publications
Bibliography
| (78) |
Custar DW, Zabawa TP, Hines J, Crews CM, Scheidt KA (2009). J Am Chem Soc 131(34):12406-12414 |
| (77) |
Leuenroth SJ & Crews CM (2009). Targeting cyst initiation in ADPKD. J Am Soc Nephrol 20(1):1-3  |
| (76) |
Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM (2008). A role for planar cell polarity signaling in angiogenesis. Angiogenesis 11(4):347-360 |
| (75) |
Rodriguez-Gonzalez A, Cyrus K, Salcius M, Kim K, Crews CM, Deshaies RJ, Sakamoto KM (2008). Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene 27(57):7201-7211 |
| (74) |
Corson TW, Aberle N, Crews CM (2008). Design and applications of bifunctional small molecules: why two heads are better than one. ACS Chemical Biology 3(11):677-692 |
| (73) |
Schneekloth AR, Pucheault M, Tae HS, Crews CM (2008). Targetted intracellular protein degradation induced by a small molecule: En route to chemical proteomics. Bioorg. Med. Chem. Lett. 18(22):5904-5908 |
| (72) |
Leuenroth S.J.,
N. Bencivenga, P. Igarishi, S.Somlo and C.M.Crews (2008). Triptolide reduces cytogenesis in a postnatal mouse model of ADPKD. J.Am.Soc.Nephrology 19(9):1659-1662. |
| (71) |
Leuenroth SJ & Crews CM (2008). Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure. Cancer Research 68(13):5257-5266 |
 (70) |
Hines J., M.Groll, M. Fahnestock, and C.M.Crews (2008). Proteasome Inhibition by fellutamide B induces nerve growth factor synthesis. Chemistry&Biology 15(5):501-512 |
| (69) |
Kim, K.B. and C.M.Crews (2008). Chemical Genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors J.Med Chem 51(9):2600-2605. |
| (68) |
Molineaux CJ, and C.M.Crews (2008). Proteasome Inhibitors. Cancer, Principles&Practice of Oncology,editors, V.T.Devita, T.S.Lawrence, and S.A.Rosenberg, p.486-490. |
| (67) |
Petri, A.F., J.S. Schneekloth, A.K. Mandal, and C.M.Crews (2007). Synthesis of the C3-C18 Fragment of Amphidinolides G and H. Organic Letters 9 (16):3001-3004. |
| (66) |
Campbell LJ and C.M.Crews
(2007). Wound Epidermis Formation and Function in Urodele Amphibian Limb Regeneration.
Cellular and Molecular Life Sciences,65:73-79 |
| (65) |
Corson TW and Crews CM. (2007). Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials. Cell, 130 (2): 769-774. |
| (64) |
Leuenroth SJ, D Okuhara, JD Shotwell, GS Markowitz, Z Yu, S Somlo, and Crews CM. (2007). Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proc Natl Acad Sci USA, 104 (11): 4389-4394. |
 (63) |
Schneekloth J.S. Jr., M. Puchaeult, C.M.Crews (2007). Construction of Highly Substituted Stereodefined Dienes by Cross-Coupling of a -Allenic Acetates. Eur. J. Org. Chemistry, 40-43. |
| (62) |
Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM (2006). A chemical and genetic approach to the mode of action of fumagillin. Chem Biol. 13(9):1001-9. |
| (61) |
Hines J., M. Roy, H. Cheng, C.M. Agapakis, R. Taylor and CM Crews.
(2006). Myriaporone 3/4 structure-activity relationship studies define a  pharmacophore targeting eukaryotic protein synthesis.
Mol Biosyst. 2(8):371-9. |
| (60) |
Yeh, J-R. J., R. Ju, C.M. Brdlik, W. Zhang, Y. Zhang, M.E. Matyskiela, J.D. Shotwell and C.M Crews.
(2006). Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect and Endothelial Cell Growth Arrest Proc Natl Acad Sci USA. 2006 Jun 21 |
| (59) |
Schneekloth Jr., J.S. , J.L. Sanders, J. Hines and C.M. Crews. (2006). Neurotrophic Peptide Aldehydes: Solid Phase Synthesis of Fellutamide B and a Simplified Analog.
