Departments M - Z
Microbial Pathogenesis
Office: 295 Congress Avenue, Room 354, 737.2404
Professors
N. W. Andrews, E. Fikrig (Internal Medicine), J. E. Galán (Chair), M. K. Hostetter (Pediatrics)
Associate Professor
C. R. Roy
Assistant Professors
B. I. Kazmierczak (Internal Medicine), W. H. Mothes
Associate Research Scientists
S. Chakrabarti, L.-M. Chen, C. Huynh, T. Kubori-Nagai, H. Nagai
Postdoctoral Fellows
D. Hofreuter, C. Huynh, S. Lee, D. Roy
Postdoctoral Associates
Y. Akeda, L. Andrade, C. G. Briones, F. Du, K. Hueffer, M. Lehmann, S. McGrath, T. Murata, S. Ninio, J. Patel, F. Sauer, M.-P. Stein, P. Uchil, O. Walton-Rossanese, J. Wilson, D. Zamboni
[Microbiology 601a and b, Seminal Papers on the Foundations of Modern Microbiology. A required course for Microbiology first- and second-year students; not for credit. Students present and discuss papers describing fundamental discoveries in areas related to microbiology. The goal is to familiarize students with the process of scientific discovery, and with the history of major developments in the field. Topics include important discoveries involving major human pathogens, fundamental processes in molecular biology, and the development of technology that had a major impact in current biomedical research. (Offered every other year.) N. Andrews, P. Tattersall.]
Microbiology 685b, Molecular Mechanisms of Microbial Pathogenesis. The course focuses on current topics related to host pathogens interactions. Each week a lecture is given on the topic followed by student presentations of seminal papers in the field. All participants are required to present a paper. N. Andrews, J. Galán, C. Roy, W. Mothes.
Molecular Biophysics and Biochemistry
Offices: JWG 304, 432.2077; SHM C106, 785.4246
Professors
D. M. Crothers (Chemistry; Emeritus), D. M. Engelman, J. Fruton (Emeritus), A. Garen, S. Ghosh (Immunobiology), N. D. F. Grindley (Chair), A. Hamilton (Chemistry), M. Hochstrasser, W. H. Konigsberg, P. Lengyel (Emeritus), R. Lifton (Genetics), I. G. Miller (Pediatrics), S. G. J. Mochrie (Physics), P. B. Moore (Chemistry), A. M. Pyle, C. M. Radding (Genetics), L. Regan, F. M. Richards (Emeritus), G. L. Schmir (Emeritus), R. G. Shulman (Emeritus), S. Simmonds (Emeritus), O. Sinanoglu (Chemistry; Emeritus), M. Snyder (Molecular, Cellular, and Developmental Biology), D. Söll, J. A. Steitz, T. A. Steitz, S. Strobel (Director of Undergraduate Studies), J. M. Sturtevant (Chemistry; Emeritus), W. C. Summers (Therapeutic Radiology), P. Sung, D. C. Ward (Genetics), H. W. Wyckoff (Emeritus)
Professor (Adjunct) of Research
K. Williams
Associate Professors
S. Baserga (Director of Medical Studies), M. Gerstein, M. Koelle, A. Koleske (Director of Graduate Admissions), A. Miranker, M. Solomon (Director of Graduate Studies), S. Wolin (Cell Biology)
Assistant Professors
T. Biederer, J. Cabral, E. De La Cruz, L. Heginbotham, V. Unger
Senior Research Scientists
C. Joyce, P. Lengyel
Research Scientists
E. Davidov, Z. Hu, W. McMurray (Laboratory Medicine), K. Tycowski, J. Wang
Visiting Research Scientists
S.-T. Kwon, L. Lewis, Y. Ma, I. Shcherbakova, L. Wang
Associate Research Scientists
R. Albright, S. Balasubramanian, J. Burton, D. Chase, A. Cheng, C. Colangelo, J. Countryman, A. R. Curran, J. Elliott, E. Folta-Stogniew, E. J. Hager, K. Hager, P. Harrison, J. B. Jewell, Z. S. Juo, S. Kamtekar, T. Kawashima, S. Mane, B. Min, D. Ostapenko, B. Ruan, X. Song, Y. Sun, L. Szewczak
Postdoctoral Fellows
S. Bailey, G. Blaha, S. Chung, G. Clayton, N. Conrad, A. Dixon, O. Emanuelsson, O. Fedorova, C. Fok, Y. Fujii, S. Granneman, A. Henn, T. Kajander, D. Klimenko, I. Laurenzi, U. Lehnert, R.-N. Li, A. Lopez Cortajarena, N. Luscombe, J. R. Lytle, T. Magliery, M. Pelletier, D. Schwartz, M. Simonovic, C. Wilson, Y. Xiong, J. Ye
Postdoctoral Associates
P. Adams, A. Ambrogelly, R. Beran, P.-J. Chang, L.-W. Chen, C.-N. Chin, M. Deng, B. Ding, A. El-Guindy, L. Feng, J. Gehman, C.-S. Goh, S. Gülich, T. Hirose, K. (S.-L.) Huang, S. Hunter, A. Jalilian, J. Karro, O. Kerscher, W. Kong, S. Kreft, L. Krejci, A. Kusmierczyk, X. Li, J. Lu, M. Macris, T. Marlovits, J. McMurry, D. Milburn, E. Myers, S. Namgoong, M. Nandineni, K. Okuda, B. Pan, R. C. Polycarpo, I. Pozdnyakova, T. Ravid, A. Rebane, Y. Reshetnyak, J. Rogowsky, G. Rosas-Sandoval, J. C. Salazar, M. Sehorn, V. Serebrov, M. Sfakianos, W. Silverman, S. VanKomen, I. Velichutina, S. J. Venkatraman, Y. Xia, J. Yu, E. Zakharova, D. Zhang, Z. Zhang
Postgraduate Associates
J. T. Hannich, E. Kutluay, A. Sauerwald
Lecturers
A. Belperron (Internal Medicine), A. Berger, J. Kahn (Pediatrics), A. Pawashe, V. Samuel (Internal Medicine), E. Thrower (Internal Medicine)
Molecular Biophysics and Biochemistry 550a, Molecular Foundations of Medicine. This course is part of the Molecules to Systems course, which is open only to first-year medical students. An introduction to the major concepts of biochemistry and molecular biology, with emphasis on the human body. Special attention is devoted to how recent advances in basic science contribute to our understanding and treatment of human disease. S. Baserga, A. Koleske, M. Solomon, D. Engelman. Conference leaders: A. Belperron, A. Berger, J. Kahn, V. Samuel, E. Thrower.
Molecular Biophysics and Biochemistry 600a, Principles of Biochemistry I. A rigorous introduction to the major concepts of biochemistry and to the process of discovery in this discipline, with emphasis on macromolecular conformation and physical processes in biochemistry. Energy metabolism, hormone signaling, and muscle contraction as examples of complex biological processes whose underlying mechanisms can be understood by identifying and analyzing the molecules responsible for these phenomena. D. Engelman, M. Solomon.
Molecular Biophysics and Biochemistry 601b, Principles of Biochemistry II. The chemistry and metabolism of nucleic acids, the mechanism and regulation of protein and nucleic acid synthesis, and selected topics in macromolecular biochemistry. S. Strobel, J. Steitz.
Molecular Biophysics and Biochemistry 602a/Cell Biology 602a/MCDB 602a, Molecular Cell Biology. A comprehensive introduction to the molecular and mechanistic aspects of cell biology for graduate students in all programs. Emphasizes fundamental issues of cellular organization, regulation, biogenesis, and function at the molecular level. S. Wolin, T. Pollard, G. Warren, and others.
Molecular Biophysics and Biochemistry 625a/Genetics 625a/MCDB 625a, Basic Concepts of Genetic Analysis. The universal principles of genetic analysis in eukaryotes are discussed in lectures. Students also read a small selection of primary papers illustrating the very best of genetic analysis and dissect them in detail in the discussion sections. While other Yale graduate molecular genetics courses emphasize molecular biology, this course focuses on the concepts and logic underlying modern genetic analysis. T. Xu, M. Koelle, R. Lifton, G. S. Roeder, M. Stern.
Molecular Biophysics and Biochemistry 642a/EMD 642a/Genetics 642a/MBIO 642a/MCDB 642a, Roles of Microorganisms in the Living World. A topical course exploring the biology of microorganisms. Emphasis is placed upon mechanisms underlying microbial adaptations and how they influence biological systems. Prerequisites: biology, chemistry, and biochemistry. L. N. Ornston, D. McMahon-Pratt, R. M. Macnab.
Molecular Biophysics and Biochemistry 650a and 651b, Laboratory Rotation for First-Year Students. Three consecutive research laboratory experiences lasting eight to ten weeks each. Required for all first-year graduate students. M. Solomon.
[Molecular Biophysics and Biochemistry 658a/Chemistry 558a, Research Topics in Biophysics. An advanced treatment of the fundamental physical properties that dictate the behavior of biological molecules. Taught with participation of a number of biophysics faculty; extends to their current research specialties. Not offered in 20032004.]
Molecular Biophysics and Biochemistry 675, Seminar for First-Year Students. Required for all first-year graduate students. A. Miranker, L. Heginbotham, and staff.
Molecular Biophysics and Biochemistry 676b, Responsible Conduct of Research. Designed for students who are beginning to do scientific research. The course seeks to describe some of the basic features of life in contemporary research and some of the personal and professional issues that researchers encounter in their work. Approximately six sessions during the spring term, run in a seminar/discussion format. Required for all first-year graduate students. V. Unger and staff.
Molecular Biophysics and Biochemistry 700b, Properties of Macromolecules. Solution properties of macromolecules. Current topics in biophysics, including hydrodynamics, stability, kinetics, and multiple equilibria. Techniques for the solution characterization of macromolecules and their interactions, including fluorescence, circular dichroism, calorimetry, and centrifugation. Prerequisites: physical chemistry and biochemistry. L. Regan, E. De La Cruz.
Molecular Biophysics and Biochemistry 701b3, Diffraction Methods. Biological applications of X-ray crystallography, small-angle X-ray, and neutron scattering and cryoelectron microscopy. J. Cabral, V. Unger.
Molecular Biophysics and Biochemistry 7o1b4, NMR Methods. Basic principles of NMR with emphasis on biological applications in the primary literature. Application areas include structure determination, drug binding, molecular recognition, protein folding, and in vivo metabolism. Prerequisites: physical chemistry and biochemistry. A. Miranker.
Molecular Biophysics and Biochemistry 705a/Genetics 705a/MCDB 505a, Molecular Genetics of Prokaryotes. Molecular aspects of the storage, replication, evolution, and expression of genetic material in prokaryotes. Prerequisites: previous or concurrent introductory courses in genetics and biochemistry. N. D. F. Grindley, C. Radding, J. Sweasy.
Molecular Biophysics and Biochemistry 710b4/C&MP 710b4, Electron Cryo-Microscopy for Protein Structure Determination. Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. The course is an introduction into the concepts and applications of high-resolution electron cryo-microscopy. This rapidly emerging new technique is the only tool known to date that allows biological macromolecules to be studied at all levels of resolution ranging from their cellular organization to near atomic detail. V. Unger, F. Sigworth.
Molecular Biophysics and Biochemistry 741a, Structure and Chemistry of Proteins and Nucleic Acids. Selected topics in the structure of proteins and nucleic acids; sequence-dependent interactions between proteins and nucleic acids; chemical modifications of DNA; chemical studies of DNA-binding proteins; catalytic RNA. Prerequisite: biochemistry. A. Pyle, D. Söll, J. Cabral.
Molecular Biophysics and Biochemistry 743b, Molecular Genetics of Eukaryotes. Selected topics in regulation of gene expression, genome structure and evolution, signal transduction, and cellular physiology, development, and carcinogenesis. Prerequisite: biochemistry or permission of the instructor. A. Koleske, A. Pyle, P. Sung.
Molecular Biophysics and Biochemistry 749a/Genetics 749a, Medical Impact of Basic Science. Consideration of examples of recent discoveries in basic science that have elucidated the molecular origins of disease or that have suggested new therapies for disease. Emphasis is placed on the fundamental principles on which these advances rely. Reading is from the primary scientific and medical literature, with emphasis on developing the ability to read this literature critically. Aimed primarily at undergraduates. Prerequisite: MB&B 600a/601b or permission of the instructor. J. Steitz, P. Sung, A. Miranker, E. De La Cruz, S. Ghosh.
Molecular Biophysics and Biochemistry 750a2, Biological Membranes. Biological membranes and their resident proteins are essential for cellular function; yet comparatively little is known about their structure and dynamics. This class provides an introduction to the biochemistry and biophysics of lipids, lipid bilayers, and lipid-derived second messengers. In addition, structural as well as functional aspects of the different classes of membrane proteins are discussed along with an outline of experimental approaches used to achieve an understanding of membrane protein structure and function at a molecular level. L. Heginbotham, V. Unger, D. Engelman.
Molecular Biophysics and Biochemistry 752a/CPSC 752a/MCDB 752a, Genomics and Bioinformatics. Genomics describes the determination of the nucleotide sequence and many further analyses to discover functional and structural information on all the genes of an organism. Topics include the methods and results of functional and structural gene analysis on a genome-wide scale as well as a discussion of the implications of this research. Bioinformatics describes the computational analysis of genomes and macromolecular structures on a large scale. Topics include sequence alignment, biological database design, comparative genomics, geometric analysis of protein structure, and macromolecular simulation. Prerequisites: EEB 122b and Math 115, or permission of the instructor. D. Söll, M. Gerstein.
Molecular Biophysics and Biochemistry 800a, Advanced Topics in Molecular Medicine. This seminar course, which covers topics in the molecular mechanisms of disease, illustrates timely issues in areas such as protein chemistry and enzymology, intermediary metabolism, nucleic acid biochemistry, gene expression, and virology. Prerequisite: a prior course in biochemistry. This course accompanies the lectures in MB&B 550a. M.D. and M.D./Ph.D. students only. S. J. Baserga, G. Miller, W. Konigsberg.
Molecular Biophysics and Biochemistry 900a or 901b, Reading Course in Biophysics. Directed reading course in biophysics. Term paper required. By arrangement with faculty.
Molecular Biophysics and Biochemistry 902a or 903b, Reading Course in Molecular Genetics. Directed reading course in molecular genetics. Term paper required. By arrangement with faculty.
Molecular Biophysics and Biochemistry 904a or 905b, Reading Course in Biochemistry. Directed reading course in biochemistry. Term paper required. By arrangement with faculty.
Neurobiology
Office: SHM C300, 785.4323
Professors
C. J. Barnstable (Ophthalmology and Visual Science), B. S. Bunney (Psychiatry), N. W. Daw (Ophthalmology and Visual Science), C. Greer (Neurosurgery), S. Hockfield (Provost), J. Kocsis (Neurology), R. H. LaMotte (Anesthesiology), C. Leranth (Obstetrics, Gynecology, and Reproductive Sciences), D. A. McCormick, P. Rakic (Chair), J. Santos-Sacchi (Surgery), I. R. Schwartz (Surgery), G. M. Shepherd, S. Strittmatter (Neurology), S. G. Waxman (Neurology)
Associate Professors
M. Alreja (Psychiatry), A. Arnsten (Director of Graduate Studies), C. Bruce, N. deLanerolle (Neurosurgery), T. Horvath (Obstetrics, Gynecology, and Reproductive Sciences), M. Picciotto (Psychiatry), V. Pieribone (Cellular and Molecular Physiology), M. L. Schwartz (Director of Medical Studies), F. Vaccarino (Child Study Center), C. van Dyck (Psychiatry)
Assistant Professors
H. Blumenfeld (Neurology), W. Chen, M. Donoghue Velleca, R. Fitzsimonds (Cellular and Molecular Physiology), M. Laubach (J. B. Pierce Laboratory), R. Matthews, D. Navaratnam (Neurology), N. Sestan, N. Tian (Ophthalmology and Visual Science), M. Yeckel
Research Scientists
M. Hines, L. D. Selemon
Associate Research Scientists
S. Antic, J. Chen, H. Friedman, W. Gao, V. Gazula, M. Migliore, E. Sybirska, W. Xiong
Postdoctoral Associates & Fellows
A. Ayoub, C. Baker, J. Bergsman, C. Broberger, C. Crasto, M. Dino, A. Duque, J. Fitzpatrick, V. Gluncic, B. Horvath, S. Janusonis, F. Jia, N. Kabbani, S. Kolk, T. Koos, U. Kraushaar, E. Markakis, B. Milojkovic, Y. Morozov, T. Morse, C. Paspalas, M. R. Rasin, M. Sarkisian, Y. Shu, M. Viapiano, M. Wang, X. Wang, Y. Wang, D. Willhite, W. Xiong, S. Zeng, Z. Zhou
Neurobiology 5oob/Neuroscience 510b, Structural and Functional Organization of the Human Nervous System. An integrative overview of the structure and function of the human brain as it pertains to major neurological and psychiatric disorders. Neuroanatomy, neurophysiology, and clinical correlations are interrelated to provide essential background in the neurosciences. Lectures in neurocytology and neuroanatomy survey neuronal organization in the human brain, with emphasis on long fiber tracts related to clinical neurology. Weekly three-hour laboratory sessions devoted to neuroanatomy in which students dissect the human brain and examine histological sections in close collaboration with faculty members. Lectures in neurophysiology cover various aspects of neural function at the cellular level, with a strong emphasis on the mammalian nervous system. Each student may participate in a weekly physiology conference with a faculty member, covering such topics as!
vision, sensory physiology, motor systems, simple nervous systems, or general neurophysiology. Clinical correlations consist of five sessions given by one or two faculty members representing both basic and clinical sciences. These sessions relate neurological symptoms to cellular processes in various diseases of the brain. Variable class schedule; contact course instructor. P. Rakic, M. Schwartz, and staff of the Department of Neurobiology with participation of the departments of Anesthesiology, Neurology, Neurosurgery, Physiology, and Psychiatry.
