Departments M - Z
Microbial Pathogenesis
Office: 295 Congress Avenue, Room 336B, 737.2404
Professors
N. W. Andrews, M. Cappello (Pediatrics), E. Fikrig (Medicine), J. E. Galan (Chair), M. K. Hostetter (Pediatrics)
Associate Professor
W. Mothes, C. R. Roy
Assistant Professors
H. F. Agaisse, B. I. Kazmierczak (Medicine), B. Lindenbach, J. D. Macmicking
Associate Research Scientists
C. G. Briones, I. Derre, F. Du, D. Hofreuter, C. Huynh, M. D. Lara-Tejero, J. Patel
The following courses in the Graduate School of Arts and Sciences are open to medical students with permission of the DGS.
MBIO 642a/EMD 642a/GENE 642a/MB&B 642a/MCDB 642a, Roles of Microorganisms in the Living World. A topical course exploring the biology of microorganisms. Emphasis on mechanisms underlying microbial adaptations and how they influence biological systems. Prerequisites: biology, chemistry, and biochemistry. N. Ornston, D. Söll, D. McMahon-Pratt.
MBIO 670a,b, Laboratory Rotation. Rotation in three laboratories. Required for all first-year graduate students. J. Sweasy.
MBIO 684b, Advanced Topics in Molecular Parasitology. An advanced graduate-level seminar course in modern parasitology. The class is focused on the reading and critical evaluation of papers from the current literature selected by the students in cellular and molecular mechanisms of parasitism. Prerequisites: EMD 680a is highly recommended; permission of the instructor. D. McMahon-Pratt, C. Tschudi.
MBIO 685b, Molecular Mechanisms of Microbial Pathogenesis. This course focuses on current topics related to host pathogens interactions. Each week a lecture is given on the topic, followed by student presentations of seminal papers in the field. All participants are required to present a paper. J. Galán, N. Andrews, C. Roy, W. Mothes, J. MacMicking, H. Agaisse, B. Lindenbach.
MBIO 700a, Seminal Papers on the Foundations of Modern Microbiology. A required course for Microbiology first- and second-year students; not for credit. The course is offered every second year, alternating with MBIO 703a, so that it can be taken once during each student’s tenure in the program. Students present and discuss papers describing fundamental discoveries in areas related to microbiology. The goal is to familiarize students with the process of scientific discovery and with the history of major developments in the field. Topics include important discoveries involving major human pathogens, fundamental processes in molecular biology, and the development of technology that has a major impact on current biomedical research. Offered every other year. P. Tattersall.
MBIO 701a,b, Research in Progress. All students, beginning in their third year, are required to present their research once a year at the Graduate Student Research-in-Progress. These presentations are intended to give each student practice in presenting his or her own work before a sympathetic but critical audience and to familiarize the faculty with the research. J. Sweasy.
MBIO 702a,b, Microbiology Seminar Series. All students are required to attend all Microbiology seminars scheduled throughout the academic year. Microbiologists from around the world are invited to describe their research. J. Sweasy.
MBIO 703a, Evasion of Host Defenses by Viruses, Bacteria, and Eukaryotic Parasites. A required course for Microbiology first- and second-year students; not for credit. The course is offered every second year, alternating with MBIO 700a, so that it can be taken once during each student’s tenure in the program. Students present and discuss papers on the strategies employed by microbial organisms to evade either cell-intrinsic defenses, such as the induction of programmed cell deatlh, or response operating at the level of the organism, such as adaptive immunity. P. Tattersall.
MBIO 734a/GENE 734a, Molecular Biology of Animal Viruses. Lecture course with emphasis on mechanisms of viral replication, oncogenic transformation, and virus-host cell interactions. D. DiMaio, G. Miller, P. Tattersall, W. Mothes, J. Rose, R. Means, M. Robek.
Molecular Biophysics and Biochemistry
Offices: JWG 304, 432.2077; SHM C106, 785.4246
Professors
S. J. Baserga, G. W. Brudvig (Chemistry), D. M. Crothers (Emeritus), D. M. Engelman, A. Garen, M. B. Gerstein, S. Ghosh (Immunobiology), N. D. Grindley, A. D. Hamilton (Provost), M. W. Hochstrasser, W. H. Konigsberg, P. Lengyel (Emeritus), R. P. Lifton (Genetics), I. Miller (Pediatrics), P. B. Moore (Chemistry), T. D. Pollard (Molecular, Cellular, and Developmental Biology), A. Pyle, L. J. Regan, F. M. Richards (Emeritus), G. L. Schmir (Emeritus), R. G. Shulman (Emeritus), M. Snyder (Molecular, Cellular, and Developmental Biology), D. G. Söll, M. J. Solomon, J. A. Steitz, T. A. Steitz, S. A. Strobel (Chair), W. C. Summers (Therapeutic Radiology), P. Sung, S. L. Wolin (Cell Biology)
Professor (Adjunct) of Research
K. R. Williams
Associate Professors
J. H. Cabral, E. M. De La Cruz, M. R. Koelle, A. J. Koleske, A. D. Miranker, V. M. Unger
Assistant Professors
T. Biederer, Y. E. Modis, A. E. Rhoades, Y. Xiong
Senior Research Scientists
C. M. Joyce, F. M. Richards
Research Scientists
J. L. Burton, P. Flory (Genetics), Z. Hu, S. M. Mane, K. Tycowski, J. Wang
Associate Research Scientists
R. A. Albright, S. Bailey, S. Balasubramanian, R. K. Beran, G. Blaha, C. Bruce, A. Cheng, G. M. Clayton, C. M. Colangelo, J. K. Countryman, A. S. El-Guindy, J. I. Elliott, O. A. Fedorova, E. J. Folta-Stogniew, E. Gulcicek, P. Kim, D. E. Klimenko, Y. Kong, T. T. Lam, I. Lomakin, A. Lopez-Cortajarena, J. R. Lytle, D. Ostapenko, T. Ravid, J. S. Rozowsky, A. Sachpatzidis, M. Simonovic, F. Yi
Lecturers
C. A. Bascom-Slack, A. A. Belperron (Medicine), R. J. Brown, E. L. Herzog (Medicine), J. S. Kahn (Pediatrics), A. B. Pawashe, M. P. Strout (Medicine), E. C. Thrower (Medicine), R. Torres
MB&B 523a/PHYS 523a, Biological Physics. An introduction to the physics of biological systems including molecular motors, protein folding, membrane self-assembly, ion pumping, and bacterial locomotion. Background concepts in probability and statistical mechanics are introduced as necessary. S. Mochrie.
MB&B 545b/CPSC 545b/CB&B 545b, Introduction to Data Mining. A study of algorithms and systems that allow computers to find patterns and regularities in databases, to perform prediction and forecasting, and to improve their performance generally through interaction with data. M. Schultz, M. Gerstein.
MB&B 550a, Molecular Foundations of Medicine. This course is part of the Molecules to Systems course, which is open only to first-year medical students. An introduction to the major concepts of biochemistry and molecular biology, with emphasis on the human body. Special attention is devoted to how recent advances in basic science contribute to our understanding and treatment of human disease. S. Baserga, M. Solomon, D. Engelman. Conference leaders: A. Belperron, J. Kahn, E. Herzog, E. Thrower, R. Torres, M. Stroud, R.J. Brown.
MB&B 600a, Principles of Biochemistry I. Discussion of the physical, structural, and functional properties of proteins, lipids, and carbohydrates, three major classes of molecules in living organisms. Energy metabolism, hormone signaling, and muscle contraction as examples of complex biological processes whose underlying mechanisms can be understood by identifying and analyzing the molecules responsible for these phenomena. M. Koelle, T. Biederer.
MB&B 601b, Principles of Biochemistry II. A continuation of MB&B 600a that considers the chemistry and metabolism of nucleic acids, the mechanism and regulation of protein and nucleic acid synthesis, and selected topics in macromolecular biochemistry. J. Steitz, S. Strobel.
MB&B 602a/CBIO 602a/MCDB 602a, Molecular Cell Biology. A comprehensive introduction to the molecular and mechanistic aspects of cell biology for graduate students in all programs. Emphasizes fundamental issues of cellular organization, regulation, biogenesis, and function at the molecular level. S. Wolin, M. Solomon, V. Unger, and staff.
MB&B 625a/GENE 625a/MCDB 625a, Basic Concepts of Genetic Analysis. The universal principles of genetic analysis in eukaryotes are discussed in lectures. Students also read a small selection of primary papers illustrating the very best of genetic analysis and dissect them in detail in the discussion sections. While other Yale graduate molecular genetics courses emphasize molecular biology, this course focuses on the concepts and logic underlying modern genetic analysis. T. Xu, M. Koelle, and staff.
MB&B 630b/MCDB 630b, Biochemical and Biophysical Approaches in Molecular and Cellular Biology. This graduate course introduces the theory and application of biochemical and biophysical methods to study the structure and function of biological macromolecules. The course considers the basic physical chemistry required in cellular and molecular biology but does not require a previous course in physical chemistry. One class per week is a lecture introducing a topic. The second class is a discussion of one or two research papers utilizing those methods. T. Pollard, E. De La Cruz, V. Unger, and staff.
MB&B 635a1u, Mathematical Methods in Biophysics. Applied mathematical methods relevant to analysis and interpretation of biophysical and biochemical data are covered. Students apply these methods (statistics and error analysis, differential equations, linear algebra, and Fourier transforms) to analyze data from research groups in MB&B. Prerequisites: MATH 120 (or equivalent) and MB&B 600a (or equivalent) or permission of instructors. Y. Xiong, E. Rhoades.
MB&B 650, Laboratory Rotation for First-Year Students. Required for all MB&B first-year graduate students. Credit for full year only. M. Solomon.
MB&B 675, Seminar for First-Year Students. Required for all first-year MB&B graduate students. Y. Modis.
MB&B 676b, Responsible Conduct of Research. Designed for students who are beginning to do scientific research. The course seeks to describe some of the basic features of life in contemporary research and some of the personal and professional issues that researchers encounter in their work. Approximately six sessions run in a seminar/discussion format. Required for all first-year MB&B graduate students. T. Biederer and staff.
[MB&B 705a/GENE 705a/MCDB 505a, Molecular Genetics of Prokaryotes. Molecular aspects of the storage, replication, evolution, and expression of genetic material in prokaryotes. Prerequisites: previous or concurrent introductory courses in genetics and biochemistry. N. D. F. Grindley, P. Sung.]
MB&B 710b4/C&MP 710b4, Electron Cryo-Microscopy for Protein Structure Determination. Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. The course is an introduction to the concepts and applications of high-resolution electron cryo-microscopy. This rapidly emerging new technique is the only method that allows biological macromolecules to be studied at all levels of resolution from cellular organization to near atomic detail. F. Sigworth, V. Unger.
MB&B 720a, Macromolecular Structure and Biophysical Analysis. An in-depth analysis of macromolecular structure and its elucidation using modern methods of structural biology and biochemistry. Topics include architectural arrangements of proteins, RNA, and DNA; practical methods in structural analysis; and an introduction to diffraction and NMR. Prerequisites: physical chemistry (may be taken concurrently) and biochemistry. A. Miranker, J. M. Cabral, A. Pyle.
MB&B 721b, Macromolecular Interactions and Dynamic Properties. This course examines dynamic properties of macromolecules, their interactions, catalytic activities, and methods for analyzing their behavior. Topics include macromolecular folding, binding interfaces, ligand interactions, and the properties of membrane proteins, enzymes, ribozymes, and molecular motors. These areas are presented together with modern methods for analysis of macromolecular associations and dynamic properties. Prerequisites: biochemistry, physical chemistry, and MB&B 720a or permission of the instructor. A. Pyle, E. Rhoades, Y. Xiong.
MB&B 730a, Methods and Logic in Molecular Biology. This course examines fundamental concepts in molecular biology through intense critical analysis of the primary literature. The objective is to develop primary literature reading and critical thinking skills. Required of and open only to first-year graduate students in MB&B. M. Solomon, A. Koleske, L. Regan.
MB&B 743b/GENE 743b/MCDB 743b, Advanced Eukaryotic Molecular Biology. Selected topics in transcriptional control, regulation of chromatin structure, mRNA processing, mRNA stability, RNA interference, translation, protein degradation, DNA replication, DNA repair, site-specific DNA recombination, somatic hypermutation. Prerequisite: biochemistry or permission of the instructor. M. Hochstrasser, A. Koleske, P. Sung.
MB&B 749a/GENE 749a, Medical Impact of Basic Science. Consideration of examples of recent discoveries in basic science that have elucidated the molecular origins of disease or that have suggested new therapies for disease. Emphasis is placed on the fundamental principles on which these advances rely. Reading is from the primary scientific and medical literature, with emphasis on developing the ability to read this literature critically. Aimed primarily at undergraduates. Prerequisite: biochemistry or permission of the instructor. J. Steitz, M. Hochstrasser, A. Miranker, P. Sung, T. Steitz.
MB&B 750a2, Biological Membranes. Biological membranes and their resident proteins are essential for cellular function; yet comparatively little is known about their structure and dynamics. This class provides an introduction to the biochemistry and biophysics of lipids, lipid bilayers, and lipid-derived second messengers. In addition, structural as well as functional aspects of the different classes of membrane proteins are discussed along with an outline of experimental approaches used to achieve an understanding of membrane protein structure and function at a molecular level. Prerequisite: biochemistry. T. Biederer, D. Engelman, J. Cabral.
MB&B 752b/CB&B 752b/CPSC 752b/MCDB 752b, Genomics and Bioinformatics. Genomics describes the determination of the nucleotide sequence and many further analyses to discover functional and structural information on all the genes of an organism. Topics include the methods and results of functional and structural gene analysis on a genome-wide scale as well as a discussion of the implications of this research. Bioinformatics describes the computational analysis of genomes and macromolecular structures on a large scale. Topics include sequence alignment, biological database design, comparative genomics, geometric analysis of protein structure, and macromolecular simulation. Prerequisites: EEB 122b and Math 115, or permission of the instructor. M. Gerstein, D. Söll, M. Snyder.
MB&B 760b3, Principles of Macromolecular Crystallography. Rigorous introduction to the principles of macromolecular crystallography, aimed at students who are planning to carry out structural studies involving X-ray crystallography or who want to obtain in-depth knowledge for critical analysis of published crystal structures. Prerequisites: physical chemistry and biochemistry. T. Steitz.
