Departments and Sections
This section provides information for all departments and some sections in the School of Medicine. Each listing provides a roster of faculty, fellows, and associates, as well as descriptions of courses.
Courses designated a meet in the fall term only. Courses designated b meet in the spring term only. Courses enclosed in brackets are not offered in the current academic year.
Faculty listings reflect approved appointments effective June 15, 2009.
Anesthesiology
Office: TMP 3, 785.2802
Professors P. G. Barash, F. R. Braveman, J. G. Collins, J. Ehrenwerth, R. L. Hines (Chair), L. M. Kitahata (Emeritus), C. J. Kopriva (Emeritus), R. H. LaMotte, P. L. Miller (Medical Informatics), P. L. Miller (Medical Informatics), T. H. Oh (Emeritus), A. C. Perrino, T. D. Rafferty, S. H. Rosenbaum, W. Rosenblatt, K. J. Ruskin, K. H. Shelley, R. N. Shiffman (Pediatrics), D. G. Silverman, R. S. Sinatra
Associate Professors S. Akhtar, C. A. Brandt (Medical Informatics), C. A. Brandt (Medical Informatics), K. Cheung (Medical Informatics), K. Cheung (Medical Informatics), S. Garwood, T. M. Halaszynski, K. Haspel, B. C. McClain, G. F. McCloskey, L. E. Niklason, C. S. Rinder, J. J. Schwartz, N. Vadivelu, S. Wang
Assistant Professors A. A. Alian, M. Anwar, R. T. Aouad, J. F. Arthur, C. Cantemir, J. H. Chung, S. Dabu-Bondoc, D. Freyle, D. J. Gaal, T. J. Golembeski, L. Grecu, A. S. Haddadin, L. E. Helgeson, K. Hernandez, A. Herrera, M. J. Higgins, N. F. Holt, B. Horvath, S. Khan, V. J. Kurup, A. M. Lobo, S. M. Luczycki, C. Ma, I. Maranets, L. N. Marenco (Medical Informatics), L. N. Marenco (Medical Informatics), K. E. Marschall, H. Mikhael, R. K. Modak, W. M. Popescu, M. Punjala, R. Ramani, R. M. Romero, H. Saadat, N. Saidi, V. Salgar, R. C. Schoenfelder, C. B. Spencer, J. L. Sramcik, R. G. Stout, H. E. Tantawy, A. K. Thung, I. Vaitkeviciute, D. W. Vaughn, J. M. Watkins-Pitchford, G. X. Zhou, Q. Zhu, J. Zickmann
Instructors W. M. Popescu, T. Wong
Research Scientists F. G. Sayward (Medical Informatics), F. G. Sayward (Medical Informatics)
Associate Research Scientists S. J. Frawley (Medical Informatics), S. J. Frawley (Medical Informatics), L. Gui, E. Lee, N. Liu (Medical Informatics), P. G. Mutalik (Medical Informatics), N. Rajeevan, M. Scotch, M. A. Shifman (Medical Informatics), M. A. Shifman (Medical Informatics), R. Wang, X. Xu
Research Affiliate Q. Gu
Clinical Professors J. D. Katz
Associate Clinical Professors K. S. Chung, L. P. Kirschenbaum, B. Kosarussavadi, A. L. Mandel, E. K. Prokop, S. B. Stone, A. D. Weinstock
Assistant Clinical Professors S. I. Assaad, C. Ayoub, P. A. Blume (Orthopaedics and Rehabilitation), M. K. Ghori, Y. Grinberg, M. Lomanto, R. G. Steadman, J. A. Wagner, L. Wang, K. T. Watson, J. C. Weinberg
Clinical Instructors M. M. Abreu, M. Dudley, D. B. Glassman, A. F. Julian
Lecturers A. M. Deshpande (Medical Informatics), A. M. Deshpande (Medical Informatics), T. J. Handler (Medical Informatics), T. J. Handler (Medical Informatics), S. LaCoursiere, N. Liu (Medical Informatics), P. Nadkarni, P. G. Thomas
Anesthesiology 103, Clinical Clerkship Full-time clinical clerkship for students. Students are assigned throughout the year to Yale-New Haven Hospital for introduction to clinical anesthesiology, including preoperative evaluation of patients, selection of anesthetic technique, and administration of anesthetics under supervision. Perioperative medicine, airway management, monitoring techniques, clinical pharmacology, and physiology are emphasized. J. Schwartz, S.Akhtar, V. J. Kurup
Anesthesiology 104, Advanced Clinical Clerkship Four-week elective, full-time clinical clerkship throughout the year (except July and August) for two students. Individualized program of instruction in anesthesia subspecialties, including cardiovascular, neurosurgical, obstetrical, and pediatric anesthesia. J. Schwartz, S.Akhtar, V. J. Kurup
Anesthesiology 141, Clinical Research One or two students—hours arranged. Participation in ongoing research by departmental faculty involving clinical responses to drugs affecting cardiopulmonary and central nervous systems. The development of individual research projects is also encouraged. D. G. Silverman et al.
Anesthesiology 142, Basic Research within Anesthesiology One or two students—hours arranged. Focuses on cardiovascular tissue engineering and on mechanical characteristics of native and engineered vascular structures. General research projects involve the culturing of implantable engineered arteries and the development of microvasculature in vitro. L. E. Niklason
Cell Biology
Office: SHM C207, 737.5603
Professors N. W. Andrews (Microbial Pathogenesis), R. Baron, M. J. Caplan (Cellular and Molecular Physiology), L. Cooley (Genetics), P. Cresswell (Immunobiology), P. De Camilli, J. E. Galan (Microbial Pathogenesis), F. Gorelick (Medicine), J. D. Jamieson, D. S. Krause (Laboratory Medicine), T. L. Lentz (Emeritus), H. Lin, V. T. Marchesi (Pathology), M. S. Mooseker (Molecular, Cellular, and Developmental Biology), M. H. Nathanson (Medicine), P. J. Novick (Adjunct), G. E. Palade (Emeritus), T. D. Pollard (Molecular, Cellular, and Developmental Biology), J. K. Rose (Pathology), J. E. Rothman (Chair), E. Ullu (Medicine), S. L. Wolin
Associate Professors C. Hashimoto, K. M. Reinisch
Assistant Professors J. S. Bogan (Medicine), D. Colon-Ramos, T. Melia, E. Stein (Molecular, Cellular, and Developmental Biology), P. A. Takizawa, D. K. Toomre
Senior Research Scientist T. L. Lentz
Associate Research Scientists S. Berman, J. Bewersdorf, L. Branden (YSM Cores), L. Branden (YSM Cores), Y. Cai, X. Chen, H. Chen, S. M. Ferguson, C. G. Giraudo, E. Karatekin, G. Lavieu, X. Lou, F. Pincet, C. Qiu, C. Rahner, S. Sim, D. H. Smith, L. Volpicelli-Daley
CBIO 502a/b, Molecules to Systems This full-year course is designed to provide medical students with a current and comprehensive review of biologic structure and function at the cellular, tissue, and organ system levels. Areas covered in the first semester include replication and transcription of the genome; regulation of the cell cycle and mitosis; protein biosynthesis and membrane targeting; cell motility and the cytoskeleton; signal transduction; nerve and muscle function. The second semester of the course covers cell and tissue organization of organ systems including respiratory, renal, gastrointestinal, endocrine, and reproductive systems. Clinical correlation sessions, which illustrate the contributions of cell biology to specific medical problems, are interspersed in the lecture schedule. Histophysiology laboratories provide practical experience with an understanding of exploring cell and tissue structure. This course is offered only to M.D. and M.D./Ph.D. students. This course runs from September to mid-May and is equivalent to three graduate credits. J. Jamieson, T. Lentz, F. Gorelick, P. Takizawa, and staff
CBIO 601a/b, Molecular and Cellular Basis of Human Disease This course emphasizes the connections between diseases and basic science using a lecture and seminar format. It is designed for students who are committed to a career in medical research, those who are considering such a career, or students who wish to explore scientific topics in depth. The first half of the course is organized in four- to five-week blocks that topically parallel CBIO 502a/b. Examples of blocks from past years include “Diseases of protein folding” and “Diseases of ion channels.” Each topic is introduced with a lecture given by the faculty. The lecture is followed by sessions in which students review relevant manuscripts under the supervision of a faculty mentor. The second half of the course focuses on the relationship of basic science to disease processes while emphasizing translational and clinical research. In addition, sessions are devoted to academic careers and cover subjects such as obtaining an academic position, promotions, and grant writing. The course is open to M.D. and M.D./Ph.D. students who are taking or have taken Cell Biology 502a/b. Student evaluations are based on attendance, participation in group discussions, formal presentations, and a written review of an NIH proposal. This course runs from September to mid-May and is equivalent to three graduate credits. F. Gorelick, J. Jamieson, and staff. M 4–5:30
CBIO 602a/MB&B 602a/MCDB 602a, Molecular Cell Biology A comprehensive introduction to the molecular and mechanistic aspects of cell biology for graduate students in all programs. Emphasizes fundamental issues of cellular organization, regulation, biogenesis, and function at the molecular level. S. Wolin, T. Melia, T. Pollard, C. Crews, and faculty
CBIO 603a/MCDB 603a, Seminar in Molecular Cell Biology A graduate-level seminar course in modern cell biology. The class is devoted to the reading and critical evaluation of classical and current papers. The topics are coordinated with the CBIO 602a lecture schedule. Thus, concurrent or previous enrollment in CBIO 602a is required. S. Wolin, T. Melia, T. Pollard, C. Crews, and faculty
CBIO 604b, Systems Cell Biology Introduction to the organization and function of cells within complex multicellular systems as encountered in the human body. Covers major tissues and organs as well as the cardiovascular, immune, and nervous systems, with special emphasis on the molecular and cellular bases of developmental processes and human diseases. Lectures supplemented by electronic-based tutorials on the histology of tissues and organs. C. Hashimoto, D. Colón-Ramos, and faculty
CBIO 606b, Advanced Seminars in Cell Biology This seminar, which meets once weekly, covers advanced topics in cell biology. Each topic is spread over two or three sessions, starts with an introductory overview, and is followed by a discussion of key papers led by an expert in the field. Special emphasis is given to application of state-of-the-art imaging techniques to topical areas covering a wide range of contemporary cell biology. D. Toomre, K. Reinisch, and faculty
CBIO 701b, Illuminating Cellular Function Introduction to the principles and practical methods of live cell imaging. Covers principles of fluorescent microscopy (including genetically encoded probes and physiological indicators), image formation, image detection, and image analysis. Includes hands-on demonstrations of state-of-the-art instrumentation, such as video-rate confocal and multi-photon microscopes. D. Toomre and faculty
CBIO 900a and 901b/GENE 900a and 901b/MCDB 900a and 901b, First-Year Introduction to Research Lab rotations, grant writing, and ethics for Molecular Cell Biology, Genetics, and Development track students. C. Hashimoto, C. Radding, F. Slack, and faculty
Cellular and Molecular Physiology
Office: SHM B147, 737.2215
Professors P. S. Aronson (Medicine), E. L. Boulpaep, T. H. Brown (Psychology), C. Canessa, L. G. Cantley (Medicine), M. J. Caplan, W. K. Chandler, L. B. Cohen, A. B. Du Bois (Epidemiology), B. E. Ehrlich (Pharmacology), B. Forbush, J. P. Geibel (Surgery), G. H. Giebisch (Emeritus), J. F. Hoffman (Emeritus), W. H. Miller (Ophthalmology and Visual Science), P. A. Preisig (Medicine), G. B. Richerson (Neurology), W. Saltzman (School of Engineering and Applied Science), J. Santos-Sacchi (Surgery), G. I. Shulman (Medicine), F. J. Sigworth, C. L. Slayman, C. W. Slayman (Genetics), T. Wang, F. S. Wright (Medicine), L. H. Young (Medicine)
Associate Professors A. Bordey (Neurosurgery), M. E. Egan (Pediatrics), V. A. Pieribone, D. Zenisek
Assistant Professors M. N. Nitabach, S. Tomita, Y. Zhou
Instructor Q. Leng
Senior Research Scientists G. H. Giebisch, J. F. Hoffman
Research Scientist D. P. Zecevic
Associate Research Scientists B. Baker, C. X. Bleau, M. Carmosino, D. W. Chester, Z. Du, A. Rivetta, L. Wang, Q. Yan, Y. Yang
C&MP 500, From Molecules to Systems: Medical Physiology This course is open only to first-year medical students. The purpose of the course is to understand complex physiological processes at the level of component molecules, cells, specific tissues, organs, organ systems, and the whole body. Lectures cover human medical physiology in eleven modules: Cell Physiology/Membrane Transport, Nerve, Muscle, Metabolism, Blood, Cardiovascular, Respiratory, Kidney, Gastrointestinal, Endocrine, and Reproduction. Two major themes emerge during the course: (1) the human body employs a multitude of approaches for regulating the environment around its individual cells, and (2) these individual cells perform tasks necessary for sustaining life in the whole organism. E. Boulpaep and staff
C&MP 520a, Current Perspectives in Physiology This seminar explores a diverse range of current topics in physiology, emphasizing readings and discussions of recent primary literature. A variety of expert physiologists present topics such as structural biology, membrane transport, signal transduction, sensory systems, and neurophysiology. Instructors guide the discussion regarding the background, the experiments, the methods, and most importantly the impact of relevant research papers. The aim of the course is to understand how physiological approaches integrate the study of organismal function from genes, to systems, to behavior and disease. S. Tomita, Y. Zhou
C&MP 550a/ENAS 550aU/MCDB 550aU, Physiological Systems The course develops a foundation in human physiology by examining the homeostasis of vital parameters within the body, and the biophysical properties of cells, tissues, and organs. Basic concepts in cell and membrane physiology are synthesized through exploring the function of skeletal, smooth, and cardiac muscle. The physical basis of blood flow, mechanisms of vascular exchange, cardiac performance, and regulation of overall circulatory function are discussed. Respiratory physiology explores the mechanics of ventilation, gas diffusion, and acid-base balance. Renal physiology examines the formation and composition of urine and the regulation of electrolyte, fluid, and acid-base balance. Organs of the digestive system are discussed from the perspective of substrate metabolism and energy balance. Hormonal regulation is applied to metabolic control and to calcium, water, and electrolyte balance. The biology of nerve cells is addressed with emphasis on synaptic transmission and simple neuronal circuits within the central nervous system. The special senses are considered in the framework of sensory transduction. W. Saltzman, E. Boulpaep
C&MP 560b/ENAS 570bU/MCDB 560bu, Cell and Molecular Physiology: Molecular Machines in Human Disease This course focuses on understanding the processes that transfer molecules across membranes at the cellular, molecular, biophysical, and physiological levels. Students learn about the different classes of molecular machines that mediate membrane transport, generate electrical currents, or perform mechanical displacement. Emphasis is placed upon the relationship between the molecular structures of membrane proteins and their individual functions. The interactions among transport proteins in determining the physiological behaviors of cells and tissues are also stressed. Molecular motors are introduced and their mechanical relationship to cell function is explored. Students also read papers from the scientific literature that establish the connections between mutations in genes encoding membrane proteins and a wide variety of human genetic diseases. E. Boulpaep, F. Sigworth
C&MP 600, Medical Physiology Case Conferences Two-term course taught in groups of ten to twelve students by the same group leader(s) throughout the year. Workshop format permits students to apply basic concepts of physiology to clinical syndromes and disease processes. Students are expected to participate actively in a weekly discussion of a clinical case that illustrates principles of human physiology and pathophysiology at the whole-body, system, organ, cellular, or molecular level. Prerequisite: C&MP 550a or permission of instructor. E. Boulpaep and staff
C&MP 610, Medical Research Scholars Program: Mentored Clinical Experience The goals of this course are to introduce MRSP students to aspects of clinically important human diseases. Students explore each disease over three half-hour sessions led by a clinician-scientist who is an expert in the relevant organ system. Students explore two disease processes per term. The first of the three sessions is devoted to a discussion of the clinical presentation, natural history, pathology, epidemiology, treatment, and prognosis of the disease process. During this session students have the opportunity to view gross or microscopic specimens of diseased tissue in association with members of the Pathology faculty. Students are assigned readings in pathology, pathophysiology, and clinical texts to prepare for the first class session. The second session focuses on translational aspects of the disease process. Students read and present papers relevant to the molecular basis of the disease and cutting-edge approaches to its therapy. In the third session students meet with patients who have experienced the disease and/or visit and explore facilities associated with diagnosis and treatment of the disease process. Prior to the third session students receive guidance as to what they will observe and how to approach the experience and, at the end of the session, the group discusses its thoughts and impressions. Students are expected to prepare for sessions, to participate actively, and to be scrupulously respectful of patients and patient facilities. M. Caplan, R. Russell