Neurobiology 501a/Neuroscience 501a, Principles of Neuroscience. A lecture survey course given jointly by the faculty of the Yale Interdepartmental Graduate Program in Neuroscience as the introductory core course for this program. Each lecture attempts to elucidate a major principle of nervous system development, structure, or function. The lectures are arranged in a sequence of five sections: cellular and molecular neurobiology, neurotransmitters and neuromodulators, development, neural systems, and neural basis of behavior. Topics include molecular structure of ion channels, single channel recording and monoclonal antibodies; synaptic transmission, second-messengers and neuropeptides; synaptogenesis; functional organization of the visual, somatosensory, and olfactory systems; and the cellular basis of behavior, including learning and memory. A short paper is required in each of the five main sections. M. Picciotto, M. Yeckel.
Neurobiology 502a, Structure and Function of Neocortex. This seminar/lecture course covers anatomical, biochemical, and physiological organization of selected sensory, motor, and association regions of cortex. Sample topics discussed include development, evolution of multiple representations, columnar organization, and plasticity of neocortex. Permission of instructor required. Faculty of the Department of Neurobiology.
Neurobiology 507b/Neurology 1o8b/Neuroscience 507b, Cellular and Molecular Mechanisms of Neurologic Disease. Molecular and cellular neuroscience has recently developed many novel and powerful techniques for understanding nervous system function. The course focuses on how these basic science advances have been translated into breakthroughs in clinical neurology. Lectures illustrate the connection of modern laboratory studies to our understanding of pathophysiologic mechanisms, to the development of diagnostic tests, and to the use of novel treatment modalities. S. Strittmatter, S. Waxman, D. Navaratnam.
Neurobiology 509b/Neuroscience 539b, Synaptic Organization of the Nervous System. Introduction to principles of neural circuit organization at the cellular level (morphology, physiology, and pharmacology). Emphasis is on mammalian systems and comparisons with lower vertebrates and invertebrates. Permission of instructor required. G. Shepherd.
Neurobiology 510, Introduction to Methods in Cellular and Molecular Neurobiology. Firsthand insight into various techniques and approaches used in neuroscience. Light microscopic techniques include various metallic impregnation methods, autoradiography, anterograde and retrograde axonal transport methods, hybridoma and recombined DNA technology, deoxyglucose metabolic method, fluorescent and immunocytochemical methods. Electron microscopy encompasses transmission, electronmicroscopic autoradiography, and immunoperoxidase methodology. Choice of techniques and hours to be arranged with individual faculty or staff members of the Department of Neurobiology.
Neurobiology 511, Introduction to Techniques Used in Electrophysiological Analysis at the Cellular Level. Includes practical training in in vivo and in vitro nervous system preparations, extracellular and intracellular recordings, sensory stimulation, dye injections, and selected neuropharmacological procedures. Choice of techniques and hours to be arranged with individual faculty or staff members of the Department of Neurobiology.
Neurobiology 524b/Neuroscience 514b, The Regulation of Cell Fate During CNS Development. This course is intended to discuss the general mechanisms that regulate cell fate during the development of the central nervous system. It focuses on the progressive specialization of cellular function beginning with the establishment of CNS polary, the acquisition of regional identity, and the determination of the fate of neural cells within the CNS. The interactions between evolutionary conserved genes and intercellular signaling systems are emphasized. The course meets twice a week for one hour each time. Each week covers one topic as detailed in the syllabus. On Wednesday, general concepts are reviewed in a seminar format, led by the course director, faculty participants, or invited speakers. On Fridays, one or two papers presented by students are discussed in detail. All class members are invited to participate in the paper presentation and discussion. F. M. Vac!
carino.
[Neurobiology 570a/Neuroscience 570a, Cellular and Network Dynamics of Sensory and Motor Functions. This course examines the circuitry and functioning of sensorimotor systems, particularly visual and oculomotor, with emphasis on data gathered from single neuron recording and functional imaging in the primate neocortex. Cortical mechanisms of perception, memory, decision making, and motor initiation are considered. Format emphasizes informal presentation, analysis, and criticism of important and recent papers in the field. Prerequisite: Neurobiology 500b. C. Bruce and faculty. Next offered in 20042005.]
Neurobiology 601, Topics in Olfactory Physiology. Advanced tutorial course. G. Shepherd.
Neurobiology 602, Topics in Cortical Development and Evolution. Advanced tutorial course. P. Rakic.
[Neurobiology 610b, Fundamentals in Neurophysiology. This course is designed for students who wish to gain a theoretical and practical knowledge of modern neurophysiology. Graduate students specializing in neurophysiology and non-neurophysiology are encouraged to attend, as the course begins at a very basic level and progresses to more complicated topics. Topics include properties of ion channels, firing properties of neurons, synaptic transmission, and neurophysiology methodology. V. Pieribone, F. Sigworth. Next offered in 20042005.]
Neurobiology 720a/MCDB 720a/Neuroscience 720a, Neurobiology. Examination of the excitability of the nerve cell membrane provides a starting point for the study of molecular, cellular, and intracellular mechanisms underlying the generation and control of behavior. H. Keshishian, P. Forscher.
Neurology
Office: LCI 708, 785.5947
Professors
T. Allison (Emeritus), J. Booss, M. B. Bracken (Epidemiology and Public Health), L. M. Brass, G. H. Glaser (Emeritus), R. D. Kerns, Jr. (Psychiatry), J. D. Kocsis (Director of Postdoctoral Studies), R. H. Mattson (Emeritus), W. I. McDonald (Visiting), L. R. Ment (Pediatrics), J. W. Prichard (Emeritus), P. Rakic (Neurobiology), B. A. Shaywitz (Pediatrics), S. S. Spencer, S. M. Strittmatter, S. G. Waxman (Chair)
Associate Professors
R. B. Duckrow, J. M. Goldstein, E. Novotny, Jr. (Pediatrics), O. A. C. Petroff, G. B. Richerson (Director, Neurology Residency Program)
Assistant Professors
J. Baehring, H. Blumenfeld (Director of Medical Studies), M. Eisa, M. Gorman, F. Hisama, D. Navaratnam, S. Novella, H. Patwa (Director, Neuroscience Clerkship), M. A. Rizzo, P. K. Stys (Visiting), D. Tkeshelashvili
Instructors
O. A. Hope, A. Javed, Y. Kogan, A. P. Rose-Innes, D. C. Weisman
Research Scientists
J. A. Black, S. Dib-Hajj
Associate Research Scientists
S. Agulian, M. Craner, O. Hadjimichael, K. Lankford, J. Preiningerova, A. Rush, A. Szekely (Genetics), H. A. Tokuno, W. Wang, Y.-M. Wu, H. Zaveri
Clinical Professors
T. N. Byrne, R. L. Lesser (Ophthalmology and Visual Science), L. Levy, S. Levy (Pediatrics), T. J. Walsh (Ophthalmology and Visual Science)
Associate Clinical Professors
R. C. Delaney, J. C. Moench, K. N. Sena, F. Testa (Pediatrics), R. S. Young (Pediatrics)
Assistant Clinical Professors
A. R. Bobowick, S. L. Bridgers II, J. B. Butler, W. A. Camp, J. B. Guarnaccia, B. B. Haak, M. Hasbani, A. Katz, M. W. Kremenitzer, A. Lo, J. H. Mashman, J. C. McVeety, R. A. Novelly, R. M. Poole, D. S. Russell (Psychiatry), M. J. Stransky, S. Tepper, J. S. Tucker, N. Werdiger
Clinical Instructors
M. Chen, T. E. Conley, R. P. Einbinder, B. Greenspan, D. J. Shiling, D. Story, M. Tolar, E. S. Tucker, P. Wade, D. Wirz
Postdoctoral Fellows
E. Fertig, B. Hains, Y. Kataoka, E. Koziorynska, L. Paige, C. Saab
Postdoctoral Associates
J. S. Choi, F. Hu, J. K. Lee, B. Li, S. Li, A. McGee, H. Nersesyan, S. Rajagopalan, M. Sasaki, H. Togashi, K. Yu
Lecturers
O. Avitzur, L. Bangalore, V. Shen
Neurology 102, Clinical Neuroscience Core Clerkship. The primary goal of this four-week clinical clerkship is to provide students with a fundamental approach to the nervous system. Specifically, this means the history, examination, diagnostic imaging, and treatment in the context of specific patients. Additionally, there is a series of lectures covering the broad range of conditions students are likely to encounter, such as trauma, stroke, infections, tumors, dementias, and seizures. Students take call with neurology residents once a week at Yale-New Haven Hospital; students assigned to neurosurgery take call with the residents on that service. After having given input on their preferences, students are placed on one of the following services for their clerkships: adult inpatient neurology, adult neurology consultation service, pediatric neurology, neurosurgery. All rotations are done at Y-NHH, the VA Connecticut Healthcare System, West Haven, or St. Rap!
haels Hospital, unless special or unusual circumstances justify taking the course at some other academic institution. H. Patwa, L. Ment, C. Duncan, H. Blumenfeld, T. N. Byrne.
Neurology 103, Clinical Neurology Elective. Assignments for the clinical neurology elective are to the Y-NHH neurology consultation service, a rotation consisting of all outpatient clinics; or to the Y-NHH Inpatient Neurology Service. Four-week blocks coinciding with clerkship dates are preferred, but scheduling of electives is somewhat flexible. Students are able to request a choice, but assignment is made to assure that there is a balanced distribution between students in the required Neuroscience Clerkship and those doing electives, in order to allow an optimal learning experience for all students. Students work directly with attending faculty, chief residents, and junior residents as well as other medical students, rotators, and support staff. In addition to in-hospital patient evaluation and care, students on a consultation service are assigned to outpatient clinics. The students participate in departmental conferences and seminars. In addition, par!
ticipation in most of the activities of the required Neuroscience Clerkship (e.g., didactic lectures) is encouraged (see Neurology 102 for description of clerkship details). The department is receptive to other specially tailored programs in areas such as epilepsy, stroke, movement disorders, neuroimmunology, etc., as well as clinical neurophysiology and research methods. H. Patwa and associates.
Neurology 104, Clinical Neurology Subinternship. Under appropriate supervision, students directly examine, diagnose, and manage patients on the neurology services at Yale-New Haven Hospital and attend daily teaching rounds and conferences. Hours to be arranged. Four-week rotations are recommended; alternative services are possible. Limited to two students each period. H. Patwa and associates.
Neurology 106b, Clinical Neurophysiology. Seminars and demonstrations in clinical applications of neurophysiology: electromyography and electroencephalography. Basic electronics are taught along with standard practice of recording and interpreting neurophysiology studies. J. M. Goldstein, H. Patwa, S. P. Novella.
Neurology 108b/Neurobiology 507b/Neuroscience 507b, Cellular and Molecular Mechanisms of Neurologic Disease. Molecular and cellular neuroscience has recently developed many novel and powerful techniques for understanding nervous system function. This course focuses on how these basic science advances have been translated into breakthroughs in clinical neurology. Lectures illustrate the connection of modern laboratory studies to our understanding of pathophysiologic mechanisms, to the development of diagnostic tests, and to the use of novel treatment modalities. S. Strittmatter, S. Waxman.
Neurology 112b, Neuro-Oncology. Neurological complications occur in approximately 2o percent of hospitalized oncology patients. The neurological complications of systemic cancer, as well as of primary CNS tumors, are discussed in depth. Issues regarding diagnosis and management of metastatic disease involving the nervous system as well as treatment-related complications are reviewed. In addition, metabolic and vascular disturbances and infections unique to the oncology patient that involve the nervous system are discussed. Specific cases are presented and arrangements are made to see specific patients during the elective period. This course is offered every three weeks with two lectures each week and is limited to three or four students per session. T. N. Byrne.
Neurology 114b, Physiology of the Mammalian Nervous System. The overall objective of this laboratory course is to introduce the student by hands-on experience to a variety of cellular electrophysiological techniques used in the study of the mammalian nervous system. Students set up a small electrophysiology laboratory and carry out experiments with the supervision of faculty. Laboratories include sucrose gap in whole nerve, single microelectrode current and voltage clamp recording of sensory neurons, field potential studies in rat hippocampal slice, and patch clamp analysis of cultured neurons. This course is limited to six to eight students. Permission of instructor is required for enrollment, 203.937.3802. J. D. Kocsis.
Neurosurgery
Office: TMP 4, 785.2805
Professors
R. Bronen (Diagnostic Radiology), W. F. Collins, Jr. (Emeritus), C. C. Duncan, C. A. Greer, C. LaMotte, J. Persing (Surgery/Plastic), J. M. Piepmeier, D. E. Redmond, Jr. (Psychiatry), D. D. Spencer (Chair), S. Spencer (Neurology), A. Van den Pol
Associate Professors
R. T. Constable (Diagnostic Radiology), N. deLanerolle, A. C. de Lotbinière, R. B. Duckrow (Neurology), M. Gunel, J. T. King, E. J. Novotny, Jr. (Pediatrics), K. J. Ruskin (Anesthesiology), M. Westerveld, A. Williamson
Assistant Professors
A. Amar, J. M. Baehring (Neurology), J. Bartolomei, H. Blumenfeld (Neurology), A. Bordey, I. Cavus (Psychiatry), V. Chiang, D. J. Gaal (Anesthesiology), M. J. Gorman (Neurology), K. Stoddard, J. Strugar, D. Tkeshelashvili (Neurology), K. Vives
Associate Research Scientists
T. Eid, P. K. Ghosh, C. Livsey, R. Mann, H. Treloar, K. Wu
Visiting Research Scientists
H. Hetherington, J. Pan
Clinical Professors
T. N. Byrne (Neurology), L. M. Davey
Associate Clinical Professors
I. Goodrich, D. E. Nijensohn
Assistant Clinical Professors
T. J. Arkins, G. M. Bloomgarden, P. S. Dickey, K. Firlik, Z. Ghogawala, E. Kornel, J. Kveton (Surgery), T. Lansen, J. K. Sabshin, J. Stern
Clinical Instructors
E. Akeyson, A. Firlik, J. Gorelick
Postdoctoral Fellows
R. Gwinn, L. Holmes, C. Iwema, A. G. OShea
Postdoctoral Associates
A. J. Bolteus, L.-Y. Fu, H. Huang, Y. Li, X. X. Liu, A. Seker, Q. Wang, G. Wollman
Lecturer
E. M. Ogle
Neurosurgery 101, Neurological Surgery. This is an externship in which the student is involved in inpatient evaluation, outpatient visits, supervised emergency and inpatient consultations. The student attends the operating room, follows patients, and is expected to correlate the clinical experience with basic neuroscience. J. Baehring, J. Bartolomei, V. Chiang, W. F. Collins, A. de Lotbinière, R. B. Duckrow, C. C. Duncan, M. Gorman, M. Gunel, J. King, J. M. Piepmeier, D. D. Spencer, J. Strugar, K. Vives.
