The broad foci of the Crews Laboratory are: 1) The application of chemical approaches to the study of biological questions. Current projects explore the modes of action of biologically active natural products in order to investigate intracellular signaling pathways and identify novel targets for drug design. 2) The investigation of the molecular mechanisms of cell dedifferentiation and wound healing in regenerating limbs. Current projects focus on the development of in vitro models of urodele limb regeneration. |