MB&B 761b4, X-Ray Crystallography Workshop. This laboratory course provides hands-on training in the practical aspects of macromolecular structure determination by X-ray crystallography. Topics include data collection, data reduction, phasing by multiwavelength anomalous diffraction and molecular replacement, solvent flattening, non-crystallographic symmetry averaging, electron density interpretation, model building, structure refinement, and structure validation. The course includes training in the use of computer programs used to perform these calculations. Prerequisites: MB&B 760b3 and a working exposure to the Unix operating system. Y. Xiong, Y. Modis, and staff.
MB&B 765b, Enzyme Mechanisms. An advanced course on the structure, function, and reaction mechanisms of protein and nucleic acid enzymes. The course covers the theoretical and practical aspects of steady-state and transient kinetic methods, kinetic isotope effects and transition-state theory, with emphasis on how these methods in combination with high-resolution structures have provided a molecular understanding of the catalytic strategy of enzymes. Topics include mechanisms of the classic metabolic enzymes; molecular motors, polymerases, and machines; electron transfer, redox enzymes, and their higher-order complexes; ribozymes and DNA enzymes; and the design and selection of novel enzymes. Prerequisites: physical chemistry and biochemistry. E. De La Cruz, G. Brudvig, S. Strobel, and staff.
MB&B 800a, Advanced Topics in Molecular Medicine. This seminar course, which covers topics in the molecular mechanisms of disease, illustrates timely issues in areas such as protein chemistry and enzymology, intermediary metabolism, nucleic acid biochemistry, gene expression, and virology. Prerequisite: biochemistry (may be taken concurrently). This course accompanies the lectures in MB&B 550a. M.D. and M.D./Ph.D. students only. S. J. Baserga, W. Konigsberg, I. G. Miller, and staff.
MB&B 900a or 901b, Reading Course in Biophysics. Directed reading course in biophysics. Term paper required. By arrangement with faculty. Open to graduate students in MB&B. M. Solomon.
MB&B 902a or 903b, Reading Course in Molecular Genetics. Directed reading course in molecular genetics. Term paper required. By arrangement with faculty. Open to graduate students in MB&B. M. Solomon.
MB&B 904a or 905b, Reading Course in Biochemistry. Directed reading course in biochemistry. Term paper required. By arrangement with faculty. Open to graduate students in MB&B. M. Solomon.
Neurobiology
Office: SHM C303, 785.4323
Professors
A. Arnsten, C. J. Barnstable (Adjunct), B. S. Bunney (Psychiatry), N. Daw (Ophthalmology and Visual Science), P. De Camilli (Cell Biology), N. C. Delanerolle (Neurosurgery), J. Gelernter (Psychiatry), C. A. Greer (Neurosurgery), T. Horvath (Comparative Medicine), J. D. Kocsis (Neurology), R. H. LaMotte (Anesthesiology), C. Leranth (Obstetrics, Gynecology, and Reproductive Sciences), P. J. Lombroso (Child Study Center), D. A. McCormick, M. Picciotto (Psychiatry), P. Rakic (Chair), J. Santos-Sacchi (Surgery), I. R. Schwartz (Surgery), G. M. Shepherd, S. M. Strittmatter (Neurology), X. Wang, S. G. Waxman (Neurology)
Associate Professors
M. Alreja (Psychiatry), H. Blumenfeld (Neurology), C. J. Bruce, W. R. Chen, M. C. Crair, S. Diano (Obstetrics, Gynecology, and Reproductive Sciences), M. Gunel (Neurosurgery), A. J. Koleske (Molecular Biophysics and Biochemistry), D. Lee, M. L. Schwartz, N. Tian (Ophthalmology and Visual Science), F. M. Vaccarino (Child Study Center), C. H. van Dyck (Psychiatry), M. F. Yeckel
Assistant Professors
S. A. Castner (Psychiatry), M. Laubach, J. A. Mazer, D. S. Navaratnam (Neurology), N. Sestan, G. V. Williams (Psychiatry)
Senior Research Scientist
N. Carnevale
Research Scientist
L. D. Selemon
Associate Research Scientists
J. Chen, A. Duque, Y. Morozov, T. M. Morse, R. N. Sachdev, M. Wang, D. C. Willhite, W. Xiong, H. Xu
NBIO 500b/NSCI 510b, Structural and Functional Organization of the Human Nervous System. An integrative overview of the structure and function of the human brain as it pertains to major neurological and psychiatric disorders. Neuroanatomy, neurophysiology, and clinical correlations are interrelated to provide essential background in the neurosciences. Lectures in neurocytology and neuroanatomy survey neuronal organization in the human brain, with emphasis on long fiber tracts related to clinical neurology. Weekly three-hour laboratory sessions devoted to neuroanatomy in which students dissect the human brain and examine histological sections in close collaboration with faculty members. Lectures in neurophysiology cover various aspects of neural function at the cellular level, with a strong emphasis on the mammalian nervous system. Each student may participate in a weekly physiology conference with a faculty member, covering such topics as vision, sensory physiology, motor systems, simple nervous systems, or general neurophysiology. Clinical correlations consist of five sessions given by one or two faculty members representing both basic and clinical sciences. These sessions relate neurological symptoms to cellular processes in various diseases of the brain. Variable class schedule; contact course instructor. M. Schwartz, P. Rakic, and staff of the Department of Neurobiology with participation of the departments of Anesthesiology, Neurology, Neurosurgery, Physiology, and Psychiatry.
NBIO 501a/NSCI 501a, Principles of Neuroscience. A lecture survey course given jointly by the faculty of the Yale Interdepartmental Graduate Program in Neuroscience as the introductory core course for this program. Each lecture attempts to elucidate a major principle of nervous system development, structure, or function. The lectures are arranged in a sequence of five sections: cellular and molecular neurobiology, neurotransmitters and neuromodulators, development, neural systems, and neural basis of behavior. Topics include molecular structure of ion channels, single channel recording and monoclonal antibodies; synaptic transmission, second-messengers and neuropeptides; synaptogenesis; functional organization of the visual, somatosensory, and olfactory systems; and the cellular basis of behavior, including learning and memory. A short paper is required in each of the five main sections. M. Picciotto, M. Yeckel.
NBIO 502a, Structure and Function of Neocortex. This course covers anatomical, biochemical, and physiological organization of selected sensory, motor, and association regions of cortex. Sample topics discussed include development, evolution of multiple representations, columnar organization, and plasticity of neocortex. Permission of instructor required. By arrangement with faculty of the Department of Neurobiology.
NBIO 507b, Cellular and Molecular Mechanisms of Neurologic Disease. Molecular and cellular neuroscience has recently developed many novel and powerful techniques for understanding nervous system function. The course focuses on how these basic science advances have been translated into breakthroughs in clinical neurology. Lectures illustrate the connection of modern laboratory studies to our understanding of pathophysiologic mechanisms, to the development of diagnostic tests, and to the use of novel treatment modalities. D. Navaratnam, S. Chandra.
NBIO 509b/NSCI 539b, Synaptic Organization of the Nervous System. Introduction to principles of neural circuit organization at the cellular level (morphology, physiology, and pharmacology). Emphasis is on mammalian systems and comparisons with lower vertebrates and invertebrates. Permission of instructor required. Offered again spring 2009. G. Shepherd, A. Williamson, M. Hines.
NBIO 510a, Introduction to Methods in Cellular and Molecular Neurobiology. Firsthand insight into various techniques and approaches used in neuroscience. Light microscopic techniques include various metallic impregnation methods, autoradiography, anterograde and retrograde axonal transport methods, hybridoma and recombined DNA technology, deoxyglucose metabolic method, fluorescent and immunocytochemical methods. Electron microscopy encompasses transmission, electronmicroscopic autoradiography, and immunoperoxidase methodology. Choice of techniques. By arrangement with individual faculty of the Department of Neurobiology.
[NBIO 524b/NSCI 514b, Neurodevelopment and Neuropsychiatric Disorders. This course is intended to discuss the general mechanisms that regulate cell fate during the development of the central nervous system. It focuses on the progressive specialization of cellular function beginning with the establishment of CNS polary, the acquisition of regional identity, and the determination of the fate of neural cells within the CNS. The interactions between evolutionary conserved genes and intercellular signaling systems are emphasized. The course meets twice a week for one hour each time. Each week covers one topic as detailed in the syllabus. On Wednesday, general concepts are reviewed in a seminar format, led by the course director, faculty participants, or invited speakers. On Fridays, one or two papers presented by students are discussed in detail. All class members are invited to participate in the paper presentation and discussion. F. Vaccarino. Next offered spring 2009.]
NBIO 570a/NSCI 570a, Cellular and Network Dynamics of Sensory and Motor Functions. This course examines the circuitry and functioning of sensorimotor systems, particularly visual and oculomotor, with emphasis on data gathered from single neuron recording and functional imaging in the primate neocortex. Cortical mechanisms of perception, memory, decision making, and motor initiation are considered. Format emphasizes informal presentation, analysis, and criticism of important and recent papers in the field. Prerequisite: Neurobiology 500b. Will be offered with sufficient enrollment. C. Bruce.
[NBIO 590a/NSCI 590a, Sensory Neuroethology: Bats and Owls, Electric Fish and Beyond. In this course we review the neurophysiology of sensory processing with particular attention to animal behavior (ethology) and computation. We begin with the classic neuroethology literature and end with current work on neocortical circuits underlying sensory processing in higher vertebrates. This seminar course meets once per week to read and discuss (mostly) primary research papers selected and presented by the students. Offered in alternate years. Next offered fall 2008. J. Mazer.]
NBIO 602, Topics in Cortical Development and Evolution. Advanced tutorial course. P. Rakic.
[NBIO 610b, Fundamentals in Neurophysiology. This course is designed for students who wish to gain a theoretical and practical knowledge of modern neurophysiology. Graduate students specializing in neurophysiology and non-neurophysiology are encouraged to attend, as the course begins at a very basic level and progresses to more complicated topics. Topics include properties of ion channels, firing properties of neurons, synaptic transmission, and neurophysiology methodology. Offered in alternate years. Next offered spring 2008. V. Pieribone, F. Sigworth.]
NBIO 720a/MCDB 720a/NSCI 720a, Neurobiology. Examination of the excitability of the nerve cell membrane provides a starting point for the study of molecular, cellular, and intracellular mechanisms underlying the generation and control of behavior. H. Keshishian, P. Forscher.
Neurology
Office: LCI 708, 785.5947
Professors
T. Allison (Emeritus), J. Booss (Emeritus), M. B. Bracken (Epidemiology), G. H. Glaser (Emeritus), B. Jabbari, R. D. Kerns (Psychiatry), J. D. Kocsis, R. H. Mattson (Emeritus), L. R. Ment (Pediatrics), G. Miller (Pediatrics), J. W. Prichard (Emeritus), P. Rakic (Neurobiology), G. B. Richerson, B. A. Shaywitz (Pediatrics), S. S. Spencer, S. M. Strittmatter, S. G. Waxman (Chair)
Associate Professors
J. M. Baehring, H. Blumenfeld, R. B. Duckrow, J. M. Goldstein, E. Novotny (Pediatrics), J. W. Pan (Neurosurgery), H. S. Patwa, O. A. Petroff
Assistant Professors
M. Carrithers, S. S. Chandra, E. J. Fertig, B. C. Hains, D. S. Navaratnam, S. Novella, J. Preiningerova, H. Tokuno
Instructors
O. Avitzur, T. Z. Fischer, N. Y. Harel, E. Irizarry, G. Rao, D. Richardson
Senior Research Scientists
R. H. Mattson
Research Scientists
J. A. Black, S. D. Dib-Hajj
Associate Research Scientists
S. K. Agulian, J. Bai, J. S. Choi, N. R. Driesen (Psychiatry), M. Estacion, E. C. Gunther, F. Hu, K. Lankford, M. Sasaki, A. M. Szekely (Genetics), X. Wang, Y. Wu, H. P. Zaveri, P. Zhao
Clinical Professors
R. L. Lesser (Ophthalmology and Visual Science), L. L. Levy, K. Marek, F. M. Testa (Pediatrics)
Associate Clinical Professors
R. C. Delaney, J. C. McVeety, J. C. Moench, K. N. Sena, S. J. Tepper, N. S. Werdiger
Assistant Clinical Professors
S. L. Bridgers, J. B. Butler, D. J. Coskun, J. B. Guarnaccia, M. Hasbani, A. Katz, J. H. Mashman, F. K. Nahm, D. S. Russell (Psychiatry), M. J. Stransky, D. Z. Tkeshelashvili
Clinical Instructors
A. R. Bobowick, L. J. Cretella, R. P. Einbinder, C. H. Gottschalk (Psychiatry), J. L. Gross, M. J. Hasbani, S. Kadimi, P. J. McAllister, A. Quan Hong, H. Sami, D. J. Shiling, K. C. Siegel, J. Yim, D. M. Zagar
Lecturers
L. Bangalore, J. Schindler
Neurology 102, Clinical Neuroscience Core Clerkship. The primary goal of this four-week clinical clerkship is to provide students with a fundamental approach to the nervous system. Specifically, this means the history, examination, diagnostic imaging, and treatment in the context of specific patients. Additionally, there is a series of lectures covering the broad range of conditions students are likely to encounter, such as trauma, stroke, infections, tumors, dementias, and seizures. Students take call with neurology residents once a week at Yale-New Haven Hospital; students assigned to neurosurgery take call with the residents on that service. After having given input on their preferences, students are placed on one of the following services for their clerkships: adult inpatient neurology, adult neurology consultation service, pediatric neurology, neurosurgery. All rotations are done at YNHH, the VA Connecticut Healthcare System, West Haven, or St. Raphael’s Hospital. H. Patwa, L. Ment, C. Duncan, H. Blumenfeld.