Neurosurgery 102, Experimental Neurological Surgery. Typically taken during completion of the thesis requirement. Specific projects are by agreement with faculty members. Ongoing laboratory research includes: the molecular neuroanatomical assessment of the epileptic focus (N. C. de Lanerolle); ultrastructural assessment of organization and plasticity in local synaptic networks (C. A. Greer); the distribution and specificity of membrane-bound proteins directing neuronal growth (A. Van den Pol); glial cell function at synapses; intercellular communication promoting neurogenesis (A. Bordey); human and animal slice electrophysiology (A. Williamson, A. Bordey); human and animal intracerebral microdialysis (D. Spencer, I. Cavus); image-guided neurosurgical robotics and biophysical studies of brain imaging (D. Spencer, J. Duncan); molecular genetics of neurological disease (M. Gunel); role of the gene Notch in neoplastic CNS tumors (K. Vives); characterization !
of ensheathing cells in promoting axonal elongation (J. Bartolomei). Clinical research includes neurotrauma (V. Chiang), neuropsychological studies (M. Westerveld, K. Stoddard), spine disease (J. Strugar, J. Bartolomei), epilepsy surgery (D. Spencer), pediatric neurosurgery outcomes (C. Duncan), neuro-oncology (J. Piepmeier), and stereotactic radiosurgery (A. de Lotbinière). Available throughout the year. Arrangements made with C. A. Greer.
Obstetrics, Gynecology, and Reproductive Sciences
Office: FMB 339, 785.4002
Professors
A. Arici, Y. Arkel (Adjunct), H. R. Behrman, M. B. Bracken (Epidemiology and Public Health), S. K. Chambers, J. Copel, R. A. Ehrenkrantz (Pediatrics), I. Gross (Pediatrics), J. Hayslett (Internal Medicine), R. B. Hochberg, E. E. Jones, E. I. Kohorn (Emeritus), C. Leranth, C. J. Lockwood (Chair), M. Mahoney (Genetics), N. Maihle, S. McCarthy (Diagnostic Radiology), F. Naftolin (Molecular, Cellular, and Developmental Biology), P. M. Sarrel (Emeritus), P. E. Schwartz, F. Sevarino (Anesthesiology)
Associate Professors
A. J. Duleba, R. Feinberg (Adjunct), F. Galerneau, J. Henrich (Internal Medicine), T. Horvath, U. Magriples, G. Mor, E. Norwitz, M. Paidas, T. Rutherford, D. Sakkas, E. Sze, H. Taylor, K. Williams
Assistant Professors
M. Azodi, R. Bercik, K. Connell, S. Diano, E. F. Funai, X.-B. Gao, Y. Huang, D. Neale, S. M. Richman, J. Reiter, E. Sapi (Adjunct), M. Small, C. Stocco
Instructors
M. O. Bahtiyar, C. Buhimschi, B. Hamar, S. D. Julien, C. B. Kallen, P. Matta, J. McAlpine, D. M. OMalley, V. Ravishankar, E. Seli, A. Sfakianaki, J. Tangir, A. Wold
Senior Research Scientist
G. Huszar
Research Scientists
H. Kliman, G. Krikun, F. Schatz
Associate Research Scientists
V. Abrahams, I. Buhimschi, E. Borok, G. Daftary, Q. Gao, D.-H. W. Ku, M. A. Gilmore-Hebert, D. Labaree, A. A. F. A. Metwaly, E. Neuber
Research Affiliates
L. Cole, V. Edusa, D. Keefe, A. Mackenzie, A. Palumbo, F. Parikh, T. Polcz, S. Rotmensch, D. Seifer, P. Whitten
Clinical Professors
M. Berman, V. Lynch, M. Minkin, W. Reguero, J. Silidker, S. Spangler, L. Wartel
Associate Clinical Professors
H. Blanchette, C. Cassin, R. Cwik, D. Greenfeld, T. Hanson, R. Kaump, W. Lieber, C. McCarthy, L. Olson, H. Simon, R. Stiller, V. Stuermer, R. Vidone, J. Whetham, L. Zamore
Assistant Clinical Professors
R. Al-Rejjal, M. Beatrice, F. Boozarjomehri, P. Brines, S. Casper, E. Chang, A. Chelouche, R. Chosak, I. Cohen, P. Coppola, E. Fine, S. Fleischman, K. Fletcher, D. Fox, G. Foye, M. Gillette, C. Kandall, E. Karlovsky, J. Knudson, T. Kumarasamy, S. Laifer, P. Lamastra, D. Lima, E. Luchansky, S. Mark (Internal Medicine), B. McDowell, L. Plisic, N. Ravski, B. Rigney, S. Rosenman, A. Strong, H. Suesserman, E. Topran, T. Zreik
Clinical Instructors
A. Asis, M. Asis, E. Berry, U. Bhuvanesh, T. Bruce, F. Cohn, J. Grosso, C. Huttler, J. Kaczmarek, K. Kearns, A. Landry, R. Lubell, B. Maloy, J. McGrade, R. Moscarelli, H. Nusbaum, E. Palluotto, A. Petruzzelli, R. Pringle, K. Rath, M. Rhee, A. Ross, D. Roth, R. Samuelson, M. Speranza, J. Stadalnik, A. Tirado, D. Tonzola, M. Tse
Postdoctoral Fellows
A. Alvero, W. Chen, N. Demir, J.-S. Park
Postdoctoral Associates
A. Abzaid, T. Hajszan, N. Foyouzi Yousefi, S. Mehri, B. J. Tarleton, Y. Zhou
Lecturers
R. D. Auerbach, M. Davis, B. Forbis, M. Haney, F. Haseltine, N. Kellett, G. Kolin, E. Kuczynski, N. Martina, V. McEvoy, L. Mosley, D. Quealy, M. Reault, J. Reinshagen, T. Santos, E. Shawn, M. Sullivan, C. Szejk, J. Vulte
Obstetrics, Gynecology, and Reproductive Sciences 103, Core Inpatient Clerkship. This core clerkship is a four-week rotation in which students serve as clinical clerks on both the obstetrics (two weeks) and the gynecology services (two weeks). At our affiliate sites, which include Bridgeport Hospital, Hospital of St. Raphael, and Danbury Hospital, the clerk functions as part of a team that participates in both gynecologic and obstetrical care. During the obstetrics portion of the rotation at Yale-New Haven Hospital, the clinical clerk is assigned to the labor floor and is expected to actively participate in patient care commensurate with his or her experience. Students are expected to work up and follow patients during labor and delivery, write notes during the intrapartum period, participate in the delivery, and participate in the patients postpartum care. Students on gynecology spend one week on the general gynecology service, where they become f!
amiliar with the common disorders encountered in gynecological practice. The student also spends one week on the gynecologic oncology service and functions as a part of that team. The rotation offers a unique opportunity for the student to learn preoperative and postoperative management of patients with complicated medical problems, review pelvic and abdominal anatomy, and become familiar with the basics of major gynecological cancer treatment including surgical management as well as chemotherapy and radiation therapy management. The clerk is expected to interview, examine, and follow patients assigned in rotation. The student is also expected to participate in operative procedures, particularly as relates to those patients that they are responsible for following. E. E. Jones.
Obstetrics, Gynecology, and Reproductive Sciences 104/Psychiatry 107, Shared Clerkship in Medical Psychiatry. This clerkship, administered jointly with the Department of Psychiatry, is designed to provide students with an understanding of the presentation of psychiatric illness in patients with co-morbid medical disorders. Emphasis is placed on screening interviews, including mental status examination; identification of symptoms; and differential diagnosis and initial treatment recommendations in patients with co-morbid and psychiatric illness. Special emphasis is placed on evaluation of psychiatric emergencies and competency to make informed medical decisions. R. Rohrbaugh and Department of Psychiatry faculty.
Obstetrics, Gynecology, and Reproductive Sciences 107, Perinatal Elective. The Maternal Fetal Medicine Division of the Department of Obstetrics, Gynecology, and Reproductive Sciences offers a four-week high-risk obstetric elective for fourth-year medical students. Ideally, only one student should be on the service at any time. In addition to doing high-risk obstetric rounds with the team and admitting emergency patients, the student is expected to attend perinatal ultrasound sessions that are held every day from 9 a.m. to 4 p.m. These are several rounds for students that include all obstetric rounds held in the department and the daily high-risk obstetric rounds. The student is on call with the high-risk chief resident and should come in at least on every third to fourth night to take part in the management of high-risk patients during labor and delivery. The evaluation of the student is based primarily on the clinical performance as well as participatio!
n at rounds and presentation of cases. J. Copel and staff.
Obstetrics, Gynecology, and Reproductive Sciences 108, Reproductive Endocrinology and Infertility Elective. A clinical elective in reproductive endocrinology and infertility. Students gain a basic knowledge of reproductive endocrine function including the physiology of the menstrual cycle and ovulation, male reproductive events, and the physiology of the climacteric and menopause. They also are introduced to disruptions in physiology and function leading to endocrine and infertility problems. Some of the common clinical problems to which students are introduced are polycystic ovarian disease and other symptoms of androgen excess, hyperprolactinemia, anovulatory syndromes, various genetic abnormalities that affect fertility, endometriosis and its sequelae, and tubal disease and its ramifications for surgery. In addition, students are exposed to the new reproductive technology such as in-vitro fertilization and the embryo transfer procedure. By the end of !
the elective, students are expected to be knowledgeable in all of the aforementioned areas through both reading and interaction with patients, faculty, and fellows. Suggested reading for the elective is Speroff, Glass, and Kase, Clinical Gynecologic Endocrinology and Infertility, 6th edition, Williams and Wilkins, publishers. In addition to being conversant with the aforementioned clinical situations, students on elective are expected to see endocrine and infertility patients in the office with faculty and fellows. Patients are interviewed and presented to the faculty member working with the students, and the cases are discussed. If appropriate, students also participate in physical examinations. Students are also expected to participate in surgical procedures on endocrine and infertility patients. Students take histories and perform physical examinations on major surgical cases at the time of hospital admission. They are expected to be present in the operating room during !
the surgery with the consent of the patient and follow the patients du
ring the postoperative recovery period. Students also have the opportunity to assist in outpatient surgical procedures done in the one-day surgical center and to observe procedures in in-vitro fertilization and the embryo transfer program. A full range of conferences and teaching sessions including the Obstetric and Gynecologic Grand Rounds are also available for students in the elective. A. Arici and staff.
Obstetrics, Gynecology, and Reproductive Sciences 109, Oncology Elective. The purpose of the oncology elective is to enhance the students knowledge of the diagnosis and management of women with gynecologic malignancies. The elective is offered to one student at a time for three to four weeks. The student is exposed to all modalities of treatment for gynecologic malignancies including radical gynecological surgery, chemotherapy, and radiation therapy. The student is expected to be an integral part of the team in the management of the patients admitted to the service. The student admits patients and takes part in their care throughout the elective period. The student is assigned to the operating room, especially to assist the patient whom he or she has evaluated. In addition, the student attends one-day surgical procedures to observe the placement of brachytherapy and other procedures, e.g., cystoscopy, proctoscopy examination under anesthesia with b!
iopsy. In the ambulatory setting, the student is exposed to the gestational trophoblastic clinic and the colposcopy clinic. A multiple-discipline tumor conference including faculty members from the divisions of Radiation Oncology and Gynecologic Pathology is held weekly. The student is also expected to attend a weekly gynecologic oncology conference and participate in the discussion. P. E. Schwartz and staff.
Ophthalmology and Visual Science
Office: BB 110, 785.2020
Professors
C. Barnstable, M. Coca-Prados, N. Daw, C. Gonzalez, W. H. Miller (Emeritus), M. L. Sears (Adjunct), M. B. Shields (Chair)
Associate Professors
B. DeBroff, L. J. Rizzolo (Surgery), J. Sinard (Pathology)
Assistant Professors
R. Adelman, Z. Klett, G. Shafranov, S. Tauber, N. Tian, C. Zeiss (Comparative Medicine)
Instructors
S. Alpert, C. L. Hagedorn, J. Membreno
Associate Research Scientists
S. Ghosh, M. Li
Research Affiliates
M. Abreu, M. Hom, S. Yanagisawa
Clinical Professors
I. W. Abrahams, A. A. Khodadoust, R. L. Lesser, D. E. Silverstone, T. J. Walsh, A. S. Wong
Associate Clinical Professors
P. Haffner, A. J. Levada, D. W. Parke, A. D. Rose, K. M. Stoessel, R. A. Wiznia
Assistant Clinical Professors
P. Branden, G. Bullwinkel, L. Doctor, J. Elman, P. Falcone, A. J. Fezza, S. Forster, K. Gagnon, P. Gaudio, S. B. Hersh, W. Larrison, E. Lim, A. Mead, M. Milner, J. Olson, P. Palmisano, A. D. Pearlstone, E. A. Petrelli, R. L. Petrelli, A. Romania, C. Sierra, C. Sklar, S. M. Soloway, D. Tom, M. L. Weitzman, B. D. Zuckerman
Clinical Instructors
D. Bacal, J. Q. Brooks, S. Castracane, N. Chaudhry, V. de Luise, P. A. Ecker, P. Guida, J. Martone, P. Masi, A. Musto, M. R. Shapiro, D. Shore, J. Sokol, S. C. Thornquist, J. Weisz
Postdoctoral Associates
B. Chen, L. Chen, Q. Fischer, Q. He, Y. Li, S. B. Patil, Y. Rao, R. Reddy, M. Salvador-Silva, H. Xu, Y. Yang
Ophthalmology and Visual Science 120, Elective in Clinical Ophthalmology. This intensive two-to-four-week elective consists of twenty half-day or forty half-day sessions during which the students observe in subspecialty clinics, evaluate patients in general ophthalmology clinics, observe ophthalmic surgery, participate in department conferences, and review independent study material provided by the department. A short presentation on a specific topic provides an opportunity to explore one aspect of ophthalmology in depth. Subspecialty experiences include corneal and external eye diseases, glaucoma, neuro-ophthalmology, oculoplastics, and retinal diseases. Each two-week elective is limited to two fourth-year students. Offered all year. S. Forster, faculty, and resident staff.
Ophthalmology and Visual Science 126, Preceptorial in Ophthalmology. In this elective the student has intensive exposure to one ophthalmic subspecialty under the direct supervision of one or two faculty members. Generally, the experience includes observing in a subspecialty clinic and the operating room, and may include completion of a minor research project. Prior to starting this elective, the student must have outlined a plan of study and obtained the approval of the supervising faculty members. Faculty members in corneal and external diseases, glaucoma, oculoplastics, and retina participate. A list is available from the director of medical studies. Limited to fourth-year students. One to four weeks. Offered all year. Faculty.
