stage model"
Engelman DM, Chen Y, Chin CN, Curran AR, Dixon AM, Dupuy AD, Lee AS, Lehnert U, Matthews EE, Reshetnyak YK, Senes A and Popot JL
FEBS Letters (2003) 555(1), 122-5. PDF

"Electrostatic fasteners hold the T cell receptor-CD3 complex together"
Engelman DM
Mol Cell (2003) 11(1), 5-6. PDF

"Sequence context strongly modulates association of polar residues in transmembrane helices"
Dawson JP, Melnyk RA, Deber CM and Engelman DM
Journal of Molecular Biology (2003) 331(1), 255-62. PDF

"Sequence motifs, polar interactions and conformational changes in helical membrane proteins"
Curran AR and Engelman DM
Current Opinion in Structural Biology (2003) 13(4), 412-7. PDF

"The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins"
Constantinescu SN, Keren T, Russ W, Ubarretxena-Belandia I, Malka Y, Kubatzky KF, Engelman DM, Lodish HF and Henis YI
J Biol Chem (2003) 278(44), 43755-63. PDF

2002 (Back to top)

"Thermostability of membrane protein helix-helix interaction elucidated by statistical analysis"
Schneider D, Liu Y, Gerstein M and Engelman DM
FEBS Letters (2002) 532(1-2), 231-6. PDF

"Rational design of 'water-soluble' bacteriorhodopsin variants"
Mitra K, Steitz TA and Engelman DM
Protein Eng (2002) 15(6), 485-92. PDF

"Genomic analysis of membrane protein families: abundance and conserved motifs"
Liu Y, Engelman DM and Gerstein M
Genome Biol (2002) 3(10). PDF

"Motifs of serine and threonine can drive association of transmembrane helices"
Dawson JP, Weinger JS and Engelman DM
Journal of Molecular Biology (2002) 316(3), 799-805. PDF

"Mutational analysis of synaptobrevin transmembrane domain oligomerization"
Bowen ME, Engelman DM and Brunger AT
Biochemistry (2002) 41(52), 15861-6. PDF

2001 (Back to top)

"Polar residues drive association of polyleucine transmembrane helices"
Zhou FX, Merianos HJ, Brunger AT and Engelman DM
Proc Natl Acad Sci USA (2001) 98(5), 2250-5. PDF

"Helical membrane proteins: diversity of functions in the context of simple architecture"
Ubarretxena-Belandia I and Engelman DM
Current Opinion in Structural Biology (2001) 11(3), 370-6. PDF

The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions"
Senes A, Ubarretxena-Belandia I and Engelman DM
Proc Natl Acad Sci USA (2001) 98(16), 9056-61. PDF

"Conversion of phospholamban into a soluble pentameric helical bundle"
Li H, Cocco MJ, Steitz TA and Engelman DM
Biochemistry (2001) 40(22), 6636-45. PDF

"Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library"
Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM and Beckwith J
Journal of Molecular Biology (2001) 313(1), 181-95. PDF

"Computation and mutagenesis suggest a right-handed structure for the synaptobrevin transmembrane dimer"
Fleming KG and Engelman DM
Proteins (2001) 45(4), 313-7. PDF

"Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants"
Fleming KG and Engelman DM
Proc Natl Acad Sci USA (2001) 98(25), 14340-4. PDF

"High-yield synthesis and purification of an alpha-helical transmembrane domain"
Fisher LE and Engelman DM
Analytical Biochemistry (2001) 293(1), 102-8. PDF

2000 (Back to top)

"Interhelical hydrogen bonding drives strong interactions in membrane proteins"
Zhou FX, Cocco MJ, Russ WP, Brunger AT and Engelman DM
Nat Struct Biol (2000) 7(2), 154-60. PDF

"Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions"
Senes A, Gerstein M and Engelman DM
Journal of Molecular Biology (2000) 296(3), 921-36. PDF

"The GxxxG motif: a framework for transmembrane helix-helix association"
Russ WP and Engelman DM
Journal of Molecular Biology (2000) 296(3), 911-9. PDF

"Helical membrane protein folding, stability, and evolution"