Neurology 103, Clinical Neurology Elective. Assignments for the clinical neurology elective are to the YNHH neurology consultation service, a rotation consisting of all outpatient clinics; or to the YNHH Inpatient Neurology Service. Four-week blocks coinciding with clerkship dates are preferred, but scheduling of electives is somewhat flexible. Students are able to request a choice, but assignment is made to assure that there is a balanced distribution between students in the required Neuroscience Clerkship and those doing electives, in order to allow an optimal learning experience for all students. Students work directly with attending faculty, chief residents, and junior residents as well as other medical students, rotators, and support staff. In addition to in-hospital patient evaluation and care, students on a consultation service are assigned to outpatient clinics. The students participate in departmental conferences and seminars. In addition, participation in most of the activities of the required Neuroscience Clerkship (e.g., didactic lectures) is encouraged (see Neurology 102 for description of clerkship details). The department is receptive to other specially tailored programs in areas such as epilepsy, stroke, movement disorders, neuroimmunology, etc., as well as clinical neurophysiology and research methods. H. Patwa and associates.
Neurology 104, Clinical Neurology Subinternship. Under appropriate supervision, students directly examine, diagnose, and manage patients on the neurology services at Yale-New Haven Hospital and attend daily teaching rounds and conferences. Hours to be arranged. Four-week rotations are recommended; alternative services are possible. Limited to two students each period. H. Patwa and associates.
Neurology 106b, Clinical Neurophysiology. Seminars and demonstrations in clinical applications of neurophysiology: electromyography and electroencephalography. Basic electronics are taught along with standard practice of recording and interpreting neurophysiology studies. J. M. Goldstein, H. Patwa, S. P. Novella.
Neurology 108b/NSCI 507b, Cellular and Molecular Mechanisms of Neurological Disease. Focuses on those diseases (Alzheimer’s, Parkinson’s, ALS and other neurodegenerative diseases, triplet repeat induced diseases, multiple sclerosis, epilepsy, etc.) in which modern neuroscience has advanced mechanistic explanations for clinical conditions. The course highlights recent molecular, electrophysiological, and imaging experiments in parsing disease mechanisms. The application of pathophysiologic understanding to therapeutics is considered. D. Navaratnam, S. Strittmatter, S. Waxman.
Neurology 112b, Neuro-Oncology. Neurological complications occur in approximately 20 percent of hospitalized oncology patients. The neurological complications of systemic cancer, as well as of primary CNS tumors, are discussed in depth. Issues regarding diagnosis and management of metastatic disease involving the nervous system as well as treatment-related complications are reviewed. In addition, metabolic and vascular disturbances and infections unique to the oncology patient that involve the nervous system are discussed. Specific cases are presented and arrangements are made to see specific patients during the elective period. This course is offered every three weeks with two lectures each week and is limited to three or four students per session. J. Baehring.
Neurology 114b, Physiology of the Mammalian Nervous System. The overall objective of this laboratory course is to introduce the student by hands-on experience to a variety of cellular electrophysiological techniques used in the study of the mammalian nervous system. Students set up a small electrophysiology laboratory and carry out experiments with the supervision of faculty. Laboratories include sucrose gap in whole nerve, single microelectrode current and voltage clamp recording of sensory neurons, field potential studies in rat hippocampal slice, and patch clamp analysis of cultured neurons. This course is limited to six to eight students. Permission of instructor is required for enrollment, 203.937.3802. J. D. Kocsis.
Neurosurgery
Office: TMP 4, 785.2805
Professors
R. A. Bronen (Diagnostic Radiology), W. F. Collins (Emeritus), R. T. Constable (Diagnostic Radiology), N. C. Delanerolle, C. C. Duncan, C. A. Greer, H. P. Hetherington, C. C. LaMotte, J. A. Persing (Surgery), J. M. Piepmeier, D. E. Redmond, Jr. (Psychiatry), K. J. Ruskin (Anesthesiology), D. D. Spencer (Chair), S. S. Spencer (Neurology), A. N. Van den Pol
Associate Professors
J. M. Baehring (Neurology), H. Blumenfeld (Neurology), A. Bordey, R. B. Duckrow (Neurology), M. Gunel, J. T. King, E. Novotny (Pediatrics), J. W. Pan, K. P. Vives, M. Westerveld, A. Williamson
Assistant Professors
K. M. Abbed, K. R. Bulsara, I. Cavus (Psychiatry), V. L. Chiang, E. J. Fertig (Neurology), D. J. Gaal (Anesthesiology), A. Louvi, D. Z. Tkeshelashvili (Neurology), H. B. Treloar
Associate Research Scientists
N. Avdievich, K. Bilguvar, L. Chen, L. Fu, P. K. Ghosh, H. Huang, Y. Li, M. N. Spann, K. Wu
Clinical Professor
L. M. Davey
Associate Clinical Professors
I. Goodrich, D. E. Nijensohn
Assistant Clinical Professors
A. P. Amar, T. J. Arkins, G. M. Bloomgarden, P. S. Dickey, K. S. Firlik, Z. Ghogawala, J. F. Kveton (Surgery), J. K. Sabshin, J. G. Strugar
Clinical Instructors
E. W. Akeyson, J. L. Gorelick
Lecturer
E. M. Lydon
Neurosurgery 101, Neurological Surgery. This is an externship in which the student is involved in inpatient evaluation, outpatient visits, supervised emergency, and inpatient consultations. The student attends the operating room, follows patients, and is expected to correlate the clinical experience with basic neuroscience. K. M. Abbed, J. Baehring, K. R. Bulsara, V. Chiang, R. B. Duckrow, C. C. Duncan, M. Gunel, J. King, J. M. Piepmeier, D. D. Spencer, K. P. Vives.
Neurosurgery 102, Investigational Neuroscience. Typically taken during completion of the thesis requirement. Specific projects are by agreement with faculty members. Ongoing laboratory research includes the molecular neuroanatomical assessment of the epileptic focus (N. C. deLanerolle); ultrastructural assessment of organization and plasticity in local synaptic networks (C. A. Greer); the distribution and specificity of membrane-bound proteins directing neuronal growth (A. Van den Pol); glial cell function at synapses; intercellular communication promoting neurogenesis (A. Bordey); human and animal slice electrophysiology (A. Williamson, A. Bordey); human and animal intracerebral microdialysis (D. Spencer, I. Cavus); image-guided neurosurgical robotics and biophysical studies of brain imaging (D. Spencer, J. Duncan, K. Vives); stimulation of the brain for chronic neurological diseases (K. Vives, R. B. Duckrow, D. Spencer); molecular genetics of neurological disease (M. Gunel); angiogenesis and neurogenesis, skull base anatomy, bypass techniques, and endovascular technology development (K. Bulsara); characterization of ensheathing cells in promoting axonal elongation (C. A. Greer). Clinical research includes neurotrauma (V. Chiang), neuropsychological studies (M. Spann), spine disease and clinical trials (K. Abbed, Z. Ghogawala), epilepsy surgery (D. Spencer, K. Vives), pediatric neurosurgery outcomes (C. Duncan), neurooncology (J. Piepmeier, J. Baehring), basic mechanisms in CNS lymphoma (J. Baehring), and stereotactic radiosurgery (V. Chiang, K. Vives). Available throughout the year. Arrangements made with C. A. Greer.
Obstetrics, Gynecology, and Reproductive Sciences
Office: FMB 331, 785.4294
Professors
A. M. Arici, H. R. Behrman, M. B. Bracken (Epidemiology), F. R. Braveman (Anesthesiology), G. N. Burrow (Medicine), J. A. Copel, R. A. Ehrenkranz (Pediatrics), I. Gross (Pediatrics), J. P. Hayslett (Medicine), R. B. Hochberg, T. Horvath (Comparative Medicine), E. I. Kohorn (Emeritus), C. Leranth, C. J. Lockwood (Chair), M. J. Mahoney (Genetics), N. J. Maihle, S. M. McCarthy (Diagnostic Radiology), P. Patrizio, P. M. Sarrel (Emeritus), P. E. Schwartz, F. A. Tavassoli (Pathology), H. S. Taylor
Associate Professors
M. Azodi, C. Bulletti (Adjunct), S. Diano, A. J. Duleba (Adjunct), C. N. Epperson (Psychiatry), S. J. Fortunato (Adjunct), E. F. Funai, F. Galerneau, S. M. Guller, J. B. Henrich (Medicine), M. Lee, U. Magriples, S. Mark (Adjunct), G. G. Mor, E. R. Norwitz, M. J. Paidas, T. J. Rutherford, D. Sakkas, N. S. Stachenfeld (Epidemiology), K. A. Yonkers (Psychiatry)
Assistant Professors
V. M. Abrahams, M. O. Bahtiyar, R. S. Bercik, C. S. Buhimschi, I. Buhimschi, K. A. Connell, X. Gao, M. K. Guess, Y. Huang, J. L. Illuzzi, J. Johnson, M. D. Lalioti, H. S. Lipkind, C. Pettker, B. W. Rackow, J. L. Reiter, S. M. Richman, E. U. Seli, A. K. Sfakianaki, C. O. Stocco, S. F. Thung
Instructors
S. A. Abdel-Razeq, J. G. Bromer, M. Cackovic, A. T. Dulay, E. J. Hodgson, P. H. Kodaman, S. Y. Lee, A. L. Leiser, G. Luo, J. Martin, E. Ratner, V. A. Rosenberg, D. Silasi, D. Vitiello, M. Wehrum
Senior Research Scientist
G. B. Huszar
Research Scientists
H. J. Kliman, G. Krikun, F. Schatz
Associate Research Scientists
A. Alvero, E. Borok, G. Daftary, H. Du, T. Hajszan, S. J. Huang, U. A. Kayisli, M. Maduro, Y. Rao, E. F. Wolff
Clinical Professors
M. R. Berman, J. Cron, D. Greenfeld, S. R. Lavietes, V. A. Lynch, M. Minkin, J. S. Silidker, L. J. Wartel, K. P. Williams
Associate Clinical Professors
R. D. Auerbach, C. M. Cassin, R. A. Cwik, T. M. Hanson, R. B. Kaump, W. A. Lieber, N. A. Ravski, H. Simon, R. J. Stiller, R. A. Vidone, L. H. Zamore
Assistant Clinical Professors
P. C. Brines, S. E. Casper, A. R. Chelouche, R. Chosak, I. M. Cohen, P. J. Coppola, E. A. Fine, S. M. Flaherty, S. J. Fleischman, W. P. Fleming, K. C. Fletcher, D. P. Fox, G. J. Foye, M. E. Gillette, C. L. Kandall, E. D. Karlovsky, G. E. Kleinman, J. M. Knudson, T. Kumarasamy, S. A. Laifer, P. M. Lamastra, D. M. Lima, E. Luchansky, E. S. Manske, I. Marcovici, B. McDowell, R. D. Moscarelli, L. Plisic, B. F. Rigney, S. D. Rosenman, D. M. Roth, D. J. Russell, J. A. Shaw, L. A. Starace-Colabella, A. Strong, H. I. Suesserman, E. A. Topran, O. J. Vincent, T. Zreik
Clinical Instructors
N. Adsuar, A. Asis, M. C. Asis, K. R. Aversa, E. A. Berry, U. Bhuvanesh, F. L. Cohn, M. Dick, M. Dube, A. Y. Edusa, J. T. Grosso, C. R. Huttler, J. C. Kaczmarek, D. R. Kopel, A. B. Landry, B. L. Maloy, J. J. McGrade, M. Mitchell, C. Negron, H. J. Nusbaum, E. Palluotto, A. T. Petruzzelli, R. Pringle, K. M. Rath, M. C. Rhee, A. M. Ross, M. L. Speranza, A. L. Tirado, D. Tonzola, M. M. Tse, M. J. Wise
Lecturers
K. Belanger (Epidemiology), F. P. Haseltine, E. Kuczynski
Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship. This core clerkship is a six-week rotation in which students serve as clinical clerks on the following services: obstetrics (two weeks), gynecology (one week), gynecology-oncology (one week), and outpatient (two weeks). At our affiliate site, Bridgeport Hospital, the clerk functions as part of a team that participates in both gynecologic and obstetrical care. The clinical services at Bridgeport Hospital virtually mirror the experience given at Yale-New Haven Hospital. During the first week of the six-week clerkship, all students attend an in-depth evening teaching session with the Gynecologic Teaching Associates (GTA). At this session, they are carefully taught pelvic and breast examination techniques, and practice these techniques with the GTA. These practice sessions prepare students to adeptly handle actual patient examinations, review techniques and instruments, as well as understand how to manage patient encounters. The students also attend a NOELLE Birth Simulator Session conducted by a senior teaching faculty member. NOELLE is a full-sized articulating female mannequin with an articulating birthing baby. NOELLE has a dilating cervix and a birthing mechanism that offers the ability to demonstrate a variety of obstetric techniques and complications. During the obstetrics portion of the rotation (one week Day Float and one week Night Float), the clinical clerk is assigned to the Labor and Delivery Unit and is expected to actively participate in patient care commensurate with his or her experience. Students are expected to work up and follow patients during the labor and delivery process, write notes during the intrapartum period, participate in vaginal deliveries, scrub in and assist in Cesarean deliveries, and participate in the patient’s postpartum care. Students on gynecology spend one week on the general Gynecology service, where they become familiar with the common disorders encountered in gynecological practice. They scrub for surgeries both at YNHH and Temple Surgical Center. The student also spends one week on the Gynecologic Oncology service and functions as a part of that team. The rotation offers a unique opportunity for the student to learn preoperative and postoperative management of patients with complicated medical problems and to review pelvic and abdominal anatomy, and offers additional exposure to gynecologic surgery. The clerk is expected to interview, examine, participate in the surgeries, and follow the patients admitted to the Gynecologic Oncology service. The students spend two weeks at YNHH Women’s Center Clinic where they actively participate in outpatient care. During these two weeks, students are supervised by both attendings and residents as they learn to take histories, perform pelvic and breast exams, and gain experience in conducting normal obstetrical visits and routine gynecological care. The student is expected to gain experience in ambulatory care gynecological topics such as contraceptive counseling, family planning, menopause management, and other common patient complaints. The recommended text for this elective is Obstetrics and Gynecology at a Glance by Errol Norwitz and John Schorge. Clerkship director: J. Illuzzi.