Orthopaedics and Rehabilitation
Office: YPB 133, 785.2579
Professors
R. Baron, G. Friedlaender (Chair), C. Gundberg, M. Horowitz, P. Jokl, L. Katz (Diagnostic Radiology), J. Lawson (Diagnostic Radiology; Emeritus), M. Panjabi, R. Pelker, T. Renshaw, W. Southwick (Emeritus)
Associate Professors
M. Baumgaertner, J. Cholewicki, J. Slade, A. Vignery
Assistant Professors
J. Grauer, M. Medvecky, J. Yue
Instructors
D. Bomback, F. Ennis, H. Greene, R. Kennon, Z. Leitze
Research Scientist
W. Horne
Associate Research Scientists
S. Balasubramanian, A. Bruzzaniti, M. Kacena, A. Sanjay
Research Affiliate
H.-Y. Qian
Clinical Professors
P. Brown, K. Keggi, J. Lynch, U. Weil
Associate Clinical Professors
H. Bradburn, R. Johnson, R. Margolis, E. Sella
Assistant Clinical Professors
M. Altman, J. Aversa, A. Axtmayer, R. Bernstein, P. Blume, D. Caminear, J. Daigneault, P. DeLuca, R. Eisen (Pathology), D. Gibson, G. Gorecki, J. Irving, J. Kelley, K. Kramer, J. Lieponis, M. Luchini, P. Luchini, J. Marsh, R. Mayor, M. Murphy, D. Novicki, T. Patel, M. Pressman, J. Raycroft, A. Reznik, D. Rosenblum, J. Shine, A. Sicklick, M. Silver, J. Sumner, C. Swigart, G. Taggart, C. Wahl, L. Weis, J. Wu
Clinical Instructors
C. Barrette, D. Bindelglass, D. Brittis, M. Clain, R. Dawe, R. Deponte, R. Diana, R. Feldman, R. Hendrikson, H. Hermele, M. Kaplan, N. Kaplan, J. Mangieri, J. McCallum, T. Moran, M. Morrison, P. Naiman, J. Perlman, A. Rice, R. Stanton, P. Stovell
Postdoctoral Fellows
C. Camerino, Y. Tominaga, S. Windahl
Postdoctoral Associates
E. Cuartas, W. Cui, C. Itzstein, H. Li, F. Morvan, A. Nakajima
Lecturers
J. Fulkerson, M. Parisi
Orthopaedics and Rehabilitation 102, Surgical Clerkship. Twelve weeks total. Students in the first clinical year spend six weeks on the general surgical service of one of the following: Yale-New Haven Hospital, VA Connecticut Healthcare System, West Haven, or Hospital of St. Raphael. Each student is integrated into the clinical team and assigned to specific patients. Responsibilities include taking histories and performing physical examinations on their patients, participating in the evaluation and management of these patients, following patients progress, and participating as assistants in the surgical operations performed upon their assigned cases. In addition, the students are expected to participate in the evaluation and care of the critically ill patient in the intensive care unit and the injured patient in the emergency room. Emphasis is placed on involving students in the process of clinical problem solving with the guidance of the residents!
and the attending preceptors. Conferences, case study groups, and rounds are held emphasizing this problem-oriented approach. Staff.
The remaining six-week period is spent as a clinical clerk in the surgical specialties. Seven specialties are offered: cardiothoracic, otolaryngology, neurosurgery, orthopaedics, pediatric, plastic and reconstructive, and urology. Each student elects three of these specialties and spends two weeks on each. While on the specialty of choice, the student is assigned patients in rotation and carries out complete histories, physical examinations, and certain procedures on these patients. While on the orthopaedic service, the student is assigned to one of the subspecialty teams, which include pediatric orthopaedics, spine, joint reconstruction, trauma, oncology, foot and ankle, hand, and sports medicine. The student is expected to participate, whenever possible, in the operative procedures performed on these patients and in their postoperative care. The student is also invited to attend the outpatient clinics in his or her assigned specialty. A series of one-hour lec!
tures, rounds, or demonstrations is given each afternoon by the surgical specialties so that the student has the opportunity of gaining knowledge of the wide field of specialties even though he or she does not participate in every specialty as a clinical clerk. Directed by individual surgical specialty chiefs.
Orthopaedics and Rehabilitation 104, Subinternship. Limited to third- and fourth-clinical years, with prior clerkship rotation. The student is an active member of one of the orthopaedic teaching teams (pediatric orthopaedics, spine, joint reconstruction, trauma, oncology, foot and ankle, hand, and sports medicine). Inpatient, outpatient, and operating room experience is supplemented by regular conferences. Limited to four students, preferably for one-month rotations, throughout the year. Arrangements must be made with Kathryn Umlauf.
Orthopaedics and Rehabilitation 108, Subinternship, Adult Reconstructive and Rehabilitative Orthopaedics, VA Connecticut Healthcare System, West Haven. The student functions as the intern on a large adult orthopaedic service. He or she attends conferences at the Veterans Affairs Connecticut Health Care System, West Haven, and at Yale-New Haven Hospital. (Y-NHH conferences include an ongoing seminar on basic sciences as related to the musculoskeletal diseases. ) The student is a full participant in the outpatient department and in the work of the operating room. This subinternship offers an intensive clinical experience with a variety of complex orthopaedic reconstructive problems. Rotations are usually for one month. By arrangement with Kathryn Umlauf.
Orthopaedics and Rehabilitation 110, Biomechanics Terminology. Presentation and explanation of some basic biochemical terms used to describe body tissues, structures, and functions. More than one hundred basic engineering terms are introduced. The format of presentation for each term is (1) a precise definition followed by units of measurement in the new S.I. system, (2) a detailed explanation, and (3) examples of its use in the everyday experience as well as in the medical field. Mathematical formations are presented whenever necessary. Eight weeks, by arrangement. M. Panjabi.
Orthopaedics and Rehabilitation 116, Basics of (Fracture) Diagnosis and Treatment. A six-week seminar in the basic elements of diagnosis and treatment of a spectrum of musculoskeletal trauma. M. Baumgaertner.
Orthopaedics and Rehabilitation 118, Musculoskeletal Anatomy. The basics of musculoskeletal anatomy from a functional anatomic and surgical perspective. The material is presented using prosected specimens. Knowledge of Anatomy 1ooa or its equivalent is assumed. M. Baumgaertner.
Orthopaedics and Rehabilitation 120, Rehabilitation Medicine at Gaylord Hospital. A four-week elective rotation designed to provide a comprehensive view of rehabilitation. The elective is composed of didactic sessions and clinical experiences in both the inpatient and outpatient setting. Areas of primary focus include spinal cord injury, head trauma, multiple trauma, amputations, pain management, occupational rehabilitation, stroke, and other neurologic rehabilitation. Specific problems, such as gait deviation, heterotropic ossification, and spasticity are addressed. Therapeutic modalitiesbracing and other durable medical equipmentare covered. The roles of allied health professionals, including physical, occupational, and speech therapies, and neuropsychology are demonstrated. Available throughout the year by arrangement with A. Sicklick and D. Rosenblum.
Pathology
Office: LH 108, 785.2759
Professors
P. W. Askenase (Internal Medicine), R. Bucala (Internal Medicine), Y. Choi (Co-Vice Chair), J. Costa (Co-Vice Chair), S. E. Downing (Emeritus), S. D. Flynn, N. Holbrook (Internal Medicine), M. Kashgarian, J. H. Kim, P. Lizardi, M. Lorber (Surgery), J. A. Madri (Director of Medical Studies), V. T. Marchesi, M. Mooseker (Molecular, Cellular, and Developmental Biology), J. S. Morrow (Chair), J. S. Pober, J. K. Rose, J. Sklar, D. F. Stern (Director of Graduate Studies), F. Tavassoli, R. Yesner (Emeritus)
Associate Professors
E. Glusac, R. Homer, D. Krause (Laboratory Medicine), R. Lazova (Dermatology), J. M. McNiff (Dermatology), A. Perkins, M. Reyes-Mugica, D. Rimm, M. Robert, J. Sinard, W. Zheng
Assistant Professors
S. Bannykh, C. Bifulco, D. Braddock, M. Chacho, S. Cowper (Dermatology), L. Hao, P. Hui, D. Jain, D. Kowalski, M. Martel, W. Min, I. Ocal, M. Pinto, L. Qin, P. Ravichandran, A. Subtil (Dermatology), D. Tuck
Instructors
A. Riba, E. Zambrano
Research Scientists
J. Brandsma (Comparative Medicine), C. Howe, D. Pradhan
Associate Research Scientists
C. Angeletti, R. Camp, G. Chatterjee, J. Czyzyk, D. Dillon, N. Kirkiles-Smith, J. Li, M. Liu, M. Mattie, N. Rose, M. Stankewich, A. Stortchevoi, Z. Walther, T. Welte, B. Yatsula, S. Zhang, Z. Zhang
Research Affiliate
S. Glantz-Tuschman
Clinical Professors
G. L. Davis, D. M. Lowell, G. Reynoso
Associate Clinical Professors
N. E. Herrera, S. H. Lee, D. F. Miller, I. Nash (Laboratory Medicine), D. J. Nelligan, R. Tennant (Emeritus), R. A. Vidone (Obstetrics, Gynecology, and Reproductive Sciences), I. M. Weisbrot
Assistant Clinical Professors
H. W. Carver II, T. E. Ciesielski, E. M. Clayton, M. T. Cronin, R. Eisen, P. Fiedler (Laboratory Medicine), N. Gelfman, G. Golenwsky, D. Graesser, I. S. Hahn, G. M. Kleinman, R. M. Kranwinkel, V. Lopez
Clinical Instructors
P. Biswas, W. G. Frederick, A. Katsnelson, S. Wain
Postdoctoral Associates
C. Cianci, A. DAlessio, J. Esparza, A. Jackson-Fisher, M. Harigopal, J. Lage, H. Li, M. Liu, A. McCabe, A. Moh, K. Okuma, Y. Xiao, X. Xu, B. Yu, J. Zhang
Postdoctoral Fellows
B. Bandarchi, K. Lezon-Geyda, T. Manes, E. C. Marginean, E. Ramsburg-Vratsanos, S. Tandon, N. Torpey, L. Tsvetkov, M. Wolfgang, X. Xu, R. Zhang, A. Zieske
Pathology 100, Pathological Basis of Human Disease. Fundamental principles underlying the pathological alterations in function and structure that constitute the reaction of the organism to injury. Pathology of diseases involving special organs and systems. Correlation of the clinical and anatomical manifestations is emphasized. J. Madri, S. Flynn, and staff.
Pathology 116, Autopsy Pathology. Participation in the autopsy service with members of the house staff in pathology. Participation in autopsies and the presentation and review of the clinical and anatomical findings of postmortem examinations with senior members of the department. Opportunities exist for correlation studies with previous biopsies, and clinical investigative and cell biologic techniques in relation to necropsy material. Six weeks minimum, full time. Limited to two students. J. Sinard and staff.
Pathology 117, Anatomic Pathology. The department offers an elective to medical students in the third and fourth years which provides a broad experience in general diagnostic techniques. Students have opportunities to participate in surgical pathology, cytology (including fine-needle aspiration), and autopsy. A daily conference is scheduled for both residents and students. In addition to direct responsibilities in the handling of the cases, the student has the opportunity to apply the special techniques of electron microscopy, immunohistochemistry, flow cytometry, and molecular diagnostics. A minimum of four weeks is suggested for this elective. Five students are accommodated every four to six weeks. J. Costa and staff.
Pathology 650b, Cellular and Molecular Biology of Cancer. A comprehensive survey of cancer research from the cellular to the clinical level. The relation of cancer to intracellular and intercellular regulation of cell proliferation is emphasized, as are animal models for cancer research. Background in molecular genetics and cell biology is assumed. D. F. Stern and A. S. Perkins.
Pathology 670b, Biological Mechanisms of Reaction to Injury. An introduction to human biology and disease as a manifestation of reaction to injury. Topics include organ structure and function, cell injury, circulatory and inflammatory responses, disordered physiology, and neoplasia. M. Kashgarian and staff.
Pathology 680a, Topics in Molecular Medicine. Readings and discussion in topics relevant to cell biology, pharmacology, and molecular medicine. The class emphasizes analysis of the primary research literature and development of presentation skills. D. Krause.
Pathology 690a, Molecular Mechanisms of Diseases. This course focuses on the molecular defects underlying fundamental human diseases. The program covers the cellular and molecular mechanisms of infectious and degenerative diseases, vascular and inflammatory processes, AIDS, and hemorrhagic disorders. The objective is to highlight the interface between experimental and molecular medicine, and how it relates to the pathogenesis of human diseases. V. T. Marchesi.
Pediatrics
Office: LMP 4085, 785.4638
Professors
W. A. Andiman, W. R. Anyan, Jr., M. D. Baker, R. S. Baltimore, G. P. Beardsley, W. R. Breg, Jr. (Genetics; Emeritus), T. Carpenter, J. A. Copel (Obstetrics, Gynecology, and Reproductive Sciences), T. F. Dolan, Jr. (Emeritus), C. C. Duncan (Neurosurgery), R. A. Ehrenkranz, M. Genel, S. Goldstein, I. Gross, J. Gryboski (Emeritus), A. Horwich (Genetics), M. Hostetter, Z. Kain (Anesthesiology), D. M. Komp (Emeritus), J. Leckman (Child Study Center), M. F. Leonard (Child Study Center; Emeritus), J. M. Leventhal, M. Lewis (Child Study Center; Emeritus), M. J. Mahoney (Genetics), L. Mayes (Child Study Center), P. L. McCarthy, L. R. Ment, I. G. Miller, H. A. Pearson (Emeritus), L. K. Pickett (Surgery; Emeritus), S. Rooney, D. S. Rowe (Emeritus), J. E. Schowalter (Child Study Center; Emeritus), J. H. Seashore (Surgery), M. R. Seashore (Genetics!
i>), E. D. Shapiro, B. A. Shaywitz, S. E. Shaywitz, N. J. Siegel, J. Sinclair (Epidemiology and Public Health; Adjunct), B. Smith (Laboratory Medicine), N. Talner (Emeritus), W. V. Tamborlane, R. J. Touloukian (Surgery), F. Volkmar (Child Study Center), J. Woolston (Child Study Center)
Associate Professors
M. Apkon, A. Bazzy-Asaad, C. Bogue, M. Brueckner, M. Cappello, S. Caprio, D. Donnelly, M. Egan, J. Fahey, B. Forsyth, A. H. Friedman, P. Gallagher, J. Gruen, B. McClain (Anesthesiology), E. Novotny, Jr., G. Pizzorno (Internal Medicine), M. Reyes-Mugica (Pathology), S. Rivkees, L. Rosenfeld (Internal Medicine), K. Santucci, D. Schonfeld, R. Shiffman, J. Van Hoff, M. Westerveld (Neurosurgery), Y. Xia
Assistant Professors
R. Antaya (Dermatology), L. Arnold, C. Baum, K. Bechtel, D. Bockenhauer, P. Bowers, R. Chapman, E. Colson, M. Farrell (Internal Medicine), A. Golioto, L. Jacobsen (Psychiatry), J. Kahn, C. Kim, J. Klig, K. Nead, R. Palazzo, L. Simon, B. Sleight, C. Snyder, D. Spiro, J. M. Stein (Internal Medicine), S. Weinzimer, C. Weitzman
Instructors
C. Cho, M. McCabe
Research Scientists
J. McGrath (Comparative Medicine), K. Pugh
Associate Research Scientists
H. Barbhaiya, V. Bhandari, T. Burgert, M. Butler, B. Chen, J. Dziura (Internal Medicine), S. Frankel, K. Freudigman, R. Fuleihan, M. Gaeta, F. Ghassemi, N. Kadan-Lottick, S. Kar, S. Lakhani, K. Marchione, E. Pinter, G. Porter, K. Schneider, S. Smith, M. Vazquez, C. Wendler, H. Yan, Z. Yu, P. Zhang, Z. Zhao
Research Affiliates
E. Kennedy, I. Ribeiro, T. Walls
Clinical Professors
M. Curnen (Epidemiology and Public Health), J. R. Gallagher (Emeritus), B. Goldberg, P. S. Goldstein, H. Jacobs, T. Kennedy, D. Kohn (Surgery), L. S. Krassner, M. Kresch, R. G. LaCamera, S. Levy, B. M. McDonald, J. McNamara, A. C. Mermann, H. Sacks (Child Study Center), M. Sklaire, M. A. Wessel, J. Zelson
Associate Clinical Professors
F. P. Anderson, R. Angoff, D. Beardsley, A. S. Beasley, K. Berkwits, J. Blanton, Jr., S. Boltax-Stern (Child Study Center), H. D. Bornstein, Jr., K. A. Bradford, M. Browne, C. Canny, R. Chessin, S. Danoff, M. Engel, J. Federico, J. B. Ferholt (Child Study Center), J. D. Ferholt, H. D. Fink, T. Flynn, J. Fong, R. Freedman, C. Goff, H. Goldenring, F. L. Gruskay, J. Gundy, J. Hen, Jr., R. Herzlinger, A. Jamshidi, L. S. McIntosh, M. Mercurio, S. Nallainathan, C. R. Palm, C. Randolph, R. Shelling, S. Spiesel, E. L. Stone, F. Testa, S. Updegrove, R. Young
Assistant Clinical Professors
R. J. Anderson, A. J. Avni-Singer, R. Berning, A. Bhargava, R. M. Biondi, S. Boulware, N. Brown, J. Burger, C. Butler, J. Calderon, D. Cheromcha, J. T. Combs, N. Condulis, N. Czarkowski, P. Czuczka, N. Deleuchtenberg, S. Dibs, C. Dorfman, D. Durante, G. Dworkin, A. R. Enriquez, S. Escalera, T. Etkin, P. Fadakar, K. Fearn, C. A. Fischbein, M. Galal, G. Germain, E. H. Gleich, A. J. Grant, G. W. Grundy, J. Gruskay, R. Halperin, J. Hamilton (Social Work), J. Harper, R. Hobbie, M. Hommel, M. Ikeda, S. Iragorri, W. D. Irving, R. Johnson, O. H. Lascano, L. Lasley, S. Lavietes (Social Work), M. Lee, D. Lowell, C. Mann, E. Marmer, A. Meyers, J. Morgan, C. Morrison, M. Pardi, A. Perez, S. Peterec, H. Pierce, M. Robert, H. Romanowitz, M. Sanyal, R. Scalettar, G. Schare, M. Schneider, C. Scott, L. Semeraro, L. Shader, R. Shea, M. Siev, W. Silberberg, M. Silverman, C. Stone, C. Summers, S. Theofanidis, S. Tsalbins, J. Tuggle III, J. Walterspiel, G. Wanerka, N!