Popot JL and Engelman DM
Annu. Rev. Biochem. (2000) 69(881-922. PDF

"Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations"
Petrache HI, Grossfield A, MacKenzie KR, Engelman DM and Woolf TB
Journal of Molecular Biology (2000) 302(3), 727-46. PDF

"Design of single-layer beta-sheets without a hydrophobic core"
Koide S, Huang X, Link K, Koide A, Bu Z and Engelman DM
Nature (2000) 403(6768), 456-60. PDF

"A view of dynamics changes in the molten globule-native folding step by quasielastic neutron scattering"
Bu Z, Neumann DA, Lee SH, Brown CM, Engelman DM and Han CC
Journal of Molecular Biology (2000) 301(2), 525-36. PDF

1990's (Back to top)

"TOXCAT: a measure of transmembrane helix association in a biological membrane"
Russ WP and Engelman DM
Proc Natl Acad Sci USA (1999) 96(3), 863-8. PDF

"The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion"
McNew JA, Weber T, Engelman DM, Söllner TH and Rothman JE
Mol Cell (1999) 4(3), 415-21. PDF

"Multistep denaturation of Borrelia burgdorferi OspA, a protein containing a single-layer beta-sheet"
Koide S, Bu Z, Risal D, Pham TN, Nakagawa T, Tamura A and Engelman DM
Biochemistry (1999) 38(15), 4757-67. PDF

"Detergents modulate dimerization, but not helicity, of the glycophorin A transmembrane domain"
Fisher LE, Engelman DM and Sturgis JN
Journal of Molecular Biology (1999) 293(3), 639-51. PDF

"A method for determining transmembrane helix association and orientation in detergent micelles using small angle x-ray scattering"
Bu Z and Engelman DM
Biophysical Journal (1999) 77(2), 1064-73. PDF

"Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization"
MacKenzie KR and Engelman DM
Proc Natl Acad Sci USA (1998) 95(7), 3583-90. PDF

"A small-angle X-ray scattering apparatus for studying biological macromolecules in solution"
Bu ZM, Perlo A, Johnson GE, Olack G, Engelman DM and Wyckoff HW
J Appl Crystallogr (1998) 31(533-43. PDF

"A solution SAXS study of Borrelia burgdorferi OspA, a protein containing a single-layer beta-sheet"
Bu Z, Koide S and Engelman DM
Protein Sci (1998) 7(12), 2681-3. PDF

"Models for the transmembrane region of the phospholamban pentamer: which is correct?"
Adams PD, Lee AS, Brünger AT and Engelman DM
Ann N Y Acad Sci (1998) 853(178-85. PDF

"A transmembrane helix dimer: structure and implications"
MacKenzie KR, Prestegard JH and Engelman DM
Science (1997) 276(5309), 131-3. PDF

"Two EGF molecules contribute additively to stabilization of the EGFR dimer"
Lemmon MA, Bu Z, Ladbury JE, Zhou M, Pinchasi D, Lax I, Engelman DM and Schlessinger J
EMBO J (1997) 16(2), 281-94. PDF

"Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix"
Hunt JF, Rath P, Rothschild KJ and Engelman DM
Biochemistry (1997) 36(49), 15177-92. PDF

"Assessment of the aggregation state of integral membrane proteins in reconstituted phospholipid vesicles using small angle neutron scattering"
Hunt JF, McCrea PD, Zaccaï G and Engelman DM
Journal of Molecular Biology (1997) 273(5), 1004-19. PDF

"A biophysical study of integral membrane protein folding"
Hunt JF, Earnest TN, Bousché O, Kalghatgi K, Reilly K, Horváth C, Rothschild KJ and Engelman DM
Biochemistry (1997) 36(49), 15156-76. PDF

"The effect of point mutations on the free energy of transmembrane alpha-helix dimerization"
Fleming KG, Ackerman AL and Engelman DM
Journal of Molecular Biology (1997) 272(2), 266-75. PDF

"Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation"
Burke CL, Lemmon MA, Coren BA, Engelman DM and Stern DF
Oncogene (1997) 14(6), 687-96. PDF

"Are there dominant membrane protein families with a given number of helices?"
Arkin IT, Brünger AT and Engelman DM
Proteins (1997) 28(4), 465-6. PDF