Obstetrics, Gynecology, and Reproductive Sciences 107, Perinatal Elective. The Maternal Fetal Medicine Division of the Department of Obstetrics, Gynecology, and Reproductive Sciences offers a four-week High-Risk Obstetrics elective for fourth-year medical students. The student functions as a Sub-Intern and team member in the care of high-risk obstetrical patients at Yale-New Haven Hospital. In addition to inpatient duties, the student attends the outpatient clinic once a week. Students also participate in prenatal ultrasound sessions as well as labor and delivery activities. Students are expected to take overnight call each Wednesday and two Saturdays of the rotation. Numerous didactic conferences are held during the rotation. It is recommended that students use the text Williams Obstetrics (Cunningham) to prepare for this experience and for research during the rotation. Evaluation of the student is based on clinical performance, participation at rounds, and the student’s presentation of one evidence-based case review to members of the MFM Division. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. Faculty coordinator: F. Galerneau.
Obstetrics, Gynecology, and Reproductive Sciences 108, Reproductive Endocrinology and Infertility Elective. The Reproductive Endocrine and Infertility division offers a four-week subinternship to students. In addition to gaining knowledge of human reproductive endocrine function, students are introduced to disruptions in physiology and function leading to endocrinological and infertility problems. Typical clinical scenarios include androgen excess syndromes, hyperprolactinemia, anovulatory syndromes, endometriosis, and genetic abnormalities associated with menstrual anomalies and/or infertility. Exposure to Advanced Reproductive Technologies (ART) is integrated into this elective. In addition to the outpatient clinic/surgery and the in-patient service, students have the opportunity to attend division-specific conferences. Evaluation of the student is based on clinical performance, participation at rounds, and presentation of a case-based review of the literature. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. It should be noted that it is necessary to travel to the Long Wharf Medical Center, 150 Sargent Drive, New Haven, for this subinternship program. There is no Yale shuttle service to this facility. There is no Night Call on this elective. Faculty coordinator: B. Rackow.
Obstetrics, Gynecology, and Reproductive Sciences 109, GYN-Oncology Elective. The purpose of the oncology elective is to enhance the student’s knowledge of the diagnosis and management of women’s gynecologic malignancies. The elective is offered to one student at a time for four weeks. The student is exposed to all modalities of treatment for gynecologic malignancies including radical gynecological surgery, chemotherapy, and radiation therapy. The student is expected to be an integral part of the team in the management of the patients admitted to the service. The student admits patients and takes part in their care throughout the elective period. The student is assigned to the operating room, especially to assist the patient whom he or she has evaluated. In addition to operating room exposure, extensive experience is gained in the postoperative management of these patients. The student attends one-day surgical procedures to observe the placement of brachytherapy and other procedures, e.g., cystoscopy, proctoscopy examination under anesthesia with biopsy. In the ambulatory setting, the student is exposed to the gestational trophoblastic disease clinic and the colposcopy clinic. On a weekly basis, students attend divisional teaching sessions as well as the multidiscipline tumor conference. There is no Night Call on this elective. The recommended text is Clinical Gynecologic Oncology (DiSaia). Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. Faculty coordinator: T. Rutherford.
Obstetrics, Gynecology, and Reproductive Sciences 110, Gallup Indian Medical Center (New Mexico) Elective. The general OB/GYN department of the Gallup Indian Medical Center (GIMC) in New Mexico offers a subinternship in Obstetrics and Gynecology to fourth-year Yale medical students. This center provides OB/GYN health care to a growing underserved population. There are no residents at GIMC and, therefore, the student gains first-assistant experience during this rotation. The center has 20,000 outpatient visits, 750 deliveries, and 400 surgical cases per year. Bedside rounds, hands-on teaching, formal and informal lectures, and weekly conferences (High-Risk OB, GYN M&M, C-Section review) are integrated into this extramural elective. Students also experience an immersion in the Navajo culture. Evaluation of students is based on clinical performance, participation at rounds, and a final case-based presentation. Night Call is approximately every 4–5 nights. The recommended text for this elective is Danforth’s Obstetrics & Gynecology. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. Students are responsible for the cost of travel, lodging, and miscellaneous expenses. Faculty coordinator: E. Manske (on site at GIMC, New Mexico).
Obstetrics, Gynecology, and Reproductive Sciences 111, Ambulatory Care OB/GYN Elective. This elective is geared to students who seek a broader exposure to outpatient care in the field of Obstetrics and Gynecology. The goal of the elective is to provide a broad exposure to outpatient gynecologic issues, such as contraception, family planning, menstrual abnormalities, pelvic pain, sexually transmitted disease, infertility, disorders of urinary continence, screening for gynecologic malignancies, and management of menopausal symptoms that are commonly encountered in the ambulatory setting. The student also has the opportunity to participate in the prenatal care of pregnant women, in order to gain a deeper understanding of the changes in maternal physiology throughout gestation, prenatal diagnosis, genetic counseling, and the outpatient management of the pregnant woman and her fetus. This four-week elective gives the student opportunities to work in the Yale-New Haven Hospital Women’s Center, the Yale Urogynecology practice, the Yale Gynecologic Oncology Colposcopy Clinic, the Yale Maternal-Fetal Medicine practice, and the private community office setting. The recommended text for this elective is Obstetrics and Gynecology at a Glance by Errol Norwitz and John Schorge. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. It should be noted that it is necessary to travel to the Long Wharf Medical Center, 150 Sargent Drive, New Haven, and other private community offices for this subinternship program. There are no Yale shuttle services to some of these off-site facilities. There is no Night Call on this elective. Faculty coordinator: J. Illuzzi.
Ophthalmology and Visual Science
Office: BB 110, 785.2020
Professors
C. J. Barnstable (Adjunct), M. Coca-Prados, N. Daw (Emeritus), C. Gonzalez (Emeritus), W. H. Miller (Emeritus), M. L. Sears (Adjunct), M. Shields, J. Sinard (Pathology), J. C. Tsai (Chair)
Associate Professors
R. A. Adelman, C. R. Bernardino, J. J. Hoh (Epidemiology), L. J. Rizzolo (Surgery), K. M. Stoessel, N. Tian, C. J. Zeiss (Comparative Medicine)
Assistant Professors
J. J. Huang, D. J. Salchow
Instructors
A. Cohen, J. E. Kempton, R. Portela
Associate Research Scientists
S. Ghosh, J. Lin, M. Liu, X. Xu
Clinical Professors
I. Abrahams, A. A. Khodadoust, R. L. Lesser, P. E. Liggett, D. E. Silverstone
Associate Clinical Professors
B. M. DeBroff, S. H. Forster, P. H. Haffner, A. J. Levada, M. S. Milner, J. J. Olson, D. W. Parke, A. D. Rose, G. Shafranov, C. A. Sklar, K. M. Stoessel, R. A. Wiznia
Assistant Clinical Professors
D. A. Bacal, P. J. Branden, G. A. Bullwinkel, N. Chaudhry, A. J. Daccache, V. P. de Luise, L. Doctor, P. A. Ecker, J. S. Elman, P. M. Falcone, A. J. Fezza, P. Gaudio, J. Geffin, S. B. Hersh, W. I. Larrison, E. S. Lim, J. F. Martone, H. R. Mayer, A. W. Mead, A. Musto, P. C. Palmisano, A. D. Pearlstone, E. A. Petrelli, R. L. Petrelli, A. Romania, A. Shayegani, C. A. Sierra, J. Sokol, S. M. Soloway, D. Tom, J. M. Weisz, M. L. Weitzman, B. D. Zuckerman
Clinical Instructors
E. J. Anderson, J. Q. Brooks, S. B. Castracane, A. H. Guerrero, P. C. Guida, M. A. Howard, Y. Kostina-O’Neil, P. E. Masi, J. J. Pasternack, M. R. Shapiro, D. P. Shore, J. E. Silbert, V. A. Tarud, S. C. Thornquist
Ophthalmology and Visual Science 120, Elective in Clinical Ophthalmology. This intensive two-to-four-week elective consists of twenty half-day or forty half-day sessions during which the students observe in subspecialty clinics, evaluate patients in general ophthalmology clinics, observe ophthalmic surgery, participate in department conferences, and review independent study material provided by the department. A short presentation on a specific topic provides an opportunity to explore one aspect of ophthalmology in depth. Subspecialty experiences include corneal and external eye diseases, glaucoma, neuro-ophthalmology, oculoplastics, and retinal diseases. Each two-week elective is limited to two fourth-year students. Offered all year. S. Forster, faculty, and resident staff.
Ophthalmology and Visual Science 126, Preceptorial in Ophthalmology. In this elective the student has intensive exposure to one ophthalmic subspecialty under the direct supervision of one or two faculty members. Generally, the experience includes observing in a subspecialty clinic and the operating room, and may include completion of a minor research project. Prior to starting this elective, the student must have outlined a plan of study and obtained the approval of the supervising faculty members. Faculty members in corneal and external diseases, glaucoma, oculoplastics, and retina participate. A list is available from the director of medical studies. Limited to fourth-year students. One to four weeks. Offered all year. Faculty.
Orthopaedics and Rehabilitation
Office: YPB 133, 785.2579
Professors
R. Baron, M. R. Baumgaertner, G. E. Friedlaender (Chair), C. M. Gundberg, M. C. Horowitz, P. Jokl, L. D. Katz (Diagnostic Radiology), M. M. Panjabi (Emeritus), R. R. Pelker, T. S. Renshaw (Emeritus), W. O. Southwick (Emeritus)
Associate Professors
J. N. Grauer, J. F. Slade, A. M. Vignery, J. J. Yue
Assistant Professors
S. D. Dodds, V. P. Eswarakumar, A. H. Haims (Diagnostic Radiology), D. M. Lindskog, M. J. Medvecky, J. S. Reach, P. G. Whang
Instructors
S. E. Adolfsen, T. J. Gillon, R. S. Lee, M. E. Oetgen, K. M. Sutton
Research Scientist
W. C. Horne
Associate Research Scientists
A. Bruzzaniti, P. C. Ivancic, L. Li, S. Lotinun
Clinical Professors
K. J. Keggi, J. K. Lynch, U. H. Weil
Associate Clinical Professors
H. B. Bradburn, R. N. Margolis, E. J. Sella
Assistant Clinical Professors
M. P. Altman, J. M. Aversa, A. L. Axtmayer, R. A. Bernstein, P. A. Blume, D. S. Caminear, M. P. Connair, J. P. Daigneault, P. A. DeLuca, D. H. Gibson, G. A. Gorecki, J. F. Irving, M. Kacena, J. D. Kelley, K. M. Kramer, J. V. Lieponis, M. A. Luchini, P. P. Luchini, J. S. Marsh, R. B. Mayor, J. D. McCallum, T. Moran, M. J. Murphy, D. C. Novicki, M. M. Pressman, J. F. Raycroft, A. M. Reznik, D. S. Rosenblum, J. J. Shine, A. B. Sicklick, M. D. Silver, J. M. Sumner, C. R. Swigart, S. L. Tomak, L. D. Weis, J. Wu, R. A. Zell
Clinical Instructors
D. F. Bindelglass, D. A. Brittis, M. R. Clain, R. V. Dawe, R. Diana, R. B. Feldman, P. D. Fragner, R. P. Hendrikson, H. I. Hermele, M. J. Kaplan, N. R. Kaplan, J. J. Key, J. V. Mangieri, M. A. Morrison, J. M. Perlman, A. Rice, D. P. Sakalkale, R. A. Stanton, P. B. Stovell, P. G. Whang, V. J. Williams
Lecturers
L. R. Brenner, G. A. Gorecki, M. J. Parisi, B. G. Smith, R. E. Stevenson
Orthopaedics and Rehabilitation 102, Surgical Clerkship. Twelve weeks total. Students in the first clinical year spend six weeks on the general surgical service of one of the following: Yale-New Haven Hospital, VA Connecticut Healthcare System, West Haven, or Hospital of St. Raphael. Each student is integrated into the clinical team and assigned to specific patients. Responsibilities include taking histories and performing physical examinations on their patients, participating in the evaluation and management of these patients, following patients’ progress, and participating as assistants in the surgical operations performed upon their assigned cases. In addition, the students are expected to participate in the evaluation and care of the critically ill patient in the intensive care unit and the injured patient in the emergency room. Emphasis is placed on involving students in the process of clinical problem solving with the guidance of the residents and the attending preceptors. Conferences, case study groups, and rounds are held emphasizing this problem-oriented approach. Staff.
The remaining six-week period is spent as a clinical clerk in the surgical specialties. Seven specialties are offered: cardiothoracic, otolaryngology, neurosurgery, orthopaedics, pediatric, plastic and reconstructive, and urology. Each student elects three of these specialties and spends two weeks on each. While on the specialty of choice, the student is assigned patients in rotation and carries out complete histories, physical examinations, and certain procedures on these patients. While on the orthopaedic service, the student is assigned to one of the subspecialty teams, which include pediatric orthopaedics, spine, joint reconstruction, trauma, oncology, foot and ankle, hand, and sports medicine. The student is expected to participate, whenever possible, in the operative procedures performed on these patients and in their postoperative care. The student is also invited to attend the outpatient clinics in his or her assigned specialty. A series of one-hour lectures, rounds, or demonstrations is given each afternoon by the surgical specialties so that the student has the opportunity of gaining knowledge of the wide field of specialties even though he or she does not participate in every specialty as a clinical clerk. Directed by individual surgical specialty chiefs.
Orthopaedics and Rehabilitation 104, Subinternship. Limited to third- and fourth-clinical years, with prior clerkship rotation. The student is an active member of one of the orthopaedic teaching teams (pediatric orthopaedics, spine, joint reconstruction, trauma, oncology, foot and ankle, hand, and sports medicine). Inpatient, outpatient, and operating room experience is supplemented by regular conferences. Limited to four students, preferably for one-month rotations, throughout the year. Arrangements must be made with K. Umlauf.
Orthopaedics and Rehabilitation 108, Subinternship, Adult Reconstructive and Rehabilitative Orthopaedics, VA Connecticut Healthcare System, West Haven. The student functions as the intern on a large adult orthopaedic service. He or she attends conferences at the Veterans Affairs Connecticut Healthcare System, West Haven, and at Yale-New Haven Hospital. (YNHH conferences include an ongoing seminar on basic sciences as related to the musculoskeletal diseases.) The student is a full participant in the outpatient department and in the work of the operating room. This subinternship offers an intensive clinical experience with a variety of complex orthopaedic reconstructive problems. Rotations are usually for one month. By arrangement with K. Umlauf.