Bioorg Med Chem Lett. 16 (14):3855-8. |
| (58) |
Gough, J.D. and C.M. Crews. (2006). Probing Protein Function with small molecules. Ernst Schering Research Foundation Chemical Genomics Workshop Proceedings. Springer-Verlag |
| (57) |
Mandal, A., J.S. Schneekloth Jr., K. Kuramochi and C.M. Crews. (2006).
Synthetic studies on amphidinolide B1. Organic Letters, 8 (3):427-30
|
 (56) |
Leuenroth, S. and C.M. Crews. (2005). Studies on Calcium Dependence Reveal Multiple Modes of Action for Triptolide. Chem Biol.12(12):1259-68 |
| (55) |
Mandal, A.K., J. S. Schneekloth, Jr., and C.M. Crews. (2005). Stereoselective Assembly of a 1,3-Diene via Coupling between an Allenic Acetate and a (B)-alkylborane: Synthetic Studies on Amphidinolide B1. Organic Letters, 7 (17):3645-8 |
|
(54) |
Mandal, A., J. Hines, and C.M.Crews. (2005). Developing Microcolin A Analogues as Biological Probes. Bioorg. Med. Chem Letters 15 (18):4043-7 |
|
(53) |
Kim, K.B., F. Fonseca, C.M. Crews. (2005). Development and Characterization of Proteasome Inhibitors Methods Enzymol.399:585-609. |
| (52) |
Schneekloth, Jr. and C. M. Crews. (2005). Chemical approaches to controlling intracellular protein degradation.
Chembiochem Jan;6(1):40-6. |
|
(51) |
Lin S, Yang ZQ, Kwok BH, Koldobskiy M, Crews CM, Danishefsky SJ. (2004). Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR. JACS. 126 (20):6347-55. |
| (50) |
Schneekloth, Jr., J.S., F. Fonseca,
M. Koldobskiy, A. Mandal, R. Deshaies, K. Sakamoto,
and C. M. Crews. (2004). Chemical Genetic Control of Protein
Levels: Selective in vivo Targeted Degradation. JACS 126 (12):3748-54 |
|
(49) |
Brdlik C., and C.M. Crews. (2004). A
Single Amino Acid Residue Defines Inhibitor Specificity
for the Methionine Aminopeptidase Family.
J.Biol.Chem. 279 :9475-80. |
| (48) |
Sakamoto, K. M., K. Kim, R. Verma, A.
Ransick, B. Stein, C. M. Crews, and R. J. Deshaies. (2003).
Development of Protacs to Target Cancer: Promoting Proteins
for Ubiquitination and Degradation. Mol
Cell Proteomics 2 (12):1350-1358. |
|
(47) |
C. M. Crews. (2003). Feeding the Machine:
Mechanisms of Proteasome-catalyzed Degradation of Ubiquinated
Proteins. Curr
Opin in Chemical Biology 7 (5): 534-9. |
| (46) |
Garrett IR, Chen D, Gutierrez G, Zhao
M, Escobedo A, Rossini G, Harris SE, Gallwitz W, Kim
KB, Hu S, Crews CM, Mundy GR. (2003). Selective inhibitors
of the osteoblast proteasome stimulate bone formation
in vivo and in vitro. J
Clin Invest. Jun; 111 (11): 1771-82. |
| (45) |
Yang Z.Q., Kwok B.H., Lin S, Koldobskiy M.A., Crews C.M.,
Danishefsky SJ. (2003). Simplified Synthetic TMC-95A/B
Analogues Retain the Potency of Proteasome Inhibitory
Activity. ChemBioChem.