C&MP 710b/MB&B 710b4, Electron Cryo-Microscopy for Protein Structure Determination Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. The course is an introduction into the concepts and applications of high-resolution electron cryo-microscopy. This rapidly emerging new technique is the only tool known to date that allows biological macromolecules to be studied at all levels of resolution ranging from their cellular organization to near-atomic detail. No specific prerequisites. However, parts of the course deal with diffraction theory and physical principles of image formation. Therefore, knowledge of calculus and basic physics is advantageous. F. Sigworth, H. Wang
Child Study Center
Office: NIHB 208, 785.2513
Professors J. P. Comer, S. L. Kagan (Adjunct), Z. Kain, Z. Kain (Adjunct), A. E. Kazdin (Psychology), R. A. King, J. F. Leckman, J. M. Leventhal (Pediatrics), P. J. Lombroso, R. W. Makuch (Public Health), S. Marans, A. S. Martin, L. C. Mayes, D. F. Musto, R. Paul, J. E. Schowalter (Emeritus), S. E. Shaywitz (Pediatrics), R. Sinha (Psychiatry), D. L. Snow (Psychiatry), P. Snyder (Adjunct), S. M. Southwick (Psychiatry), S. S. Sparrow (Emeritus), F. R. Volkmar (Chair), J. Woolston, H. Zhang (Public Health)
Associate Professors S. J. Berkowitz, H. Blumberg (Psychiatry), B. W. Forsyth (Pediatrics), E. L. Grigorenko, S. M. Horwitz (Public Health), J. Kaufman (Psychiatry), A. Klin, T. J. McMahon (Psychiatry), E. C. Miguel (Adjunct), M. N. Potenza (Psychiatry), L. Sadler (Nursing), L. D. Scahill (Nursing), M. E. Schwab-Stone, M. W. State, D. Stubbe, J. K. Tebes (Psychiatry), F. M. Vaccarino, C. C. Weitzman (Pediatrics), M. Westerveld (Neurosurgery)
Assistant Professors K. Chawarska, N. L. Close, R. Feldman (Adjunct), W. S. Gilliam, H. E. Goff (Psychiatry), Y. Kim, M. C. Rosario-Campos (Adjunct), N. E. Suchman (Psychiatry), J. E. Swain, V. Weersing (Adjunct), M. Yazgan (Adjunct)
Instructor J. Meyer
Senior Research Scientist S. S. Sparrow
Research Scientists G. M. Anderson, M. K. Pruett (Psychiatry), V. R. Seitz
Associate Research Scientists M. Akbar, M. A. Babyonyshev, K. M. Balestracci, B. Bi, S. J. Bishop-Josef, L. L. Booth, P. R. Britto, F. E. Brown, L. Cardona, M. J. Crowley, S. L. Durso, C. Emmons, D. B. Findley, M. Finn-Stevenson, M. Finn-Stevenson, M. A. Goyette-Ewing, H. Hahn, L. Hart, Y. Kataoka-Sasaki, K. Koenig, N. Landi, M. A. Levett, S. L. Macari, J. C. McPartland, D. Morgos, T. M. Newman, S. S. Nicholls, Y. B. Poncin, L. M. Quirmbach, G. J. Ramsay, C. T. Rowland, D. H. Saul, C. A. Saulnier, C. Singh, K. M. Smith, S. S. Sparrow, S. S. Stahl, C. S. Stover, D. Sukhodolsky, K. D. Tsatsanis, B. Vander Wyk, P. Ventola, E. M. Warnick, J. M. Wolf
Research Affiliates C. Dolsten, L. Jarvin, E. O. Vanbergeijk
Clinical Professors J. Adnopoz, R. Angoff (Pediatrics), T. W. Downey, T. W. Downey, R. Evans, P. Fonagy, A. S. Kaufman, N. Laor, S. R. Levy (Pediatrics), D. O. Lewis, K. D. Pruett, D. Reiss, H. S. Sacks, E. R. Shapiro
Associate Clinical Professors S. Boltax-Stern, C. Canny (Pediatrics), P. M. Cohen, L. Combrinck-Graham, K. Dahl, L. Deutsch, J. B. Ferholt, N. M. Haynes, D. Koenigsberg, J. G. Narad, E. A. Perlswig, J. D. Saccio, A. H. Schwartz, M. Target, A. P. Thies, L. A. Vitulano, T. Zanker
Assistant Clinical Professors H. A. Allen, A. J. Avni-Singer (Pediatrics), M. W. Azeem, E. Becker-Dunn (Psychiatry), M. Berkman, D. Bober, L. A. Bogen, K. H. Brody, P. Cantor, P. B. Chappell, J. T. Collins, A. Colonna, A. Colonna, A. Colonna, H. Edelson-Costa, G. E. Epstein-Wilf, S. Felsenfeld, D. Flanagan, R. P. Franks, M. G. Fromm, C. L. Gallo, G. D. Gammon, R. M. Greenbaum, F. X. Gregory, A. G. Hess, W. Hill, I. R. Jennings, E. O. Jennings, H. P. Kahn, M. D. Kaplan, R. G. King, R. G. King, R. G. King, P. K. Leebens, D. I. Lowell, A. S. Lustbader, M. Lustick, J. A. Madigan, J. P. Marachi, R. S. McWilliam, J. C. Meyers, S. J. Migdole, E. S. Millman, C. Mills, N. Moss, S. F. Nagler, R. N. Nikolov, F. J. Ninivaggi, B. F. Nordhaus, J. F. Poll, M. D. Powers, G. R. Racusin (Psychiatry), W. Roosen, H. L. Sacks, L. P. Siegel, A. G. Smaller, R. Sotsky, F. J. Streets (Dean), P. Van Wattum, S. Werblood, C. P. Wiles, L. D. Zimmerman
Clinical Instructors J. C. Allen, J. E. Arias, A. Aujla, B. J. Barile, K. M. Barrett, L. Brinkerhoff, L. Budnick, K. F. Clougherty, J. D. Cunningham, M. B. de-Naclerio, S. W. Dobuler, D. M. Dodge, L. M. Donovan, K. E. Dubois-Walton, J. Eisenberg, G. E. Epstein-Wilf, S. S. Fleming, J. A. Gallalee, S. Gossart-Walker, S. Gossart-Walker, J. L. Grimsley, K. Hammel, L. C. Hayden, P. Hetherington, C. Hogan, K. Holdt, R. Jones, N. Kennedy, B. A. Keyes, E. M. Kimball, B. Kleine, A. C. Koegler, A. T. Kravitz, E. Kressley, J. S. Landau, W. S. Levine, M. Lyons, M. Lyons, J. P. Marachi, W. Marans, B. L. Mason, M. A. McCarthy, C. Migdole, S. Monteleone, B. Murray, S. Peck, D. Perera, H. C. Pizzanello, R. Plant, K. D. Pruett, R. G. Pugliese, J. Radawich, N. Rauschenberg, B. N. Rickler, R. A. Ritvo, P. B. Rockholz, P. I. Sadowitz, C. Schaefer, C. Schnaitmann, J. Schoenleber, A. Schuch, A. W. Silver, A. N. Smoke-Collins, T. M. Spence, A. M. Stachelski, B. Taggart, M. D. Teperman, E. O. Tongul, G. Weiss, C. White, G. O. Winn, V. Zecchini
Lecturers K. F. Bailey, L. G. Barbieri, D. L. Bella, K. Carlson, C. J. Cooper, D. M. Esserman, J. Gillette, J. M. Gruendel, M. Gunsalus, D. P. Hauser, S. Heidmann, C. M. Horwitz, N. L. Kaufman, B. D. Kerman, S. S. Luthar, L. B. Nash, C. H. Olson, R. Paul, D. L. Pauls, J. P. Platner, C. Reberkenny-Frisketti, B. P. Rourke, C. Savo, B. B. Sherman, V. M. Shiller, C. B. Sicher, D. Smolover, J. Stoneman, C. A. Talbot, P. K. Thomas, E. C. Wolff
The Child Study Center is a multidisciplinary academic department of the School of Medicine for the study and care of children from birth through adolescence and their families. Child psychiatrists, psychologists, pediatricians, social workers, psychoanalysts, biomedical scientists, nurses, and other professionals collaboratively engage in research and treatment programs on various aspects of children’s growth and development, both normal and deviant. Research programs include child development, psychiatric disorders, social systems and schools, mental retardation, psychosomatic conditions, crisis and trauma, and treatment. Clinical services are provided in general and specialized outpatient clinics, in the Child Psychiatry Inpatient Service in the Children’s Hospital of Yale-New Haven, and in the Child and Adolescent Psychiatry Consultation-Liaison Service. The center provides courses and other academic opportunities for undergraduates and graduate students in various disciplines concerned with children and families, as well as specialized training in child psychiatry, psychology, social work, and clinical research.
CHLD 122b, Aspects of Child and Adolescent Development in the Practice of Medicine CAD explicitly deals with normal development, and specifically emphasizes social, cognitive, and emotional aspects of this lifelong process. It seeks to heighten the student’s awareness of how different phases of development intersect with the clinical practice of medicine. It covers different schools of thought and approaches to developmental processes, leading to a better understanding of (among others) cognitive, language, motor, social, sexual, and interpersonal milestones, from birth through senescence. Since it can be challenging to understand the importance of these normative processes in a clinical vacuum, the course complements the lectures given in the first hour (11 a.m. to noon) with clinical applications and extensive videotaped examples of that developmental phase in the second (noon to 1 p.m.). This approach provides the main “formula” for the course. First year, spring term, 16 hours. A. Martin and faculty
CHLD 222, Childhood Psychopathology Students are offered lectures, workshops, and videotapes of children with major or common psychiatric disorders usually first evident during infancy, childhood, and adolescence, including autism, mental retardation, attention deficit hyperactivity disorder, school phobia, learning disabilities, Tourette’s Syndrome, obsessive-compulsive disorder, and adolescent disorders. Second year. R. A. King and faculty
CHLD 322, Developmental, Psychiatric, and Psychological Assessment of Infants, Children, and Adolescents A series of lectures on developmental assessment (DA), psychological testing (P), and the Mental Status Examination (MSE) of children is offered to all students on the Pediatric Clerkship. Students may have the opportunity to observe such evaluations while on the Pediatric Clerkship. Further opportunities to observe DA and P, and to perform mental status examinations of children, are provided during the Child Psychiatry track of the Psychiatry Clerkship. L. Mayes, N. Close, M. Kaplan, and faculty
CHLD 323, The Child Psychiatry Track of the Psychiatry Core Requirement This track is offered to four students per six-week rotation (three at the Children’s Psychiatric Inpatient Service (CPIS) of Yale-New Haven Hospital, one at the Consultation-Liaison (CL) track of the pediatrics wards at YNHH). The CPIS and CL rotations meet the requirements for the “patient in crisis” and “interface with medicine” requirements of the core psychiatric clerkship of the third year. Both rotations provide extensive opportunities to observe and practice the process used to evaluate, diagnose, and plan the treatment of the child and his or her family. The rotations additionally provide for interview and write-up tutoring experiences, with both child and adult psychiatric patients. The track has three components: (a) a set of core experiences and lectures, (b) a group of optional selective experiences (such as visits to a therapeutic school), and (c) practica and directed readings. The practicum includes interviewing, working up, and writing reports on inpatients under the supervision of a child psychiatry tutor. In addition, each student prepares a written presentation related to an area of interest in child psychiatry. A. Martin, D. Stubbe, Y. Poncin, L. Cardona, and faculty
CHLD 324, Electives in Research Medical students join with faculty and postdoctoral research fellows in participating in patient-oriented or laboratory-based research projects. Students participate in weekly research seminars and multidisciplinary work groups as well as being directly engaged in some aspect of a new or ongoing research project with a faculty mentor. The elective is full time and has a minimum duration of three months. As of 2006, there is one available slot for a year-long research rotation for fifth-year medical students. J. Leckman, A. Martin, and faculty
CHLD 325/Psychiatry 325, Child Psychiatry Elective, Yale Child Study Center The aim of this elective is to provide the student with an intensive experience in infant, child, and adolescent psychiatry. The curriculum includes assessments of normal development and psychopathology in childhood, treatment methods, and research in major disorders of childhood. The elective takes advantage of the wide range of ongoing seminars, conferences, and clinical services in place at the Child Study Center and at Riverview Hospital in Middletown, Connecticut. Teaching methods include seminars, conferences, field observations, ward rounds, and practica selected by the student following consultation with the director of medical studies. Open to fourth-year students throughout the year. A. Martin, D. Stubbe, L. Siegel, and faculty. To enroll in this advanced clinical elective, please contact Dr. Martin directly.
Comparative Medicine
Office: 375 Congress Avenue, LSOG 117, 785.2525
Professors T. L. Horvath (Chair), R. O. Jacoby (Emeritus), M. W. Sleeman (Adjunct)
Associate Professors J. L. Brandsma, F. R. Homberger (Adjunct), J. D. Macy, P. C. Smith, C. J. Zeiss
Assistant Professors C. J. Booth, J. A. Carlson, Q. Gao, M. S. Lawrence (Adjunct), E. A. Markakis, S. R. Wilson, X. Yang
Senior Research Scientist R. O. Jacoby
Research Scientists S. R. Compton, J. M. McGrath, T. P. Nottoli, G. Yao
Associate Research Scientists J. A. Goodrich, I. Levy, Y. Nie, M. S. Rodeheffer, Y. Sun
Dermatology
Office: LCI 501, 785.4092
Professors J. L. Bolognia, D. E. Brash (Therapeutic Radiology), I. M. Braverman, P. Cresswell (Immunobiology), R. L. Edelson (Chair), F. M. Foss (Medicine), E. J. Glusac (Pathology), P. W. Heald (Emeritus), D. J. Leffell, J. M. McNiff, L. M. Milstone (Emeritus), J. S. Pober (Immunobiology), R. E. Tigelaar, L. D. Wilson (Therapeutic Radiology)
Associate Professors R. J. Antaya, M. W. Bosenberg, S. E. Cowper, M. Girardi, C. A. Herrick, R. Lazova
Assistant Professors S. Z. Aasi, J. N. Choi, A. Galan, S. Imaeda, C. J. Ko, A. Subtil, M. M. Tomayko
Instructors K. A. Choate, K. Mariwalla
Senior Research Scientist R. Halaban
Research Scientists C. L. Berger, A. K. Chakraborty, M. S. Kluger, L. M. Milstone
Associate Research Scientists D. J. Hanlon, V. Muthusamy, W. Zhang
Research Affiliate J. M. Pawelek
Clinical Professors K. A. Arndt, I. Dvoretzky, M. T. Johnson, R. C. Savin, K. L. Watsky
Associate Clinical Professors A. Bronin, F. M. Castiglione, I. S. Cohen, D. M. Davidson, L. M. Donofrio, J. S. Dover, J. W. Edelglass, R. S. Kahan, T. P. Kugelman, R. C. Langdon, E. B. Milstone, P. I. Schneiderman, P. E. Shapiro, L. A. Sibrack, A. Zalka
Assistant Clinical Professors M. R. Alexiades-Armenakas, J. N. Alter, A. V. Atton, S. H. Barrett, S. H. Bender, P. M. Bevilacqua, D. L. Bilinski, S. E. Book, C. B. Carroll, T. Chartier, C. Chess, K. A. Cohen, L. A. Daman, K. M. Diette, S. B. Dietz, W. Epstein, D. L. Feinberg, M. A. Gohara, B. Goldberg, M. J. Goldstein, D. R. Greene, W. S. Jacoby, M. Kaminer, J. D. Knispel, S. A. Kolenik, L. C. Kugelman, J. C. Lehrman, S. P. Lerner, A. B. Lewis, L. E. Luck, E. A. Markstein, E. R. Marsh, B. J. McGrath, D. R. Miller, E. Mirrer, E. Naidorf, M. P. Noonan, W. A. Notaro, R. G. Oshman, B. J. Richter, J. G. Sansing, N. K. Sherline, N. R. Silverman, J. R. Zirn
Clinical Instructors S. Chavel, O. R. Colegio, M. P. Coolidge, D. Correale, J. M. Grant-Kels, J. Moss, M. I. Oestreicher, J. B. Sabetta, J. Wilder, B. Zubkov
Lecturer L. K. Friedlaender
Dermatology 120 Instruction in the evaluation and management of patients with dermatologic problems in both outpatient and inpatient settings. Emphasis is on common dermatologic problems and cutaneous pathophysiology. Ambulatory patients are seen at Yale Dermatology Associates (2 Church St. South), Yale-New Haven Hospital Primary Care Center and the VA Connecticut Healthcare System, West Haven. Inpatient rounds are made at Yale-New Haven Hospital. Grand rounds and weekly lectures are also an important feature of the elective. Course is offered for four four-week sessions. S. Aasi, R. Antaya, J. Bolognia, M. W. Bosenberg, I. M. Braverman, K. Choate, J. Choi, O. Colegio, S. Cowper, R. L. Edelson, A. Galan, M. Girardi, E. Glusac, C. Herrick, S. Imaeda, C. Ko, R. Lazova, D. Leffell, J. McNiff, L. Milstone, A. Reszko, A. Subtil, R. E. Tigelaar, M. Tomayko
Diagnostic Radiology
Office: TE-2, 785.6938
Professors J. J. Abrahams, J. A. Brink (Chair), R. A. Bronen, M. I. Burrell, R. E. Carson, R. T. Constable, E. A. Cornelius (Emeritus), A. M. Curtis, Y. Ding, J. S. Duncan, H. P. Forman, M. G. Glickman (Emeritus), R. J. Gusberg (Surgery), H. P. Hetherington (Neurosurgery), L. D. Katz, E. Kier, J. P. Lawson (Emeritus), S. M. McCarthy, B. L. McClennan, J. Pollak, I. Prohovnik (Adjunct), A. T. Rosenfield (Emeritus), D. L. Rothman, L. M. Scoutt, C. Shaw (Emeritus), A. J. Sinusas (Medicine), B. Sumpio (Surgery), J. H. Sunshine (Adjunct), G. Sze, I. Tocino, F. J. Wackers (Emeritus), J. C. Weinreb, R. I. White, B. L. Zaret (Medicine)
Associate Professors J. E. Aruny, H. Blumberg (Psychiatry), S. Bokhari, D. W. Cheng, R. de Graaf, R. K. Fulbright, T. R. Goodman, A. H. Haims, H. Y. Huang, F. Hyder, G. M. Israel, M. H. Johnson, W. S. Kubal, G. F. Mason, C. R. Miller, J. W. Pan (Neurosurgery), L. E. Philpotts, A. N. Rubinowitz, R. R. Russell (Medicine), L. H. Staib, J. K. Staley-Gottschalk (Psychiatry), H. D. Tagare, M. G. Tal, C. R. Taylor, S. W. Woods (Psychiatry)
Assistant Professors L. Andrejeva, M. H. Arici, K. E. Baker, D. Cornfeld, I. Doddamane, R. J. Hooley, L. J. Horvath, R. H. Kent, J. D. Kirsch, H. R. Mojibian, H. Moukaddam, J. A. Obando, X. Papademetris, P. Pawha (Adjunct), C. Poon (Adjunct), E. Reiner, S. Sampath, E. M. Shapiro, C. J. Silva, P. Varma
Senior Research Scientist R. G. Shulman (Molecular Biophysics and Biochemistry)
Research Scientists F. D’Errico, M. Hampson, J. Wang
Associate Research Scientists D. E. Befroy, H. Chahboune (School of Engineering and Applied Science), S. V. Chelikani, G. M. Chowdhury, D. Coman, J. Gallezot, B. S. Ganganna, P. Herman, L. Jiang, C. Juchem, D. C. Labaree, P. G. Mutalik (Medical Informatics), M. Negishi, V. Neklesa, K. Purushothaman, M. Qiu, J. R. Ropchan, Y. Wang, Y. Yue
Research Affiliates S. Caprio, G. R. Gindi, A. B. Leber
Clinical Professors D. B. Nunez, M. S. Shin, J. D. Slavin
Associate Clinical Professors G. R. Berg, V. J. Caride, G. Fishbone, L. W. Hammers, E. A. Hyson, T. R. McCauley, I. Zubal
Assistant Clinical Professors W. E. Allen, R. D. Becker, S. B. Berger, T. Berkmen, M. Carino, T. M. Catanzano, J. I. Cheema, C. C. Colton, J. K. Crowe, A. R. Daftary, H. M. Dey, W. N. Friedman, H. W. Gahbauer, R. Gonzalez, B. D. Griffith, K. M. Johnson, A. Kalyanpur, S. J. Karidas, I. Kinori, J. Klein, R. A. Knobelman, C. T. Kubiak, P. H. Kuo, S. A. Messana, A. R. Niakosari, G. S. Novick, M. Obrzut, Z. Protopapas, R. Sadar, Y. Safriel, S. Saluja, J. P. Seibyl, S. Sheikh, B. D. Simonds, M. I. Straub, S. J. Sullivan, R. R. Tash, N. W. Tishkoff, J. Wruble
Clinical Instructors C. T. Kubiak, F. L. Lin, N. Malguria, J. A. Obando