Orthopaedics and Rehabilitation 110, Biomechanics Terminology. Presentation and explanation of some basic biochemical terms used to describe body tissues, structures, and functions. More than one hundred basic engineering terms are introduced. The format of presentation for each term is (1) a precise definition followed by units of measurement in the new S.I. system, (2) a detailed explanation, and (3) examples of its use in the everyday experience as well as in the medical field. Mathematical formations are presented whenever necessary. Eight weeks, by arrangement. P. Ivancic.
Orthopaedics and Rehabilitation 116, Basics of (Fracture) Diagnosis and Treatment. A six-week seminar in the basic elements of diagnosis and treatment of a spectrum of musculoskeletal trauma. M. Baumgaertner.
Orthopaedics and Rehabilitation 118, Musculoskeletal Anatomy. The basics of musculoskeletal anatomy from a functional anatomic and surgical perspective. The material is presented using prosected specimens. Knowledge of Anatomy 100a or its equivalent is assumed. M. Baumgaertner.
Orthopaedics and Rehabilitation 120, Rehabilitation Medicine at Gaylord Hospital. A four-week elective rotation designed to provide a comprehensive view of rehabilitation. The elective is composed of didactic sessions and clinical experiences in both the inpatient and outpatient setting. Areas of primary focus include spinal cord injury, head trauma, multiple trauma, amputations, pain management, occupational rehabilitation, stroke, and other neurologic rehabilitation. Specific problems, such as gait deviation, heterotropic ossification, and spasticity are addressed. Therapeutic modalities—bracing and other durable medical equipment—are covered. The roles of allied health professionals, including physical, occupational, and speech therapies, and neuropsychology are demonstrated. Available throughout the year by arrangement with A. Sicklick and D. Rosenblum.
Pathology
Office: LH 108, 785.2759
Professors
R. Bucala (Medicine), J. Chen (Therapeutic Radiology), Y. Choi, J. Costa, S. E. Downing (Emeritus), G. E. Friedlaender (Orthopaedics and Rehabilitation), E. J. Glusac, N. J. Holbrook (Medicine), M. Kashgarian, J. H. Kim (Emeritus), D. S. Krause (Laboratory Medicine), P. M. Lizardi, J. A. Madri, N. J. Maihle (Obstetrics, Gynecology, and Reproductive Sciences), V. T. Marchesi, J. M. McNiff (Dermatology), J. S. Morrow (Chair), M. Reyes-Mugica, D. L. Rimm, J. K. Rose, J. Sinard, J. L. Sklar, D. F. Stern, F. A. Tavassoli, R. Yesner (Emeritus)
Associate Professors
J. L. Brandsma (Comparative Medicine), G. Haines, R. J. Homer, D. Jain, R. Lazova (Dermatology), W. Min, V. Parkash, M. E. Robert, G. S. Shadel
Assistant Professors
C. Bifulco, V. Bossuyt, D. Braddock, S. E. Cowper (Dermatology), L. Hao, P. Hui, S. H. Kleinstein, C. J. Ko (Dermatology), D. Kowalski, M. O. Krauthammer, T. Kyriakides, M. Martel, R. Means, T. Mezzetti, K. A. Mitchell, M. M. Pinto, P. Ravichandran, A. K. Riba, M. Robek, A. Subtil (Dermatology), C. Theoharis, D. P. Tuck, Z. Walther, C. M. Zalles, E. V. Zambrano
Instructors
A. Galan (Dermatology), M. Harigopal
Senior Research Scientists
J. H. Kim, R. Yesner
Research Scientists
C. L. Howe, D. Pradhan
Associate Research Scientists
S. Agarwal, R. L. Camp, A. Chattopadhyay, H. Chen, C. D. Cianci, J. K. Czyzyk, P. Gershkovich, M. A. Gilmore-Hebert, Y. He, S. M. Kar, S. Lang, H. Li, Q. Li, D. Luo, X. Ma, N. F. Rose, M. C. Stankewich, A. Stortchevoi, Y. Wu, B. Yatsula, H. Zhang
Clinical Professors
G. L. Davis, D. M. Lowell
Associate Clinical Professors
P. N. Fiedler, D. F. Miller
Assistant Clinical Professors
W. Carver, T. E. Ciesielski, N. A. Gelfman, G. M. Golenwsky, R. N. Kranwinkel
Clinical Instructors
W. G. Frederick, A. Katsnelson, G. M. Kleinman, S. L. Wain
Pathology 100, Pathological Basis of Human Disease. Fundamental principles underlying the pathological alterations in function and structure that constitute the reaction of the organism to injury. Pathology of diseases involving special organs and systems. Correlation of the clinical and anatomical manifestations is emphasized. J. Madri, S. Flynn, and staff.
Pathology 116, Autopsy Pathology. Participation in the autopsy service with members of the house staff in pathology. Participation in autopsies and the presentation and review of the clinical and anatomical findings of postmortem examinations with senior members of the department. Opportunities exist for correlation studies with previous biopsies, and clinical investigative and cell biologic techniques in relation to necropsy material. Six weeks minimum, full time. Limited to two students. J. Sinard and staff.
Pathology 117, Anatomic Pathology. The department offers an elective to medical students in the third and fourth years which provides a broad experience in general diagnostic techniques. Students have opportunities to participate in surgical pathology, cytology (including fine-needle aspiration), and autopsy. A daily conference is scheduled for both residents and students. In addition to direct responsibilities in the handling of the cases, the student has the opportunity to apply the special techniques of electron microscopy, immunohistochemistry, flow cytometry, and molecular diagnostics. A minimum of four weeks is suggested for this elective. Five students are accommodated every four to six weeks. J. Costa and staff.
Pathology 620a and b, Laboratory Rotations in Experimental Pathology. Laboratory rotations for first-year graduate students. D. Stern.
Pathology 630b, Biomaterial-Tissue Interactions. An in-depth survey of the interactions between tissues and biomaterials, with an emphasis on the molecular- and cellular-level events that influence the performance and longevity of clinically relevant devices. Background in chemistry and cell biology is assumed. Open to advanced undergraduates with permission of the organizer. T. Kyriakides.
Pathology 650b, Cellular and Molecular Biology of Cancer. A comprehensive survey of cancer research from the cellular to the clinical level. The relation of cancer to intracellular and intercellular regulation of cell proliferation is emphasized, as are animal models for cancer research. Background in molecular genetics and cell biology is assumed. D. F. Stern and R. Means.
Pathology 670b, Biological Mechanisms of Reaction to Injury. An introduction to human biology and disease as a manifestation of reaction to injury. Topics include organ structure and function, cell injury, circulatory and inflammatory responses, disordered physiology, and neoplasia. M. Kashgarian and staff.
Pathology 680a, Seminar in Pharmacology and Molecular Medicine. Readings and discussion in topics relevant to tumor biology, epithelial-mesenchymal transition, tumor angiogenesis, and metastases. The class emphasizes analysis of primary research literature and development of presentation skills. W. Min.
Pathology 690a, Molecular Mechanisms of Disease. This course covers aspects of the fundamental molecular and cellular mechanisms underlying various human diseases. Many of the disorders discussed represent major forms of infectious, degenerative, vascular, neoplastic, and inflammatory disease. Additionally, certain rarer diseases that illustrate good models for investigation and/or application of basic biologic principles are covered in the course. The objective is to highlight advances in experimental and molecular medicine as they relate to understanding the pathogenesis of disease and the formulation of therapies. J. Sklar and M. Robek.
Pediatrics
Office: LMP 4085, 785.4638
Professors
W. A. Andiman, W. R. Anyan (Emeritus), R. S. Baltimore, G. P. Beardsley, M. Cappello, S. Caprio, T. O. Carpenter, J. A. Copel (Obstetrics, Gynecology, and Reproductive Sciences), T. F. Dolan (Emeritus), C. C. Duncan (Neurosurgery), R. A. Ehrenkranz, R. L. Fisher (Medicine), B. W. Forsyth, A. H. Friedman, M. Genel (Emeritus), I. Gross, A. L. Horwich (Genetics), M. K. Hostetter (Chair), Z. Kain (Anesthesiology), D. M. Komp (Emeritus), J. F. Leckman (Child Study Center), J. M. Leventhal, M. J. Mahoney (Genetics), L. Mayes (Child Study Center), P. L. McCarthy, L. R. Ment, G. Miller, I. Miller, P. K. Mistry, R. Moss (Surgery), H. A. Pearson (Emeritus), S. A. Rivkees, S. A. Rooney (Emeritus), D. J. Schonfeld (Adjunct), M. R. Seashore (Genetics), E. D. Shapiro, B. A. Shaywitz, S. E. Shaywitz, R. N. Shiffman, N. S. Talner (Emeritus), W. V. Tamborlane, R. J. Touloukian (Surgery), F. R. Volkmar (Child Study Center), J. Woolston (Child Study Center)
Associate Professors
R. J. Antaya (Dermatology), C. R. Baum, A. Bazzy-Asaad, D. Beardsley, K. A. Bechtel, C. W. Bogue, M. Brueckner, E. R. Colson, D. F. Donnelly, M. E. Egan, J. T. Fahey, P. G. Gallagher, J. R. Gruen, M. R. Mercurio, E. Novotny, D. S. Pashankar, G. Pizzorno (Medicine), K. Pugh, M. Reyes-Mugica (Pathology), L. E. Rosenfeld (Medicine), S. A. Ryan, K. Santucci, T. Shinoka (Surgery), J. Van Hoff, S. A. Weinzimer, C. C. Weitzman, M. Westerveld (Neurosurgery), Y. Xia
Assistant Professors
L. D. Arnold, A. G. Asnes, J. D. Asnes, K. J. Banasiak, S. Bhaduri-McIntosh, V. Bhandari, S. Bhargava, M. J. Bizzarro, C. K. Breuer (Surgery), T. S. Burgert, R. L. Chapman, L. Chen, K. Y. Ching, B. R. Doolittle (Medicine), K. B. Dorsey, A. M. Fenick, E. J. Fertig (Neurology), J. N. Grauer (Orthopaedics and Rehabilitation), M. R. Grossman, D. C. Hersh, A. L. Hsiao, S. Z. Husain, N. Kadan-Lottick, M. K. Khokha, G. Kupfer, M. Langhan, R. A. Martinello (Medicine), M. E. McCabe, M. A. McKee (Surgery), E. Michaelides (Surgery), F. D. Pashankar, G. A. Porter, M. Vazquez, B. P. Weeks, P. G. Weiss
Instructors
K. L. Hodges, S. Iragorri, K. A. Mangold, M. C. Marcy, C. L. Patterson
Senior Research Scientist
M. Genel
Research Scientists
J. D. Dziura (Medicine), J. M. McGrath (Comparative Medicine), K. C. Schneider
Associate Research Scientists
L. Ardeshirpour, A. L. Benin, E. M. Bruscia, R. D. Bungiro, E. Cengiz, C. A. Dinauer, B. Dondji, A. E. Esquibies, S. Ghatpande, J. E. Goodwin, J. S. Kahn, H. Kocinsky, I. Lazar, K. E. Marchione, P. A. McChesney, H. Meng, V. T. Mihaylova, E. Paintsil (Pharmacology), E. Pinter, M. S. Rosenthal, V. Schulz, K. L. Swan, C. C. Wendler, H. Z. Zhang (Genetics)
Clinical Professors
R. Angoff, P. Goldstein, H. Jacobs, T. L. Kennedy, R. G. LaCamera, B. M. McDonald, A. C. Mermann, C. Randolph, M. W. Sklaire, F. M. Testa, J. H. Zelson
Associate Clinical Professors
F. P. Anderson, M. Apkon, K. M. Berkwits, R. M. Biondi, H. D. Bornstein, K. A. Bradford, C. Canny, R. D. Chessin, S. J. Danoff, H. D. Fink, J. S. Fong, R. M. Freedman, M. W. Galal, G. S. Germain, C. W. Goff, F. L. Gruskay, J. H. Gundy, J. Hen, R. A. Herzlinger, S. K. Nallainathan, S. M. Peterec, R. L. Shelling, S. Z. Spiesel, E. L. Stone, S. C. Updegrove, C. C. Wood, R. S. Young
Assistant Clinical Professors
R. J. Anderson, A. Avni-Singer, J. W. Blanton, S. Boulware, N. B. Brown, J. Burger, C. G. Butler, J. G. Calderon, A. Cameron, D. P. Cheromcha, J. T. Combs, N. Condulis, N. Czarkowski, M. E. Dilorenzo, C. L. Dorfman, D. H. Dreyfus, A. Driggers, D. P. Durante, G. G. Dworkin, S. I. Escalera, T. Etkin, K. A. Fearn, C. A. Fischbein, M. B. Flaherty-Hewitt, M. Gaeta, B. Gardner, E. H. Gleich, A. Golioto, D. L. Griffin, J. A. Gruskay, R. B. Halperin, R. J. Hobbie, M. K. Ikeda, W. D. Irving, T. V. Jackson, D. E. Karas (Surgery), S. Kayani, L. K. Lasley, S. J. Lavietes, M. A. Lee, A. Liebling, D. I. Lowell, C. F. Mann, A. Meyers, J. L. Morgan, C. L. Morrison, H. J. Pierce, U. P. Puranik, M. F. Robert, O. Rose, M. A. Sanyal, M. Seli, L. Semeraro, L. B. Shader, R. J. Shea, M. Siev, B. K. Singletary (Surgery), E. C. Springhorn, C. P. Summers, J. Talwalkar, S. Tsalbins, A. Vaezy, G. R. Wanerka, S. A. Weiner, R. F. Whelan, E. Wiesner, R. D. Windom, J. Wynne
Clinical Instructors
P. M. Alvino, E. Bailey, L. Berlin, S. Bogursky, K. R. Burke, M. F. Canarie, R. E. Carroll, J. Cersonsky, B. V. Citarella, A. M. Coughlin, R. G. Dorr, B. G. Freeman, K. Y. Goldberg, A. Gork, L. E. Gray, M. E. Groth, J. E. Harwin, A. M. Hoefer, M. S. Hogan, F. C. Holmes, L. R. Jayanthi, M. L. Kim, H. Kipperman, D. A. Listman, R. Lockhart, E. A. Lomotan, A. Matczuk, C. Menzies, C. L. Miliaresis, C. Nicolosi, S. Pai, M. Pouliot, R. F. Ramos (Medicine), D. T. Richards, S. K. Simon, S. J. Slattery, J. H. Stein, S. M. Storeygard, D. C. Torres, L. A. Waldman, S. A. Walsh, J. L. Young, R. A. Zlotoff (Medicine)
Lecturers
C. D. Cook, J. J. Roney, S. J. Santacroce (Nursing)
Pediatrics 103, Third-Year Clerkship. The Pediatric Third Clerkship is an eight-week required rotation based on a national curriculum developed specifically for students beginning their clinical rotations. The students spend four weeks in the inpatient setting and four weeks in the outpatient setting. During the outpatient rotation, students are exposed to primary care as well as specialty care in the ambulatory setting. The inpatient portion of the rotation takes place at Yale-New Haven Hospital or Bridgeport Hospital. The objectives of the eight-week clerkship include improvement in knowledge as well as clinical skills such as history taking, physical examination skills, and problem solving. During the rotation, students are observed performing these skills by designated supervisors. They have the opportunity to supplement and complement their clinical experiences by completing computer-based cases, by working with a simulated model, and by interviewing standardized adolescent patients. Attention is paid to optimizing exposure to all pediatric age groups. The clinical experience is enhanced by a weekly interactive teaching session run by pediatric faculty members specifically for the third-year students. E. Colson, M. Bizzarro.