Jun 6; 4 (6): 508-13. |
| (44) |
Yeh, J.R. and C.M. Crews. (2003). Chemical Genetics:
Adding to the Developmental Biology Toolbox
Developmental Cell, Vol. 5, 11-19. |
| (43) |
C.M. Crews and J.B. Shotwell. (2003). Small-molecule
inhibitors of the cell cycle: an overview. Progress
in Cell Cycle Research,
Vol. 5, 125-133. |
| (42) |
Koh, B. and C.M. Crews. (2002). Chemical Genetics: A Small
Molecule Approach to Neurobiology Neuron
14;36(4):563-566 |
| (41) |
Shotwell, J.B., Koh, B.,Choi, H.W., Wood, J.L.,
C.M. Crews. (2002). Novel Inhibitors of NF-kB Signalling: Design
and Synthesis of a Biotinylated Isopanepoxydone Affinity
Reagent. Bioorganic
and Medicinal Chemistry Letters 12 (23): 3463-3466
|
| (40) |
Shotwell, J.B., Krygowski, E.S., Hines, J., Koh,
B., Huntsman, E.W.D., Choi, H.W., Schneekloth Jr., J.S.,
Wood, J.L., and C.M. Crews. (2002). Total Synthesis of Luminacin
D Organic
Letters, 5;4(18):3087-3089 |
| (39) |
Ndubuisi, M., Kwok, B., Vervoort, J., Elofsson,
M. and C.M. Crews. (2002). Characterization of p34, a specific
p-nitrophenyl phosphatase from EL4 cells Biochemistry,
41(24):7841-7848 |
| (38) |
Sakamoto, K.M., Kim, K.B., Kumagai, A., Mercurio,
F., C.M. Crews, and R.J. Deshaies. (2001). Protacs:
Chimeric Molecules that Target Proteins to the SCF
Complex for Ubiquitination and Degradation, Proc.
Natl. Acad. Sci. USA 98(15):8554-8559.
|
| (37) |
Kwok H.B., Koh, B., Ndubuisi, M., Elofsson, M.,
and C.M. Crews. (2001). The Target of the Anti-inflammatory
Agent Parthenolide from the Medicinal Herb Feverfew
Chemistry
& Biology 8:759-766. |
 (36) |
Myung, J., Kim, K.,C.M. Crews. (2001). Proteasome
Inhibition: Mechanism and Inhibitors. Medicinal
Research Reviews,
21:245-273. |
| (35) |
Myung, J., Kim, K., Lindsten, K., Dantuma, N., and
C. M. Crews. (2001). Lack of Proteasome Active Site Allostery
as Revealed by Subunit Specific Inhibitors. Molecular
Cell, 7(2):411-420. |
| (34) |
Princiotta, M.F., Schubert, U., Chen, W., Bennink,
J. R., Myung, J., C.M. Crews and J. W. Yewdell. (2001).
Cells Adapted to the Proteasome Inhibitor NLVS Require
Enzymatically Active Proteasomes For Continued Survival.
Proc.
Natl. Acad. Sci. USA, 98(2):513-518. |
| (33) |
Shotwell, J.B., Hu, S., Medina, E., Abe, M., Cole,
R., Crews, C.M., and J.L. Wood. (2000). Efficient stereoselective
synthesis of isopanepoxydone and panepoxydone: A re-assignment
of relative stereochemistry. Tetrahedron
Letters,
41:9639-9643. |
| (32) |
Schwarz, K., de Giuli, R., Schmidtke, G., Kostka,
S., van den Broek, M., Kim, K., Messerle, M., Koszinowski,
U.H., C.M. Crews, Kraft, R., and M. Groettrup. (2000).
The selective proteasome inhibitors lactacystin and
epoxomicin can be used to either up- or downregulate
antigen presentation at non-toxic doses
J.
Immunology, Jun 15; 164(12): 6147-57. |
| (31) |
Yeh, J., Mohan, R., and C.M. Crews. (2000). The Antiangiogenic
Agent TNP-470 requires p53 and p21CIP/WAF
for Endothelial Cell Growth Arrest, Proc.
Natl. Acad. Sci. USA, Nov 7:97 (23) :12782-12787.
|
| (30) |
Groll, M., Kim, K., and Huber,R. and C.M. Crews.