"Structural perspectives of phospholamban, a helical transmembrane pentamer"
Arkin IT, Adams PD, Brünger AT, Smith SO and Engelman DM
Annual review of biophysics and biomolecular structure (1997) 26(157-79. PDF

"Structure of the transmembrane cysteine residues in phospholamban"
Arkin IT, Adams PD, Brünger AT, Aimoto S, Engelman DM and Smith SO
J Membr Biol (1997) 155(3), 199-206. PDF

"Surface point mutations that significantly alter the structure and stability of a protein's denatured state"
Smith CK, Bu Z, Anderson KS, Sturtevant JM, Engelman DM and Regan L
Protein Sci (1996) 5(10), 2009-19. PDF

"A zinc-binding domain involved in the dimerization of RAG1"
Rodgers KK, Bu Z, Fleming KG, Schatz DG, Engelman DM and Coleman JE
Journal of Molecular Biology (1996) 260(1), 70-84. PDF

"Coassembly of synthetic segments of shaker K+ channel within phospholipid membranes"
Peled-Zehavi H, Arkin IT, Engelman DM and Shai Y
Biochemistry (1996) 35(21), 6828-38. PDF

"Leucine side-chain rotamers in a glycophorin A transmembrane peptide as revealed by three-bond carbon-carbon couplings and 13C chemical shifts"
MacKenzie KR, Prestegard JH and Engelman DM
J Biomol NMR (1996) 7(3), 256-60. PDF

"Fourier transform infrared spectroscopy and site-directed isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban"
Ludlam CF, Arkin IT, Liu XM, Rothman MS, Rath P, Aimoto S, Smith SO, Engelman DM and Rothschild KJ
Biophysical Journal (1996) 70(4), 1728-36. PDF

"Crossing the hydrophobic barrier: insertion of membrane proteins"
Engelman DM
Science (1996) 274(5294), 1850-1

"Mapping the lipid-exposed surfaces of membrane proteins"
Arkin IT, MacKenzie KR, Fisher L, Aimoto S, Engelman DM and Smith SO
Nat Struct Biol (1996) 3(3), 240-3. PDF

"Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching"
Adams PD, Engelman DM and Brünger AT
Proteins (1996) 26(3), 257-61. PDF

"Small angle x-ray scattering studies of magnetically oriented lipid bilayers"
Hare BJ, Prestegard JH and Engelman DM
Biophysical Journal (1995) 69(5), 1891-6. PDF

"Structural model of the phospholamban ion channel complex in phospholipid membranes"
Arkin IT, Rothman M, Ludlam CF, Aimoto S, Engelman DM, Rothschild KJ and Smith SO
Journal of Molecular Biology (1995) 248(4), 824-34. PDF

"Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban"
Adams PD, Arkin IT, Engelman DM and Brünger AT
Nat Struct Biol (1995) 2(2), 154-62. PDF

"Rotational orientation of transmembrane alpha-helices in bacteriorhodopsin. A neutron diffraction study"
Samatey FA, Zaccaï G, Engelman DM, Etchebest C and Popot JL
Journal of Molecular Biology (1994) 236(4), 1093-104. PDF

"A dimerization motif for transmembrane alpha-helices"
Lemmon MA, Treutlein HR, Adams PD, Brünger AT and Engelman DM
Nat Struct Biol (1994) 1(3), 157-63. PDF

"Specificity and promiscuity in membrane helix interactions"
Lemmon MA and Engelman DM
Q Rev Biophys (1994) 27(2), 157-218.

"Specificity and promiscuity in membrane helix interactions"
Lemmon MA and Engelman DM
FEBS Letters (1994) 346(1), 17-20. PDF

"Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel"
Arkin IT, Adams PD, MacKenzie KR, Lemmon MA, Brünger AT and Engelman DM
EMBO J (1994) 13(20), 4757-64. PDF

"Glycophorin A helical transmembrane domains dimerize in phospholipid bilayers: a resonance energy transfer study"
Adair BD and Engelman DM
Biochemistry (1994) 33(18), 5539-44. PDF

"Mutations can cause large changes in the conformation of a denatured protein"
Flanagan JM, Kataoka M, Fujisawa T and Engelman DM
Biochemistry (1993) 32(39), 10359-70. PDF

"Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling"

Engelman DM, Adair BD, Brünger A, Flanagan JM, Hunt JF, Lemmon MA, Treutlein H and Zhang J
Soc Gen Physiol Ser (1993) 48(11-21.