Pediatrics 128, Hematology–Oncology. A survey of the normal and abnormal hematology and the common malignancies of infancy and childhood. Students make initial rounds with the attending and the ward team at 7.30 a.m. The mornings are then spent in clinic seeing outpatients who come for therapy or follow-up. More extended bedside rounds, including time allotted for family discussions, take place in the afternoon. Students are expected to prepare a brief presentation for the team. One student, full time for two weeks, throughout the academic year. G. Kupfer and staff.
Pediatrics 139, Pediatric Neurology. Students participate in the pediatric neurology clinic and the learning disorders unit and see neurology patients on the pediatric wards. Up to two students, full time, for three weeks, throughout the academic year. L. R. Ment, G. Miller, E. Novotny, B. Shaywitz, S. Shaywitz.
Pediatrics 143b/Surgery 136b, Pediatric Surgery. A general survey of pediatric surgical problems based on illustrated case summaries and subject presentation by students, with selected readings from the literature. Limited to six students, first and last six weeks of spring term. Once weekly, time to be arranged. C. K. Breuer, R. J. Touloukian, M. A. Mckee, R. L. Moss.
Pediatrics 144, Clinical Clerkship in Pediatric Cardiology. Developmental aspects of cardiovascular function as applied to infants and children in a clinical setting. Students are assigned to various members of the pediatric cardiology staff. Emphasis on physical diagnosis, use of noninvasive methods, and clinical physiologic correlates. Observation of catherization and operative procedures. One student every four weeks throughout the year. J. Asnes, M. Brueckner, J. Fahey, A. H. Friedman, G. Porter, B. Weeks.
Pediatrics 146, Clinical Pediatric Infectious Diseases. Students participate in daily consultation rounds, Pediatric AIDS Clinic, and pediatric infectious diseases clinic. Students also participate in pediatric infectious disease rounds by presenting the case studies of one or more inpatients whom they have examined to a group of faculty and fellows. Rounds last approximately two hours (Wednesday morning). Emphasis is placed on correlation of the clinical problem and its practical management with principles of infectious disease epidemiology and clinical microbiology (bacteriology, virology, and parasitology). Limited to two students per three- to six-week period throughout the academic year. W. Andiman, R. Baltimore, M. Cappello, J. Kahn, G. Miller, G. Shapiro, M. Vazquez.
Pediatrics 148, Pediatric Endocrinology and Metabolism. An extensive exposure to clinical pediatric endocrinology, in particular problems of growth, sexual development, thyroid disorders, adrenal diseases, obesity, type 1 and 2 diabetes mellitus, and other disorders of carbohydrate metabolism. A full six-week elective includes daily clinics in general endocrinology, diabetes, and hyper lipidemia/obesity, and the inpatient service, generally concentrated in the Children’s Clinical Research Center. One student, full-time, six weeks, throughout the academic year. S. Boulware, T. Burgert, S. Caprio, T. Carpenter, E. Cengiz, M. Genel, M. Kim, S. Rivkees, K. Swan, W. V. Tamborlane, S. Weinzimer.
Pediatrics 152, Subinternship. Senior students serve as intern equivalents in order to gain experience in providing care to pediatric patients. During the subinternship, students are directly responsible for the care of their assigned patients while under the supervision of senior residents and attending physicians. Subinterns spend four weeks on service. They are assigned to either the School Age and Adolescent unit, the Infant and Toddler unit, or the Respiratory, Research, and Oncology (ROR) unit in the Department of Pediatrics at Yale-New Haven Children’s Hospital. D. Hersh and staff.
Pediatrics 153, Pediatric Gastroenterology/Hepatology. A general survey of clinical pediatric gastroenterology and hepatology with particular emphasis on inflammatory bowel disease, malabsorption, diarrheal disorders, nutrition, and liver disease. The elective includes daily inpatient rounds including rounds with pediatric liver transplant service, three weekly GI clinics, inherited metabolic liver disease clinic, and several weekly clinicopathologic conferences, as well as observation of endoscopic procedures. One student, full-time, three or six weeks, throughout the academic year. S. Husain, P. Mistry, D. Pashankar.
Pediatrics 154, Pediatric Respiratory Medicine. Students participate in the daily activities of the service in both the inpatient rounds and outpatient clinics. These include the evaluation of respiratory function in a variety of diseases including asthma, cystic fibrosis, bronchopulmonary dysplasia, pneumonia, aspiration syndromes, obstructive sleep disorders, and care of technology-dependent infants and children. Emphasis is on physical diagnosis. Rotations through the pulmonary function laboratory and the Children’s Sleep Center are available. Laboratory experience can be arranged. Participation in seminars and journal club are expected. One student, every two weeks, throughout the academic year. A. Bazzy-Asaad, S. Bhargava, M. Egan, A. Esquibies, P. Weiss.
Pediatrics 155, Pediatric Emergency Medicine. Senior students have the opportunity to evaluate and help manage a broad range of acute pediatric illnesses and injuries. Students are supervised by a Pediatric Emergency Medicine specialist. Clinical duties are scheduled by the program director. One student, full time, every four weeks throughout the year. L. D. Arnold and staff.
Pharmacology
Office: SHM B204, 785.4372
Professors
G. K. Aghajanian (Psychiatry), K. S. Anderson, H. R. Behrman (Obstetrics, Gynecology, and Reproductive Sciences), B. S. Bunney (Psychiatry), E. S. Canellakis (Emeritus), Y. Cheng, E. Chu (Medicine), J. R. Cooper (Emeritus), C. M. Crews (Molecular, Cellular, and Developmental Biology), P. S. Dannies, R. S. Duman (Psychiatry), B. E. Ehrlich, R. E. Handschumacher (Emeritus), J. R. Howe, D. K. Jorkasky (Adjunct), L. K. Kaczmarek, N. J. Maihle (Obstetrics, Gynecology, and Reproductive Sciences), A. C. Nairn (Psychiatry), M. Picciotto (Psychiatry), W. H. Prusoff (Emeritus), J. Ritchie (Emeritus), S. Rockwell (Therapeutic Radiology), R. H. Roth (Psychiatry), G. Rudnick, A. C. Sartorelli, J. Schlessinger (Chair), W. C. Sessa, S. G. Waxman (Neurology), D. Wu
Associate Professors
A. M. Bennett, M. P. DiGiovanna (Medicine), Y. Ha, R. Heimer (Epidemiology), M. E. Hodsdon (Laboratory Medicine), E. Lolis, G. Pizzorno (Medicine)
Assistant Professors
T. Boggon, D. A. Calderwood, S. Jordt, B. E. Turk
Senior Research Scientists
J. R. Cooper, W. H. Prusoff
Associate Research Scientists
R. P. Baumann, M. Bordonaro, V. Gazula, R. Hu, K. Ishiguro, W. Lam, I. Lax, Z. Lin, S. Lu, Q. Miao, E. Paintsil, P. G. Penketh, A. D. Pivazyan, H. Qin, H. A. Seow, K. Shyam, P. Sliz, Z. Tao, C. Wang, Y. Wang, G. Yang, C. Ying, J. Yu, W. Zhang, Y. Zhang, Y. Zhu
Lecturer
R. J. Levine (Medicine)
PHAR 502a and b, Seminar in Pharmacology. A seminar given by a department faculty member on his or her area of interest to teach students how to critically evaluate papers and to improve the ability of students to give oral presentations.
PHAR 504a, Pharmacology I: Maintaining and Restoring Homeostasis. Lectures cover drug-receptor interactions, control of messenger systems and channels, and regulation of physiological systems. P. Dannies and staff.
PHAR 504b, Pharmacology II: Interfering Selectively. Lectures cover antibiotics, immunotherapy, and chemotherapy. E. Lolis and staff.
PHAR 506a and b, Methods in Pharmacological Research (Rotations). Students work in laboratories of faculty of their choice. The period spent in each laboratory is one term. W. Sessa.
PHAR 508b, Neuropharmacology. An intensive examination of current understanding of the sites and mechanisms involved in drug action on single nerve cells and on the brain. Emphasis on basic functions and illustrative examples of their disturbance by drugs. J. Howe.
PHAR 518b, Current Topics in Cancer and Viral Therapy. This course discusses current and evolving topics in cancer and viral mechanisms of disease and potential treatments. Y. Cheng, E. Lolis.
Psychiatry
Office: 300 George Street, Suite 901, 785.2117
Professors
G. K. Aghajanian, M. D. Bell, S. J. Blatt, M. B. Bowers (Emeritus), B. S. Bunney (Chair), K. M. Carroll, J. P. Comer (Child Study Center), R. S. Duman, M. H. Ebert, P. L. Errera (Emeritus), J. Ford, J. J. Frost (Diagnostic Radiology), J. Gelernter, E. H. Griffith, C. M. Grilo, G. Heninger (Emeritus), R. E. Hoffman, M. A. Hoge, S. C. Jacobs, H. G. Jarecki (Adjunct), P. I. Jatlow (Laboratory Medicine), R. D. Kerns, R. A. King (Child Study Center), J. H. Krystal, J. F. Leckman (Child Study Center), A. Martin (Child Study Center), J. W. Mason (Emeritus), C. Mazure, T. H. McGlashan, D. F. Musto (Child Study Center), A. C. Nairn, S. S. O’Malley, G. D. Pearlson, M. Picciotto, S. M. Powsner, D. M. Quinlan, D. E. Redmond, Jr., R. Rosenheck, R. H. Roth, B. J. Rounsaville, R. S. Schottenfeld, M. J. Sernyak, M. H. Sheard (Emeritus), R. Sinha, W. H. Sledge, D. L. Snow, S. M. Southwick, J. S. Strauss (Emeritus), C. H. van Dyck, F. R. Volkmar (Child Study Center), B. E. Wexler, S. W. Woods, H. V. Zonana
Associate Professors
M. Alreja, L. M. Anez, S. A. Ball, M. Baranoski, K. L. Behar, R. Belitsky, H. Blumberg, A. Buchanan, V. D. Calhoun (Adjunct), N. L. Cooney, L. Davidson, R. A. Desai, R. J. DiLeone, D. C. D’Souza, C. J. Easton, C. N. Epperson, E. L. Giller (Adjunct), L. S. Godleski, M. Hampson (Diagnostic Radiology), K. A. Hawkins, L. K. Jacobsen, M. Jean-Baptiste, J. Kaufman, J. S. Kaufman, K. A. Kiehl (Adjunct), P. D. Kirwin, S. Krishnan-Sarin, R. T. Malison, S. Martino, G. F. Mason (Diagnostic Radiology), D. H. Mathalon, S. McKee, T. J. McMahon, A. Neumeister, M. A. Norko, D. A. Oren (Adjunct), I. L. Petrakis, M. N. Potenza, R. M. Rohrbaugh, M. I. Rosen, G. Sanacora, M. Sofuoglu, J. K. Staley-Gottschalk, J. L. Steiner, T. H. Styron, G. D. Tamagnan (Adjunct), J. R. Taylor, J. K. Tebes, D. F. Tolin (Adjunct), K. A. Yonkers
Assistant Professors
D. Aikins, P. B. Allen, R. C. Andres-Hyman, M. Assaf (Adjunct), R. S. Astur (Adjunct), S. R. Axelrod, J. E. Beauvais, L. E. Bedregal, R. D. Beech, Z. Bhagwagar, M. O. Bonarrigo, D. Brunner (Adjunct), G. J. Bryson, S. A. Castner, I. Cavus, M. C. Chawarski, L. Chwastiak, C. Connell, K. P. Cosgrove, C. A. Crusto, M. E. Delphin, M. M. Desai, P. H. Desan, C. G. Edelen, D. C. Fehon, J. M. Fiszdon, L. M. Frantsve, H. Gunduz-Bruce, N. Hansen, I. Harpaz-Rotem, A. Kaffman, S. Kendell (Adjunct), A. S. Klee, S. D. Kruger, D. M. LaPaglia, C. Li, S. Lim, R. Lugo, X. Luo, P. K. Maciejewski, S. Madonick (Adjunct), N. Maltby (Adjunct), E. A. Markakis, R. Masheb, K. A. McKiernan (Adjunct), R. S. McWilliam (Child Study Center), P. T. Morgan, P. M. Morrissey (Adjunct), M. V. Pantalon, M. Paris, H. L. Paxton, E. B. Perry, C. Pittenger, A. N. Ponce, M. L. Randall, A. M. Rasmusson, S. G. Resnick, P. Ridgway, C. Sanislow, S. N. Sathyanesan, D. J. Sells, A. A. Simen, G. Sirugo (Adjunct), P. Skudlarski (Adjunct), D. Small, V. H. Srihari, H. R. Steinberg, S. Steinberg (Adjunct), N. E. Suchman, T. P. Sullivan, R. R. Tampi, C. Tek, E. S. Tek, B. A. Toll, P. Van Wattum (Child Study Center), D. Vojvoda, N. Ward, M. A. White, K. M. Wilkins, G. V. Williams, W. A. Williams, P. Zimbrean, L. D. Zimmerman (Child Study Center), Z. Zimolo
Instructors
L. G. Chepenik, M. Ranganathan
Senior Research Scientists
M. B. Bowers, J. D. Elsworth, G. Heninger
Research Scientists
A. Margolin, B. Morrow, J. Olausson, J. Poling, E. Ralevski
Associate Research Scientists