(2000). The Molecular Basis for the Selectivity of an
 ',
 '-epoxyketone
Proteasome Inhibitor revealed by Crystal Structural
Analysis of an Epoxomicin:20S Proteasome Complex,
J. Am. Chem. Soc., 122:1237-1238. |
| (29) |
C.M. Crews and Mohan, R. (2000). Small Molecule-based
Manipulation of the Cell Cycle. Curr.
Opin. Chem. Biol., 4:47-53. |
 (28) |
Kim, K., Myung, J., Sin, N., and C.M. Crews. (1999).
Proteasome Inhibition by the Natural Products Eponemycin
and Epoxomicin: Insights into Specificity and Potency,
Bioorganic
& Medicinal Chemistry Letters, 9:3335-3340. |
| (27) |
Elofsson, M., Splittgerber,
U., Myung, J., and C.M. Crews. (1999). Towards Subunit-specific
Proteasome Inhibitors: Synthesis and Evaluation of Peptide
',
'-epoxyketones
Chemistry
& Biology, 6:811-822. |
| (26) |
Sin, N., K.B.Kim, M. Elofsson,
L. Meng, H.Auth, B. H. B. Kwok, and C.M. Crews. (1999).
Total Synthesis of the Potent Proteasome Inhibitor Epoxomicin:
A Useful Tool for Understanding Proteasome Biology.
Bioorganic & Medicinal Chemistry Letters, 9 :2283-2288. |
| (25) |
Meng, L., Mohan, R., Kwok, B.H.K., Elofsson, M.,
N. Sin and C.M. Crews. (1999). Epoxomicin, a potent
and selective proteasome inhibitor, exhibits in vivo
antiinflammatory activity. Proc.
Natl. Acad. Sci. USA, Aug 31; 96 (18):10403-10408. |
| (24) |
Crews, C.M. and U. Splittgerber. (1999). Chemical
Genetics: Exploring and Controlling Cellular Processes
with Chemical Probes Trends
in Biochemical Sciences, 24 :317-320. |
| (23) |
Meng, L., Kwok, B.H. B, Sin, N.; and Crews, C. M.
(1999). Eponemycin Exerts its Antitumor Effect through
Inhibition of Proteasome Function Cancer
Research, 59: 2798-2801. |
| (22) |
Liu, S., J. Widom, C.W. Kemp, C.M. Crews, and J.
Clardy. (1998). Atomic Structure of Human Methionine
Aminopeptidase 2 Complexed with the Angiogenesis Inhibitor
Fumagillin. Science
282: 1324-1327. |
| (21) |
Meng, L., N.Sin, and C.M. Crews. (1998). The antiproliferative
agent, didemnin B, uncompetitively inhibits palmitoyl
protein thioesterase.
Biochemistry 37 (29):10488-10492. |
| (20) |
Sin, N., L. Meng, H.Auth, and C.M. Crews. (1998).
Eponemycin Analogs: Syntheses and use as probes of angiogenesis
Bioorganic
& Med.Chem.6:1209-1217. |
| (19) |
Wen, J.J., and C.M. Crews. (1998) Synthesis of 9-Fluorenylmethoxycarbonyl
Protected Amino Aldehydes Tetrahedron
Asymmetry, 9 (11): 1855-1858. |
| (18) |
Elofsson, M. and C.M.Crews. (1998). Tightening the
Nuts and Bolts. Trends in Biotechnology, 16:147-149. |
| (17) |
Wen, J.J., and C.M. Crews. (1998). Towards the semi-synthesis
of Didemnin M. Solution and solid phase synthesis
of a pseudotetrapeptide: pGlu-Glny[COO]Ala-Pro-OH. Tetrahedron
Letters,
39 (8):779-782. |
| (16) |
Sin, N., L.Meng, M.Q.W.Wang, J.J.Wen, W.G.Bornmann,
and C.M. Crews. (1997) Fumagillin covalently binds and
inhibits methionine aminopeptidase, MetAP-2 Proc.