Lecturers J. Arora, J. Bhawnani, G. J. Conlogue, F. Tokoglu
Diagnostic Radiology 121, Diagnostic Radiology Clerkship The four-week clerkship introduces the student to the basic principles of all forms of radiologic interpretation. Each day the students rotate through a section of the department of diagnostic imaging, including gastrointestinal, genitourinary, chest, musculoskeletal, neuroradiology, pediatrics, computed tomography, magnetic resonance, nuclear medicine, ultrasound, vascular and interventional radiology, and emergency radiology. Five days of elective time may be spent in a subspecialty area of the students’ choice. In addition to participating in the daily film reading with residents and staff, the students receive an introduction to the role of that section in the diagnosis and management of disease. Self-teaching materials are available in the radiology library. The students attend the department resident conferences twice daily as well as specific student seminars. Clerkships are offered at Yale-New Haven Hospital. A two-week diagnostic radiology elective is not offered. Prerequisites: None. Full-time: No on-call responsibilities. Limited to six students every four weeks. J. Abrahams, A. Haims, and staff
Diagnostic Radiology 134, Clinical Internship in Vascular and Interventional Radiology This elective is designed as an introduction to vascular and interventional radiology: the use of radiological imaging to guide procedures in various organ systems of the body and the evaluation and management of patients who are candidates for these. In the vascular system, this includes arterial and venous angiography, angioplasty, stenting, embolization for bleeding, tumors (such as uterine fibroids), and vascular malformations, venous reflux management, inferior vena cava filter placement, hemodialysis access management, and placement of a variety of venous access devices. Nonvascular experience includes percutaneous approaches to biliary and urinary track pathology, drainage of abscesses and other fluid collections, and tumor ablation. Students also participate in the interventional radiology clinic and admitting service. Electives last two to four weeks, but additional time can be arranged. This rotation is limited to one student at a time. J. Pollak, J. Aruny, and staff
Diagnostic Radiology 135, Clinical Clerkship in Pediatric Diagnostic Radiology Introduction to the clinical care of infants, children, and adolescents through the use of integrated diagnostic imaging. Students participate through review of imaging studies with residents and attendings; observation of fluoroscopic, ultrasound, computed tomography (CT), and MRI procedures; and attendance at daily clinical conferences. Students are encouraged to use the teaching file and also to add an interesting case. Elective periods of two to four weeks are possible, times to be arranged, limited to one student per period. R. Goodman and staff
Diagnostic Radiology 137, Clinical Clerkship in Neuroradiology This rotation is designed as an introduction to neuroradiology. The student becomes an integral part of the neuroradiology team which consists of the resident, fellow, and attending physician. A number of teaching conferences are offered including a daily case review session. The student is exposed to the various subsections of neuroradiology including neuro CT, neuro MR, and neuro special procedures, e.g., angiography, myelography, CT biopsy, interventional angiography. J. Abrahams, G. Sze, and staff
Section of Education
Office of Education: ESH 305, 737.4190
Office of Student Research: ESH 308, 785.6633
Sect Ed 101, Intensive Pedagogical Experience in Laboratory Research Techniques Intensive one-week summer course in biomedical research protocols and techniques is open to first-year medical students at Mount Desert Island Biological Laboratory in Bar Harbor, Maine. Four biomedical research topics are the focus of each course: (1) physiological studies of chloride transport in an intact epithelial organ from Squalus acanthias; (2) ion channel gene expression in a heterologous expression system (Xenopus oocytes); (3) studies in isolated tubule preparations, including immunocytochemistry of phosphorylated vs. non-phosphorylated co-transporters, tissue processing, confocal microscopy, Western blots, and antibody design; molecular biology of membrane proteins and transporters in shark salt gland, including methods in RNA, cDNA, PCR, cloning, and sequencing. J. Forrest, D. Forbush, N. Aaronson, and staff
Sect Ed 102, Organization and Leadership This course is an introduction to topics in the field of organizational behavior. It is designed to offer participants an opportunity to explore a variety of concepts that relate to the effective and humane management of organizations. Though medicine was once a profession made up primarily of individual practitioners, it is increasingly true that medical professionals, both clinicians and researchers, are now involved in collective endeavors that require coordinated efforts to produce meaningful results. This is the domain of organizational behavior and the subject matter of this course. D. Berg
Sect Ed 103, Applied Principles of Clinical Research (First-Year Seminars)—Office of Student Research The purpose of this intensive two-week course is to provide an overview of the objectives, research strategies, and methods of conducting patient-oriented research. Topics include research designs, how to ask a research question, data collection, how to write a protocol, bias in studies, qualitative methods, etc. Emphasis is placed on applying concepts to students’ actual research projects. Sessions are workshops that combine didactics and use students’ projects to illuminate concepts. Students must have declared interest in conducting patient-oriented research by May. Consent of instructor required. Two weeks in summer to be announced. Staff
Sect Ed 104, Applied Principles of Clinical Research (Fifth-Year Seminars)—Office of Student Research The purpose of this intensive two-week course is to provide an overview of the objectives, research strategies, and methods of conducting patient-oriented designs, how to ask a research question, data collection, how to write a protocol, bias in studies, qualitative methods, etc. Emphasis is placed on applying concepts to students’ actual research projects. Sessions are workshops that combine didactics and use students’ projects to illuminate concepts. Students must be funded for one year of research. Consent of instructor required. Two weeks in summer to be announced. Staff
Sect Ed 105, Pre-Clinical Clerkship This course, extending throughout the first two years, is intended to teach medical students skills in communication, medical history taking, and physical examination, as well as end-of-life care. The format of the course involves several large group sessions for the purpose of demonstrating or modeling interview techniques and many small group sessions in which students get a chance to observe and practice specific skills. An integral part of the Pre-Clinical Clerkship is the tutorial program in which groups of four students meet with their tutor(s) weekly over a two-year period to practice their newly learned skills on patients in the hospital or clinic.
In the first year, students learn the basics of interviewing patients in formal sessions and the clinical tutorials. Emphasis is placed on a patient-centered approach utilizing standardized patients. Students also learn how to perform a complete physical examination in structured, supervised sessions in which they examine one another. Other activities include practicing their observation skills in an art museum, understanding the skills needed in the care of children, and understanding how to assess geriatric patients, as well as end-of-life care.
During their second year, students are learning more sophisticated skills in obtaining a medical history, the components of a proper patient write-up, and the elements of oral patient presentations. Standardized patients are used again for teaching interviewing skills, but also for breast, pelvic, scrotal, and rectal examinations. At the beginning of their second term, students are evaluated on their ability to perform a complete history and physicial examination at the Clinical Skills Assessment Program at UConn utilizing their standardized patients.
Students pass the Pre-Clinical Clerkship by attending all the skill-building sessions; demonstrating the ability to perform a complete history and physical exam from memory (at UConn); and having acquired the skills needed on the wards according to their tutor(s). Limited to medical students. M. Bia
Sect Ed 106, Mechanisms of Disease Course: Organs/Systems The purpose of this course is to bridge the preclinical and clinical years and to teach students to use preclinical data in a clinical context. It introduces the pathologic variation of the normal physiologic mechanisms that the students have already learned. This required course is offered in a continuum from September through March for second-year medical students. It consists of thirteen integrated discrete organ-system-based modules that present disease processes from various disciplinary perspectives. The components include pathology, laboratory medicine, diagnostic radiology, preventive medicine, geriatrics, pharmacology, clinical medicine, pediatrics, surgery, and potentially others as indicated by the subject matter.
For each module, representatives from each discipline meet and create a course that presents a comprehensive overview of the organ/system, progressing and building information in a way that allows students to form a basis on which to add knowledge throughout their careers.
Material is taught in a variety of formats including lectures, small group workshops that discuss patient cases, and laboratories. The modules are Hematology; Cardiovascular System; Clinical Neuroscience; Clinical Psychiatry; Endocrine Systems; Reproductive Medicine; Digestive Diseases; Musculo-Skeletal System; Renal/Urology Systems; Respiratory; Ophthalmology; Oncology; and Dermatology. Each module has a module director who is the faculty coordinator. These modules provide excellent preparation for clinical work on the wards as well as preparation for the second-year USMLE Board Exam, the questions of which use a clinical paradigm. Course is limited to second-year medical students. M. P. DiGiovanna
Sect Ed 107b, Professional Responsibility Through a series of lectures and small group case discussions, this course examines physicians’ responsibilities to their patients, their colleagues, their communities, and to society at large. The course examines the nature of the physician-patient relationship and its ethical underpinnings, as well as the legal, social, and economic contexts in which it operates. It focuses on the physician’s obligations in several areas, including care for the underserved and vulnerable, respect for patients’ privacy and confidentiality, obtaining informed consent for treatment, respecting the right to refuse treatment, respecting reproductive choices, and dealing with issues at the end of life. Finally, the course examines the flaws and strengths of the U.S. health care system, and the personal and social consequences of recent changes in the way health care is organized and financed in this country. J. S. Hughes
Sect Ed 108b, Integrative Clinical Medicine This three-work course is required of fourth-year students in the spring term immediately prior to the internship match. Conceived more than ten years ago as a capstone to four years of medical school training, the ICM course provides a review of some of the knowledge and skills needed for internship and beyond, a forum for a comprehensive and critical evaluation of clinical cases, a chance to review some of the historical and economic factors that inform the practice of medicine, and an opportunity to reflect on the social, ethical, psychological, and even spiritual challenges of a life in medicine. Throughout the three weeks the emphasis is on the interplay among biological, social, and psychological factors in determining the health and illness of our patients as well as ourselves. Much of the course takes place in small groups of ten to twelve students under the guidance of an experienced clinician facilitator. Several of the small group sessions deal with the management of a clinical case with a view toward preparation for internship, but also including the social context of the case and the impact of economic, family, and societal factors as determinants of illness. In addition there are a number of clinical review sessions, including an ICU “crash course,” several lectures on emergency medicine, a review of empiric antibiotic choices, instruction on how to sign out to colleagues, sessions on how to discuss DNR orders with patients, how to provide adequate pain relief for palliative care, and an intern panel discussion of what life is really like on and off the wards. The course includes a number of optional sessions on “nonbiological” topics throughout the course, including lectures on topics in the history of medicine, how to avoid “burnout,” sessions on leadership and team functioning on the wards, the role of spirituality in medicine, updates on the political economy of the health care system, and the microeconomics of real-world medical practice. Also included are sessions on mistakes in medicine, dealing with difficult patients, end-of-life care, doctor-patient communication, race and gender issues in the hospital, and issues in professionalism and medical ethics. The course concludes with a session on “What you need to know about internship that nobody else will tell you” and finishes just before noon on Match Day. Director: J. S. Hughes
Sect Ed 109, Student Research, Study Design, and Thesis Information–Office of Student Research This course has two overarching goals. The first is to instill in students an understanding of the value of the Yale student research program and thesis and to provide a primer for success in the thesis. Emphasis is placed on how to choose an excellent thesis project and mentor in laboratory or clinical research, as well as in the areas of epidemiology and public health, international medicine, or medicine and the humanities. Students are instructed on the importance of the research environment, the selection of the best possible up-to-date methods, the importance of issues related to human investigation, and the requirements for HIC approval of protocols for medical student research. The second area of emphasis is to provide students with the basics in designing laboratory and clinical studies, including the use of power calculations, proper control groups, practical biostatistical measurements and their applications for research, and methods for efficient searching of the literature and online databases. Limited to medical students. J. Forrest, faculty, and staff
Sect Ed 110, The Yale Journal of Biology and Medicine (YJBM) The course provides an educational opportunity for students in medicine, public health, nursing, and the biological sciences to gain experience in all aspects of academic publishing. The Journal publishes online four times a year through PubMed Central and receives manuscripts on a wide variety of topics in basic and clinical sciences from authors around the world. Alongside participating faculty members, students review and select articles for publication and have the opportunity to review books and write articles showcasing their research or sharing clinical experiences from Yale and abroad. Student editors are chosen each year from the School of Medicine and the Combined Program in the Biological and Biomedical Sciences. The editorial staff meets monthly. J. Bender, faculty adviser
Sect Ed 158, Primary Care Clerkship The Primary Care Clerkship provides students with an opportunity to acquire knowledge and develop clinical and interpersonal skills applicable to outpatient primary care practice. Students are assigned to a community-based office or clinic where they care for patients under supervision by a family practitioner, internist, or pediatrician on Mondays, Wednesdays, and Fridays for one month. On Tuesdays and Thursdays students attend a case-based Workshop Program based on common disorders and core skills relevant to primary care practice. Director: F. Haeseler with a faculty made up of physician educators who share a commitment to practice-based teaching.
Sect Ed 158-1, Primary Care Wednesday Evening Clinic This one-year weekly outpatient clerkship in the Primary Care Center provides experience in the longitudinal care of adults. Students are directly responsible for care of medical problems and preventive care as well as coordination of specialty care for their own patient panel. There are weekly pre-clinic conferences which include Journal Club and primary care case-centered topics presented by students or specialty attendings. Students also become acquainted with the administration of outpatient clinic medicine. The clinic is held every Wednesday evening, 5–9 p.m., except the day before Thanksgiving and between Christmas and New Year’s. It is open to a limited number of fourth-year students and fulfills the primary care requirement. Students must have completed Hospital Medicine I and II of the Core Medicine Clerkship and Ambulatory Medicine as well as two other third-year Clerkships, preferably Psychiatry and Obstetrics, Gynecology, and Reproductive Sciences. Director: K. P. White; staffed by M. Dillard and rotating attending physicians.