D. Barry, K. T. Bergquist, R. A. Black, F. Bois, D. H. Brunzell, D. A. Cavallo, T. Chaplin, J. A. Cramer, N. R. Driesen, C. H. Duman, E. H. Flanagan, H. Fox, T. C. Greig, D. J. Guarnieri, A. A. Heapy, S. M. Hyman, J. S. Jane, J. H. Kalmar, W. J. Kasprow, R. Liu, L. M. Maccarelli, R. A. Miller, M. S. Neale, E. E. O’Brien, R. S. Palmer, P. H. Rosenberger, J. R. Saksa, T. Schmutte, M. A. Silva, G. W. Valentine, J. J. Vanderploeg, F. Wang, A. H. Weinberger, M. Wu, B. Yang, H. Zhang, W. Zito, L. Zuo
Clinical Professors
D. N. Berg, D. A. Carlson, G. H. Flamm, D. G. Greenfeld, D. Laub, D. O. Lewis, E. Prelinger, C. E. Riordan, S. Ritvo (Child Study Center), H. L. Ruben, L. D. Siggins, J. L. Young
Associate Clinical Professors
J. Allison, V. A. Altshul, R. M. Balsam, D. S. Bialos, S. Boltax-Stern (Child Study Center), E. A. Brett, C. Chiles, J. J. Ciarcia, V. Coric, J. De Figueiredo, L. Deutsch (Child Study Center), A. Evans, L. B. Fierman, J. Geller, R. L. Goettsche, K. Grady, L. L. Harkness, O. F. Hills, R. J. Hoffnung, D. Johnson, D. Koenigsberg (Child Study Center), C. C. Kovel, K. Liebmann, K. M. Long, J. S. Lustman, B. McKee, D. C. Moore, C. A. Morgan, M. S. Okasha, R. B. Ostroff, H. R. Pearsall, E. A. Perlswig (Child Study Center), R. Peters, J. Phillips, S. H. Phillips, S. G. Possick, M. Rowe, E. R. Ryan, J. M. Schnitt, S. J. Schreiber, A. P. Siegal, E. W. Snyder, R. Stern, A. P. Thies (Child Study Center), E. C. Wolff (Child Study Center), T. Zanker (Child Study Center)
Assistant Clinical Professors
A. C. Adis, A. M. Almai, J. A. Amatruda, P. T. Amble, M. M. Amer, S. R. Atkins, C. B. Baker, J. Ballew, A. L. Balter, L. C. Barr, M. V. Barrios, L. A. Bayer, B. R. Becker, E. Becker-Dunn, R. S. Behrends, M. Beitel, C. D. Bellamy, C. C. Bemis, S. Bender, D. E. Bendor, E. H. Berger, R. L. Bergeron, T. Bergherr, S. Bers, S. J. Bittner, H. C. Blue, D. Boltas, K. F. Bonese, T. E. Brown, A. Brownlow, A. Buonopane, L. V. Calabrese, A. Cappiello, R. Casey, L. I. Chaikovsky, J. Charney, J. R. Check, D. E. Ciancimino, J. C. Cline, J. T. Collins (Child Study Center), C. Cottrol, L. W. Cross, W. F. Dailey, C. Dike, C. Doebrick, N. Donegan (Psychology), D. B. Douglas, V. M. Dreisbach, M. T. Dreyfus, L. K. Driscoll, J. J. Erdos, R. D. Fallot, P. R. Falzer, D. C. Fehon, S. Feuerstein, J. F. Fickes, S. Finkelstein, D. A. Fisk, F. G. Fortunati, P. A. Fountain, P. Fox, E. R. Frazer, T. A. Freeman, D. Fried, T. Glinberg, C. T. Goldberg, L. I. Goldstein, K. Gonsai, L. R. Gonzalez, G. Gonzalez-Haddad, D. M. Gordon, C. H. Gottschalk, E. G. Grottole, C. S. Grove, L. B. Grunebaum, J. C. Harland, D. D. Hawkins, S. R. Hill, M. Hillbrand, K. Holtzman, S. J. Houlding, J. M. Jackson, D. D. Jacobson, C. Jean, A. Kaner, M. Kang, K. G. Kennedy, S. Khan, S. Kidd, B. Klink, B. E. Knox, F. E. Koerner, R. E. Kravitz, J. Kremer, J. Kurt, M. M. Kurtz, A. Lamba, H. M. Lankenau, D. Laub, K. M. Lazzarini, B. Lee, N. E. Legow, R. C. Lewis, H. J. Lin, E. B. Littman, H. G. Lizcano, D. B. London, C. Lozano, H. Lubin, M. Mandelkern, B. F. Marcus, C. A. Markle, R. Masheb, R. W. McCleary, B. B. McConnell, B. Meandzija, A. W. Meisler, N. C. Mellos, D. M. Mender, R. M. Meyer, R. M. Milstein, S. Mohamed, B. A. Moore, V. R. Morrow, F. C. Mueller, P. V. Mulinski, J. Myer, E. D. Nasper, J. Nields, F. J. Ninivaggi (Child Study Center), D. O. Nudel, K. F. Nuro, N. D. Olson, C. A. Opsahl, A. G. Oren, R. M. Ownbey, N. Panza, C. W. Pearson, D. Pilkey, J. F. Poll (Child Study Center), M. L. Prevey, G. R. Racusin, J. Rakfeldt, I. S. Rathbone, D. R. Rau, A. Resnick, G. Richardson, J. P. Robbins, J. E. Robinson, J. L. Rosen, V. C. Rosen, B. S. Rothschild, M. P. Roy, N. Roy, R. Rubin, D. S. Russell, J. A. Sabbatino, N. Sahay, D. K. Sakheim, K. M. Salisbury, D. Salomy, C. Sanders, L. C. Sanfilippo, A. P. Sawyer, J. O. Schechter, R. R. Schreibman, J. S. Schwartz, J. L. Scott, K. Scrimenti, S. R. Segall, J. P. Seibyl (Diagnostic Radiology), K. A. Sevarino, J. K. Shepard, D. E. Sholomskas, M. F. Sperrazza, A. D. Spivack, S. Sreenivasan, D. A. Stayner, M. C. Stevens, W. A. Stewart, M. Stitelman, G. E. Sturges, D. C. Tate, A. N. Tessler, B. Tobin, J. L. Tondora, S. E. Tressel, L. A. Trevisan, K. Trueblood, M. Tupper, D. J. Wallington, S. D. Wayne, Jr., J. M. Wexler, R. S. White, C. V. Wiseman, C. M. Young, R. J. Yun, S. O. Zimmerman
Clinical Instructors
M. Bailey, V. V. Carvalho, V. Coggshall, D. J. Flanigan, C. Grazia, M. C. Grenough, C. M. Hunnicutt, L. C. Hyman, W. Levy, J. Nields, J. N. Rascati, S. J. Rathi, S. H. Rodrigues, D. J. Suscovich, M. B. Vollmar, E. Weiss
Lecturers
J. D. Alvaro, C. Atkins, C. M. Barber, F. Begum, D. A. Berv, J. L. Callahan, R. A. Cole, C. Conrad, H. F. Crabbe, G. H. Davis, K. Degen, A. R. Demac, C. E. Desmond, P. J. Dileo, P. A. Dillon, L. K. Frisman, S. G. Goodson, J. B. Gordon, G. Greenberg, F. Grossman, M. A. Kalacznik, A. Kalafa, B. C. Klein, R. H. Klein, J. Klugman, A. L. Labruzza, L. Lager, R. B. Lenoci, L. M. Lothstein, S. S. Luthar, R. B. Makover, K. Marcus, J. H. Meyer, A. P. Miano, M. L. Mitchell, I. Moses, R. L. Munich, C. S. Naungayan, M. Nicholas, A. Oberkirch, M. J. Orlosky, R. T. Phillips, J. M. Pisciotta, M. K. Pruett, M. D. Rego, W. Reich, E. B. Rubin, S. L. Satel, A. J. Sholomskas, G. H. Sirkin, P. F. Thomas, R. K. Westheimer
The Department of Psychiatry teaches in both preclinical and clinical years. The pre-clinical course is a study of medical behavioral science, rather than an introduction to clinical psychiatry. Specific clinical skills, such as interviewing and the recognition and management of psychiatric syndromes, are taught later in the curriculum and especially during the required clinical clerkship in Psychiatry. Electives are available for students with special interest in selected areas. All advanced clinical electives are numbered in the 200s. The required core clinical clerkship (Psychiatry 106) is a prerequisite for enrollment in any of these advanced clinical electives; an advanced clinical elective may not be taken instead of the required core clinical clerkship. Please note: All students signing up for a seminar elective must also register with the Medical Student Education Office, Department of Psychiatry, 785.2089 (pending approval of the instructor).
Psychiatry 101a, Patient-Centered Interviewing: The Patient’s Story. This segment of the Pre-Clinical Clerkship focuses on the experience of illness—how people react to and cope with illness. The various psychosocial factors and psychological defenses which impact on the experience of illness, such as age, gender, social supports, socioeconomic status, and coping style, are examined. There is an emphasis on the patient interview and techniques for eliciting the patient’s story in an empathic and effective manner. The format includes lectures, demonstration interviews, and practice with standardized patients. R. Belitsky and Departments of Psychiatry and Medicine faculty.
Psychiatry 101b, Biological Basis of Behavior. Lectures are integrated with the Neurology course, and include principles and neural mechanisms of learning and memory; neural systems involved in fear and anxiety; neural systems involved in reward and drug addiction; neural systems involved in stress; and neural systems involved in attention. Following each lecture, a psychiatrist interviews patients diagnosed with obsessive-compulsive disorder, panic disorder, cocaine abuse, post-traumatic stress disorder, and schizophrenia. These 1.5-hour clinical presentations, which include time for questions, link psychiatric symptoms to the neural mechanisms discussed in the lecture on that day. 2.5 hours per week. Department of Psychiatry faculty.
Psychiatry 106, Clinical Clerkship. Skills and knowledge needed for the general practice of medicine are acquired in a clinical psychiatric setting. There is a “Patients in Crisis” component that emphasizes: conducting a competent screening interview in order to identify symptoms of a psychiatric or substance abuse disorder; performing a complete mental status examination of a patient who is emotionally disturbed or mentally ill; making a differential diagnosis, and planning for further evaluation and tests that would be useful in deciding among various diagnostic possibilities; making recommendations for biological, psychosocial, and/or social treatment interventions; assessing whether or not dangers to or from a patient exist; and understanding indications and procedures for lawful involuntary commitment of a patient to a mental hospital for treatment. There is also a “Psychiatry at the Interface with Medicine” component designed to provide students with an understanding of the presentation of psychiatric illness in patients with co-morbid medical disorders. Emphasis is placed on screening interviews, including mental status examination; identification of symptoms; and differential diagnosis and initial treatment recommendations of patients with co-morbid medical and psychiatric illness. Special emphasis is placed on evaluation of psychiatric emergencies and competency to make informed medical decisions. Additionally, students have the opportunity to learn and develop clinical skills through carefully designed outpatient experiences. R. Rohrbaugh and Department of Psychiatry faculty.
Psychiatry 203, Subinternship in Hospital Psychiatry, Inpatient Division, Connecticut Mental Health Center. Intensive work with inpatients who suffer from major psychiatric disorders with or without substance abuse. Emphasis is on assessment, acute treatment, and arrangement of continuing care in the community. The clerk functions as an integral member of a multidisciplinary treatment team. Clinical research participation is encouraged. Opportunities available to explore special areas of interest (e.g., forensics, psychopharmacology, administrative) with Connecticut Mental Health Center faculty. The elective is given on the inpatient service, CMHC. Scheduled throughout the year during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 106. Maximum registration: two students. S. Jacobs, M. Jean-Baptiste, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 205, Subinternship in Medical Psychiatry (Consultation Psychiatry), Yale-New Haven Hospital, 2039 Clinic Building. This is an advanced clinical elective for third- and fourth-year students who have a particular interest in the psychiatric disorders that can occur in medical-surgical patients. The staff has special interests in differential diagnosis of medical vs. psychiatric illness, in psychopharmacology, and in computer applications in psychiatry. Each student works up patients in parallel with advanced residents in inpatient and emergency department settings. Teaching occurs on daily walk rounds. Scheduled throughout the year during regular clerkship rotations (except July and August) for a minimum of four weeks. (NOTE: Fourth-year students will be given preference.) Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. P. Desan, T. Stewart, W. H. Sledge, A. Papsun, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 206, Advanced Clinical Elective in Law and Psychiatry. This clerkship program affords opportunities for fourth-year medical students to observe and participate in “competency to stand trial” evaluations with a clinical team that makes these assessments at the New Haven Correctional Center. In addition, they may attend Law School classes with students who represent psychiatric patients, observe civil commitment procedures, attend probate court hearings, as well as the criminal proceedings in local New Haven Superior Courts. Students attend work seminars where case evaluations and write-ups are discussed and prepared, and read appropriate legal cases and psychiatric literature. Students may be able to participate in parts of evaluations of insanity defense, custody determination, and other forensic issues. They attend the Law and Psychiatry Seminar during their rotation. Scheduled throughout the year (except August) during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 106. Maximum registration: two students. H. Zonana and staff. To enroll in this advanced clinical elective, please contact R. Rohrbaugh.