. Weinberger, N. Weinstein, P. Weiss, R. F. Whelan, E. Wiesner, R. D. Windom, C. Wood, C. Woods, J. Wynne
Clinical Instructors
R. Adamenko, P. Alvino, J. Anderson, A. Atton (Dermatology), S. Baum, L. Berlin, M. Birmingham, M. Brochin, K. Burke, A. Cameron, R. Carroll, J. Cersonsky, A. Coughlin, M. Dilorenzo, J. Dipisa, A. Dobos, Jr., R. Dorr, D. Dreyfus, A. Driggers, U. Emenike, M. Flaherty-Hewitt, W. Flynn, B. Freeman, D. Gallo-Van Ess, G. Ganea, B. Gardner, S. Gardner, G. J. Germano, M. A. Glenn, K. Goldberg, L. Gray, D. Griffin, M. Groth, J. Harwin, A. Hoefer, F. Holmes, D. Idelson, T. V. Jackson, E. James, L. Jayanthi, B. Jubelirer, S. Kayani, H. Kipperman, M. Legris, S. Leib, A. Liebling, D. Lippi, R. Lockhart, J. Lopez, C. Menzies, A. Mrozowski, N. Naran, C. Nicolosi (Social Work), M. Pouliot, U. Puranik, D. Richards, O. T. Rose, M. Shaw, S. Simon, M. P. Smith, E. Springhorn, J. Stein, N. Stein, S. C. Stein, D. Torres, A. Vaezy, M. Vincent, L. Waldman, M. Willers, J. Young
Postdoctoral Fellows and Associates
B. Baker, S. Bankole, A. Benin, S. Bhaduri-McIntosh, M. Bizzarro, R. Bungiro, K. Calcagni, H. Chen, L. Chen, R. Cong, J. Delaney, E. Dokmeci, W. Eppich, F. Esper, A. Esquibies, E. V. Faustino, A. S. Gork, S. Gygax, Z. Hao, M. Held, A. Hsiao, M. Hunter, S. Husain, B. Jones, T. Kelly, K. Kevill, J. Khan, J. Kim, M. Kim, H. Kocinsky, A. Kollewe, M. Kuniyasu, I. Lazar, B. Lechner, L. Li, D. Lu, Q. Luu, M. Ma, J. Mieszczanek, C. Miliaresis, S. Mootien, T. Murray, J. Nedrelow, E. Paintsil, L. Plant, H. Quian, S. Rajan, M. Riordan, S. Sehgal, M. Seli, Y. Senturias, A. Shetty, T. Shih, H. Sohn, R. Sreedharan, S. Walsh, B. Weeks, S. Weiner, R. Weiss, C. Wildens, A. Wu, C. Yeckel, P. Zhao, J. Zhu
Lecturers
C. Cook, K. Feiden, P. Killeen, J. Mande
Pediatrics 103, Third-Year Clerkship. The Pediatric Clerkship consists of three different clinical experiences and a core curriculum. One clinical experience is a two-week ambulatory rotation in an academic primary care setting. Another two-week rotation allows students to join a pediatrics subspecialty team or to work in a private pediatric practice. The third clinical experience consists of a four-week rotation on the inpatient service at the Yale-New Haven Childrens Hospital or a Bridgeport hospital. One afternoon each week is devoted to pediatric grand rounds and teaching conferences in which the core curriculum is presented. At each venue, adequate time is allotted to read about relevant clinical problems, present cases to an attending or resident, examine children of various ages, and attend didactic or case-review conferences. W. A. Andiman.
Pediatrics 104, Outpatient Clerkship. Students assume responsibility, under supervision, for comprehensive care of children. They evaluate children referred to the clinic with diagnostic problems. Special emphasis is placed on problems related to the ambulatory patient. Senior students only. One student, full time, for three weeks. P. L. McCarthy and staff.
Pediatrics 128, HematologyOncology. A survey of the normal and abnormal hematology and the common malignancies of infancy and childhood. Students make initial rounds with the attending and the ward team at 7.30 a.m. The mornings are then spent in clinic seeing outpatients who come for therapy or follow-up. More extended bedside rounds, including time allotted for family discussions, take place in the afternoon. Students are expected to prepare a brief presentation for the team. One student, full time for three or more weeks, throughout the academic year. J. Van Hoff and staff.
Pediatrics 139, Pediatric Neurology. Students participate in the pediatric neurology clinic and the learning disorders unit and see neurology patients on the pediatric wards. Up to two students, full time, for three weeks, throughout the academic year. L. R. Ment, E. Novotny, B. Shaywitz, S. Shaywitz, M. Engel, S. Levy, F. Testa.
Pediatrics 143b/Surgery 136b, Pediatric Surgery. A general survey of pediatric surgical problems based on illustrated case summaries and subject presentation by students, with selected readings from the literature. Limited to six students, first and last six weeks of spring term. Once weekly, time to be arranged. J. H. Seashore, R. J. Touloukian, L. Moss.
Pediatrics 144, Clinical Clerkship in Pediatric Cardiology. Developmental aspects of cardiovascular function as applied to infants and children in both a clinical and a laboratory setting. Students are assigned to various members of the pediatric cardiology staff. Emphasis on physical diagnosis, use of noninvasive methods, and clinical physiologic correlates. Up to two students every four weeks throughout the year. M. Brueckner, J. Fahey, A. H. Friedman, C. Snyder, P. Bowers, G. Porter.
Pediatrics 146, Clinical Pediatric Infectious Diseases. Students participate in daily consultation rounds, Pediatric AIDS Clinic, and pediatric infectious diseases clinic. Students also participate in pediatric infectious disease rounds by presenting the case studies of one or more inpatients whom they have examined to a group of faculty and fellows. Rounds last approximately two hours (Wednesday morning). Emphasis is placed on correlation of the clinical problem and its practical management with principles of infectious disease epidemiology and clinical microbiology (bacteriology, virology, and parasitology). Limited to two students per three- to six-week period throughout the academic year. W. Andiman, R. Baltimore, M. Cappello, J. Kahn, G. Miller, G. Shapiro, M. Vazquez.
Pediatrics 148, Pediatric Endocrinology and Metabolism. An extensive exposure to clinical pediatric endocrinology, in particular problems of growth, sexual development, thyroid disorders, and diabetes mellitus and other disorders of carbohydrate metabolism. A full six-week elective includes five weekly general endocrinology clinics, two weekly diabetes clinics, and a hyper lipidemia/obesity clinic, and the inpatient service, generally concentrated in the Childrens Clinical Research Center. One student, full-time, six weeks, throughout the academic year. S. Boulware, T. Burgert, S. Caprio, T. Carpenter, M. Genel, S. Rivkees, W. V. Tamborlane, S. Weinzimer.
Pediatrics 152, Subinternship. Senior students serve as advanced clinical clerks in order to gain experience in providing care to pediatric patients. During the subinternship, students are directly responsible for the care of their assigned patients, under the supervision of resident and attending physicians. Subinternships are served for four-week periods on one of the inpatient teams or in the Pediatric Emergency Department in the Department of Pediatrics at the Childrens Hospital at Yale-New Haven. A. Friedman and staff.
Pediatrics 153, Pediatric Gastroenterology/Hepatology. A general survey of clinical pediatric gastroenterology and hepatology with particular emphasis on inflammatory bowel disease, malabsorption, diarrheal disorders, nutrition, and liver disease. The elective includes daily inpatient rounds, three weekly clinics, and several weekly clinicopathologic conferences, as well as observation of endoscopic procedures. One student, full-time, three or six weeks, throughout the academic year. S. Escalera, F. Daum.
Pediatrics 154, Pediatric Respiratory Medicine. During the elective, students are exposed to a range of activities in the Section of Respiratory Medicine. These include the evaluation of respiratory and pulmonary function in a variety of disease conditions, and care of infants and children with respiratory diseases such as asthma, cystic fibrosis, bronchopulmonary dysplasia, pneumonia, aspiration syndromes, and obstructive sleep disorders. Emphasis is on physical diagnosis. Rotations through the pulmonary function laboratory and the Childrens Sleep Center. Laboratory experience can be arranged. Participation in seminars, journal club, and patient rounds and clinics. Two students, every four weeks, throughout the academic year. A. Bazzy-Asaad, M. Egan, R. Palazzo.
Pediatrics 155, Pediatric Emergency Medicine. Senior students have the opportunity to evaluate and manage a broad range of acute pediatric illnesses under direct attending supervision. Participation in daily teaching conferences, mock codes, and clinical practice exercises is encouraged. Clinical duties are distributed over five six-hour clinical shifts per week. Up to two students every four weeks, throughout the academic year. A four-week rotation is recommended. M. D. Baker and staff.
Pharmacology
Office: SHM B204, 785.4372
Professors
G. K. Aghajanian (Psychiatry), K. S. Anderson (Director of Medical Studies), G. P. Beardsley (Pediatrics), H. R. Behrman (Obstetrics, Gynecology, and Reproductive Sciences), B. S. Bunney (Psychiatry), E. S. Canellakis (Emeritus), Y. C. Cheng, E. Chu (Internal Medicine), J. R. Cooper (Emeritus), P. S. Dannies, R. S. Duman (Psychiatry), B. E. Ehrlich, R. E. Handschumacher (Emeritus), L. K. Kaczmarek, A. Nairn (Psychiatry), W. H. Prusoff (Emeritus), J. M. Ritchie (Emeritus), S. C. Rockwell (Therapeutic Radiology), R. H. Roth, Jr. (Psychiatry), G. Rudnick (Vice Chair), A. C. Sartorelli, J. Schlessinger (Chair), W. Sessa (Director of Graduate Studies), S. G. Waxman (Neurology)
Associate Professors
A. Bennett, C. M. Crews (Molecular, Cellular, and Developmental Biology), M. P. DiGiovanna (Internal Medicine), V. Gribkoff (Adjunct), R. Heimer (Epidemiology and Public Health), J. Howe, E. Lolis, M. Picciotto (Psychiatry), G. Pizzorno (Internal Medicine)
Assistant Professors
Y. Ha, I. Lax
Research Scientists
D. Stagg, Y.-L. Zhu (Visiting)
Associate Research Scientists
A. Bhattacharjee, R. P. Baumann, Jr., M. Bordonaro, V. Eswarakumar, M. Fornaro, K. Ishiguro, D. Johnson, S. Kolli, D. Lazarova, Z. Li, Z. P. Lin, M.-C. Liu, E. Murakami, S.-Y. Park, P. Penketh, A. Pivazyan, A. M. Rice, A. Robert, K. Shyam, G. Sowa, M. Stephan, G. Yang, Y. Zhang, Y.-L. Zhu
Research Affiliates
M. Belcourt, W. Gao, Z. Jiang, P. Klein, S.-H. Liu, V. Mandiyan, T. McCabe, J. Mei, R. F. Tilton
Postdoctoral Fellows
P. M. Bauer, M. Beckman, J. P. Bingham, K. Chou, G. Crichlow, H. Ding, H.-H. Hsia, W. Joiner, S. Zoellner
Postdoctoral Associates
E. Ackah, A. Bhattacharjee, E. Boadu, R. Desai, V. P. Eswarakumar, L.-Y. Fu, C. Furdui, W. Gao, Y. Gao, W. Hinz, R. Hu, Y. Iwakiri, Y. Kaulin, S. Kolli, P. Krishnan, W. Lam, B. Lamothe, D. L. Lazarova, Y. Lee, C. H. Leung, Q. Li, Y. Li, Z. Li, Z. P. Lin, J.-Y. Li0u, D. Mattoon, X. Mei, Q. Miao, E. Murakami, S.-Y. Park, A. Sachpatzidis, M. Sachsamanoglou, Y. Sato, A. Sau, H. A. Seow, Z. Takacs, E. C. Thrower, C.-J. Wang, Y. Wang, H. Yeo, J. Yu, H. Zeng, H. Zhang, Y. Zhang, Y. Zhang, Y. W. Zhang
Lecturers
J. G. Collins (Anesthesiology), L. M. Dembry (Internal Medicine), G. E. Gardiner, R. J. Levine (Internal Medicine), J. M. Pawelek (Dermatology), A. Scriabine
Pharmacology 502a/b, Seminar in Pharmacology. A seminar given by a department faculty member on his or her area of interest to teach students how to critically evaluate papers and to improve the ability of students to give oral presentations.
Pharmacology 504a, Pharmacology I: Maintaining and Restoring Homeostasis. Lectures cover drug-receptor interactions, control of messenger systems and channels, and regulation of physiological systems. P. Dannies and staff.
Pharmacology 504b, Pharmacology II: Interfering Selectively. Lectures cover antibiotics, immunotherapy, and chemotherapy. P. Dannies and staff.
Pharmacology 506a/b, Methods in Pharmacological Research (Rotations). Students work in laboratories of faculty of their choice. The term in each laboratory is one term. Hours to be arranged. W. Sessa.
[Pharmacology 508b, Neuropharmacology. An intensive examination of current understanding of the sites and mechanisms involved in drug action on single nerve cells and on the brain. Emphasis on basic functions and illustrative examples of their disturbance by drugs. Next offered Spring 2005. J. M. Ritchie.]
Pharmacology 518b, Current Topics in Cancer and Viral Therapy. This course discusses current and evolving topics in cancer and viral mechanisms of disease and potential treatments. C. Cheng, E. Lolis.
Psychiatry
Office: GB 618, 785.2117
Professors
G. K. Aghajanian, S. J. Blatt, M. B. Bowers, Jr. (Emeritus), B. S. Bunney (Chair), K. M. Carroll, J. P. Comer (Child Study Center), R. S. Duman, M. H. Ebert, M. Edelson (Emeritus), P. L. Errera (Emeritus), J. E. Gelernter, E. Griffith, G. Heninger (Emeritus), M. A. Hoge, S. C. Jacobs, P. Jatlow (Laboratory Medicine), M. Johnson (Psychology), R. D. Kerns, Jr., K. K. Kidd (Genetics), R. A. King (Child Study Center), T. R. Kosten, J. H. Krystal, M. Lewis (Child Study Center; Emeritus), G. F. Mahl (Emeritus), J. W. Mason (Emeritus), C. M. Mazure,T. H. McGlashan, D. Musto (Child Study Center), A. C. Nairn, S. S. OMalley, G. Pearlson, D. M. Quinlan, F. Redlich (Emeritus), D. E. Redmond, Jr., M. Reiser (Emeritus), R. Rosenheck, R. H. Roth, Jr., B. J. Rounsaville, R. Schottenfeld, J. E. Schowalter (Child Study Center; Emeritus), M. J. Sernyak, Jr., !