Sect Ed 159, Principles of Human Anatomy and Development This course, designed specifically for first-year medical students, provides an opportunity to dissect or observe all structures of the human body. Lectures, conferences, models, radiology, and Web-based curriculum materials are included. Four students are assigned to each cadaver; students work on different regions simultaneously. L. J. Rizzolo and staff
Sect Ed 160a/b, Special Dissections in Anatomy A laboratory designed to meet the needs of individual students. Any part of the cadaver may be dissected. Each student is assigned an anatomist and/or clinical specialist to act as consultant(s). Prerequisite: Sect Ed 159. Staff
Epidemiology and Public Health
Office: LEPH 210, 785.2867
Professors S. Aksoy, W. A. Andiman (Pediatrics), M. Y. Armstrong (Emeritus), R. S. Baltimore (Pediatrics), M. B. Bracken (Epidemiology), E. H. Bradley (Public Health), K. D. Brownell (Psychology), R. Bucala (Medicine), M. Cappello (Pediatrics), E. B. Claus, P. D. Cleary (Dean), V. T. DeVita (Medicine), V. T. DeVita (Medicine), A. B. Du Bois (Emeritus), E. Fikrig (Medicine), D. Fish (Epidemiology), H. P. Forman (Diagnostic Radiology), G. Friedland (Medicine), T. M. Gill (Medicine), R. Heimer (Epidemiology), W. J. Hierholzer (Emeritus), T. R. Holford (Public Health), R. I. Horwitz (Medicine), S. M. Horwitz (Emeritus), J. R. Ickovics (Epidemiology), S. C. Jacobs (Psychiatry), J. F. Jekel (Emeritus), E. H. Kaplan (School of Management Admin), S. V. Kasl, H. M. Krumholz (Medicine), B. P. Leaderer (Epidemiology), L. S. Levin (Emeritus), R. W. Makuch (Public Health), L. E. Marks (Epidemiology), L. C. Mayes (Child Study Center), S. T. Mayne, R. McCorkle (Nursing), D. McMahon-Pratt, I. Miller (Pediatrics), A. Ostfeld (Emeritus), A. D. Paltiel (Public Health), C. L. Patton (Emeritus), P. N. Peduzzi (Adjunct), J. Powell, H. A. Risch, R. Rosenheck (Psychiatry), N. H. Ruddle (Emeritus), N. H. Ruddle (Emeritus), P. Salovey, M. J. Schlesinger (Public Health), E. D. Shapiro (Pediatrics), E. D. Shapiro (Pediatrics), J. L. Sindelar (Public Health), D. L. Snow (Psychiatry), J. T. Stitt (Emeritus), J. A. Stolwijk (Emeritus), G. H. Tignor (Emeritus), M. E. Tinetti (Medicine), C. White (Emeritus), D. Zelterman, H. Zhang (Public Health), H. Zhao (Public Health), T. Zheng
Associate Professors S. H. Busch, M. Cappello (Pediatrics), D. C. Cone (Surgery), L. C. Degutis (Surgery), L. Dembry (Medicine), L. Dembry (Medicine), R. A. Desai (Psychiatry), R. Dubrow (Epidemiology), A. P. Galvani (Epidemiology), E. L. Grigorenko (Child Study Center), J. J. Hoh (Epidemiology), M. L. Irwin, B. A. Jones, A. C. Justice (Medicine), A. C. Justice (Medicine), D. Katz (Adjunct), Q. Lan (Adjunct), B. Levy (Epidemiology), J. H. Lichtman, H. Lin, L. M. Niccolai, M. M. Pettigrew, J. Prah Ruger (Public Health), M. B. Russi (Medicine), A. N. Sofair (Medicine), N. S. Stachenfeld (Epidemiology), J. K. Tebes (Psychiatry), C. Tschudi, H. Yu, Y. Zhu
Assistant Professors C. L. Barry, M. L. Bell (Assessments & Unrestricted), M. M. Ciarleglio (Adjunct), M. M. Desai (Epidemiology), M. M. Desai (Epidemiology), M. A. Diuk-Wasser, A. J. Epstein (Public Health), J. M. Fletcher, Y. Guan, P. S. Keenan, T. Kershaw, K. Khoshnood (Epidemiology), T. T. Lewis, S. Ma, X. Ma, K. M. McCarty, A. M. Molinaro, I. M. Nembhard (Public Health), C. W. Yeckel (Epidemiology), C. W. Yeckel (Epidemiology), Y. Zhang
Senior Research Scientists J. E. Childs (Epidemiology), L. E. Munstermann, N. H. Ruddle (Epidemiology)
Research Scientists N. Abdala, K. Belanger (Epidemiology), B. Cartmel (Epidemiology), L. Curry (Public Health), W. T. Gallo, J. F. Gent, R. Gueorguieva, D. Schulman-Green (Nursing), N. Sun, M. E. Ulcickas Yood
Associate Research Scientists G. M. Attardo, K. L. Bentley, L. Calvocoressi, N. P. Connally, S. A. Davis, J. Dong, L. E. Grau, L. M. Grosso, N. G. Kolev, P. J. Krause (Epidemiology), L. Lu, L. Lundsberg, A. B. Mason, M. M. Tomita, S. Usmani-Brown, B. L. Weiss, C. Wu
Research Affiliates V. Chakrapani, V. H. Hodgkinson, L. A. Magnarelli, S. Malov, C. B. Ocampo-Duran, N. G. Saravia, M. Singer, R. Skochilov, M. Torban, W. J. Ugarte Guevara, M. R. Weeks, Z. Zagdyn
Clinical Professors J. B. Borak (Epidemiology), M. G. Curnen
Associate Clinical Professors M. L. Cartter, R. Dubrow (Epidemiology), J. L. Hadler, G. S. Moore, D. Shenson
Assistant Clinical Professors S. Kebede, M. V. Roberto (Epidemiology), L. E. Sosa
Clinical Instructors D. L. Humphries, J. E. Rawlings
Lecturers H. M. Allen, E. Anderson, J. F. Anderson, T. G. Andreadis, D. D. Aye, T. J. Balcezak (Medicine), L. C. Barry (Medicine), K. Belanger (Epidemiology), M. G. Bochenek, A. L. Boissevain, M. P. Borgstrom, E. A. Bortnichak, J. Bradley, M. M. Callaway (Public Health), M. M. Callaway (Public Health), P. F. Canny, G. L. Capozzalo (Public Health), B. Cartmel (Epidemiology), P. A. Charpentier, J. E. Childs (Epidemiology), K. H. Clark, J. G. Culhane, L. Curry (Public Health), R. D’Aquila, M. G. Dale, A. S. Darefsky, H. G. Dove, J. D. Dunn, A. J. Durante, P. D. Ehrenkranz, C. Fields, A. Foltz, B. Fontes, S. D. Geballe, B. D. Gifford, W. A. Gillespie, G. L. Ginsberg, C. H. Grantham-Millman, N. E. Groce (Epidemiology), J. F. Jekel (Public Health), B. Jennings, B. D. Kerker, K. Khoshnood (Epidemiology), P. J. Krause (Epidemiology), S. Langer, R. A. Lavely, M. Lee, L. S. Levin (Public Health), D. Li, J. R. Mande, L. G. Marc, R. Marcus, J. A. Mattera, S. M. Merz, L. M. Mueller, J. M. Mullen (Epidemiology), J. M. Mullen (Epidemiology), J. E. Otero, C. K. Pope, W. P. Quinn, T. W. Ruger, B. Schachtel, S. S. Spangler, J. A. Sparer (Medicine), D. E. Stevens, J. T. Stitt (Epidemiology), J. A. Stolwijk (Epidemiology and Public Health), M. H. Stowe (Medicine), P. H. Van Ness (Medicine), C. White (Public Health), D. Wild, K. A. Yonkers (Psychiatry), J. A. Zaccagnino, F. Zhao
The Department of Epidemiology and Public Health, which also functions as the nationally accredited Yale School of Public Health, offers a wide variety of courses across several divisions. Many of these are also available for medical student enrollment. The course catalogue and registration procedures may be obtained by contacting the YSPH Registrar’s Office.
Genetics
Office: SHM I308, 785.2649
Professors E. A. Adelberg (Emeritus), A. E. Bale, S. J. Baserga (Molecular Biophysics and Biochemistry), D. E. Brash (Therapeutic Radiology), W. R. Breg (Emeritus), L. Cooley, D. C. DiMaio, J. M. Eisenstadt (Emeritus), B. G. Forget (Medicine), J. E. Gelernter (Psychiatry), P. M. Glazer (Therapeutic Radiology), A. L. Horwich, P. B. Kavathas (Laboratory Medicine), K. K. Kidd, R. P. Lifton (Chair), H. Lin (Cell Biology), M. J. Mahoney, C. M. Radding (Emeritus), G. Roeder (Molecular, Cellular, and Developmental Biology), L. E. Rosenberg (Adjunct), M. R. Seashore, C. W. Slayman, S. Somlo (Medicine), J. B. Sweasy (Therapeutic Radiology), P. J. Tattersall (Laboratory Medicine), S. M. Weissman, T. Xu, H. Zhao (Public Health)
Associate Professors M. Brueckner (Pediatrics), K. Cheung (Medical Informatics), J. H. Cho (Medicine), J. R. Gruen (Pediatrics), V. Reinke, M. W. State (Child Study Center)
Assistant Professors A. J. Giraldez, M. Hammarlund, N. B. Ivanova, M. K. Khokha (Adjunct), T. Kim, P. Li, J. Lu, J. Noonan, Z. Sun, S. D. Weatherbee
Research Scientists W. A. Fenton, E. I. Golub, E. C. Goodwin, J. R. Kidd, E. T. Matloff, J. M. McGrath (Comparative Medicine), A. J. Pakstis, C. M. Radding
Associate Research Scientists L. M. Boyden, A. Canaan, G. W. Farr, S. Guo, A. M. Hudson, W. Ji, D. Li, T. Li, Z. Lian, J. Lian, Y. Lu, M. Lu, M. C. Mahajan, K. Mishra, D. N. Nguyen, D. Palejev, X. Pan, P. M. Rabinovich, J. J. Rinehart, A. M. Szekely, J. Wang, Y. Yasukochi, Y. You, J. Zhang, H. Z. Zhang
GENE 500b, Principles of Human Genetics A genetics course taught jointly for graduate students and medical students covering current knowledge in human genetics as applied to the genetic foundations of health and disease. A. Bale
GENE 603b/IBIO 603b, Teaching in the Science Education Outreach Program (SEOP) TAs, along with volunteers, teach three projects in Genetics to seventh-graders in two or three New Haven schools. In addition TAs take a short course on teaching and serve as science judges. For more details visit www.seop.yale.edu. P. Kavathas, at 785.6223
GENE 625a/MB&B 625a/MCDB 625a, Basic Concepts of Genetic Analysis The universal principles of genetic analysis in eukaryotes are discussed in lectures. Students also read a small selection of primary papers illustrating the very best of genetic analysis and dissect them in detail in the discussion sections. While other Yale graduate molecular genetics courses emphasize molecular biology, this course focuses on the concepts and logic underlying modern genetic analysis. T. Xu, A. Giraldez, T.H. Kim, M. Koelle, R. Lifton, S. Roeder
GENE 631a/BIS 631a, Topics in Genetic Epidemiology This course discusses the role of human genetics in epidemiology and public health, focusing on the epidemiology of Mendelian disorders and the genetic and environmental contributions to common, complex familial traits. Topics of discussion include (1) study designs for assessing the importance of genetic factors (population-based as well as family-based designs such as high-risk pedigrees and twin studies), (2) methods for determining mode of inheritance, and (3) the identification and mapping of genes through linkage analyses, candidate-gene approaches, genome-wide association studies, and admixture mapping. Applications of these approaches to clinical medicine are presented. Prerequisites: BIS 505a and BIS 505b (or equivalent) as well as course work in basic genetics. Hongyu Zhao, Elizabeth Claus, Kenneth Kidd
[GENE 642a/EMD 642a/MB&B 642a/MBIO 642a/MCDB 642a, Roles of Microorganisms in the Living World]
GENE 675, Graduate Student Seminar Students gain experience in preparing and delivering seminars and in discussing presentations by other students. A variety of topics in molecular, cellular, developmental, and population genetics are covered. Required for all second-year students in Genetics. Graded Sat/Unsat. J. Noonan and staff
[GENE 734a/MB&B 734a/MBIO 734a, Molecular Biology of Animal Viruses]
GENE 743b/MB&B 743bU/MCDB 743b, Advanced Eukaryotic Molecular Genetics Selected topics in regulation of gene expression, genome structure and evolution, signal transduction, and cellular physiology, development, and carcinogenesis. Prerequisite: biochemistry or permission of the instructor. A. Koleske, M. Hochstrasser, P. Sung
GENE 749a/MB&B 749aU, Medical Impact of Basic Science Consideration of examples of recent discoveries in basic science that have elucidated the molecular origins of disease or that have suggested new therapies for disease. Emphasis is placed on the fundamental principles on which these advances rely. Reading is from the primary scientific and medical literature, with emphasis on developing the ability to read this literature critically. Aimed at undergraduates. Prerequisite: MB&B 600a/601b or permission of the instructor. J. Steitz, E. De La Cruz, M. Hochstrasser, A. Miranker, L. Regan, P. Sung
GENE 777b/MCDB 677b, Mechanisms of Development This is an advanced course on mechanisms of animal development focusing on the genetic specification of cell organization and identity during embryogenesis and somatic differentiation. The use of evolutionarily conserved signaling pathways to carry out developmental decisions in a range of animals is highlighted. Course work includes student participation in critical analysis of primary literature, and a final research proposal term paper. V. Reinke, L. Cooley, X.-W. Deng, S. Holley, A. Monteiro, F. Slack, Z. Sun
GENE 840a,b, Medical Genetics Clinic Rotation. A clinical rotation offering medical and graduate students the opportunity to participate in the Genetic Consultation Clinic, genetic rounds, consultation rounds, and genetic analysis of clinical diagnostic problems. By arrangement with instructor. M. R. Seashore
GENE 901b/CBIO 901b/MCDB 901b, First-Year Introduction to Research Laboratory rotations, topic-based seminars for Molecular Cell Biology, Genetics, and Development (MCGD) track students. K. Reinisch, M. State
GENE 921a/b, Reading Course in Genetics and Molecular Biology Directed reading with faculty. Term paper required. Permission of Genetics DGS is required.
History of Medicine
Office: SHM L132, 785.4338
Professors D. Kevles (History), D. F. Musto (Child Study Center), F. Snowden (History), W. C. Summers (Therapeutic Radiology), J. H. Warner (Chair)
Associate Professors S. E. Lederer (Adjunct), N. Rogers
Assistant Professors P. Bertucci (History), B. J. Strasser
Research Affiliates T. A. Appel, C. A. Morgan (Psychiatry)
Lecturer N. Bhattacharya
Yale College and Graduate School courses open to medical students:
HSHM 235b/HIST 234b, Epidemics and Society in the West The impact of epidemic diseases such as bubonic plague, cholera, malaria, and aids on society, public health, and the medical profession in comparative and international perspective. Popular culture and mass hysteria, the mortality revolution, urban renewal and rebuilding, sanitation, the germ theory of disease, the emergence of scientific medicine, and debates over the biomedical model of disease. F. Snowden
HSHM 240a/HIST 121a/HUMS 307a, The Making of Modern Science, 1400–1800 The origins of Western scientific culture and its connections with curiosity, ingenuity, and artisanal knowledge. Key topics in the historiography of early modern science, including the scientific revolution and the trial of Galileo. P. Bertucci
HSHM 413a/HIST 145a, X-Ray Visions: Medical Imaging since 1895 The development of X rays, CT, MRI, ultrasound, and nuclear medicine. Their impact on diagnostic medicine, the legal system, and culture (high and low). Topics include the nature of invention—how new technologies appear; the economics of medicine in relation to technology; the role of warfare in invention; and the impact of these technologies on the arts. B. Kevles
HSHM 426a/HIST 148a, History of Astronomy An introduction to the history of astronomy from antiquity to modern times. The relationship between astronomy and astrology; visual representations in astronomy; astronomy, sociability, and gender. I. Dal Prete
HSHM 431b/HIST 146Jb/HUMS 474b, Science and Spectacle in the Enlightenment The central role of the human body in medical and experimental research; the spread of nonconventional therapies; the rise of a public culture of science; and attempts to naturalize gender roles. Focus on the Enlightenment. P. Bertucci
HSHM 461a/NELC 871au, Ancient Egyptian Medicine Development of medical thought, disease theory, and surgical technique in ancient Egypt from early pharaonic times until the Graeco-Roman periods. Close reading of texts in translation and secondary literature. H.W. Fischer-Elfert
HSHM 470a and 471b, Directed Reading Readings directed by members of the faculty in selected topics in the history of science or the history of medicine. Subjects depend on the interests of students and faculty. Weekly conferences; required papers. Staff
[HSHM 631bU, The Cultures of Western Medicine: A Historical Introduction]
HSHM 634aU/AMST 879aU/HIST 914aU, Media and Medicine in Modern America An exploration of the relationships among medicine, health, and the media in the United States from 1870 through the present. Focus on newspapers, magazines, professional journals, advertising, exhibitions, radio, film, television, and the Internet; and on interactions among researchers, health professions, medical and public health institutions, journalists, advocacy organizations, the state, industry, and the public. Topics include the changing role of the media in shaping conceptions of the body; creating new diseases; influencing health and health policy; crafting the image of the medical profession; informing expectations of medicine and constructions of citizenship; and the medicalization of American life. John Harley Warner, Gretchen Berland
HSHM 635bU/HIST 945bU, Science, Arms, and the State A history of chemical, nuclear, and biological weapons in the twentieth century that focuses on the integration in the United States of national security policy making, scientific research, and military innovation, including its consequences for the scientific community, the civilian economy, public attitudes toward weapons of mass destruction, and political movements to control them. D. Kevles
HSHM 639aU/HIST 913aU, American Medicine and the Cold War Examination of the social, cultural, and political history of American medicine, focusing on the period 1945–1960. Topics include the defeat of national health insurance; racism in health care, including “separate but equal” hospital policy; patient activism especially among mental health and leprosy inmates; the role of gender in defining medical professionalism and family health; rise of atomic medicine; McCarthyism in medicine; and the polio vaccine trials and the making of science journalism. N. Rogers
[HSHM 640aU, Molecules, Life, and Disease in the Twentieth Century]
HSHM 647bU/HIST 906bU, Medicine and Public Health in Latin America, 1820–2000 Surveys the history of medicine in Latin America from Independence to the present, focusing on the relationships of disease and public health with the construction of state and nation in the countries of the region. Themes include medicine’s role in the production and reproduction of race and ethnicity, the treatment of indigenous medical traditions, the sources and consequences of international disease-control efforts, and persisting inequalities in health and health care. M. Espinosa
HSHM 648aU/HIST 910aU, Health and Medicine in Modern Britain, 1850–1990 This lecture course surveys the development of modern medical institutions and practice in the context of economic, political, and social change in modern Britain. It examines the impact of industrialization, urbanization, and demography effects on the practice and institutions of sanitation and preventive medicine; changing relationships between doctors and patients and between individuals and medical institutions such as hospitals and asylums; and the emergence of scientific medicine, bacteriology, and parasitology. Topics include the relationship between late Victorian science and eugenic theories of degeneration; the impact of the two World Wars on British medicine and surgery; and the establishment of the National Health Service in postwar Britain. N. Bhattacharya
HSHM 649bU/HIST 911bU, State Medicine in Colonial India, 1850–1947 This lecture course examines the infrastructure of public health and western medical institutions in colonial India, and focuses on Indian responses to colonial medical policies; the ideological and political influences in health policy; the institutionalization of western medicine and sanitary ideals; and the implementation and responses to western ideals of public health in a colonial society. Topics include colonial governance and the question of health; the institutionalization of the Indian Medical Service; public health training in medical colleges; the emergence of tropical medicine; epidemic control of plague and cholera; medicine and religion; and Gandhi and the critique of western civilization. N. Bhattacharya
HSHM 650au/HIST 908au, Medicine and Colonialism in Modern Asia This seminar explores the history of modern medicine in colonial Asia, including South Asia (India, Sri Lanka, Bangladesh, Pakistan) and southeast and east Asia (Malay Straits, Philippines, Sumatra, Hong Kong). It examines western medical institutions and practices such as colonial medical services; hospitals; town planning and urbanization; the theories and construction of diseases of the tropics such as tropical neurasthenia; colonial discourse on race and disease; and the implementation of international health programs in tropical countries in the twentieth century. N. Bhattacharya
HSHM 651bu/HIST 909bu, Race, Disease, and Medical Geography in the British Empire This seminar examines the histories of colonization, settlement, race, and habitation in the British Empire from the eighteenth to the twentieth century. We study discourses of climate and medical geography in the eighteenth century; race and miscegenation in the British Empire in the nineteenth century; British debates concerning acclimatization and settlement in the tropical colonies; European concerns about racial degeneration; and ecologies of tropical diseases. N. Bhattacharya
[HSHM 670bU, Magic Bullets and Wonder Pills]
HSHM 676a/HIST 938a/LAW 20441, The Engineering and Ownership of Life This seminar explores the history of intellectual innovation and intellectual property protection in living matter. Focusing on the United States in world context, it examines arrangements outside the patent system as well as within it. Topics include agriculture, medicine, biotechnology, and law. May be taken as a reading or research course. D. Kevles
HSHM 677bU/AMST 882bU/HIST 939bU, Genetics, Reproduction, and Society A history of modern biology, especially evolution, genetics, and molecular biology, within its social, economic, legal, and cultural context. Topics include eugenics and sterilization, the Scopes trial, contraception and abortion, new reproductive technologies, medical genetics, the Human Genome Project, and human cloning. D. Kevles
[HSHM 680bU, History of Chinese Science]
HSHM 701a/HIST 930a, Problems in the History of Medicine An examination of the variety of approaches to the social and cultural history of medicine. Readings are drawn from recent literature in the field, sampling writings on health care, illness experiences, public health, and medical cultures in Europe, the Americas, Africa, and Asia from antiquity to the twentieth century. Topics include the role of gender, class, ethnicity, race, religion, and region in the experience of health care and sickness; the intersection of lay and professional understandings of the body; and the role of the marketplace in shaping professional identities and patient expectations. John Harley Warner
HSHM 702b/HIST 931b, Problems in the History of Science Study of secondary literature, recent and older, in the history of the physical and life sciences from the Renaissance to the early twentieth century. Students acquire familiarity with the development of science in general and of its major branches, including its content, instruments and methods, and social-institutional settings, and an acquaintance with various approaches that historians have followed in interpreting these events. Paola Bertucci
[HSHM 706a, Collecting Nature]
HSHM 710a/HIST 921a, Methods for the Social Studies of Science, Technology, and Medicine Exploration of the methods and debates in the social studies of science, technology, and medicine. This course covers the history of the field and its current intellectual, social, and political positioning. It emphasizes the debates on constructivism and relativism, and provides critical tools to address the relationships among science, technology, medicine, and society. Paola Bertucci
[HSHM 715a, Science and Travel: Collections, Explorations, and Networks]
HSHM 730a/HIST 905a, Disease and Medicine in the Caribbean, 1492–2000 Readings on the interactions of medicine and disease with the social, economic, cultural, political, and military histories of the Caribbean region from 1492 to the present. Topics include the Columbian exchange and demographic collapse; the connections between race, slavery, and disease; the role of disease in the loss and gain of empire; the influence of U.S. public health policies; and the Cuban health care system since the Revolution. Mariola Espinosa
[HSHM 736b, Health Politics, Body Politics]
[HSHM 740b, The Cultures of American Medicine]
HSHM 741a/HIST 915a, Science and Religion: A Historical Perspective This course provides a historical perspective on the relationship between science and religion. It analyzes their complex intertwining from antiquity to modern Europe and America, with particular emphasis on Latin and Islamic middle ages, Renaissance astrology and cosmology, chronology and the geological sciences, embryology and evolutionism. Ivano Dal Prete
HSHM 742b/HIST 917b, Life Sciences in Early Modern Europe This course explores the multifaceted world of medical and biological research between the Renaissance and the end of the eighteenth century. Emphasis is placed on the role of medical knowledge in the scientific revolution, the development of microscopy and instrument-making, and social and cultural issues raised by debates on animal and human generation. Ivano Dal Prete
HSHM 914a or b, Research Tutorial I By arrangement with faculty.