"The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices"
Treutlein HR, Lemmon MA, Engelman DM and Brünger AT
Biochemistry (1992) 31(51), 12726-32. PDF

"Sequence specificity in the dimerization of transmembrane alpha-helices"

Lemmon MA, Flanagan JM, Treutlein HR, Zhang J and Engelman DM
Biochemistry (1992) 31(51), 12719-25. PDF

"Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices"
Lemmon MA, Flanagan JM, Hunt JF, Adair BD, Bormann BJ, Dempsey CE and Engelman DM
J Biol Chem (1992) 267(11), 7683-9. PDF

"Bacteriorhodopsin reconstituted from two individual helices and the complementary five-helix fragment is photoactive"
Kataoka M, Kahn TW, Tsujiuchi Y, Engelman DM and Tokunaga F
Photochem Photobiol (1992) 56(6), 895-901.

"Thermodynamic measurements of the contributions of helix-connecting loops and of retinal to the stability of bacteriorhodopsin"
Kahn TW, Sturtevant JM and Engelman DM
Biochemistry (1992) 31(37), 8829-39. PDF

"Bacteriorhodopsin can be refolded from two independently stable transmembrane helices and the complementary five-helix fragment"
Kahn TW and Engelman DM
Biochemistry (1992) 31(26), 6144-51. PDF

"Truncated staphylococcal nuclease is compact but disordered"
Flanagan JM, Kataoka M, Shortle D and Engelman DM
Proc Natl Acad Sci USA (1992) 89(2), 748-52. PDF

"Forces involved in the assembly and stabilization of membrane proteins"
Cramer WA, Engelman DM, Von Heijne G and Rees DC
FASEB J (1992) 6(15), 3397-402. PDF

"Intramembrane helix-helix association in oligomerization and transmembrane signaling"
Bormann BJ and Engelman DM
Annual review of biophysics and biomolecular structure (1992) 21, 223-42. PDF

"Small-angle X-ray scattering studies of calmodulin mutants with deletions in the linker region of the central helix indicate that the linker region retains a predominantly alpha-helical conformation"
Kataoka M, Head JF, Persechini A, Kretsinger RH and Engelman DM
Biochemistry (1991) 30(5), 1188-92. PDF

"Structure-function studies of bacteriorhodopsin XV. Effects of deletions in loops B-C and E-F on bacteriorhodopsin chromophore and structure"
Gilles-Gonzalez MA, Engelman DM and Khorana HG
J Biol Chem (1991) 266(13), 8545-50. PDF

"The "microassembly" of integral membrane proteins: applications & implications"
Popot JL, Engelman DM, Zaccai G and de Vitry C
Prog Clin Biol Res (1990) 343(237-62

"Membrane protein folding and oligomerization: the two-stage model"
Popot JL and Engelman DM
Biochemistry (1990) 29(17), 4031-7. PDF

1980's (Back to top)

"Tertiary structure of bacteriorhodopsin. Positions and orientations of helices A and B in the structural map determined by neutron diffraction"
Popot JL, Engelman DM, Gurel O and Zaccaï G
Journal of Molecular Biology (1989) 210(4), 829-47. PDF

"Melittin binding causes a large calcium-dependent conformational change in calmodulin"
Kataoka M, Head JF, Seaton BA and Engelman DM
Proc Natl Acad Sci USA (1989) 86(18), 6944-8. PDF

"Limitations of the lipid state hypothesis for atherosclerosis are revealed by X-ray diffraction measurements"
Burks C, Hong S, Ho M and Engelman DM
Atherosclerosis (1989) 77(1), 43-51. PDF

"Topography of integral membrane proteins: hydrophobicity analysis vs. immunolocalization"
McCrea PD, Engelman DM and Popot JL
Trends Biochem Sci (1988) 13(8), 289-90. PDF

"Positions of S2, S13, S16, S17, S19 and S21 in the 30 S ribosomal subunit of Escherichia coli"
Capel MS, Kjeldgaard M, Engelman DM and Moore PB
Journal of Molecular Biology (1988) 200(1), 65-87. PDF