M. Sheard (Emeritus), W. H. Sledge, D. L. Snow, S. Southwick, J. S. Strauss (Emeritus), F. R. Volkmar (Child Study Center), B. Wexler, H. V. Zonana
Associate Professors
M. Alreja, K. Avants, S. A. Ball, R. Belitsky, M. Bell, N. Boutros, C. Bradberry, A. Buchanan, N. L. Cooney, J. Cubells, Jr., L. Davidson, R. A. Desai, E. Diaz, D. C. DSouza, E. Giller (Adjunct), C. Grilo, K. Hawkins, R. E. Hoffman, J. Kaufman, D. Lipschitz, R. Malison, A. Martin (Child Study Center), S. Martino, G. Mason, T. McMahon, H. R. Pearsall, I. L. Petrakis, M. Picciotto, S. Powsner, H. Prigerson, M. Pruett, R. Rohrbaugh, M. I. Rosen, W. Shi, K. J. Sikkema, R. Sinha, J. L. Steiner, J. Taylor, J. Tebes, C. van Dyck, S. W. Woods, K. A. Yonkers
Assistant Professors
W. Abi-Saab (Adjunct), P. B. Allen, L. Anez Nava, R. S. Astur (Adjunct), S. Axelrod, C. B. Baker, R. Berman (Adjunct), H. Blumberg, D. Brunner (Adjunct), I. Cavus, M. Chawarski, L. Chwastiak, M. Desai, P. Desan, C. Doebrick, C. Easton, C. Edelen, C. N. Epperson, D. Fehon, T. George, G. Gonzalez-Haddad, L. Jacobsen, M. Jean-Baptiste, J. Kaufman, S. Krishnan-Sarin, S. D. Kruger, J. A. S. Lappalainen, D. Leslie, P. Maciejewski, R. Masheb, D. Mathalon, S. McKee, B. Moore, D. Northrup, M. V. Pantalon, E. Perry, Jr., J. Poling, M. Potenza, A. Rasmusson, C. Ripple, G. Sanacora, C. Sanislow III, G. Shahar, G. Sirugo (Adjunct), M. Sofuoglu, J. Staley Gottschalk, T. Styron, N. Suchman, G. Tamagnan (Adjunct), R. Tampi, D. Vojvoda, N. Ward, Z. Zimolo
Instructors
C. Connell, C. Crusto, D. Gordon, N. Hansen, N. G. Hurwitz, J. L. Tondora
Senior Research Scientists
D. V. Cicchetti (Child Study Center), J. D. Elsworth
Research Scientists
R. Baldwin, K. Behar, A. F. Fontana, T. Kosten, A. Margolin, A. Oliveto-Beaudoin, R. W. Robin
Associate Research Scientists
D. J. Abi-Saab, I. Achara-Abrahams, R. M. Arnold, M. Aslan, D. Barry, L. Bedregal, G. J. Bryson, B. Caldarone, J. Cramer, K. DAvanzo, C. M. DSa, L. Fenton, J. M. Fiszdon, M. Hampson (Diagnostic Radiology), G. Insabella, A. Jaffe, W. Kasprow, O. Korzyukov, J.-L. Li, C. Lozano-Blanco, X. Luo, W. Lynch, L. Maccarelli, D. Martin, C. Milligan, B. Morrow, M. Mouratidis, S. S. Nicholls, E. Ralevski, S. N. Sathyanesan, K. Scrimenti, D. Shelton, F. Struve, T. Sullivan, H. J. Toll, M. Wu, X.-Y. Zhang, W. Zito
Research Affiliates
D. Aikins, J. Bombace, L. Frisman, S. Luthar, G. Marek, K. McKnight, J. Miwa, J. D. Otis, C. L. Seibyl, E. Triffleman, S. A. Wyatt, J. H. Zhang
Clinical Professors
D. Berg, D. Carlson, T. W. Downey (Child Study Center), G. H. Flamm, C. W. Gardner, Jr., D. G. Greenfeld, S. A. Leavy (Retired), E. Prelinger (Psychology), L. W. Reiser, C. E. Riordan, H. L. Ruben, H. S. Sacks (Child Study Center), L. D. Siggins
Associate Clinical Professors
J. Allison, V. Altshul, R. Balsam, D. Bialos, S. Boltax-Stern (Child Study Center), E. Brett, C. Chiles, J. Ciarcia, G. Cohn (Retired), R. A. Cooper, J. De Figueiredo, A. Evans, J. B. Ferholt (Child Study Center), L. B. Fierman, J. Geller, R. L. Goettsche, K. Grady, L. Harkness, R. J. Hoffnung, D. Johnson, J. A. Kleeman, R. Klein, C. C. Kovel, J. Laffal (Retired), D. Laub, K. O. Liebmann, J. Lustman, B. McKee, L. J. Micheels, D. C. Moore, C. A. Morgan III, M. Norko, R. Ostroff, D. Perlick, R. Peters, Jr., J. Phillips, S. H. Phillips, Jr., S. G. Possick, M. Rowe, M. A. Rubenstein, E. R. Ryan, R. Sallick, J. Schnitt, S. J. Schreiber, A. H. Schwartz (Child Study Center), A. Siegal, E. W. Snyder, R. Stern, T. Stewart, G. J. Watstein, J. Young
Assistant Clinical Professors
A. Adis, R. Ahrens, A. Almai, P. Amble, C. Atkins, S. Atkins, A. Balter, M. Baranoski, L. C. Barr, M. Barrios, B. Becker, R. Behrends, C. Bemis, S. Bender, D. Bendor, E. Berger, T. Bergherr, S. J. Bittner, T. Brown, A. Brownlow, L. V. Calabrese, V. D. Calhoun, W. Campbell, C. Carlson, R. Casey, L. I. Chaikovsky, J. Check, J. Chilakamarri, D. Ciancimino, A. Cinquanta, J. C. Cline, J. T. Collins (Child Study Center), V. Coric, C. Cottrol, L. W. Cross, W. F. Dailey, G. H. Davis, M. E. Delphin, C. E. Desmond, C. Dike, N. Donegan, D. B. Douglas, M. T. Dreyfus, L. K. Driscoll, J. Erdos, P. Falzer, M. Felts, J. Fickes, S. Finkelstein, G. J. Firman, P. A. Fountain, P. Fox, E. R. Frazer, J. Frey, D. Fried, R. Giebisch, T. Glinberg, P. B. Goldblatt, L. Goldstein, K. Gonsai, C. Gonzalez, L. Gonzalez, C. Gottschalk, C. Greene, K. Grimmell, E. Grottole, C. S. Grove, L. Grunebaum, K. F. Hall, F. A. Hameedi, Y. Han, J. C. Harland, E. Hart, S. Hill, W. L. Hill, Jr., M.!
Hillbrand, O. Hills, K. Holtzman, S. Horowitz, S. Houlding, D. D. Jacobson, H. G. Jarecki, C. Jean, A. Kaner, K. Kennedy, S. Khan, K. Kiehl, R. G. King (Child Study Center), P. Kirwin, B. Klink, B. Knox, F. E. Koerner, R. Kravitz, J. L. Kurt, M. M. Kurtz, A. Lamba, H. Lankenau, D. Lapaglia, J. H. Lederer, B. Lee, N. E. Legow, J. M. Levine, R. D. Lewis, S. Lewis, E. Littman, H. Lizcano, D. London, K. Long, H. Lubin, M. Mandelkern, B. Marcus, C. A. Markle, C. Maynard, S. M. McCants, R. McCleary, B. B. McConnell, B. Meandzija, A. Meisler, A. Miano, D. W. Mickley, S. J. Migdole, T. Miller, R. M. Milstein, F. Minichiello, A. Mitra, V. Morrow, F. C. Mueller, P. V. Mulinski, J. Murray, E. Nasper, M. Newell, J. Nields, D. Nudel, K. Nuro, A. M. Oberkirch, M. S. Okasha, N. Olson, A. Oren, D. Oren, R. Ownbey, A. Papsun, M. Paris, C. Pearson, L. Perone, W. Phillips, D. Pilkey, G. Plotke, M. L. Prevey, G. Racusin, J. Rakfeldt, I. Rathbone, A. Resnick, L. Robertson, J. Robinson, !
C. T. Rotenberg, B. S. Rothchild, M. Roy, N. Roy, R. Rubin, D. S. Russ
ell, J. A. Sabbatino, J. K. Sadowitz, K. Salisbury, C. Sanders, A. Sawyer, R. Sbriglio, B. E. Scanley, R. Schreibman, J. Scott, Jr., S. R. Segall, J. P. Seibyl, J. K. Shepard, D. Sholomskas, S. E. Silverman, S. Sreenivasan, D. Stayner, M. C. Stevens, W. A. Stewart, M. Stitelman, D. C. Tate, A. Tessler, B. Tobin, P. Torop, L. Trevisan, M. Tupper, S. H. Tworkowski, D. Wallington, S. D. Wayne, Jr., R. Weingarten, R. S. White, C. Wiseman, B. Zigun, S. Zimmerman
Clinical Instructors
T. Alford, M. Bailey, J. Beauvais, E. Becker-Dunn, C. G. Burns, C. Camp, M. K. Champion, J. F. Chapman, V. Coggshall, J. F. Collins, I. M. Dineen, D. Fisk, S. Fitzpatrick, D. Flanigan, C. Grazia, M. C. Grenough, W. Levy-Massarani, M. McCarthy, P. Mohrer, M. Nicholas, C. Nickou, J. N. Rascati, S. Rathi, S. P. Rathi, S. H. Rodrigues, M. E. Savage, S. J. Sokol, M. F. Sperrazza, D. J. Suscovich, H. Temporini, J.-A. Vitarelli, M. Vollmar, E. Weiss, S. E. Wolf
Lecturers
J. D. Alvaro, L. Ameen, B. Backus, S. Berman, D. Berv, K. Berv, E. Bialek, A. Blank, Jr., W. Boutelle, L. Brauer, J. Bristol, E. Coley, C. Conrad, H. Crabbe, D. Davis, A. Demac, P. J. Dileo, A. Dworetz, C. Feldman, N. R. Gluck, M. L. Glucksman, S. Goodson, J. Gordon, G. Greenberg, E. G. Halstead, M. Kalacznik, A. Kalafa, A. Koleszar, A. Labruzza, L. Lager, R. Lenoci, N. Lifton, R. Makover, K. Marcus, A. Mares, J. H. Meyer, M. Mitchell, I. Moses, R. L. Munich, J. I. Novick, K. Owen, R. Phillips, S. A. Quinlan, M. Rego, W. Reich, B. G. Rifkin, D. Rightmer, A. Rodriguez, J. A. Roth, E. B. Rubin, S. L. Satel, K. D. Schultz, D. Schwartz, A. Sholomskas, G. H. Sirkin, R. Z. Solomon, W. Spear, C. Tesluk, P. Thomas, M. Vythilingam, R. Westheimer
The Department of Psychiatry teaches in both preclinical and clinical years. The pre-clinical course is a study of medical behavioral science, rather than an introduction to clinical psychiatry. Specific clinical skills, such as interviewing and the recognition and management of psychiatric syndromes, are taught later in the curriculum and especially during the required clinical clerkship in Psychiatry. Electives are available for students with special interest in selected areas. All advanced clinical electives are numbered in the 2oos. The required core clinical clerkship (Psychiatry 106) is a prerequisite for enrollment in any of these advanced clinical electives; an advanced clinical elective may not be taken instead of the required core clinical clerkship. Please note: All students signing up for a seminar elective must also register with the Medical Student Education Office, Department of Psychiatry, 785.2089 (pending approval of the instructor).
Psychiatry 101a, Patient-Centered Interviewing: The Patients Story. This segment of the Pre-Clinical Clerkship focuses on the experience of illnesshow people react to and cope with illness. The various psychosocial factors and psychological defenses which impact on the experience of illness, such as age, gender, social supports, socioeconomic status, and coping style, are examined. There is an emphasis on the patient interview and techniques for eliciting the patients story in an empathic and effective manner. The format includes lectures, demonstration interviews, and practice with standardized patients. R. Belitsky and departments of Psychiatry and Medicine faculty.
Psychiatry 101b, Biological Basis of Behavior. Lectures are integrated with the Neurology course, and include principles and neural mechanisms of learning and memory; neural systems involved in fear and anxiety; neural systems involved in reward and drug addiction; neural systems involved in stress; and neural systems involved in attention. Following each lecture, a psychiatrist interviews patients diagnosed with obsessive-compulsive disorder, panic disorder, cocaine abuse, post-traumatic stress disorder, and schizophrenia. These 1.5-hour clinical presentations, which include time for questions, link psychiatric symptoms to the neural mechanisms discussed in the lecture on that day. 2.5 hours per week. Department of Psychiatry faculty.
Psychiatry 106, Core Clinical Clerkship. Skills and knowledge needed for the general practice of medicine are acquired in a clinical psychiatric setting. These include the ability to conduct a competent screening interview in order to identify symptoms of a psychiatric or substance abuse disorder; to perform a complete mental status examination of a patient who is emotionally disturbed or mentally ill; to make a differential diagnosis, and to plan for further evaluation and tests that would be useful in deciding among various diagnostic possibilities; to make recommendations for biological, psychosocial, and/or social treatment interventions; to assess whether or not dangers to or from a patient exist; and to understand indications and procedures for lawful involuntary commitment of a patient to a mental hospital for treatment. R. Rohrbaugh and Department of Psychiatry faculty.
Psychiatry 107/Obstetrics, Gynecology, and Reproductive Sciences 104, Shared Clerkship in Medical Psychiatry. This clerkship, administered jointly with the Department of Obstetrics, Gynecology, and Reproductive Sciences, is designed to provide students with an understanding of the presentation of psychiatric illness in patients with co-morbid medical disorders. Emphasis is placed on screening interviews, including mental status examination; identification of symptoms; and differential diagnosis and initial treatment recommendations in patients with co-morbid medical and psychiatric illness. Special emphasis is placed on evaluation of psychiatric emergencies and competency to make informed medical decisions. R. Rohrbaugh and Department of Psychiatry faculty.
Psychiatry 203, Subinternship in Hospital Psychiatry, Inpatient Division, Connecticut Mental Health Center. Intensive work with inpatients who suffer from major psychiatric disorders with or without substance abuse. Emphasis is on assessment, acute treatment, and arrangement of continuing care in the community. The clerk functions as an integral member of a multidisciplinary treatment team. Clinical research participation is encouraged. Opportunities available to explore special areas of interest (e.g., forensics, psychopharmacology, administrative) with Connecticut Mental Health Center faculty. The elective is given on the inpatient service, CMHC. Scheduled throughout the year during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 1o6. Maximum registration: two students. S. Jacobs, M. Jean-Baptiste, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 205, Subinternship in Medical Psychiatry, Yale-New Haven Hospital, 2039 Clinic Building. This is an advanced clinical elective for third- and fourth-year students who have a particular interest in the psychiatric disorders that can occur in medical-surgical patients. The staff has special interests in differential diagnosis of medical vs. psychiatric illness, in psychopharmacology, and in computer applications in psychiatry. Each student works up patients in parallel with advanced residents in inpatient and emergency department settings. Teaching occurs on daily walk rounds. Scheduled throughout the year during regular clerkship rotations (except July and August) for a minimum of four weeks. (NOTE: Fourth-year students will be given preference. ) Prerequisite: Psychiatry 1o6. Maximum registration: one student per rotation. P. Desan, T. Stewart, S. Powsner, W. H. Sledge, A. Papsun, and staff. To enroll in this subinternship, please contact R. R!
ohrbaugh.
Psychiatry 206, Advanced Clinical Elective in Law and Psychiatry. This clerkship program affords opportunities for fourth-year medical students to observe and participate in competency to stand trial evaluations with a clinical team that makes these assessments at the New Haven Correctional Center. In addition, they may attend Law School classes with students who represent psychiatric patients, observe civil commitment procedures, attend probate court hearings, as well as the criminal proceedings in local New Haven Superior Courts. Students attend work seminars where case evaluations and write-ups are discussed and prepared, and read appropriate legal cases and psychiatric literature. Students may be able to participate in parts of evaluations of insanity defense, custody determination, and other forensic issues. They attend the Law and Psychiatry Seminar during their rotation. Scheduled throughout the year (except August) during regular cler!
kship rotations for a minimum of four weeks. Prerequisite: Psychiatry 1o6. Maximum registration: two students. H. Zonana. To enroll in this advanced clinical elective, please contact R. Rohrbaugh.