Natl. Acad. Sci. USA, 94: 6099-6103. |
| (15) |
Crews, C.M. (1996). Deciphering Isozyme Function:
Exploring Cell Biology with Chemistry in the Post-Genomic
Era Chemistry
and Biology 3: 961-965. |
| (14) |
Crews, C.M., W.S. Lane, and S.L. Schreiber. (1996).
Didemnin binds to the palmitoyl protein thioesterase
responsible for infantile neuronal ceroid lipofuscinosis
Proc.
Natl. Acad. Sci. USA, 93: 4316-4319. |
| (13) |
Erikson, R.L., A.A. Alessandrini , C.M. Crews. (1995).
Mek1, Mapk/Erk Kinase The Protein Kinase Facts Book
p.275-277. |
| (12) |
Crews, C.M., J.L. Collins, W.S. Lane, M.L. Snapper,
and S.L. Schreiber. (1994). GTP-dependent binding of
the antiproliferative agent didemnin to elongation factor
1a. J.
Biol. Chem. 269: 15411-15414. |
| (11) |
Brott, B.K., Alessandrini, A., Largaespada, D. A.,
Copeland, N. G., Jenkins, N. A., Crews, C.M. and R.L.
Erikson. (1993). MEK2 is a kinase related to MEK1 and
is differentially expressed in murine tissues. Cell
Growth Differ. 4 (11): 921-9. |
| (10) |
Huang, W., A. A. Alessandrini, C.M. Crews, R.L.
Erikson. (1993). Raf-1 forms a stable complex with MEK1
and activates MEK1 by serine phosphorylation. Proc.
Natl. Acad. Sci. USA, 90: 10947-10951. |
| (9) |
Macdonald, S.G., C.M. Crews, L. Wu,
J. Driller, R. Clark, R.L. Erikson, F. McCormick. (1993).
Reconstitution of the raf-1-MEK-ERK signal transduction
pathway in vitro. Mol.
Cell. Biol., 13: 6615-6620. |
| (8) |
Crews, C.M. and R.L. Erikson. (1993). Extracellular
signals and reversible protein phosphorylation: What
to MEK of it all. Cell.
74: 215-217. |
| (7) |
Crews, C.M., A.A. Alessandrini, and R.L. Erikson.
(1992). Erks: Their fifteen minutes has arrived.
Cell
Growth and Differentiation, 3: 135-142. |
| (6) |
Calvo, V., C.M. Crews, T.A. Vik, and B.E. Bierer.
(1992). Interleukin 2 stimulation of p70 S6 kinase is
inhibited by the immunosuppressant rapamycin. Proc
Natl. Acad. Sci. USA, 89: 7571-7575. |
| (5) |
Alessandrini, A.A., C.M. Crews, and R.L. Erikson.
(1992). Phorbol ester stimulates a protein tyrosine/threonine
kinase that phosphorylates and activates the Erk1 gene
product. Proc.
Natl. Acad. Sci. USA, 89: 8200-8204. |
| (4) |
Crews, C.M. and R.L. Erikson. (1992). Purification
of a protein tyrosine/threonine kinase that phosphorylates
and activates the Erk1 gene product: Relationship to
the yeast gene byr1. Proc.
Natl. Acad. Sci. USA, 89: 8205-8209. |
| (3) |
Crews, C.M., A.A. Alessandrini, and R.L. Erikson.
(1992) The primary structure of MEK, a protein kinase
that phosphorylates and activates the ERK gene product.
Science,
258: 478-480. |
| (2) |
Crews, C.M., A.A. Alessandrini, and R.L. Erikson.
(1991). The Erk1 gene product is a serine / threonine
protein kinase that has the potential to phosphorylate
tyrosine. Proc.
Natl. Acad. Sci. USA, 88: 8845-8849. |
| (1) |
Alcorta, D., C.M. Crews, L.J. Sweet, L. Bankston,
S.W. Jones, and R.L. Erikson. (1989). Molecular
characterization of chicken and mouse homologs of the
Xenopus ribosomal S6 kinase, Rsk. Mol.
Cell. Biol., 9: 3850-3859. |
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