Psychiatry 208, Subinternship in Consultation-Liaison Psychiatry at the VA Connecticut Healthcare System (VACHS), West Haven, Connecticut. The Consultation-Liaison Service at the VACHS West Haven provides consultation to acute medical and surgical units, specialized rehabilitation units, and outpatient primary care clinics. Students participate in the management of patients with close supervision from attending staff. The goals of the rotation are (1) to increase skill in conducting a psychiatric interview which maximizes the collection of pertinent clinical data; (2) to use the data collected in formulating and implementing treatment plans emphasizing the interplay of biological and psychological factors in the patients’ presentation; (3) to experience the satisfaction of caring for patients with complex medical and psychiatric illness. Scheduled throughout the year for a minimum of four weeks. Open to third- and fourth-year medical students. Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. C. Chiles and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 209, Substance Abuse Elective. An elective clinical training experience in substance abuse for interested third- and fourth-year students. The primary training site is the Outpatient Service at the VA Connecticut Healthcare System (VACHS) in West Haven. The substance abuse elective is scheduled for four weeks. This experience is an intensive one in which students work closely with addicted patients with chronic mental illness. Students interested in learning about medical detoxification from alcohol and/or opiates may participate in an intensive two-week elective in the Ambulatory School of Medicine Detoxification Clinic at the VACHS. Students learn about the evaluation and treatment of alcohol withdrawal and detoxification. Patients with benzodiazepine and opiate dependence are also treated in this clinic. Prerequisite: Psychiatry 106. Maximum registration: two students. VACHS Faculty: L. Trevisan, I. Petrakis. Contact person (for VACHS): I. Petrakis, Psychiatry. To enroll in this advanced clinical elective, please contact R. Rohrbaugh.
Psychiatry 210, Subinternship in Hospital Psychiatry, Inpatient Division, Yale-New Haven Psychiatric Hospital. Intensive work with patients who suffer from major psychiatric disorders and range in age from college students to middle age. Emphasis is on assessment, acute treatment, and arrangement of post-discharge follow-up care in the community. The subintern is an advanced clerk functioning as a member of the multidisciplinary treatment team, taking on primary clinician and psychiatric/medical responsibilities for patients under the supervision of senior clinicians. The elective is given on the inpatient service at Y-NHPH; clinical research and outpatient involvement may be options. This subinternship is available throughout the year, during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. R. M. Milstein, M. Bowers, R. Hoffman, R. Tampi, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 211, Subinternship in Clinical Neuroscience, Clinical Neuroscience Research Unit Inpatient Division. This clerkship offers senior medical students the opportunity to work closely with a variety of patients who are hospitalized during their participation and treatment in research protocols. The Clinical Neuroscience Research Unit (CNRU) is a thirteen-bed inpatient ward with associated outpatient clinics and basic science laboratories on the third floor of the Connecticut Mental Health Center (CMHC). Supervised implementation of novel psychopharmacology, exposure to multiple aspects of clinical and basic science research, and in-depth experience with individual and group psychotherapies are educational aspects of this elective. Patients’ diagnostic categories include depression, obsessive-compulsive disorder, schizophrenia, cocaine abuse, and substance abuse. Scheduled throughout the year for a minimum of four weeks. Prerequisites: Psychiatry 101 and 106. Maximum registration: one student per rotation. R. Malison, G. Heninger, V. Coric, Z. Bhagwagar, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 214, Subinternship in Psychotic Disorders at G8W and the Schizophrenia Research Clinic at the VA Connecticut Healthcare System (VACHS) in West Haven, the Clinical Neuroscience Research Unit and the Psychopharmacology Intervention Program at the Connecticut Mental Health Center, the Community Care Center in West Haven. This subinternship is designed to provide an integrative exposure to the interface of psychopharmacology and psychosocial treatments for chronic psychotic disorders. Each individual requesting a subinternship is asked to outline his or her interest in psychotic disorders. Based on this information, a faculty mentor is assigned and a clinical program prepared that provides greater depth in the relevant areas. An effort is made to provide exposure to both hospital- and community-based treatments as well as clinical neuroscience advances. Within all treatment settings, subinterns have closely supervised direct clinical contact with patients. Subinterns are invited to attend academic conferences within the Department of Psychiatry focused on clinical and neuroscience issues relevant to psychosis. The goals of the rotation are (1) to expose the subintern to established and experimental medication treatments for psychotic disorders, particularly schizophrenia; (2) to expose the subintern to rehabilitative approaches to schizophrenia; (3) to expose the subintern to community-based treatments for chronic mental illness. Scheduled throughout the year for a period of six to eight weeks. Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. C. D’Souza, M. Bell, J. Cubells, L. Davidson, L. Harkness, S. Kruger, J. Krystal, and staff. To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 238, Subinternship in Early Psychosis: STEP Clinic. STEP (Specialized Treatment Early in Psychosis) is a multidisciplinary team-based treatment for individuals presenting early in the course of a psychotic illness. This clinic offers unique opportunities in the assessment and treatment of a population that is difficult to access in other clinical settings. Trainees have the opportunity to observe structured research assessments and interpretation of these scales in light of careful clinical follow-up. Given the diagnostic and prognostic heterogeneity of illnesses presenting with psychosis, this experience provides the opportunity to develop clinical expertise in diagnosis and management of a range of mental health issues. The enriched treatment includes cognitive-behavioral group therapy, family psycho-education groups, and cognitive remediation in addition to vocational support with a focus on rapidly reintegrating patients back to age-appropriate social, educational, and employment goals. Students have the opportunity to observe or participate in any of these treatments. The multidisciplinary and pluralistic nature of the intervention presents a rich opportunity to participate in collaborative care with other mental health disciplines. Trainees can also participate in regular seminars sponsored by the STEP and PRIME (Prevention through Risk Identification, Management, and Education) clinics. The latter is a research clinic focused on prodromal psychosis. Positions: 1-2. Site: Connecticut Mental Health Center (CMHC).
Scholarship: STEP is designed as a service delivery model with a built-in observational cohort and experimental pragmatic randomized controlled trial. Trainees are invited to take an active role in the various domains of scholarship including community and clinician education efforts, publication, and learning about clinical research design. V. Srihari (clinic director), J. Pollard (project director and family interventions coordinator, STEP clinic), C. Tek, (program director, Psychosis Team), L. Hyman (team leader, Psychosis Team), S. Woods (director, PRIME Clinic), J. Saksa (CBT coordinator, STEP Clinic), B. Walsh (clinical coordinator, PRIME Clinic). To enroll in this subinternship, please contact R. Rohrbaugh.
Psychiatry 325/CHLD 325, Child Psychiatry Elective, Yale Child Study Center. The aim of this elective is to provide the student with an intensive experience in infant, child, and adolescent psychiatry. The curriculum includes assessments of normal development and psychopathology in childhood, treatment methods, and research in major disorders of childhood. The elective takes advantage of the wide range of ongoing seminars, conferences, and clinical services in place at the Child Study Center. Teaching methods include seminars, conferences, field observations, ward rounds, and School of Medicine practica selected by the student following consultation with the director of medical studies, Child Study Center. Open to fourth-year students throughout the year. A. Martin, D. Stubbe, J. Woolston, and staff. To enroll in this advanced clinical elective, please contact A. Martin directly at 688.6016 or 785.3370.
Surgery
Office: FMB 102, 785.2697
Professors
J. J. Abrahams (Diagnostic Radiology), L. M. Bartoshuk (Emeritus), M. Centrella, F. C. Detterbeck, G. D’Onofrio, S. J. Dudrick, J. A. Elefteriades, S. H. Emre, H. E. Foster, J. P. Geibel, B. G. Green, R. J. Gusberg, G. L. Hammond (Emeritus), B. Kinder (Emeritus), J. A. Kirchner (Emeritus), G. S. Kopf, D. R. Lannin, G. L. Larkin, S. B. Leder, D. J. Leffell (Dermatology), A. Lofqvist (Adjunct), W. E. Longo, B. Lytton (Emeritus), L. M. Manuelidis, I. M. Modlin, R. Moss, J. A. Persing, S. M. Powsner (Psychiatry), S. H. Rosenbaum (Anesthesiology), W. Rosenblatt (Anesthesiology), A. T. Rosenfield (Diagnostic Radiology), D. A. Ross, P. E. Rubin (Adjunct), R. R. Salem, J. Santos-Sacchi, C. T. Sasaki, I. R. Schwartz, J. H. Seashore (Emeritus), Y. H. Son (Therapeutic Radiology), B. Sumpio, R. J. Touloukian, R. Udelsman (Chair), R. M. Weiss
Associate Professors
J. E. Aruny (Diagnostic Radiology), M. S. Bogucki, J. W. Colberg, D. C. Cone, D. C. Cronin, K. A. Davis, L. C. Degutis, R. N. Formica (Medicine), B. J. Grube, S. Hashim, M. H. Johnson (Diagnostic Radiology), L. J. Kaplan, W. K. Kelly (Medicine), T. L. McCarthy, D. Narayan, J. Pollak (Diagnostic Radiology), L. J. Rizzolo, R. A. Rosenthal, J. H. Shin, T. Shinoka, W. B. Stewart, G. Tellides, J. G. Thomson
Assistant Professors
A. Arvelakis, R. L. Bell, D. M. Black, D. J. Boffa, L. Bontempo, D. M. Botta, C. K. Breuer, C. H. Cha, A. Dardik, H. A. Deshpande (Medicine), D. Duffey, A. Duffy, L. V. Evans, A. R. French, A. Geirsson, J. M. Hammel, K. J. Jubanyik, R. W. Kim, D. Kowalski (Pathology), P. E. Krochmal, R. Kulkarni, S. Kulkarni, S. M. Luczycki (Anesthesiology), F. Y. Lui, L. L. Maerz, M. Matthew, M. A. McKee, E. Michaelides, E. P. Monico, C. Moore, H. C. Moscovitz, B. E. Muhs, M. R. Osborne, V. Parwani, M. F. Perkal, K. E. Roberts, S. A. Roman, B. Safdar, J. E. Sather, K. M. Schuster, I. Schwartz, D. Singh, J. A. Sosa, H. E. Tantawy (Anesthesiology), A. F. Tarabar, A. Tomassoni, E. M. Uchio, C. M. Van Gelder, C. N. Walker, C. R. Wira, N. Young
Instructors
A. J. Carter, J. C. Escalon, M. W. Katigbak
Senior Research Scientists
G. L. Hammond, J. Latifpour
Associate Research Scientists
S. Bian, W. Gao, M. S. Kidd, L. Song
Clinical Professors
S. Ariyan, M. Arons, J. E. Fenn, J. F. Kveton, S. B. Nuland, R. S. Stahl, E. Yanagisawa
Associate Clinical Professors
N. A. Atweh, M. S. Beinfield, Z. N. Chicarilli, J. M. Dowaliby, R. C. Fazio, A. J. Graham, H. L. Horton, R. K. Houlihan, K. Koral, K. Lee, R. Lena, R. A. Lowlicht, W. B. McCullough, N. M. Passarelli, J. T. Schultz, J. M. Serling, L. W. Skope, S. A. Stein, B. S. Weisbart
Assistant Clinical Professors
D. I. Astrachan, P. A. Barcewicz, H. Cedarbaum, B. Y. Cha, P. F. Corso, R. J. Dean, R. H. Delfini, R. W. DeNatale, M. L. Dewar, A. T. Dioguardi, T. G. Duplinsky, J. Federico, P. E. Fidler, S. V. Flagg, S. I. Friedman, S. Fusi, R. Garvey, A. R. Goldstein, R. T. Golia, R. D. Grossman, J. Henley, R. H. Hirokawa, G. E. Horblitt, N. R. Horowitz, R. B. Kaplan, D. E. Karas, D. B. Keck, J. C. Kirchner, S. B. Levine, J. Maisel, M. Margolies, D. M. Mello, S. Mitra, D. J. Muller, M. K. O’Brien, G. Opin, P. M. Opin, M. M. Perez, M. F. Perkal, G. J. Price, C. Rambus, D. D. Roberts, J. C. Salomon, R. F. Schlessel, M. J. Schpero, S. Shah, R. K. Shaw, B. K. Singletary, R. E. Steller, T. F. Sweeney, J. L. Tanenbaum, A. F. Tarabar, S. C. Thornton, R. Tross, D. Wasson, M. H. Weinstein, M. J. Werdmann, A. E. Wilk, K. Yanagisawa, K. Zuckerman
Clinical Instructors
J. A. Arons, S. Baker, P. W. Barrett, C. B. Beckman, M. S. Bianchi, W. R. Butler, K. A. Carmody, S. A. Chekijian, B. S. Chervin, W. Cholewczynski, E. M. Cozzi, P. Demir, T. Fabian, L. J. Fliegelman, P. L. Fortgang, N. A. Gordon, T. A. Kelly, B. M. Kirrane, J. R. Klenoff, T. H. Lesnik, W. Manson, A. A. McKelvey, V. Parwani, D. Passaretti, H. F. Reilly, J. F. Schmidt, J. J. Tagliarini, E. M. Vining, E. S. Weinstein, D. Wohl
Lecturers
L. Acton, L. M. Bow, H. C. Briggs, E. Browne, K. J. Burns, S. C. Carroll, N. Collins, G. M. Faherty, B. C. Fichandler, J. Freund, S. Ghofrany, R. C. Haug, G. M. Hayner, T. M. Herbert, R. Iassogna, S. Jolie, S. E. Kapadia, H. M. Keiser-Pedersen, T. Kimberly, E. B. Larned, H. L. Lisitano, D. S. MacMillan, P. R. Martinez, A. Meiman, J. Mendes, T. G. Michalewski, J. D. Midgley, T. A. Morris, D. B. Nelson, M. C. Persinger, P. P. Possenti, C. Powell, E. A. Roessler, A. M. Ruszkowski, T. E. Sanford, P. G. Sasaki, M. T. Strong, K. S. Sylvester, D. E. Tichy, C. D. Walker, J. O. Williams
Surgery 103, Surgical Clerkship. This is a twelve-week block that includes a four-week core experience on one of the general surgery services at either Yale-New Haven Hospital or the West Haven VA Hospital (Gastroenterology, Oncology, Trauma, and VAMC), a four-week rotation that is divided into two weeks on Anesthesia and two weeks on Emergency Medicine, and an additional four-week subspecialty rotation on which students may select two 2-week subspecialty services, which are completed at Yale-New Haven Hospital (Cardiac, Endocrine, Orthopedics, Otolaryngology, Pediatrics, Peripheral Vascular, Plastic Surgery, Thoracic, Transplant, and Urology).
During all of the rotations on the Surgery services, the students can expect to be integrated into the clinical teams, working up patients to which they are assigned and participating in the evaluation and management of these patients (in both the inpatient and outpatient settings). I |