Psychiatry 208, Subinternship in Consultation-Liaison Psychiatry at the VA Connecticut Healthcare System (VACHS), West Haven, Connecticut. The Consultation-Liaison Service at the VACHS West Haven provides consultation to acute medical and surgical units, specialized rehabilitation units, and outpatient primary care clinics. Students participate in the management of patients with close supervision from attending staff. The goals of the rotation are (1) to increase skill in conducting a psychiatric interview which maximizes the collection of pertinent clinical data; (2) to use the data collected in formulating and implementing treatment plans emphasizing the interplay of biological and psychological factors in the patients presentation; (3) to experience the satisfaction of caring for patients with complex medical and psychiatric illness. Scheduled throughout the year for a minimum of four weeks. Open to third- and fourth-year medical students. Prere!
quisite: Psychiatry 1o6. Maximum registration: one student per rotation. C. Chiles, J. Myer. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 209, Substance Abuse Elective. An elective clinical training experience in substance abuse for interested third- and fourth-year students. The primary training site is the Outpatient Service at the VA Connecticut Healthcare System (VACHS) in West Haven. The substance abuse elective is scheduled for four weeks. This experience is an intensive one in which students work closely with addicted patients with chronic mental illness. Students interested in learning about medical detoxification from alcohol and/or opiates may participate in an intensive two-week elective in the Ambulatory Detoxification Clinic at the VACHS. Students learn about the evaluation and treatment of alcohol withdrawal and detoxification. Patients with benzodiazapene and opiate dependence are also treated in this Clinic. Prerequisite: Psychiatry 106. Maximum registration: two students. VACHS Faculty: L. Trevisan, I. Petrakis. Contact person (for VACHS): I. Petrakis, Psychiatr!
y. To enroll in this advanced clinical elective, please contact R. Rohrbaugh.
Psychiatry 210, Subinternship in Hospital Psychiatry, Inpatient Division, YaleNew Haven Psychiatric Hospital. Intensive work with patients who suffer from major psychiatric disorders and range in age from college students to middle age. Emphasis is on assessment, acute treatment, and arrangement of post-discharge follow-up care in the community. The subintern is an advanced clerk functioning as a member of the multidisciplinary treatment team, taking on primary clinician and psychiatric/medical responsibilities for patients under the supervision of senior clinicians. The elective is given on the inpatient service at YNHPH; clinical research and outpatient involvement may be options. This subinternship is available throughout the year, during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 1o6. Maximum registration: one student per rotation. R. M. Milstein, M. Bowers, and staff. To enroll in this subinternship!
, please contact R. Rohrbaugh.
Psychiatry 211, Subinternship in Clinical Neuroscience, Clinical Neuroscience Research Unit Inpatient Division. This clerkship offers senior medical students the opportunity to work closely with a variety of patients who are hospitalized during their participation and treatment in research protocols. The Clinical Neuroscience Research Unit (CNRU) is a thirteen-bed inpatient ward with associated outpatient clinics and basic science laboratories on the third floor of the Connecticut Mental Health Center (CMHC). Supervised implementation of novel psychopharmacology, exposure to multiple aspects of clinical and basic science research, and in-depth experience with individual and group psychotherapies are educational aspects of this elective. Patients diagnostic categories include depression, obsessive-compulsive disorder, schizophrenia, cocaine abuse, and substance abuse. Scheduled throughout the year for a minimum of four weeks. Prerequisites: Psychiat!
ry 1o1 and 1o6. Maximum registration: one student per rotation. R. Malison, V. Coric, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 212, Subinternship in Post-Traumatic Stress Disorder, National Center for PTSD at the VA Connecticut Healthcare System (VACHS), West Haven, Connecticut. This clerkship offers senior medical students the opportunity to participate in the research and clinical activities of the National Center for PTSD. This experience includes exposure to a research program that has taken a national leadership role in identifying the effects of severe psychological trauma on brain structure and function using a variety of neuropharmacological, neuropsychological, and brain imaging modalities. The patients under study include men and women who have been exposed to physical and sexual abuse and the trauma associated with combat. Scheduled throughout the year for a minimum of four weeks. Prerequisite: Psychiatry 1o6. Maximum registration: two students per rotation. S. Southwick and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 214, Subinternship in Psychotic Disorders at G8W and the Schizophrenia Research Clinic at the VA Connecticut Healthcare System (VACHS) in West Haven, the Clinical Neuroscience Research Unit and the Psychopharmacology Intervention Program at the Connecticut Mental Health Center, the Community Care Center in West Haven. This subinternship is designed to provide an integrative exposure to the interface of psychopharmacology and psychosocial treatments for chronic psychotic disorders. Each individual requesting a subinternship is asked to outline his or her interest in psychotic disorders. Based on this information, a faculty mentor is assigned and a clinical program prepared that provides greater depth in the relevant areas. An effort is made to provide exposure to both hospital- and community-based treatments as well as clinical neuroscience advances. Within all treatment settings, subinterns have closely supervised direct clinical contact with !
patients. Subinterns are invited to attend academic conferences within the Department of Psychiatry focused on clinical and neuroscience issues relevant to psychosis. The goals of the rotation are (1) to expose the subintern to established and experimental medication treatments for psychotic disorders, particularly schizophrenia; (2) to expose the subintern to rehabilitative approaches to schizophrenia; (3) to expose the subintern to community-based treatments for chronic mental illness. Scheduled throughout the year for a period of six to eight weeks. Prerequisite: Psychiatry 1o6. Maximum registration: two students per rotation. C. DSouza, M. Bell, J. Cubells, L. Davidson, L. Harkness, S. Kruger, J. Krystal, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 325/Child Study 325, Child Psychiatry Elective, Yale Child Study Center. The aim of this elective is to provide the student with an intensive experience in infant, child, and adolescent psychiatry. The curriculum includes assessments of normal development and psychopathology in childhood, treatment methods, and research in major disorders of childhood. The elective takes advantage of the wide range of ongoing seminars, conferences, and clinical services in place at the Child Study Center. Teaching methods include seminars, conferences, field observations, ward rounds, and practica selected by the student following consultation with the director of medical studies, Child Study Center. Open to fourth-year students throughout the year (except July and August). A. Martin, D. Stubbe, J. Woolston, and staff. To enroll in this advanced clinical elective, please contact A. Martin directly at 688.6016 or 785.3370.
Surgery
Office: FMB 102, 785.2697
Professors
J. J. Abrahams (Otolaryngology; Diagnostic Radiology), L. M. Bartoshuk (Otolaryngology), M. Centrella (Plastic), E. Crelin (Emeritus), S. J. Dudrick (Co-terminus with St. Mary Hospital; Gastroenterology), J. A. Elefteriades (Cardiothoracic), J. P. Geibel (Gastroenterology), B. G. Green (Co-terminus with Pearce Laboratory; Otolaryngology), R. J. Gusberg (Director of Medical Studies; Vascular), G. L. Hammond (Cardiothoracic), B. K. Kinder (Oncology), J. A. Kirchner (Emeritus), G. S. Kopf (Cardiothoracic), D. R. Lannin (Oncology), S. B. Leder (Otolaryngology), D. J. Leffell (Otolaryngology; Dermatology), A. Lofqvist (Otolaryngology; Adjunct), W. E. Longo (Gastroenterology), M. I. Lorber (Transplant), B. Lytton (Emeritus), L. M. Manuelidis (Neuropathology), C. F. McKhann (Emeritus), I. M. Modlin (Gastroenterology), J. A. Persing (Plastic), L. K. Pickett (Emeritus), R. Rabinovici (Trauma), S. H. Rosenbaum (Trauma; Anesthesiology), W. Rosenblatt (Otolaryngology; Anesthesiology), P. E. Rubin (Otolaryngology; Adjunct), J. Santos-Sacchi (Otolaryngology), C. T. Sasaki (Otolaryngology), I. R. Schwartz (Otolaryngology), J. H. Seashore (Pediatric), Y. H. Son (Otolaryngology; Therapeutic Radiology), B. E. Sumpio (Vascular), R. J. Touloukian (Pediatric), R. Udelsman (Chair; Oncology and Endocrinology), R. M. Weiss (Urology), H. K. Wright (Emeritus)
Associate Professors
K. R. Anderson (Urology), M. S. Bogucki (Emergency Medicine), J. W. Colberg (Urology), D. C. Cone (Emergency Medicine), L. C. Degutis (Emergency Medicine), G. DOnofrio (Emergency Medicine), H. Foster, Jr. (Urology), H. L. Frankel (Trauma), A. L. Friedman (Transplant), V. Gahtan (Vascular), M. Johnson (Otolaryngology; Diagnostic Radiology), L. J. Kaplan (Trauma), T. L. McCarthy (Plastic), R. L. Moss (Pediatric), L. J. Rizzolo (Gross Anatomy), R. A. Rosenthal (Oncology; Chief, VA), D. Ross (Otolaryngology), R. R. Salem (Oncology), J. A. Schriver (Emergency Medicine), W. B. Stewart (Gross Anatomy), G. Tellides (Cardiothoracic), J. G. Thomson (Plastic)
Assistant Professors
J. Aruny (Vascular; Diagnostic Radiology), P. Barrett (Cardiothoracic), R. L. Bell (Gastroenterology), S. M. Bowers (Emergency Medicine), C. Breuer (Pediatric), P. A. Brewer (Emergency Medicine), C. Cha (Gastroenterology), M. Coady (Cardiothoracic), A. Dardik (Vascular), L. V. Evans (Emergency Medicine), L. Geiselhart (Transplant), H. M. Hojman (Trauma), J. Joe (Otolaryngology), S. W. Jolin (Emergency Medicine), K. J. Jubanyik-Barber (Emergency Medicine), E. L. Kelley (Vascular), M. A. McKee (Pediatric), E. P. Monico (Emergency Medicine), C. Moore (Emergency Medicine), H. C. Moscovitz (Emergency Medicine), D. Narayan (Plastic), A. Poma (Emergency Medicine), S. Roman (Oncology), J. H. Shin (Plastic), J. A. Sosa (Oncology), M. Tandon (Trauma), E. Uchio (Urology), A. Weihl (!
Emergency Medicine), J. Yang (Trauma)
Instructors
C. Kwon (Cardiothoracic), K. Moinuddeen (Cardiothoracic), J. Portereiko (Trauma)
Senior Research Scientist
J. Latifpour (Urology)
Associate Research Scientists
Y. Bai (Cardiothoracic), W. Chang (Plastic), W. Li (Vascular), C. Rahner (Gross Anatomy), Y. Wang (Cardiothoracic), T. Yi (Transplant)
Research Affiliates
P. Biancani (Urology), M. Fiorella (Otolaryngology), D. Teso (Vascular)
Clinical Professors
S. Ariyan (Plastic), M. S. Arons (Plastic), J. E. Fenn (Gastroenterology), D. W. Kohn (Dental; Pediatrics), S. B. Nuland (Gastroenterology), R. B. Reinhold (Gastroenterology), R. S. Stahl (Plastic), E. Yanagisawa (Otolaryngology)
Associate Clinical Professors
N. A. Atweh (Trauma), M. S. Beinfield (Gastroenterology), Z. N. Chicarilli (Plastic), J. M. Dowaliby (Otolaryngology), R. C. Fazio (Dental), A. J. Graham (Gastroenterology), J. R. Hernandez (Otolaryngology), H. L. Horton (Dental), R. K. Houlihan (Gastroenterology), J. P. Kelly (Dental), K. Koral (Dental), K. J. Lee (Otolaryngology), R. Lena (Urology), W. B. McCullough (Gastroenterology), N. M. Passarelli (Gastroenterology), J. M. Serling (Dental), L. W. Skope (Dental), S. A. Stein (Gastroenterology), H. Stern (Cardiothoracic), A. L. Toole (Cardiothoracic), B. S. Weisbart (Dental)
Assistant Clinical Professors
H. Abrams (Gastroenterology), P. A. Barcewicz (Gastroenterology), M. Baron (Dental), A. Baskin (Urology), J. S. Berkley (Dental), G. Bosker (Emergency Medicine), K. Bradley (Emergency Medicine), J. M. Brogden (Gastroenterology), J. Cacace (Emergency Medicine), P. H. Cain (Dental), D. Card (Urology), H. Cedarbaum (Dental), B. Y. Cha (Dental), K. A. Ciardiello (Gastroenterology), D. G. Cloutier (Dental), M. L. DAiuto (Trauma), R. J. Dean (Urology), R. H. Delfini (Dental), R. W. DeNatale (Vascular), M. L. Dewar (Cardiothoracic), A. T. Dioguardi (Dental), T. G. Duplinsky (Dental), J. P. Escandon (Otolaryngology; Anesthesiology), J. Federico (Cardiothoracic), P. E. Fidler (Trauma), S. V. Flagg (Plastic), J. M. Flynn (Emergency Medicine), A. R. French (Emergency Medicine), S. I. Friedman (Otolaryngology), S. Fusi (Plastic), R. Garvey (Gastroenterology), A. R. Goldstein (Dental), R. T. Golia (Dental), L. G. Graff (Emergency Medicine), R. D. Grossman (Dental), J. Henley (Otolaryngology), R. H. Hirokawa (Otolaryngology), G. Horblitt (Dental), N. R. Horowitz (Gastroenterology), J. A. Huttner (Dental), M. E. Ivy (Trauma), B. Jordan (Emergency Medicine), R. B. Kaplan (Dental), D. E. Karas (Otolaryngology), G. J. Katigbak (Emergency Medicine), D. B. Keck (Dental), J. C. Kirchner (Otolaryngology), P. A. Kraus (Urology), P. E. Krochmal (Emergency Medicine), J. W. Kunkel (Emergency Medicine), D. Kusovitsky (Dental), J. Kveton (Otolaryngology), E. M. Kwasnik (Gastroenterology), H. A. Laffaye (Gastroenterology), T. E. Lamonte (Emergency Medicine), S. B. Levine (Otolaryngology), J. R. Loeffler (Otolaryngology), G. Long
streth (Gastroenterology), R. A. Lowlicht (Otolaryngology), J. Maisel (Emergency Medicine), M. Margolies (Dental), S. Mitra (Otolaryngology), G. E. Mombello (Plastic), D. J. Muller (Dental), A. Napolitano (Emergency Medicine), S. H. Natkin (Dental), G. R. Nicastri (Gastroenterology), R. Nierenberg (Emergency Medicine), M. K. OBrien (Gastroenterology), G. Opin (Plastic), P. M. Opin (Dental), R. J. Parker (Dental), J. A. Passarelli (Gastroenterology), M. M. Perez (Emergency Medicine), M. F. Perkal (Gastroenterology), E. G. Polokoff (Gastroenterology), R. P. Ponn (Cardiothoracic), T. Ponn (Gastroenterology), G. J. Price (Plastic), C. Rambus (Emergency Medicine), J. Razzak (Emergency Medicine), K. Restifo (Emergency Medicine), D. D. Roberts (Otolaryngology), J. C. Salomon (Plastic), J. E!
. Sather (Emergency Medicine), R. F. Schlessel (Gastroenterology), M. J. Schpero (Dental), S. Shah (Gastroenterology), S. Shahabuddin (Emergency Medicine), R. K. Shaw (Cardiothoracic), B. K. Singletary (Dental), J. A. Sirleaf (Emergency Medicine), E. Slusky (Dental), R. E. Steller (Dental), G. Strothers (Otolaryngology), R. F. Stroup (Urology), T. F. Sweeney (Vascular), J. M. Tan (Emergency Medicine), J. L. Tanenbaum (Dental), A. Tarabar (Emergency Medicine), G. Terranova (Emergency Medicine), S. C. Thornton (Gastroenterology), D. Tran (Trauma), R. Tross (Plastic), M. B. Wallack (Dental), J. F. Walsh (Urology), D. Wasson (Gastroenterology), H. K. Watson (Plastic), M. A. Wayne (Emergency Medicine), M. H. Weinstein (Plastic), M. J. Werdmann (Emergency Medicine), A. E. Wilk (Dental), !
J. A. Wilkinson (Emergency Medicine), J. M. Willett (Otolary
ngology), K. Yanagisawa (Otolaryngology), E. Young (Otolaryngology)
Clinical Instructors
P. W. Alberti (Otolaryngology), J. P. Antoci (Urology), J. A. Arons (Plastic), D. Ashmead IV (Plastic), D. Astrachan (Otolaryngology), C. B. Beckman (Cardiothoracic), M. S. Bianchi (Otolaryngology), M. W. Bradway (Oncology), J. A. Camilleri (Urology), E. Chen (Otolaryngology), B. Chervin (Otolaryngology), T. Coffey (Otolaryngology), P. Demir (Urology), R. J. Devito (Urology), S. M. Einbinder (Dental), R. A. Feldman (Urology), P. D. Fischer (Plastic), M. J. Flanagan (Urology), P. L. Fortgang (Otolaryngology), A. Friedler (Dental), R. A. Gaito, Jr. (Otolaryngology), N. A. Gordon (Otolaryngology), M. Grushka (Otolaryngology), I. Guttenberg (Otolaryngology), D. G. Hesse (Urology), R. P. Hung (Dental), R. J. Ippolito (Gastroenterology), V. B. Khachane (Cardiothoracic), T. !