HSHM 915a or b, Research Tutorial II By arrangement with faculty.
HSHM 919b/HIST 940b/WGSS 732b, Research in Twentieth-Century U.S. Health, Medicine, and the Body Research seminar in twentieth-century U.S. health, medicine, and the body, with primary focus on each student completing her/his own major research paper. Projects chosen from post-Civil War period, with emphasis on the twentieth century. Class sessions also explore research techniques, writing styles, and the interrogation of sources. Naomi Rogers
HSHM 920a or b, Independent Reading By arrangement with faculty.
HSHM 930a or b, Independent Research By arrangement with faculty.
In addition to formal course offerings and tutorials offered in the School of Medicine, Yale College, and the Graduate School, section activities in the History of Medicine are supplemented by a number of related historical medical programs. Colloquia in the History of Science and Medicine are held fortnightly and are open to the School of Medicine community. The section sponsors an annual Frederic L. Holmes Lecture, and the Department of Surgery sponsors the annual Samuel Clark Harvey Memorial Lecture. The Nathan Smith Club, which annually awards the John F. Fulton Memorial Award, is composed of medical students interested in medical history who assemble monthly in the homes of various faculty. The Beaumont Medical Club, founded at Yale in 1920, sponsors six lectures in the History of Medicine during the academic year and annually selects a Beaumont Lecturer and a George Rosen Lecturer in the History of Medicine. Section faculty are available for M.D. thesis supervision.
The section faculty work with the Department of History to offer a Ph.D. program in the History of Science and Medicine. In addition, there is an M.A. program designed particularly for those who plan to combine teaching or scholarship in these fields with a professional career in medicine or the life sciences. For further information concerning admissions and the program itself, consult the Graduate School bulletin.
Immunobiology
Office: TAC S531, 785.3857
Professors J. R. Bender (Medicine), A. L. Bothwell, H. Bottomly (Emeritus), J. E. Craft (Medicine), P. Cresswell, M. V. Dhodapkar (Medicine), J. A. Elias (Medicine), R. A. Flavell (Chair), S. Ghosh (Adjunct), K. Herold, P. B. Kavathas (Laboratory Medicine), R. M. Medzhitov, J. S. Pober, J. S. Pober, D. G. Schatz, M. J. Shlomchik (Laboratory Medicine), R. E. Tigelaar (Dermatology)
Associate Professors A. Iwasaki, E. R. Meffre, W. D. Shlomchik (Medicine), B. Su
Assistant Professors T. H. Chi, S. Kaech
Senior Research Scientist H. Bottomly
Research Scientist E. E. Eynon
Associate Research Scientists V. Ablamunits, M. Ciubotaru, P. R. Clark, W. Cui, D. Hawiger, O. I. Henegariu, H. Huang, Y. Huang, W. Ip, Y. Ji, M. Kamanaka, I. Kawikova, N. C. Kirkiles-Smith, E. B. Kopp, J. H. Li, M. Liu, T. D. Manes, Y. Nakayama, Y. Suarez, M. M. Wan, P. A. Wearsch, B. Yatsula, T. Yi
Lecturers J. W. Huleatt, I. Mills
For a complete listing of BBS courses, see http://info.med.yale.edu/bbs/
IBIO 100a, Immunology for Students of Medicine Immunology and its application to clinical situations. 12 hours lecture, 8 hours tutorials
IBIO 530a/MCDB 530a, Biology of the Immune System The development of the immune system. Cellular and molecular mechanisms of immune recognition. Effector responses against pathogens. Human diseases including allergy, autoimmunity, immunodeficiency, HIV/AIDS. A. Iwasaki
IBIO 531b, Advanced Immunology The historical development and central paradigms of key areas in immunology. The course attempts to develop a clear understanding of how these paradigms were established experimentally. Landmark studies are discussed to determine how the conclusions were obtained and why they were important at the time they were done. Lecture and discussion format; readings of primary research papers and review articles. Prerequisite: Immunobiology 530a or equivalent. Enrollment limited to 15. T. Chi and staff
IBIO 538b, Advanced Immunology Seminar: B Cell Development David Schatz, Eric Meffre, Mark Shlomchik
IBIO 600a, Introduction to Research Introduction to the research interests of the faculty. Required for all first-year BBS Immunology Track students. Pass/Fail. A. Bothwell and staff
IBIO 601b, Fundamentals of Research Seminar discussing proper conduct of research. Required for first- and second-year Immunobiology students. A. Bothwell and staff
IBIO 603b/GENE 603b, Teaching in the Science Education Outreach Program (SEOP) TAs, along with volunteers, teach three projects in Genetics to seventh-graders in two or three New Haven schools. In addition, TAs take a short course on teaching and serve as science judges. Dates and times to be determined. For more details visit www.seop.yale.edu. BBS teaching credit. P. Kavathas
Internal Medicine
Office: LMP 1072, 785.4119
Professors R. J. Alpern, F. Altice, V. A. Andriole (Emeritus), P. S. Aronson, P. W. Askenase, W. P. Batsford, J. R. Bender, N. Berliner (Adjunct), M. J. Bia, F. J. Bia (Emeritus), H. J. Binder (Emeritus), L. K. Bockenstedt, P. K. Bondy (Emeritus), J. L. Boyer, A. E. Broadus, R. Bucala, G. N. Burrow (Emeritus), H. S. Cabin, C. Canessa (Cellular and Molecular Physiology), L. G. Cantley, E. Chu, M. W. Cleman, L. S. Cohen (Emeritus), D. L. Coleman (Emeritus), J. P. Concato, H. O. Conn (Emeritus), L. M. Cooney, L. M. Cooney, D. L. Cooper, D. L. Cooper, J. Costa (Pathology), J. E. Craft, G. V. Desir, V. T. DeVita, V. T. DeVita, M. V. Dhodapkar, T. P. Duffy, S. C. Edberg (Laboratory Medicine), J. A. Elias (Chair), D. G. Federman, E. Fikrig, R. L. Fisher, B. G. Forget, J. N. Forrest, F. M. Foss, T. R. Fried, G. Friedland, R. S. Galvin (Adjunct), G. Garcia-Tsao, J. B. Gee (Emeritus), R. H. Gifford (Emeritus), T. M. Gill, J. A. Goffinet (Emeritus), F. Gorelick, R. J. Groszmann (Emeritus), J. P. Hayslett (Emeritus), K. Herold (Immunobiology), W. J. Hierholzer (Emeritus), N. J. Holbrook (Adjunct), E. S. Holmboe (Adjunct), R. I. Horwitz (Emeritus), J. S. Hughes, S. J. Huot, S. Inouye (Adjunct), K. L. Insogna, S. E. Inzucchi, C. Jaffe (Emeritus), F. S. Kantor, C. R. Kapadia, W. N. Kernan, H. M. Krumholz, F. A. Lee, R. J. Levine, H. Levitin (Emeritus), R. P. Lifton (Genetics), T. J. Lynch (Chair), R. L. Mahnensmith, S. E. Malawista, M. J. Mamula, J. C. Marsh (Emeritus), J. C. Marsh (Emeritus), R. A. Matthay, R. A. Matthay, P. K. Mistry (Pediatrics), V. Mohsenin, M. H. Nathanson, P. G. O’Connor, P. A. Preisig, D. D. Proctor, V. J. Quagliarello, A. Rastegar, C. Redlich, F. F. Richards (Emeritus), H. M. Rinder (Laboratory Medicine), S. H. Rosenbaum (Anesthesiology), R. S. Sherwin, G. I. Shulman, M. Simons, A. J. Sinusas, B. R. Smith (Laboratory Medicine), S. Somlo, R. Soufer, H. M. Spiro (Emeritus), M. Strazzabosco (Adjunct), M. Sznol, L. Tanoue, M. E. Tinetti, E. Ullu, F. S. Wright, J. J. Wysolmerski, L. H. Young, B. L. Zaret
Associate Professors A. K. Abu-Alfa, N. R. Angoff, H. R. Aslanian, J. M. Baehring (Neurosurgery), D. Beardsley (Pediatrics), G. K. Berland, D. C. Biemesderfer, R. S. Braithwaite, D. M. Bravata (Adjunct), J. Brennan, J. H. Cho, G. L. Chupp, G. W. Cline, H. Cohen (Adjunct), L. E. Cohn, S. T. Crowley, L. Dembry, M. P. DiGiovanna, M. P. DiGiovanna, J. A. Dranoff, M. A. Drickamer, J. Evans, D. A. Fiellin, R. N. Formica, A. H. Fortin, L. Fraenkel, F. J. Giordano, D. R. Goldstein, M. L. Green, C. P. Gross, B. I. Gulanski, L. N. Harris, L. N. Harris, S. G. Haskell, J. B. Henrich, R. J. Homer (Pathology), D. Jain (Pathology), P. A. Jamidar, E. A. Jonas, A. C. Justice, I. Kang, B. I. Kazmierczak, W. K. Kelly, W. K. Kelly, J. E. Kerstetter (Adjunct), H. Kluger, M. J. Kozal, J. Lacy, J. Lacy, R. J. Lampert, C. Lee, P. Lee, Y. Liu, S. Mark (Adjunct), P. Marks, R. A. Marottoli, R. L. McNamara, W. Z. Mehal, A. B. Nagar, C. R. Parikh, A. J. Peixoto, M. A. Perazella, K. F. Petersen, S. E. Pfau, P. M. Rabinowitz, A. B. Reisman, M. S. Remetz, M. O. Rigsby, M. E. Robert (Pathology), C. Rochester, M. G. Rose, M. G. Rose, L. E. Rosenfeld, K. S. Russell, R. R. Russell, M. B. Russi, M. M. Sadeghi, M. Sadigh, M. W. Saif, M. W. Saif, M. Schilsky, S. E. Seropian, S. E. Seropian, J. F. Setaro, A. C. Shaw, W. D. Shlomchik, W. D. Shlomchik, M. D. Siegel, A. N. Sofair, L. Solomon, R. Sutton, M. Sznol, A. V. Wisnewski, Z. Yin (Adjunct)
Assistant Professors C. Abraham, M. M. Abu-Khalaf, M. M. Abu-Khalaf, D. R. Anderson, D. E. Antin-Ozerkis, W. S. Asch, L. C. Barry, I. M. Birnbaum (Adjunct), J. S. Bogan, A. J. Borad, J. B. Braunstein (Adjunct), G. R. Brescia, D. Brissette, R. D. Bruce, H. Cain, B. C. Cambi, S. S. Cha (Adjunct), H. H. Chao, S. I. Chaudhry, J. Chen, G. G. Chung, G. G. Chung, C. Chung, L. Chwastiak (Psychiatry), J. F. Clancy, K. A. Crothers, J. P. Curtis, N. K. Dahl, H. A. Deshpande, B. R. Doolittle, D. W. Dunne, P. J. Ellis, M. S. Ellman, L. E. Fiellin, C. A. Fragoso, J. S. Francis, R. L. Garcia, A. Garino, D. S. Geller, I. Genao, S. N. Gettinger, S. N. Gettinger, R. Gonzalez-Colaso, M. Gulati, C. G. Gunderson, S. F. Hay, J. Herrin (Adjunct), E. L. Herzog, J. J. Hill, E. H. Holt, S. Honiden, L. I. Horwitz, C. J. Howes, A. B. Imaeda, S. Ishibe, Y. Iwakiri, F. Jadbabaie, S. Jeffery (Adjunct), G. Y. Jenq, M. Juthani-Mehta, S. S. Kashaf, R. G. Kibbey, H. Kluger, R. Koski (Adjunct), J. D. Kravetz, P. Kumar, G. J. L’Italien (Adjunct), J. J. Lee, J. J. Lee, L. Lee, J. K. Lim, L. E. Lincoln, F. M. Lobo, C. S. Loeser, C. M. Macica, A. Mani, P. S. Marshall, R. A. Martinello, J. R. McArdle, R. J. McCrimmon, K. C. McKenzie, E. C. McNay (Adjunct), B. P. Mobo, J. P. Moriarty, V. A. Morris, N. D. Nanda, M. Nunez-Smith, P. Oray-Schrom, M. A. Pisani, D. Psyrri, D. Psyrri, J. T. Puchalski, T. E. Quan, R. A. Rienzo, J. P. Rising (Adjunct), J. R. Rosenbaum, F. J. Roux, C. B. Ruser, S. Russo, C. J. Sakr (Adjunct), V. T. Samuel, J. R. Satchell-Jones, S. M. Schnittman (Adjunct), A. R. Schwartz, A. Sheth, W. D. Shlomchik, W. D. Shlomchik, U. Siddiqui, J. M. Siner, J. F. Spelman, S. A. Springer, L. G. Suter, E. S. Swenson, T. H. Taddei, O. A. Taiwo, J. M. Tetrault, D. G. Tobin, T. K. Trow, A. Vashist (Adjunct), L. S. Vasquez, G. Vorobiof, G. Vorobiof, K. Wagner, L. M. Walke, Y. Wang (Adjunct), M. L. Warner, J. M. Weber, A. C. Weihl, L. M. Whitman, D. M. Windish, R. Worthington (Adjunct), J. Xu, H. K. Yaggi
Instructors K. M. Akgun, Y. Auguste, S. Coca, E. J. Edelman, S. Halene, M. Harma, F. Hasan, S. R. Holt, H. Jain, N. Kim, C. M. Kwong, C. Louis-Ashby, B. J. Malm, E. I. Mandel, T. Moin, T. A. Molisse, M. Murakami, S. Nikiforow, M. Padda, C. Partovian, P. Protiva, Y. Qyang, T. Sallam, R. Scandrett, J. Stoehr, R. P. Streeter, D. Tirziu, E. Wang, S. H. Wrzesinski
Senior Research Scientists H. J. Binder, L. S. Cohen, R. J. Groszmann, P. W. Heald (Dermatology), H. Levitin, P. McPhedran, R. R. Montgomery, W. M. Philbrick, F. F. Richards, C. J. Soroka, F. J. Wackers, F. J. Wackers, C. K. Wells, L. Wen
Research Scientists H. G. Allore, D. I. Baker, J. D. Dziura, R. E. Hendler, L. Leng, S. Narasimhan, J. C. Schmitz, H. Velazquez, C. M. Viscoli, Z. Zhuang
Associate Research Scientists S. Alfano, M. Aslan, D. E. Befroy (Diagnostic Radiology), A. A. Belperron, Y. Cai, S. Cai, O. Chan, J. J. Chang, J. Choi, R. Cong, A. K. Coskun, C. A. Da Silva, N. De Rekeneire, Y. Deng, K. Dong, H. A. Doyle, E. Drye, J. D. Dziura, R. Fiorotto, H. G. Foellmer, A. Gallagher, G. N. Gathungu, L. Geng, J. L. Goulet, M. T. Guerra, X. Guo, J. Guo, W. K. Gurr, M. Hao, C. H. He, M. Hedl, R. I. Herzog, Y. Huang, Z. Jiang, R. Ju, M. Kang, K. Kim, M. N. Krishnan, T. C. Kyriakides, A. A. Lanahan, W. Lee, L. Lei, H. Li, G. Li, H. Li, M. Li, Q. Liu, T. Liu, D. Liu, B. Ma, R. Mamillapalli, K. M. Mattocks, G. J. McAvay, T. E. Murphy, Y. Ning, T. Z. O’Connor, R. K. Papas, J. Pedra, S. Radke, M. Razavian, J. M. Rhodes, M. M. Shaw, C. Spirli, A. G. Sreih, M. H. Stowe, M. P. Strout, F. A. Struve, B. Sun, N. Tai, N. Tai, L. Tang, J. Tao, R. B. Thomson, E. C. Thrower, X. Tian, J. N. Van Houten, P. H. Van Ness, M. V. Volkova, L. Wan, P. Wang, Z. Wang, Y. Wang, M. Yang, T. Yarovinsky, Z. Ye, K. Yu, J. Yu, J. Zhang, P. Zhang, X. Zhang
Research Affiliates A. Arjona, A. Elfiky, S. Faramarzi, R. Marfatia
Clinical Professors J. Alexander, S. J. Angelo, J. Belsky, J. B. Borak (Epidemiology), J. M. Boyce, M. H. Brand, E. Citkowitz, K. L. Cohen, N. Dainiak, J. W. Dobbins, L. R. Farber, F. O. Finkelstein, D. S. Fischer, M. H. Floch, L. Friedman, P. N. Herbert, A. S. Kliger, N. J. Marieb, C. A. McPherson, M. Moser, D. N. Podell, R. T. Schoen, M. H. Schoenfeld, C. B. Seelig, C. B. Sherter, R. J. Vender, S. M. Winter, B. J. Wu
Associate Clinical Professors J. R. Anthony, S. Aronin, S. A. Atlas, T. J. Balcezak, L. A. Barakat, M. C. Bennick, S. N. Bobrow, S. T. Bogardus, S. D. Brenner, G. K. Buller, M. M. Burg, J. P. Cleary, L. E. Cohn, F. Comite, E. L. Cooney, W. B. Crede, G. Dillard, C. A. Disabatino, K. J. Dobuler, A. B. Douglass, S. M. Epstein, E. L. Etkind, J. M. Fessel, J. J. Garsten, D. I. Geisser, R. A. Gelfand, J. Gerber, M. P. Golden, A. V. Granata, J. M. Grant, L. E. Grauer, T. P. Greco, F. D. Haeseler, H. L. Haronian, H. L. Haronian, K. A. Hutchinson, G. J. Hutchinson, R. M. Jarrett, S. G. Jones, S. W. Kingsley, S. J. Kra, J. D. Lawrason, A. Lebowitz, A. L. Levy, A. L. Levy, M. Litchman, W. S. Long, W. B. Lundberg, R. W. Lyons, C. A. Manthous, E. P. Mardh, A. M. Marino, A. B. Mayerson, E. M. Mazur, R. M. McLean, T. P. Meehan, I. D. Mickenberg, D. J. Miller, E. D. Moritz, S. J. Moses, P. B. Nussbaum, P. N. Peduzzi, J. M. Perlotto, J. L. Renda, N. J. Rennert, J. H. Revkin, J. R. Sabetta, M. L. Schwartz, A. L. Silber, M. F. Simms, D. S. Smith, L. Solomon, G. A. Sprecace, J. F. Sullivan, H. L. Taubin, F. J. Troncale, E. Vosburgh, J. J. Votto, S. B. Weissman, S. Wolfson, S. W. Zarich