"Refolding of bacteriorhodopsin in lipid bilayers. A thermodynamically controlled two-stage process"
Popot JL, Gerchman SE and Engelman DM
Journal of Molecular Biology (1987) 198(4), 655-76. PDF

"Transmembrane topography of the nicotinic acetylcholine receptor delta subunit"
McCrea PD, Popot JL and Engelman DM
EMBO J (1987) 6(12), 3619-26. PDF

"A complete mapping of the proteins in the small ribosomal subunit of Escherichia coli"
Capel MS, Engelman DM, Freeborn BR, Kjeldgaard M, Langer JA, Ramakrishnan V, Schindler DG, Schneider DK, Schoenborn BP and Sillers IY
Science (1987) 238(4832), 1403-6.

"Localization of two chymotryptic fragments in the structure of renatured bacteriorhodopsin by neutron diffraction"
Trewhella J, Popot JL, Zaccaï G and Engelman DM
EMBO J (1986) 5(11), 3045-9. PDF

"Reformation of crystalline purple membrane from purified bacteriorhodopsin fragments"
Popot JL, Trewhella J and Engelman DM
EMBO J (1986) 5(11), 3039-44. PDF

"Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins"
Engelman DM, Steitz TA and Goldman A
Annual review of biophysics and biophysical chemistry (1986) 15(321-53. PDF

"Calcium-induced increase in the radius of gyration and maximum dimension of calmodulin measured by small-angle X-ray scattering"
Seaton BA, Head JF, Engelman DM and Richards FM
Biochemistry (1985) 24(24), 6740-3. PDF

"Stability of transmembrane regions in bacteriorhodopsin studied by progressive proteolysis"
Dumont ME, Trewhella J, Engelman DM and Richards FM
J Membr Biol (1985) 88(3), 233-47. PDF

"Positions of proteins S14, S18 and S20 in the 30 S ribosomal subunit of Escherichia coli"
Ramakrishnan V, Capel M, Kjeldgaard M, Engelman DM and Moore PB
Journal of Molecular Biology (1984) 174(2), 265-84. PDF

"Neutron scattering and the 30 S ribosomal subunit of E. coli"
Moore PB, Engelman DM, Langer JA, Ramakrishnan VR, Schindler DG, Schoenborn BP, Sillers IY and Yabuki S
Basic Life Sci (1984) 27(73-91.

"Neutron scattering shows that cytochrome b5 penetrates deeply into the lipid bilayer"
Gogol EP and Engelman DM
Biophysical Journal (1984) 46(4), 491-5. PDF

"Inelastic neutron scattering studies of hexokinase in solution"
Engelman DM, Dianoux AJ, Cusack S and Jacrot B
Basic Life Sci (1984) 27(365-80

"Pair distribution functions of bacteriorhodopsin and rhodopsin in model bilayers"
Pearson LT, Chan SI, Lewis BA and Engelman DM
Biophysical Journal (1983) 43(2), 167-74. PDF

"Bacteriorhodopsin remains dispersed in fluid phospholipid bilayers over a wide range of bilayer thicknesses"
Lewis BA and Engelman DM
Journal of Molecular Biology (1983) 166(2), 203-10. PDF

"Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles"
Lewis BA and Engelman DM
Journal of Molecular Biology (1983) 166(2), 211-7. PDF

"Neutron diffraction analysis of cytochrome b5 reconstituted in deuterated lipid multilayers"
Gogol EP, Engelman DM and Zaccai G
Biophysical Journal (1983) 43(3), 285-92. PDF

"Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose"
Jacrot B, Cusack S, Dianoux AJ and Engelman DM
Nature (1982) 300(5887), 84-6. PDF

"Positions of proteins S6, S11 and S15 in the 30 S ribosomal subunit of Escherichia coli"
Ramakrishnan VR, Yabuki S, Sillers IY, Schindler DG, Engelman DM and Moore PB
Journal of Molecular Biology (1981) 153(3), 739-60. PDF

"Conformation of liquid N-alkanes"
Goodsaid-Zalduondo F and Engelman DM
Biophysical Journal (1981) 35(3), 587-94. PDF

"The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis"
Engelman DM and Steitz TA
Cell (1981) 23(2), 411-22. PDF