H. Lesnik (Otolaryngology), R. A. Levin (Otolaryngology), H. Lin (Emergency Medicine), J. R. Lyons (Plastic), V. Mansourian (Gastroenterology), T. V. Martin (Urology), R. J. Miles (Otolaryngology), A. J. Namon (Otolaryngology), W. J. Pite (Dental), V. Prabhat (Otolaryngology), J. P. Roach (Urology), S. J. Salzer (Otolaryngology), J. F. Schmidt (Otolaryngology), R. R. Steckel (Cardiothoracic), C. M. Van Gelder (Emergency Medicine), E. M. Vining (Otolaryngology), T. W. Vris (Otolaryngology), D. Wohl (Dental)
Postdoctoral Fellows
K. Amankwah (Vascular), T. Anthony (Pediatric), C. Ariyan (Transplant), H. Asada (Vascular), H. Barquero (Neuropathology), D. Eisenberg (Urology), M. Fukuhara (Gross Anatomy), I. Hatzaras (Cardiothoracic), Y. Hoshino (Vascular), M. Kidd (Gastroenterology), F. Kudo (Vascular), Y. Luo (Gross Anatomy), R. Moomiaie (Cardiothoracic), Y. Nie (Trauma), K. Nishimura (Vascular), J. Portereiko (Trauma), H. Ranjbaran Jahromi (Cardiothoracic), L. Simarro Gonzalez (Neuropathology), F. Tamarkin (Urology), P. Tang (Cardiothoracic), E. Vucic (Gastroenterology), C. Walker (Neurology), H. Zhang (Neuropathology), L. Zhang (Transplant)
Postdoctoral Associates
C. Baker (Neuropathology), A. Iakimov (Cardiothoracic), J. Kim (Cardiothoracic), V. Rybalchenko (Otolaryngology), L. Song (Otolaryngology), M. Yono (Urology), F. Zhang (Trauma)
Lecturers
L. Acton (Otolaryngology), H. C. Briggs (Gross Anatomy), E. Browne (Emergency Medicine), N. S. Bruno (Otolaryngology), N. Collins (Plastic), H. L. Ferrillo (Otolaryngology), B. C. Fichandler (Plastic), S. Ghofrany (Gross Anatomy), S. Jolie (Otolaryngology), S. E. Kapadia (Gross Anatomy), H. M. Keiser-Pederson (Vascular), M. Kiessling (Emergency Medicine), W. L. Mackey (Pediatric), D. S. MacMillan (Emergency Medicine), A. Meiman (Emergency Medicine), D. C. Newton (Emergency Medicine), P. Possenti (Trauma), C. Powell (Otolaryngology), K. Yanagisawa (Otolaryngology)
Surgery 103, Surgical Clerkship. This is an eight-week block that includes a four-week core experience on one of the general surgery services at either Yale-New Haven Hospital or the West Haven VA Hospital, a two-week rotation on Anesthesia, and an additional two weeks during which the students can choose among several specialties (Vascular Surgery, Endocrine Surgery, Emergency/Trauma Surgery, Pediatric Surgery, or Emergency Medicine).
During all of the rotations on the Surgery services, the students can expect to be integrated into the clinical teams, working up patients to which they are assigned and participating in the evaluation and management of these patients (in both the in-patient and outpatient settings). In addition to knowledge acquisition, emphasis is placed on the development of basic clinical skills as well as surgical problem-solving skills.
During the four-week core general surgery experience, each student is assigned to a clinical preceptor who is responsible for monitoring progress, reinforcing core concepts, and facilitating skill development. Throughout the eight-week clerkship, there is a core curriculum, a series of problem-oriented interactive sessions focused on fundamental surgical problems. In addition there is a weekly case study seminar, directed by students, focused on role-playing and emphasizing surgical decision making, doctor-patient interactions, and the development of teaching skills.
At the outset of the clerkship, the students receive an outline of learning objectives (for both knowledge and skills). At the conclusion of the clerkship there is a self-assessment examination and an exit interview.
Surgery 122, Subinternship, Plastic Surgery. Clinical experience as an intern on a large clinical ward. The student has experience in the management of craniofacial anomalies, burns, trauma, hand surgery, head and neck surgery, reconstructive surgery of the head and neck and extremities, microsurgery, as well as surgery of the congenital anomalies and cosmetic surgery. Limited to one fourth-year student per month with a minimum of one-month rotations. Arrangements must be made with J. A. Persing.
Surgery 123b, Biochemical and Metabolic Foundations of Plastic and Reconstructive Surgery. A course designed to provide in-depth understanding of the molecular events underlying the diverse clinical phenomena encountered in plastic surgery. Topics include fluid electrolyte metabolism in the burn patient, biochemistry and metabolism of collagen and its relation to scarring and connective tissue disorders, normal wound healing, and disorders of the same. Offered for four weeks during the spring term, two hours per week by arrangement. Limited to two fourth-year students. J. A. Persing.
Surgery 129, Cardiopulmonary Transplantation. Intensive exposure to laboratory and clinical aspects of cardiac, cardiopulmonary, and pulmonary transplantation. Special emphasis on the relation between ongoing laboratory studies and clinical practice in this field. Clinical involvement in preoperative assessment of prospective transplant candidates, donor procurement, intraoperative management, and postoperative immunosuppression. Limited to one student by arrangement with J. Elefteriades.
Surgery 130, Subinternship, Cardiothoracic. Intensive exposure to preoperative and postoperative management of adult and pediatric cardiothoracic surgical patients and to intraoperative conduct of surgical procedures, with active participation in the operating room and in regular conferences. Students attend regular seminars covering major areas of cardiothoracic surgery with members of the faculty, and may be required to present a seminar on a subject in cardiothoracic surgery to faculty and resident staff. Limited to two students in the second clinical year. Three or six weeks by arrangement with J. Elefteriades.
Surgery 131, Subinternship, General Thoracic. Intensive exposure to preoperative and postoperative management of general thoracic surgical patients and to the intraoperative conduct of surgical procedures involving the lung, the chest wall, the thymus, and the esophagus. Included is an organized lecture series covering the entire field of general thoracic surgery. Students are expected to present a seminar at the conclusion of the subinternship, focusing on a specialized topic in general thoracic surgery. Six weeks by arrangement with J. Elefteriades.
Surgery 141, Outpatient Otolaryngology. This is an opportunity for those students who have not had exposure in otolaryngology to spend time with a full-time attending otolaryngologist seeing outpatients in an office setting. Timing is quite flexible and a student may spend one to three mornings or afternoons each week for one to four weeks. By arrangement with C. T. Sasaki and the full-time otolaryngology staff.
Surgery 142, Emergency Medicine. The student participates in the evaluation and treatment of adult emergency patients, learning appropriate work-up and therapy. Students are expected to attend morning conferences four mornings per week and to work four twelve-hour shifts that may include nights and weekends. Prerequisite: Surgery 103.
Surgery 143, Care of the Intensive Care Unit Patient. Didactic and clinical sessions in the Yale-New Haven Hospital SICU prepare the student to provide basic treatment for the critically ill patient. Topics include cardiopulmonary resuscitation, airway and ventilator management, assessment of the multiple trauma patient, and management of sepsis. Prerequisite: Surgery 1o3. Three to four weeks, by arrangement. R. Rabinovici, S. Rosenbaum.
Surgery 144, Trauma Surgery. The student functions as an extern and participates actively in trauma service rounds, teaching conferences, trauma resuscitation, and operative management of trauma cases. Students are expected to attend conferences and take inhouse call with the chief resident of the trauma service. Prerequisite: Surgery 103. R. Rabinovici.
Surgery 150, Plastic and Reconstructive Surgery. Evaluation and reconstructive surgery of deformities of congenital, traumatic, and neoplastic origin. Includes inpatient, outpatient, and operating room experience, supplemented by regular conferences. Limited to two students; available throughout the year. J. A. Persing.
Surgery 151, Subinternship, General Surgery. (Four weeks) Offered throughout the academic year at both Yale-New Haven Hospital and VA Connecticut Healthcare System, West Haven. Limited to second clinical year, one or two students per month. Arrangements must be made with D. C. Andersen.
Surgery 152, Advanced Senior Seminar, General Surgery. This is a weekly evening seminar series covering advanced and controversial topics in general surgery. Three one-hour sessions include dinner at faculty homes and run from October through February. Reprints of pertinent articles provided prior to each seminar. Staff.
Surgery 153, Subinternship, Otolaryngology. This clinical experience is independent of the third-year Surgery/Otolaryngology rotation, and takes place on an individual basis. It includes operating room experience, ward responsibilities, and involvement in outpatient ENT. Yale-New Haven Hospital, the Hospital of St. Raphael, and the VA Connecticut Healthcare System, West Haven, are available for the rotation. Minimum rotation of four weeks; limited to one student. J. F. Kveton, C. T. Sasaki.
Surgery 158, Surgery at Waterbury Hospital. A well-supervised fourth-year clerkship including teaching rounds, operating room experience, outpatient clinical experience, and conferences in radiology, pathology, oncology, vascular surgery, and general surgery. Daily ICU rounds are conducted with an attending physician. Six weeks, for one or two students, with room and meals provided. E. Kwasnik and staff.
Surgery 159, Subinternship, Urology. Varied clinical studies, in-depth experience in all forms of urology. Limited to clinical years. One student per month, for three to four weeks. R. Weiss and staff.
Surgery 160, Surgery at St. Marys Hospital, Waterbury. Six-week subinternship in an affiliated community hospital of 4oo beds, consisting of ward and operative experience, teaching rounds, and conferences. An independent general surgical residency exists at St. Marys. S. Dudrick and staff.
Surgery 165, Surgery at Bridgeport Hospital. For a student contemplating a career in clinical surgery, an opportunity to function as a team member with residents and attending staff in a large community hospital. General surgery with fundamental pre- and postoperative care, appropriate operating room activity, basic bedside diagnostic and therapeutic hands-on experience, emphasis on intensive care unit, trauma, and burns. Each student is expected to present a twenty-minute research or clinical topic of choice at completion of the course. Room and board available on duty. Limited to one or two students for six- to eight-week rotations in the fourth year. Staff.
Surgery 171, Subinternship, Peripheral Vascular Surgery. A practical experience in the diagnosis and management of vascular disease, including pre- and postoperative care. The scope of the experience includes orientation to the noninvasive vascular diagnostic laboratory, outpatient care in the Yale Vascular Center, and inpatient management (including patients in the OR, ICU, and the vascular surgery unit). Four weeks, by arrangement with B. Sumpio and staff.
Surgery 172, Subinternship, Transplantation Surgery. This intensive clinical experience emphasizes the preoperative assessment, intraoperative care, and postoperative management of patients suffering end-stage organ system failure who are cared for by transplantation. Emphasis also includes the management of immunosuppressive medication regimens and the care of post-transplant problems. Available throughout the year, one or two students, for one month. Arrangements with M. Lorber and staff.
Surgery 173, Experimental Transplantation Surgery and Immunobiology. Clinical and laboratory studies into problems relevant to the field of organ transplantation. Students work under the tutelage of a member of the faculty in the Division of Organ Transplantation. Original projects must be mutually agreed upon, and may include studies into the immunology of allograft rejection, the mechanism of immunosuppressive drug action, immunological monitoring of patients following transplantation, or biochemical markers to potentially identify early rejection of renal, hepatic, pancreatic, or small bowel allografts. Available throughout the year, one or two students, time commitment by arrangement. M. Lorber and staff.
Surgery 174, Subinternship in Surgical Oncology. Intensive exposure to surgical aspects of the treatment of cancer in clinic, hospital, and operating room. The interaction between surgery, medical oncology, and radiation therapy is experienced by following patients receiving multiple forms of therapy. Available throughout the year, one or two students, preferably for one-month rotations. Arrangements with R. R. Salem.
Surgery 175, Pediatric Cardiac Surgery. Intensive exposure to pediatric cardiac surgery with emphasis on preoperative evaluation and postoperative management. The student observes the changes in pre- and postoperative physiology and spends much of the time following postoperative patients. The student is exposed to the use of ventilators in the pediatric patient, inotropic and vaso-dilating agents, evaluation and treatment of low cardiac output state, and the use of pacemakers. Weekly conferences include surgical conferences, preoperative conferences, catheterization conference, pre- and postoperative clinics, as well as weekly sessions with the attending staff. Some technical experience and instruction are provided in the operating room according to the students interest. Limited to one student per month except August, September, and December. G. S. Kopf and staff. Arrangements to be made with G. Kopf.
Surgery 176, Subinternship in Pediatric Surgery. In-depth exposure to the broad spectrum of pediatric surgical problems of the abdomen, chest, head and neck, and pelvis. The student obtains experience with correction of congenital anomalies, management of trauma, care of the critically ill child, and management of solid tumors. The subintern is an integral part of the pediatric surgical team and is expected to take in-house night call every third night. Contact R. Touloukian.
Therapeutic Radiology
Office: HRT 140, 785.2956
Professors
D. Brash, J. J. Fischer, P. M. Glazer (Chair), B. G. Haffty, R. Nath (Physics), R. E. Peschel, S. Rockwell, W. D. Rupp, R. J. Schulz (Emeritus), Y. H. Son, W. C. Summers, P. Sung (Molecular Biophysics and Biochemistry)
Professor of Research
K. B. Low, Jr. (Adjunct)
Associate Professors
S. J. Baserga (Molecular Biophysics and Biochemistry), F. dErrico, S. Higgins, J. Knisely, K. B. Roberts, J. Sweasy, L. D. Wilson
Assistant Professors
J. Deng, A. Khan, M. Moran, H. Song, Z. Yun
Instructor
S. Khosravi
Research Scientist
D. B. Fischer
Associate Research Scientists
P. Havre, Q. Lin, V. Mihaylova, F. Rogers, W. Zhang
Research Affiliate
W. P. Summers
Associate Clinical Professors
Z. Chen, A. H. Knowlton, P. Pathare, N. Yue
Postdoctoral Fellows
C. Brdlik, J. Lloyd
Postdoctoral Associates
S. Dalal, K.-H. Kim, T. Lang, M. Maitra, I. Mihaylova
Lecturers
J. Bond, R. Vera
Therapeutic Radiology 101, Clinical Clerkship in Radiation Therapy. A flexible program designed to introduce the medical student to radiation therapy. The biological and physical bases of radiation therapy, together with clinical practice and ongoing research. Clinical exposure to patients with malignant disease, with between seventy and one hundred treated daily in the department. The student takes part in departmental conferences, clinics, lectures, and individual teaching sessions. Limited to two students at any time. B. G. Haffty and staff.
Therapeutic Radiology 102, Clinical Radiobiology. This course is designed to provide residents in radiation oncology with a comprehensive review of clinical radiobiology as it applies to the practice of radiation therapy. The course is open to residents and fellows in other disciplines interested in radiobiology as it applies to clinical oncology. The course participant attends approximately twenty lectures in clinical radiobiology, which are delivered throughout the academic year between September and June. Scheduling by arrangement with B. G. Haffty.
Therapeutic Radiology 201b, A Survey of Radiobiology. A review of the interaction of radiation on living organisms, progressing from DNA damage to complex mammalian systems. Modern concepts in molecular biology and cell kinetics are emphasized in understanding the sequelae of this interaction and the mechanism by which the organism responds to the injury produced. Fourteen sessions. By arrangement with Radiobiology staff.
Therapeutic Radiology 305, Principles and Methods of Radiation Dosimetry. A graduate-level course for physics students or medical students with a strong physics background who want to learn about radiation dosimetry as it applies to medical practice. Topics include X-ray spectra, ionization chambers, X-ray exposure and the roentgen, mass energy-absorption coefficients, the Bragg-Gray principle, stopping power and linear energy transfer, chemical dosimeters, instrumentation, and physical aspects of radiology. Approximately twenty hours of tutorial sessions. Scheduling by arrangement with instructor. R. Nath.
Therapeutic Radiology 306, Laboratory Projects in Radiation Dosimetry. Students are given problems that relate to and supplement long-term, ongoing radiation dosimetry projects within the department. Prerequisite: Therapeutic Radiology 3o5, or its equivalent. Scheduling by arrangement with instructor. R. Nath.
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