Assistant Clinical Professors R. M. Aaronson, G. G. Abdelsayed, A. J. Accomando, E. D. Agin, R. Ahmadi, Y. Amoateng-Adjepong, C. A. Arnold, P. Asiedu, J. M. Banatoski, A. Bedford, A. M. Bekui, C. A. Berken, L. Berman, J. M. Blumberg, N. A. Bonheim, R. S. Borrus, L. Bridger, J. A. Brier, D. Brock, C. M. Brunet, L. Burgo-Black, A. R. Cadariu, C. A. Caldwell, B. J. Chan, D. M. Chess, J. O. Cho, L. M. Chou, J. J. Chuong, M. I. Chustecki, M. A. Ciampi, P. K. Clarke, G. M. Cohen, M. Cohen, J. D. Cooper, R. B. Cooper, J. A. Cosgriff, A. J. Cusano, S. B. D’Cunha, M. A. Demetrius, D. Desir, V. C. Dicola, J. T. Dreznick, M. H. Driesman, D. J. Eilbott, T. D. Eisen, J. M. Elser, J. J. Ernstoff, N. Fahmi, E. Fan, I. Feintzeig, D. Fine, S. M. Fink, A. F. Fisher, F. A. Flatow, F. A. Flatow, J. F. Flint, R. S. Folman, M. J. Franco, L. A. Freed, T. M. Fynan, J. E. Gage, L. S. Galante, P. N. Geimer, P. Genecin, R. S. Generoso, B. J. Gerstenhaber, A. E. Ghantous, H. C. Gift, E. M. Ginsberg, P. M. Ginsburg, P. A. Goldberg, S. M. Gordon-Dole, A. B. Gorelick, D. I. Grayer, J. A. Green, M. S. Grogan, E. M. Grubman, M. S. Guoth, T. K. Gupta, K. A. Haedicke, L. W. Hammers (Diagnostic Radiology), J. H. Hansson, H. L. Haronian, J. K. Henchel, D. G. Hill, C. F. Hollander, D. Hollister, F. Homayounrooz, X. Hong, K. J. Hunt, R. G. Huntley, J. Iannarone, C. D. Illick, S. S. Jacoby, P. E. Jaffe, P. M. Jenei, L. Jung, H. P. Kaplan, K. A. Kaplove, M. E. Katz, R. E. Kaufman, R. D. Kayne, M. A. Kazakoff, J. M. Kenkare, G. J. Kerins, H. Knight, H. M. Kramer, C. R. Kramer, M. L. Kraus, S. H. Kunkes, S. P. Lagarde, S. Lam, G. I. Lancaster, R. A. Lanzi, U. Latif, R. E. Lebson, R. J. Lewis, H. M. Likier, L. S. Lim, R. I. Lovins, J. A. Magaldi, M. A. Mankus, M. E. Mann, M. A. Marieb, B. A. Martell, V. Martin, U. Masiukiewicz, S. W. McCalley, R. J. McDonald, K. C. McKenzie, C. C. McNair, C. F. McNamara, S. G. Menon, J. A. Merritt, K. Michels-Ashwood, S. P. Mickley, D. T. Miller, E. A. Mirabile-Levens, J. Morris, M. M. Munteanu, J. I. Nadelmann, R. J. Nardino, H. Nawaz, A. M. Nelson, E. A. Nolfo, R. Nudel, S. P. O’Mahony, E. Obeid, G. Oliver, B. R. Olson, J. A. Orell, J. R. Ouellette, W. T. Panullo, L. A. Panzini, W. N. Pearson, B. Peck, P. E. Pertel, W. R. Petricone, D. Phanumas, B. M. Priest, P. H. Pronovost, H. L. Quentzel, H. H. Reinhart, C. R. Rethy, N. I. Riegler, B. Ringstad, B. A. Roach, D. Rocklin, D. Roer, P. R. Rogol, S. D. Rossner, M. C. Rubinstein, K. D. Sabbath, D. M. Sack, R. T. Sadock, O. V. Sakharova, J. A. Salvana, L. Sanders, S. Sandur, C. B. Sankey, S. L. Saunders, R. R. Savino, A. Schaffner, G. S. Schleiter, J. A. Schmierer, H. M. Schwartz, A. O. Seltzer, J. Seltzer, N. Shah, M. L. Sher, J. M. Shi, W. Y. Shih, R. S. Silverman, K. S. Sinusas, M. L. Skluth, A. R. Skopek, M. J. Smith, R. M. Stark, M. A. Stehney, S. D. Stocker Giles, B. C. Swirsky, T. Taylor, B. S. Thomas, J. Toksoy, J. Tomanelli, J. E. Topal, R. Torres, D. H. Trock, K. J. Twohig, J. G. Uberti, H. D. Uderman, R. Umashanker, S. Varano, G. S. Varbaro, M. D. Virata, C. A. Walters, H. Ward, W. S. Warren, R. B. Wein, J. J. Weiner, D. A. Weinshel, A. C. Wells, K. P. White, K. P. White, H. S. Wilkes, D. M. Wolfsohn, A. Wormser, K. H. Yang, J. Yu, M. Zain, C. S. Zalis, J. S. Zaretzky, J. S. Zesk, F. R. Zwas
Clinical Instructors O. T. Akande, R. G. Ali, O. Aliyu, S. A. Alston, L. Ameti, G. R. Angstreich, V. S. Argento, S. Asefaw, H. H. Atkins, P. Bahuguna, S. Banerjee, K. M. Baran, S. M. Bernheim, R. D. Black, M. E. Blam, A. P. Blanco, S. J. Blander, M. L. Blitzer, J. J. Bowen, T. Braverman, R. Breier, J. A. Brunetti, D. M. Buonocore, D. M. Buonocore, L. L. Calo, A. W. Camp, H. Carey, E. M. Carlson, K. D. Carr, D. L. Casey, S. B. Chabria, J. P. Chandler, V. A. Chang, J. J. Chang, E. H. Chanko, C. Chen, J. M. Chua-Reyes, P. R. Cimino, T. M. Clarke, S. Coca, D. L. Copen, R. Cordido, W. L. Cushing, L. J. Cuzzone, S. A. D’Souza, M. L. Dam, A. R. Datunashvili, J. D. Demayo, S. Dey, P. Dhawan, T. A. Doherty, T. A. Doherty, D. H. Dumont, A. M. Dunn, C. M. Edelmann, D. J. Edwards, R. Elias, J. Estrada, D. E. Evans, S. J. Farber, E. H. Francois, J. H. Fullerton, G. Gangu, M. W. Garber, H. B. Garfinkel, V. Gassman, R. D. Gibbs, C. E. Glass, G. Goldenberg, P. C. Greco, G. A. Guadagnoli, S. S. Hahn, W. B. Hale, C. M. Hamill, J. M. Hammond, D. J. Hass, J. Hauser, G. Henry, J. C. Hlawitschka, S. M. Hoq, J. Huang, L. J. Huang, O. T. Imevbore, B. A. Indeck, D. L. Jacoby, K. Joshi, V. Joshi, M. Juthani-Mehta, C. Kalser, S. V. Kanade, J. A. Kane, G. Kelley, J. D. Kenkare, D. C. King, Y. Kiyota, L. Knoll, A. Kohli-Pamnani, A. A. Kramer, E. D. Kulaga, M. E. Kulaga, S. J. Kwon, M. Lataillade, M. Lee, T. H. Liao, E. Liben, C. R. Libertin, F. A. Loria, C. P. Loscalzo, M. D. Marcus, K. McArthur, C. J. Michos, J. D. Miller, C. Mindru, C. B. Mittleman, N. Mobashery, B. P. Mobo, D. Moll, B. T. Montague, R. F. Morrison, A. S. Murray, K. G. Nair, G. J. Napolitano, E. R. Nash, S. Nawaz, K. K. Nelson, H. C. Nolasco, S. N. Novack, C. Nwangwu, C. J. O’Connor, K. Olson, M. Orias, J. R. Orlinick, O. I. Otolorin, W. W. Paramanathan, T. E. Pellechi, J. R. Perry, A. A. Peterson, J. F. Pezzimenti, L. Pham, K. C. Pham, L. J. Phillips, V. Popov, P. T. Porello, S. E. Possick, D. T. Price, H. R. Pun, N. G. Ragovis, S. Raissi, R. F. Ramos, M. Rho, A. J. Rodriguez, R. R. Rohatsch, L. S. Rome, L. S. Rome, S. E. Rosener, M. Rosenthal, S. T. Rottinghaus, S. R. Rubenstein, J. Samuel, S. M. Santana, K. A. Schneider, M. B. Schwartz, K. V. Schwartz, A. E. Selkin, S. Sharma, J. F. Shea, B. V. Sheynberg, G. P. Shields, B. A. Skudlarska, M. L. Smith, D. N. Smith, G. Spivack, D. C. Stair, R. H. Stember, K. P. Swan, A. Taneja, G. F. Tansino, M. B. Taylor, J. A. Testa, T. Thomas, M. K. Tighe, V. B. Tola, J. E. Topal, C. G. Torres-Viera, P. C. Tortora, M. C. Trager, G. E. Tratt, J. S. Urbanetti, C. Vaid, D. J. Van Rhijn, I. Vashist, J. S. Waldman, O. G. Weis, S. C. Widman, D. H. Witt, A. Yee, F. Zarcu-Power, R. A. Zlotoff
Lecturers D. Acampora, L. Alaparthi, F. D. Alfano, A. Alfirii, S. K. Apgar, W. H. Arend, M. Barnes, M. R. Bernbach, R. J. Brandenburg, M. Chomiak, S. A. Cohen, R. M. Cohen, M. S. Cook, M. B. Courtney, K. E. Dahl, M. Derosa, D. L. Dobkin, G. Draper-Ralls, W. J. Farrell, G. E. Ferrucci, M. J. Finnegan, M. S. Habboosh, E. J. Hamilton, J. P. Hauptman, J. Honig, P. R. Huvelle, K. G. Kett, J. A. Leach, M. S. Lee, R. Leventhal, P. G. Levinson, E. Lu, G. Lucas, A. J. McCabe, S. McGarvey, D. McGowan, K. Nix, J. J. O’Connell, J. K. Pacini, S. Pasha, A. E. Perrin, J. L. Quaranta, A. Radebold, R. S. Rhee, R. T. Rozett, V. Sawicki, M. D. Simmons, M. D. Slade, J. A. Sparer, A. J. Stannard, M. E. Stoklosa, L. Street, Y. Wang, J. Yerzak
Internal Medicine 103, Core Medicine Clerkship The Internal Medicine Clerkship comprises three one-month rotations: Hospital Medicine I, Hospital Medicine II, and Ambulatory Medicine. Students are assigned to complete these rotations in a specific order determined by the clerkship directors. During the Hospital Medicine clerkships, students serve as clinical clerks at participating hospitals. Students interview and examine patients, write admission and progress notes, and work with medical teams in the care of patients. Between Hospital Medicine I and Hospital Medicine II, students receive graduated responsibility for patient care. Conferences and teaching rounds are held daily. During the Ambulatory Medicine component of the clerkship, students complete a curriculum including general medicine practice, subspecialty practice, and classroom instruction. Clinical preceptors enable students to have an active part in patient evaluation and treatment commensurate with each student’s experience and capability. Students interview and examine patients, develop differential diagnoses, present to preceptors, discuss treatment with patients, and write visit notes. At all clinical sites, students routinely telephone patients in follow-up. The overall course director is J. McArdle. The director for the ambulatory component is W. N. Kernan, Jr. Clinical precepting and classroom teaching involves over 100 physicians in the Department of Medicine.
Internal Medicine 122, Endocrine Clerkship The student participates as an active member of the endocrine training program, making daily rounds with the endocrine fellows, residents, and attending physicians. Inpatient consultation, a variety of endocrine clinics, and regularly scheduled metabolism-endocrine conferences are part of the rotation. Full time for three weeks. Offered during elective time. Limited to two students at a time throughout the year. J. Bogan, A. E. Broadus, B. Gulanski, R. G. Hendler, E. H. Holt, K. L. Insogna, S. Inzucchi, R. S. Sherwin, G. I. Shulman, J. Wysolmerski
Internal Medicine 123, Renal Clerkship This clerkship in clinical nephrology offers the student an opportunity for in-depth learning regarding problems in fluid and electrolyte disturbances, acute renal failure, chronic renal failure, and hypertension. Emphasis is placed on problem recognition, pathophysiologic diagnosis, evidence-based clinical judgment, and management based on pathophysiologic principles. The primary activity involves the inpatient consultation service in which the student works up and follows several patients per week, and participates in daily rounds with the attending physicians, postdoctoral fellows, and residents on service. Students participate in the weekly renal conferences. An introduction to hemodialysis, peritoneal dialysis, renal transplantation, and renal biopsy histology is also provided. Students have the opportunity to visit patients on rounds in the hemodialysis units. The clerkship is limited to two students per hospital; full-time participation is expected. Students should have completed the Internal Medicine clerkship. Rotations can be three- to six-weeks’ duration, although, to derive benefit, at least four weeks is recommended. The elective is offered at both Yale-New Haven Hospital and the VA Connecticut Healthcare System, West Haven. A. Abu-Alfa, P. S. Aronson, M. J. Bia, U. Brewster (supervisor), L. Cantley, S. Crowley, G. V. Desir, R. Formica, J. Forrest, A. Peixoto, J. P. Hayslett, S. Huot, R. Mahnensmith, M. Perazella, A. Rastegar, S. Somlo
Internal Medicine 136, Digestive Disease Conference Each Friday afternoon from 2 to 3:30 p.m., current patients with gastrointestinal and liver problems of medical, surgical, pediatric, pathologic, or radiologic interest are presented and discussed. This is a practical series of discussions intended to interest anyone from a second-year student to a practitioner. Active participation by all who come is encouraged. Meets in Fitkin. J. Dranoff and Digestive Disease faculty
Internal Medicine 137, Clinical Gastroenterology Clerkship The student participates in the daily activities of the Gastroenterology Service. The student is an integral part of the GI team and should plan to spend full time on the elective at Yale-New Haven Hospital or the VA Connecticut Healthcare System, West Haven. Activities include rounds, consultations, conferences at both hospitals, and special procedures, including gastrointestinal endoscopy. Students also participate in outpatient clinics held by the various physicians of the section. This is an opportunity to see a wide variety of gastrointestinal problems and patients, with discussion and review. Offered to one student each at Yale-New Haven Hospital and VA Connecticut Healthcare System. Rotations should be four weeks in duration. Students should have completed the Internal Medicine clerkship. Digestive Disease faculty
Internal Medicine 141, Cardiology Clerkship The student participates in the daily activities of the Cardiology Consultation Service, including rounds, consultations, seminars, and conferences dealing with clinical cardiology, nuclear cardiology, echocardiography, cardiac catheterization, and other special procedures. This is a full-time elective requiring a full day’s activities but no night call. The training experience emphasizes the physiologic basis for clinical manifestations of cardiovascular diseases, and their therapy. The elective is limited to three students at Yale-New Haven Hospital and two students at the VA Connecticut Healthcare System, West Haven. The elective lasts a minimum of three weeks; six weeks is recommended if possible. Students must have completed basic Internal Medicine clerkships prior to clerkship. Following an initial Cardiology Clerkship, individual electives can be designed for specific cardiology laboratories or activities such as the coronary care unit, cardiac catheterization laboratory service, echocardiography, nuclear cardiology, electrophysiology, etc. W. P. Batsford, J. R. Bender, J. J. Brennan, M. Burg, H. S. Cabin, B. Cambi, J. Clancy, M. W. Cleman, L. S. Cohen, J. Curtis, F. Giordano, D. Goldstein, H. Haronian, C. Howes, F. Jadbabaie, S. Katz, H. M. Krumholz, R. Lampert, F. A. Lee, L. V. Lee, A. Mani, R. McNamara, S. E. Pfau, M. Remetz, L. Rosenfeld, K. Russell, R. Russell, M. Sadeghi, J. F. Setaro, R. Scandrett, A. J. Sinusas, R. Soufer, A. Vashist, F. J. Wackers, L. H. Young, B. L. Zaret. The individual supervisor is selected from the above participating faculty on a monthly basis.