"Cholesteryl myristate conformation in liquid crystalline mesophases determined by neutron scattering"
Burks C and Engelman DM
Proc Natl Acad Sci USA (1981) 78(11), 6863-7. PDF

"Bacteriorhodopsin is an inside-out protein"
Engelman DM and Zaccai G
Proc Natl Acad Sci USA (1980) 77(10), 5894-8. PDF

"Path of the polypeptide in bacteriorhodopsin"
Engelman DM, Henderson R, McLachlan AD and Wallace BA
Proc Natl Acad Sci USA (1980) 77(4), 2023-7. PDF

1970's (Back to top)

"Positions of proteins S10, S11 and S12 in the 30 S ribosomal subunit of Escherichia coli"
Schindler DG, Langer JA, Engelman DM and Moore PB
Journal of Molecular Biology (1979) 134(3), 595-620. PDF

"Substrate binding closes the cleft between the domains of yeast phosphoglycerate kinase"
Pickover CA, McKay DB, Engelman DM and Steitz TA
J Biol Chem (1979) 254(22), 11323-9. PDF

"On the feasibility and interpretation of intersubunit distance measurements using neutron scattering"
Moore PB and Engelman DM
Meth Enzymol (1979) 59(629-38. PDF

"Yeast hexokinase in solution exhibits a large conformational change upon binding glucose or glucose 6-phosphate"
McDonald RC, Steitz TA and Engelman DM
Biochemistry (1979) 18(2), 338-42. PDF

"Small angle X-ray scattering of dimeric yeast hexokinase in solution"
McDonald RC, Engelman DM and Steitz TA
J Biol Chem (1979) 254(8), 2942-3. PDF

"Neutron-scattering measurement of protein pair scattering functions from ribosomes containing deuterated proteins"
Engelman DM
Meth Enzymol (1979) 59(656-69. PDF

"The planar distributions of surface proteins and intramembrane particles in Acholeplasma laidlawii are differentially affected by the physical state of membrane lipids"
Wallace BA and Engelman DM
Biochim Biophys Acta (1978) 508(3), 431-49. PDF

"X-ray and neutron small-angle scattering studies of the complex between protein S1 and the 30-S ribosomal subunit"
Laughrea M, Engelman DM and Moore PB
Eur J Biochem (1978) 85(2), 529-34. PDF

"Neutron-scattering studies of the ribosome of Escherichia coli: a provisional map of the locations of proteins S3, S4, S5, S7, S8 and S9 in the 30 S subunit"
Langer JA, Engelman DM and Moore PB
Journal of Molecular Biology (1978) 119(4), 463-85. PDF

"Triangulation of proteins in the 30 S ribosomal subunit of Exherichia coli"
Moore PB, Langer JA, Schoenborn BP and Engelman DM
Journal of Molecular Biology (1977) 112(2), 199-227. PDF

"Model calculations of protein pair interference functions"
Moore PB and Engelman DM
Journal of Molecular Biology (1977) 112(2), 228-34. PDF

"The influence of lipid state on the planar distribution of membrane proteins in Acholeplasma laidlawii"
Wallace BA, Richards FM and Engelman DM
Journal of Molecular Biology (1976) 107(3), 255-69. PDF

"The production of deuterated E. coli"
Moore PB and Engelman DM
Brookhaven Symp Biol (1976) 27), V12-V23

"Compositional mapping of cholesteryl ester droplets in the fatty streaks of human aorta"
Hillman GM and Engelman DM
Journal of Clinical Investigation (1976) 58(4), 1008-18. PDF

"Protein pair distance determination in the 30 S ribosomal subunit of E. coli"
Engelman DM, Moore PB and Schoenborn BP
Brookhaven Symp Biol (1976) 27), IV20-IV37

"Neutron-scattering studies of the ribosome"
Engelman DM and Moore PB
Sci Am (1976) 235(4), 44-54.

"Molecular organization of the cholesteryl ester droplets in the fatty streaks of human aorta"
Engelman DM and Hillman GM
Journal of Clinical Investigation (1976) 58(4), 997-1007. PDF

"A neutron scattering study of the distribution of protein and RNA in the 30 S ribosomal subunit of Escherichia coli"
Moore PB, Engelman DM and Schoenborn BP
Journal of Molecular Biology (1975) 91(1), 101-20. PDF

"Neutron scattering measurements of separation and shape of proteins in 30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7"
Engelman DM, Moore PB and Schoenborn BP
Proc Natl Acad Sci USA (1975) 72(10), 3888-92. PDF

"Determination of quaternary structure by small angle neutron scattering"
Engelman DM and Moore PB
Annu Rev Biophys Bioeng (1975) 4(00), 219-41. PDF

"The use of x-ray scattering in the study of lipid bilayer planar organization"
Engelman DM
Biophysical Journal (1975) 15(9), 940-4. PDF

"Asymmetry in the 50S ribosomal subunit of Escherichia coli"
Moore PB, Engelman DM and Schoenborn BP
Proc Natl Acad Sci USA (1974) 71(1), 172-6. PDF

"Molecular mechanism for the interaction of phospholipid with cholesterol"
Rothman JE and Engelman DM
Nature New Biol (1972) 237(71), 42-4

"The planar organization of lecithin-cholesterol bilayers"
Engelman DM and Rothman JE
J Biol Chem (1972) 247(11), 3694-7. PDF

"A new method for the determination of biological quarternary structure by neutron scattering"
Engelman DM and Moore PB
Proc Natl Acad Sci USA (1972) 69(8), 1997-9. PDF

"The molecular structure of the membrane of Acholeplasma laidlawii"
Engelman DM
Chem Phys Lipids (1972) 8(4), 298-302. PDF

"Bilayer structure in membranes"
Wilkins MH, Blaurock AE and Engelman DM
Nature New Biol (1971) 230(11), 72-6

"Structural comparisons of native and reaggregated membranes from Mycoplasma laidawii and erythrocytes using a fluorescence probe"
Metcalfe SM, Metcalfe JC and Engelman DM
Biochim Biophys Acta (1971) 241(2), 422-30. PDF

"Structural comparisons of native and reaggregated membranes from Mycoplasma laidlawii and erythrocytes by x-ray diffraction and nuclear magnetic resonance techniques"
Metcalfe JC, Metcalfe SM and Engelman DM
Biochim Biophys Acta (1971) 241(2), 412-21. PDF

"Structural comparisons of native and reaggregated membranes"
Engelman DM, Metcalfe JC and Metcalfe SM
Br J Pharmacol (1971) 41(2), 382P. PDF

"Lipid bilayer structure in the membrane of Mycoplasma laidlawii"
Engelman DM
Journal of Molecular Biology (1971) 58(1), 153-65. PDF

"X-ray diffraction studies of phase transitions in the membrane of Mycoplasma laidlawii"
Engelman DM
Journal of Molecular Biology (1970) 47(1), 115-7. PDF

1960's (Back to top)

"Current models for the structure of biological membranes"
Stoeckenius W and Engelman DM
The Journal of Cell Biology (1969) 42(3), 613-46. PDF

"Surface area per lipid molecule in the intact membrane of the human red cell"
Engelman DM
Nature (1969) 223(5212), 1279-80. PDF

"Characterization of the plasma membrane of Mycoplasma laidlawii. IV. Structure and composition of membrane and aggregated components"
Engelman DM and Morowitz HJ
Biochim Biophys Acta (1968) 150(3), 385-96. PDF

"Characterization of the plasma membrane of Mycoplasma laidlawii. III. The formation and aggregation of small lipoprotein structures derived from sodium dodecyl sulfate-solubilized membrane components"
Engelman DM and Morowitz HJ
Biochim Biophys Acta (1968) 150(3), 376-84. PDF

"Characterization of the plasma membrane of Mycoplasma laidlawii. II. Modes of aggregation of solubilized membrane components"
Terry TM, Engelman DM and Morowitz HJ
Biochim Biophys Acta (1967) 135(3), 391-405. PDF

"Characterization of the plasma membrane of Mycoplasma laidlawii. I. Sodium dodecyl sulfate solubilization"
Engelman DM, Terry TM and Morowitz HJ
Biochim Biophys Acta (1967) 135(3), 381-90. PDF

Yale University

Department of Molecular Biophysics and Biochemistry
Center for Structural Biology
Yale University