Internal Medicine 142, Infectious Diseases The goal of this clerkship is to broaden a student’s experience and diagnostic skills in infectious diseases. Students participate as active members of the consultation service and training program in infectious diseases (Yale-New Haven and VA Connecticut Healthcare System, West Haven, hospitals). This requires a full-time daily commitment of four weeks although shorter clerkships are possible when justified. Activities include daily rounds with both fellows and attending physicians, attendance at all weekly subspecialty conferences, workup of several new consultations each week, formal case presentations, directed reading and library research, and case write-ups for review by the fellow and/or attending physician. Students are encouraged to work closely with fellows and to present cases. Training in clinical microbiology, including bacteriology, virology, and parasitic and fungal infections is conducted daily. Limited to a maximum of two students for each four-week period throughout the year. Outside students accepted through the Office of the Assistant Dean. Completion of all basic clinical clerkships is preferred, though only the basic clinical clerkship in Internal Medicine is required. R. Altice, L. Dembry, E. Fikrig, G. J. Francis, H. Friedland, M. Juthani-Mehta, B. Kazmierczak, M. Kozal, R. Martinello, V. J. Quagliarello, M. Rigsby, A. Shaw, S. Springer, J. Topal, K. Wagner
Internal Medicine 143, Externship in HIV/AIDS Students desiring an intensive, more advanced experience with the care of HIV-infected persons may spend one month as a subintern on the Donaldson Firm. The Donaldson Firm offers a combined general internal medicine/HIV ward experience. Previously, Donaldson admitted only HIV-infected persons. However, with the advent of highly active antiretroviral therapy and effective opportunistic infection (OI) prophylaxis, the HIV inpatient census has decreased and both HIV-infected and general medical patients are cared for. The firm practices a multidisciplinary HIV care approach. There are two firms that admit HIV-infected patients. Each is comprised of an attending, one resident, two interns, and one third-year medical student. On average, approximately 50 percent of the patients are HIV-infected. Students who elect an externship on Donaldson function as an integral member of one of the two HIV teams. The subintern assumes primary responsibility for his/her patient under the direct supervision of the medical resident. Activities include supervised initial evaluation and daily management of patients with HIV disease; daily rounds with the team; case presentations to the attending physician; and attendance of tri-weekly attending rounds, during which various HIV-related infections and noninfectious problems are discussed. In addition, the student works closely with members from social work, nursing, pastoral care, and discharge planning to better appreciate the multidisciplinary nature of HIV care. Students can arrange to attend one outpatient HIV clinic per week in the Nathan Smith Clinic in order to supplement their inpatient experience with the ambulatory aspects of HIV disease. This elective accommodates one student per month and offers a unique opportunity to participate in comprehensive HIV care in the AIDS Care Program, preferably upon completion of all basic clinical clerkships. A previous medical or surgical subinternship is useful preparation. Outside students are accepted through the Office of the Assistant Dean. Supervising faculty include: F. L. Altice, N. Angoff, D. Bruce, J. Francis, M. Juthani-Mehta, G. H. Friedland, B. Kazmierczak, V. Quagliarello, A. Shaw, S. Springer, J. Topal, K. Wagner
Internal Medicine 146, Hematology Clerkship This clerkship provides intensive exposure to clinical hematology by direct participation in the activities of a busy clinical hematology service. Students work up new patients and consultations (at least two patients per week), and attend outpatient clinic on Tuesday mornings, where they may be assigned to see one new patient or two follow-up patients. Students also attend daily hematology ward rounds, bone marrow readings, weekly inpatient and outpatient clinical review, and clinical teaching conferences. Students may limit participation to include only attendance at daily conferences, bone marrow readings, and hematology clinic or consultation service. One or two students for three to six weeks throughout the year. D. Beardsley, M. Dhodapkar, T. P. Duffy, B. G. Forget, S. Halene, P. Marks, P. McPhedran, H. Rinder, B. Smith, L. Solomon, M. Strout
Internal Medicine 151/EHS 575a,b, Introduction to Occupational and Environmental Medicine This course is geared toward those interested in specialty careers in occupational and environmental medicine, environmental health, or preventive medicine. The material covers clinical toxicology, exposure assessment, and the major clinical occupational and environmental diseases. This didactic course meets two hours weekly throughout the year, beginning in September. J. Mobo, M. Russi, and Occupational and Environmental Medicine faculty
Internal Medicine 152, Occupational and Environmental Medicine This full-time clinical elective emphasizes recognition, management, and prevention of occupational diseases. Approximately five half-days are spent in outpatient clinics; the remainder of the time involves workplace evaluations, clinical follow-up, and didactic teaching sessions. This course is full time, limited to two students per rotation, scheduling year-round. P. Rabinowitz, C. Redlich, M. Russi, J. Sparer, O. Taiwo, J. Mobo, and J. Hill
Internal Medicine 155, Advanced Clinical Clerkships (“Sub Internship”) Students serve as advanced clinical clerks on the floors of one of the following hospitals: Yale-New Haven Hospital; VA Connecticut Healthcare System, West Haven; or Waterbury Hospital, Waterbury. The students function in a role that allows for a high degree of involvement in patient care and permits autonomy in arriving at individual management plans, yet with adequate supervision at all times. Students function either as a pair in place of a first-year resident (intern) or, together with an intern in the event that no other student is available for that rotation. The Sub Interns admit patients to the medical service under the close supervision of an upper-level resident in charge of the service and the attending physician. In addition to daily work rounds and teaching-attending rounds, Sub Interns are expected to participate in Intern Morning Report once a week and at other departmental teaching conferences. The purpose of the course is to provide advanced undergraduate education in inpatient internal medicine beyond that received in the third-year clerkship. The rotation provides the opportunity for students to increase their overall knowledge of and experience with a wide variety of disease processes. In addition, the experience provides the Sub Intern with the opportunity to build upon skills of data gathering acquired during the third-year clerkship, to develop the ability to analyze complex data in logical fashion, and ultimately, based on these analyses, to be able to arrive at clinical decisions and to set priorities. By following a larger number of patients more closely than during third-year clerkships, students increase their clinical acumen, improve their technical skills, and develop an appropriate level of clinical confidence. The setting allows the development of an increased sense of patient care responsibility from admission to discharge of the patient. Offered throughout the year for periods of four weeks each, to students who have completed their required medical clerkships. C. R. Kapadia, program director
Internal Medicine 156, Clerkship in Liver Disease The student becomes integrated into the team of physicians involved in inpatient and outpatient clinical hepatology. This team normally consists of a faculty attending, one to two postdoctoral fellows in liver disease, and one medical student. The student is expected to see inpatient consultations, discuss the findings with the fellow, and ultimately present the patient to the attending. Additionally, the student sees patients in the Liver Outpatient Clinic three mornings per week. Attendance is expected at weekly liver biopsy, clinical and research conferences, and students may also attend the Liver Transplantation Clinic. This elective represents an intensive experience in hepatology, and during the rotation period the student is introduced to problems in the clinical management of liver disease and also gains a growing appreciation of the role of the liver in systemic disease. This elective is offered at Yale-New Haven Hospital (Drs. Boyer, Dranoff, Garcia-Tsao, Lim, Mehal, Nathanson, Schilsky, Strazzabosco, Swenson, and Taddei) or the VA Connecticut Healthcare System (Drs. Chung, Garcia-Tsao, and Imaeda). Three or six weeks, full time
Internal Medicine 157, Gastroenterology Clinical rounds and clinics with local and Yale affiliated gastroenterologists based at Bridgeport Hospital; conferences on gastrointestinal problems with emphasis on physiologic, radiologic, and pathologic correlation; gastrointestinal radiology conferences; demonstrations of endoscopy (including fiberoptic visualization of the esophagus, stomach, duodenum, colon); other procedures, such as biopsy (liver, esophagus, stomach, small intestine, colon, and rectum), cytology (esophagus, stomach, pancreaticobiliary, and colon), polypectomy, laser, bicap, ERCP, sphincterotomy, sclerotherapy, and PEG. Emphasis on diagnosis and clinical management of gastrointestinal disease of all types. Available to fourth-year students throughout the year at Bridgeport Hospital. G. Abdelsayed
Internal Medicine 159, Lung Diseases Students work closely with faculty and staff of the pulmonary group and participate in daily consulting and intensive care rounds. Students assist in the examination and treatment of patients with various cardiopulmonary diseases, including tuberculosis, chronic obstructive airways disease, asthma, lung cancer, interstitial lung diseases, respiratory lung infection, and other diagnostic problems. They receive practical instruction in lung function tests and their interpretation, in clinical and laboratory methods used for diagnosis and management, and in fiberoptic bronchoscopy. Didactic lectures are given at the weekly Yale State Chest conference. D. Antin-Ozerkis, H. Cain, G. Chupp, L. Cohn, M. Gulati, S. Honiden, P. Lee, P. Marshall, R. Matthay, J. McArdle, V. Mohsenin, M. Pisani, C. Redlich, C. Rochester, F. Roux, M. Siegel, L. Tanoue, T. Trow
Internal Medicine 180, Rheumatology Students participate in the inpatient Rheumatology consult service at Yale-New Haven Hospital and the VA Connecticut Healthcare System, West Haven. Students attend two general arthritis clinics at the VA Connecticut Healthcare System, one general arthritis clinic in the Dana 3 clinic at Yale-New Haven, and spend one or two afternoons per week with an attending rheumatologist in a private practice setting on Dana 3. They complete a core curriculum in Rheumatology and fill out pre- and post-rotation evaluation forms. Formal conferences include Rheumatology Grand Rounds, which are held each Wednesday at 8 a.m., and a Case Conference at 9 a.m. Optional conferences include a Rheumatology research-in-progress meeting held Friday mornings at 9 a.m. If interested, students may opt to combine Rheumatology and Allergy and Clinical Immunology. Rotation limited to two students for each period of four to six weeks throughout the year. L. Bockenstedt, R. Bucala, J. Craft, J. Evans, L. Fraenkel, I. Kang, S. Malawista, M. Mamula, R. Montgomery, L. Suter and selected members of the part-time community faculty
Internal Medicine 181, Medical Oncology Clerkship An intensive exposure to medical oncology including diagnosis, staging, evaluation and combined modality therapy, supportive care, and management of problems associated with cancer. Students work under the direct supervision of the attending staff and participate in the care and management of patients on the inpatient service and in the outpatient clinic. They join oncology morning rounds and present patients at the Clinical Oncology Conference. Limited to two students for two to six weeks throughout the calendar year. D. L. Cooper, program director
Internal Medicine 182/Psychiatry 209, Addictions Medicine Clerkship Offered jointly by the departments of Internal Medicine and Psychiatry. The Yale University School of Medicine offers an elective clinical training experience in Addictions Medicine for interested third- and fourth-year medical students. The primary training sites are the inpatient psychiatric service for dual diagnosis patients at the Connecticut Mental Health Center, the outpatient substance abuse treatment services at the Connecticut Mental Health Center, the APT Foundation Central Medical Unit, and the Primary Care Center at Yale-New Haven Hospital. H. R. Pearsall, P. G. O’Connor. The Addictions Medicine Clerkship is an elective that is scheduled for four weeks. (Slightly longer or shorter training experiences are available by contacting H. R. Pearsall. ) Students participate as medical student clerks on the Dual Diagnosis Unit at Connecticut Mental Health Center. This experience is an intensive one, and involves working closely with addicted patients with chronic mental illness. In addition to the inpatient experience, students participate in outpatient treatment under the supervision of clinicians at the Substance Abuse Treatment Unit and the Central Medical Unit, and in the substance abuse assessment and referral services of the Primary Care Center. Students are also invited to participate in the Substance Abuse Research Seminar as well as other educational activities of the Inpatient Division and the Substance Abuse Treatment Unit. For students desiring an intensive focus in one of the three areas of teaching (inpatient dual diagnosis, outpatient substance abuse treatment, or substance treatment in a primary care setting), a schedule can be tailored to provide more time in the setting of interest. H. R. Pearsall, P. G. O’Connor
Internal Medicine 184, Medical Informatics We explore topics in informatics, such as the definition and scope of the specialty, software engineering, networking and networks, database management systems, information retrieval, the electronic medical record, clinical decision support, and medical decision science. By arrangement with the instructor. R. N. Shiffman
Internal Medicine 187, Infectious Disease The elective emphasizes clinical diagnosis and treatment of patients with infectious diseases, hospitalized at the Hospital of Saint Raphael. Students make rounds with infectious disease fellows and with the infectious disease attending physician. Rounds include discussions of many common infectious diseases problems and of approaches to appropriate use of antibiotics. Students are expected to follow critically ill patients diligently, and may be asked to review articles regarding infections affecting patients followed by the infectious diseases service. J. M. Boyce, S. Weissman, M. Virata, M. Golden, A. Fisher
Internal Medicine 188, Renal The elective is supervised by the Renal Service at the Hospital of St. Raphael. Discussions are held concerning glomerular, tubulo-interstitial, acid-base, and electrolyte disorders. The student participates by performing initial consultations on four or five new inpatients per week, as well as actively participating in the follow-up care of interesting renal, electrolyte, and acid-base problems being followed in the hospital. Student participation in the weekly outpatient Renal Clinic is encouraged. Participation in the outpatient hemodialysis unit and outpatient continuous ambulatory peritoneal dialysis facility is an optional feature of the elective. Formal attending/teaching rounds are held daily for renal fellows, residents, and students participating in the elective. Conferences include biweekly renal conference at the Hospital of St. Raphael, weekly renal conference at Yale-New Haven Hospital, and weekly hemodialysis and continuous ambulatory peritoneal dialysis conferences. The renal fellows at the Hospital of St. Raphael help in the supervision of the students. H. Carey, S. Chang, T. Eisen, F. O. Finkelstein, J. Hansson, S. Shirani, D. Smith
Internal Medicine 189, Pulmonary Critical Care Supervised clinical rotation in the Medical Intensive Care Unit of the Hospital of St. Raphael. In a multidisciplinary environment, the student shares responsibility for a variety of critically ill patients. Ample opportunity to develop experience and skills in the management of acute respiratory failure, mechanical ventilation, and different forms of hemodynamic shock. A working understanding of cardiopulmonary physiology, arterial blood gases, and acid-base abnormalities in the assessment and management of respiratory disorders is obtained with the direct supervision of the full time pulmonary/critical care attending (Drs. H. Knight and R. Elias) as well as fellowship trainees from the Yale Pulmonary/critical care training program.
Internal Medicine 193, Subinternship in Medicine, Hospital of St. Raphael This subinternship allows the senior student the opportunity to assume more responsibility for patients and continuity of care. Working as a member of the team, the subintern has major responsibilities in initial assessment, plan formulation, and ongoing inpatient management, and will have the opportunity to provide outpatient hospital follow-up. Full-time medical directors provide supervision, feedback, and training. B. Wu, R. Nardino, and colleagues
Internal Medicine 195, Medical Intensive Care Unit Elective This rotation exposes highly qualified fourth-year students to the broad spectrum of medical critical care. Students are on call every fourth night with an intern and resident pair, assisting them in the admission of patients. Students follow patients in the MICU and assist in their care with their intern and resident. It provides the opportunity for participating in the acute management of common life-threatening Illnesses such as sepsis, pulmonary edema, DKA, GI bleeding, acute respiratory failure, acute kidney injury, coma, drug overdoses, metabolic acidosis, and hypertensive emergencies. Students are expected to learn about the pathophysiology and treatment of these disorders in this non-subinternship setting. Basic cardiac life support training is expected. All students should be able to demonstrate satisfactory completion of a Medicine II clerkship before taking this elective. Director: M. Siegel
Internal Medicine 500, Methods of Clinical Research This composite course begins with an intensive set of summer classes during July and the first two weeks of August. The course resumes in September and continues throughout the remainder of the academic year, ending in early June. The overall curriculum integrates several distinct components. The summer term contains sessions on statistics, epidemiology, clinical and health services research methods, health economics, and community-based participatory research. The fall term contains more advance statistics and research methods, as well as several sessions on health policy, social and behavioral influences on health, and community-based research. The spring term contains remaining topics in research methods and several sessions on health management. Summer sessions are held four times a week (ten hours); fall sessions are held three times a week (six and one-half hours); spring sessions are held two times a week (five hours). Permission of director required. Director: H. Krumholz
Internal Medicine 502, Clinical Clerkship, The Connecticut Hospice, Branford, Connecticut This fifty-two-bed inpatient program at the nation’s first hospice provides intensive palliative care for patients with terminal illnesses. The medical, psychosocial, and spiritual needs of these patients and their families are met through the coordinated efforts of an interdisciplinary team of physicians, nurses, social workers, pharmacists, and clergy. When cure is no longer realistic, the goal of therapy becomes symptom control to enable the patient to carry on an alert and pain-free existence. To achieve this goal, a careful physical assessment and noninvasive diagnostic studies can permit the use of focused therapeutic approaches, carefully selected to meet the needs of the individual patient. The specialized hospice care program emphasizes control of pain and other symptoms with a wide spectrum of both pharmacologic and nonpharmacologic modalities. Students participate in the care and management of hospice inpatients, potentially serving as primary physician for selected patients, under the close supervision of the hospice staff physicians and/or medical director. They participate in morning rounds, family conferences, and weekly Interdisciplinary Team Conferences. A two- or four-week rotation is offered. The four-week rotation includes time spent in the home care program, attending team conferences, and making home visits. The home care program encompasses eighty-nine cities and towns throughout Connecticut. Contact Louis Gonzalez at 203.315.7502
Internal Medicine 504, Bone Marrow Transplantation A one-month rotation on the adult bone marrow transplantation unit. Daily inpatient rounds are held. Students are involved in the care of the patients, including the performance of procedures, and attend a daily bone marrow transplant clinic for patient follow up. Weekly clinical conferences are also attended. A suggested reading program is provided. Students are required to present a short discussion about a topic of their choice. D. Cooper
Humanities in Medicine
The courses listed below are offered through the Program for Humanities in Medicine for 2008–2009. Further information is available from Dr. Thomas Duffy or Clara Gyorgyey at 203.785.6102. Schedules of courses are flexible. Students who are interested in any (or all) of the following courses, or have other interests that could be addressed through this program, are asked to indicate this on the sign-up sheet. No obligation even if students sign up.
Internal Medicine 505, Poetry and Medicine Hope, courage, devotion, anguish, pain, illness, and death—the substance of all great literature is also fundamental to medicine. Poetry and Medicine, a bi-monthly seminar elective, introduces students to works of poetry, illuminating the ethical, moral, and psychological issues continually confronting their profession. The course helps students develop an understanding of the ways in which interpreting literature enhances their interactions with patients and clarifies some dimensions of their work. Course schedule: Bi-monthly meetings at a mutually determined time. P. Kirwin, T. Duffy
Internal Medicine 509b, Pregnancy and Neonatal Loss For first-year students. This elective centers around what a physician feels when his/her patient dies and how he/she can come to a resolution with regard to this loss. In particular, focus on the expression of feelings through letter writing, poetry, and face-to-face encounters with family members. Introduction to “case histories” based upon the lecturer’s experiences. Course schedule: six meetings at a mutually determined time. Please contact the instructor by e-mail: berman@hygeia.org. M. R. Berman
Investigative Medicine
Office: Edward S. Harkness Building (ESH), basement 18–19, 785.6842
Professors T. M. Gill (Medicine), H. M. Krumholz (Medicine), E. D. Shapiro (Pediatrics), G. Tellides (Surgery), M. E. Tinetti (Medicine)
Associate Professors D. A. Fiellin (Medicine), J. R. Gruen (Pediatrics)
IMED 625a, Principles of Clinical Research The purpose of this intensive two-week course is to provide an overview of the objectives, research strategies, and methods of conducting patient-oriented research. Topics include competing objectives of clinical research, principles of observational studies, principles of clinical trials, principles of meta-analysis, interpretation of diagnostic tests, prognostic studies, causal inference, qualitative research methods, and decision analysis. Sessions generally combine a lecture on the topic with discussion of articles that are distributed in advance of the sessions. Consent of instructor required. Two weeks, July 27–August 7, 2009. E. Shapiro
IMED 630a, Ethical and Practical Issues in Clinical Investigation This term-long course addresses topics that are central to the conduct of clinical investigation, including ethics of clinical investigation, scientific fraud, technology transfer, and interfacing with the pharmaceutical industry. Practical sessions include scientific presentations and teaching, NIH peer review process, journal peer review process, and career development models of academia. This course provides guidelines and a framework for the clinical investigator to obtain funding for, conduct, and present a clinical study. Format consists of didactic presentation followed by discussion. Consent of instructor required. H. Binder
IMED 635a or b, Directed Reading in Investigative Medicine An independent study course for first-year students in the Investigative Medicine program. Topics are chosen by the student, and reading lists are provided by faculty for weekly meetings to discuss articles. Six sessions are required; dates/times by arrangement. Consent of instructor required. J. Craft
IMED 645a, Introduction to Biostatistics in Clinical Investigation This course provides an introduction to statistical concepts and techniques commonly encountered in medical research. Previous course work in statistics or experience with statistical packages is not a requirement. Topics to be discussed include study design, probability, comparing sample means and proportions, survival analysis, and sample size/power calculations. The computer lab incorporates lecture content into practical application by introducing the statistical software package SPSS to describe and analyze data. Consent of instructor required. Two weeks, July 13–24, 2009. H. Binder
IMED 650a, Seminars in Clinical Investigation In this term-long seminar course a range of topics is covered in the format of an interactive seminar. Topics including detailed evaluation of study designs (cohort studies, case-control studies, and clinical trials), development and validation of indices, review of approaches to methodology and issues related to implementation of the methodology (assuring quality of the data, qualitative research methods, estimation of sample size and statistical power), and introduction to finding sources to fund grant proposals. The format for most of the seminars consists of a didactic presentation followed by intensive discussion of research articles and research protocols. Students lead the discussion in the critical analysis and evaluation of the articles. Attendance and active participation are required. Consent of instructor required. E. Shapiro
IMED 655b, Writing Your First Grant In this term-long course, students gain intensive, practical experience in evaluating and preparing grants, including introduction to NIH study section format. The course gives new clinical investigators the essential tools to design and to initiate their own proposals for obtaining grants to do research and to develop their own careers. The course is limited to students who plan to submit grant proposals (usually for either a K-23 or a K-08 grant). Attendance and active participation are required. Consent of instructor required. E. Shapiro
IMED 660a, Methods in Clinical Research, Part I E. Shapiro
IMED 661a, Methods in Clinical Research, Part II E. Shapiro
IMED 662b, Methods in Clinical Research, Part III This yearlong course, presented by the Robert Wood Johnson Clinical Scholars Program, presents in depth the methodologies used in patient-oriented research, including methods in biostatistics, clinical epidemiology, health services research, community-based research, and health policy. Consent of instructor required. E. Shapiro
IMED 680b, Topics in Human Investigation This course teaches students about the process through which novel therapeutics are designed, clinically tested, and approved for human use. It is divided into two main components, with the first devoted to moving a chemical agent from the bench to the clinic, and the second to outlining the objectives and methods of conducting clinical trials to the FDA approval process. The first component describes aspects of structure-based drug design and offers insight into how the drug discovery process is conducted in the pharmaceutical industry. The format includes background lectures with discussions, labs, and computer tutorials. The background lectures include a historical perspective on drug discovery, the current paradigm, and important considerations for future success. The second component of the course provides students with knowledge of the basic tools of clinical investigation and how new drugs are tested in humans. A series of lectures and discussions provide an overview of the objectives, research strategies, and methods of conducting patient-oriented research, with a focus on design of trials to test therapeutics. Each student is required to participate (as an observer) in an HIC review, in addition to active participation in class. Consent of instructor required. J. Craft, K. Anderson
Laboratory Medicine
Office: CB 407, 688.2446
Professors A. Baumgarten (Emeritus), F. J. Bia (Medicine), J. R. Bove (Emeritus), Y. Choi (Pathology), R. K. Donabedian (Emeritus), S. C. Edberg, P. I. Jatlow, P. B. Kavathas, D. S. Krause, M. Landry, P. McPhedran (Emeritus), H. M. Rinder, D. Seligson (Emeritus), M. J. Shlomchik, J. L. Sklar (Pathology), B. R. Smith (Chair), E. L. Snyder, P. J. Tattersall
Associate Professors S. M. Campbell, M. E. Hodsdon, C. S. Rinder (Anesthesiology), G. E. Stack, Y. Wu
Assistant Professors J. G. Howe, J. H. McClaskey
Instructors S. C. Eisenbarth, C. A. Tormey
Senior Research Scientist S. F. Cotmore
Research Scientists G. M. Anderson (Child Study Center), A. M. Haberman
Associate Research Scientists L. Devine, T. Eid, C. Keeler, A. Khalil, L. Li, T. S. Murray (Pediatrics), P. Zhang
Clinical Professors B. P. Griffith, R. A. Levine, S. C. Wardlaw
Associate Clinical Professors P. N. Fiedler (Pathology), D. R. Mayo, I. Nash, T. J. Tinghitella
Assistant Clinical Professors S. R. Gray, I. V. Kaplan, H. Malkus, R. R. Rathbone, C. A. Rauch, N. Shafi, M. Velleca, J. C. West
Clinical Instructor S. C. Eisenbarth
Lecturers M. Champion, S. A. Cohen, N. Drew, D. Ferguson, P. E. Marone, R. L. Ross
Laboratory Medicine 102b This lecture, laboratory, and seminar course deals with scientific use of clinical laboratories (hematology, clinical chemistry, immunology, blood banking) as a basis for the understanding, diagnosis, and treatment of disease. Emphasis is on the selection and interpretation of laboratory tests used in the practice of medicine as well as on acquiring some understanding of the technology used in the clinical laboratories. Lectures and laboratories are integrated into the new organ-based modular system of clinical instruction for second-year medical students. Second-year course. M. L. Landry and associates
Laboratory Medicine 123a, Medical Microbiology This course focuses on both basic microbial pathophysiology and medical microbiology. The course is divided into four sections, consisting of microbial physiology and genetics, bacteriology and mycology, virology, and parasitology. Microbial pathogenesis is taught as it relates to human infectious disease on the cellular and molecular levels. The unique structures, lifestyles, and roles in producing disease of medically important microbes are taught in lecture, laboratory, and small group settings. Laboratory sessions employ a case-based approach to teach the effective use of laboratory testing in the diagnosis and management of infectious diseases. Microscopy, culture and biochemical, immunological, and molecular techniques are demonstrated and discussed, and simple tests such as Gram stain and rapid antigen tests are performed. Problem-based learning sessions in clinical infectious disease are offered in the last half of the course to provide a bridge from the science of the microbe to the management of infected patients. Second-year course. S. Campbell, M. L. Landry, T. Tinghitella, and associates
Laboratory Medicine Elective 131 The Department of Laboratory Medicine offers a two- or four-week elective with rotations through the clinical laboratories, including Blood Bank, Therapeutic Apheresis, Clinical Chemistry, Toxicology, Hematology and Coagulation, Flow Cytometry, Immunology, Molecular Diagnostics, Microbiology, and Virology. The student works closely with residents, fellows, attendings, and laboratory staff; works up clinical cases under supervision; and attends morning report, case conference, journal club, clinical rounds, and didactic sessions. The student also has the opportunity to work with the resident on call for at least one weekend day during the elective. The student can rotate through all laboratories, or focus on specific laboratories of interest. The goals of the elective are to learn appropriate usage and interpretation of laboratory tests, and to gain a better understanding of the theoretical, technological, and clinical underpinnings of Laboratory Medicine. This elective is appropriate for students considering a career in Laboratory Medicine or combined Laboratory Medicine and Pathology, but also for all students who will use clinical laboratory testing in their careers. Electives are for two weeks or four weeks, and are limited to one student per session. M. L. Landry and associates
Laboratory Medicine and Surgical Pathology Elective The Departments of Laboratory Medicine and Pathology offer a four-week elective that combines two weeks of Laboratory Medicine and two weeks of Surgical Pathology. In Laboratory Medicine, students rotate through the clinical laboratories, including Blood Bank, Therapeutic Apheresis, Clinical Chemistry, Toxicology, Hematology and Coagulation, Flow Cytometry, Immunology, Molecular Diagnostics, Microbiology, and Virology. The student works closely with residents, fellows, attendings, and laboratory staff; works up clinical cases under supervision; and attends conferences and didactic sessions. The goals are to learn appropriate usage and interpretation of laboratory tests, and to gain a better understanding of the theoretical, technological, and clinical underpinnings of Laboratory Medicine.
In Surgical Pathology, students rotate through specialty and general anatomic surgical pathology, frozen section, hematopathology, renal and electron microscopy, molecular diagnostics, cytology, and autopsy. The students work with residents, fellows, attendings, and laboratory staff, participate in work up of clinical cases under supervision, attend tumor boards and other clinical conferences and didactic sessions. The goals are to understand the basic principles of diagnostic anatomic pathology and its role in clinical medicine. This elective is appropriate for students considering a career in Laboratory Medicine and/or Pathology, but also for all students who will use laboratory and pathology tests in their careers.
Electives are for 4 weeks, and are limited to one to two students per session. M. L. Landry and D. Rimm
Laboratory Medicine Teaching Sessions for Third-Year Medical Students The purpose of the Laboratory Medicine Teaching Sessions is to introduce third-year students on their clinical rotations to basic concepts of laboratory diagnosis. On the first afternoon of their Internal Medicine rotations at Yale-New Haven Hospital, students visit four laboratories: Blood Bank, Hematology, Chemistry, and Microbiology/Virology. In each laboratory the faculty use clinical cases together with relevant slides, culture plates, or other test data to illustrate the use and interpretation, as well as pitfalls, of laboratory tests. These teaching sessions should also serve to encourage and facilitate communication with the laboratories after the students return to the wards. Third-year course. M.L. Landry and associates
Microbial Pathogenesis
Office: 295 Congress Avenue, Room 336B, 737.2404
Professors N. W. Andrews (Adjunct), M. Cappello (Pediatrics), E. Fikrig (Medicine), J. E. Galan (Chair), M. K. Hostetter (Pediatrics), C. R. Roy
Associate Professors C. Ben Mamoun (Medicine), C. Jacobs-Wagner (Molecular, Cellular, and Developmental Biology), B. I. Kazmierczak (Medicine), W. H. Mothes, R. Sutton (Medicine)
Assistant Professors H. F. Agaisse, P. Kumar (Medicine), B. Lindenbach, J. D. MacMicking
Associate Research Scientists C. G. Briones, I. Derre, F. Du, D. Hofreuter, M. D. Lara-Tejero, S. Ninio
The following courses in the Graduate School of Arts and Sciences are open to medical students with permission of the DGS.
[MBIO 642a/EMD 642a/GENE 642a/MB&B 642a/MCDB 642a, Roles of Microorganisms in the Living World]
MBIO 670a,b, Laboratory Rotation Rotation in three laboratories. Required for all first-year graduate students. J. Sweasy
MBIO 680a/EMD 680a, Molecular and Cellular Processes of Parasitic Eukaryotes An introductory graduate-level topic-based course in modern parasitology: for each topic there is an introductory lecture followed by a journal club-like discussion session of relevant papers selected from the literature. This course provides an introduction to basic biological concepts of parasitic eukaryotes causing diseases in humans. Topics include strategies used by parasitic eukaryotes to establish infections in the host and approaches to disease control, through either chemotherapy, vaccines, or genomics. In addition, emphasis is placed on evaluating the quality and limitation of scientific publications and developing skills in scientific communication. Permission of instructor is required. D. McMahon-Pratt, C. Tschudi
MBIO 684b/EMB 684b, Advanced Topics in Molecular Parasitology An advanced graduate-level seminar course in modern parasitology. The class is focused on the reading and critical evaluation of papers from the current literature selected by the students in cellular and molecular mechanisms of parasitism. Prerequisites: EMD 680a is highly recommended; permission of the instructor. D. McMahon-Pratt, C. Tschudi
MBIO 685b, Molecular Mechanisms of Microbial Pathogenesis This course focuses on current topics related to host pathogens interactions. Each week a lecture is given on the topic, followed by student presentations of seminal papers in the field. All participants are required to present a paper. J. Galán, C. Roy, W. Mothes, J. MacMicking, H. Agaisse, B. Lindenbach
[MBIO 700a, Seminal Papers on the Foundations of Modern Microbiology]
MBIO 701a,b, Research in Progress All students, beginning in their third year, are required to present their research once a year at the Graduate Student Research-in- Progress. These presentations are intended to give each student practice in presenting his or her own work before a sympathetic but critical audience and to familiarize the faculty with the research. C. Roy
MBIO 702a,b, Microbiology Seminar Series All students are required to attend all Microbiology seminars scheduled throughout the academic year. Microbiologists from around the world are invited to describe their research. C. Roy
[MBIO 703a, Evasion of Host Defenses by Viruses, Bacteria, and Eukaryotic Parasites]
[MBIO 734a/GENE 734a, Molecular Biology of Animal Viruses]
Molecular Biophysics and Biochemistry
Offices: JWG 304, 432.2077; SHM C106, 785.4246
Professors S. J. Baserga, G. W. Brudvig (Chemistry), D. M. Crothers (Emeritus), D. C. DiMaio (Genetics), D. M. Engelman, A. Garen, M. B. Gerstein, S. Ghosh (Immunobiology), N. D. Grindley, M. W. Hochstrasser, W. H. Konigsberg, P. Lengyel (Emeritus), J. Loria (Chemistry), I. Miller (Pediatrics), P. B. Moore (Chemistry), T. D. Pollard (Molecular, Cellular, and Developmental Biology), T. D. Pollard (Molecular, Cellular, and Developmental Biology), A. Pyle, L. J. Regan, R. G. Shulman (Emeritus), M. Snyder (Molecular, Cellular, and Developmental Biology), D. G. Soll, M. J. Solomon, T. A. Steitz, J. A. Steitz, S. A. Strobel (Chair), W. C. Summers (Therapeutic Radiology), P. Sung, S. L. Wolin (Cell Biology)
Professor (Adjunct) of Research K. R. Williams
Associate Professors T. Biederer, E. M. De La Cruz, M. R. Koelle, A. J. Koleske, A. D. Miranker, V. M. Unger
Assistant Professors Y. E. Modis, A. E. Rhoades, H. Wang, Y. Xiong
Senior Research Scientist C. M. Joyce
Research Scientists J. L. Burton, J. H. Cabral, S. M. Mane, K. Tycowski, J. Wang
Associate Research Scientists S. Balasubramanian, G. Blaha, C. Bruce, W. Cao, C. M. Colangelo, J. K. Countryman, A. S. El-Guindy, J. I. Elliott, O. A. Fedorova, E. J. Folta-Stogniew, E. Gulcicek, A. Henn, H. Henn, C. A. Innis, Y. Kong, Y. Kwon, T. T. Lam, I. Lomakin, A. Lopez-Cortajarena, J. R. Lytle, D. Ostapenko, J. S. Rozowsky, A. Sachpatzidis, J. Ye, K. Zhang
Research Affiliates O. Andreev, E. Myers-Arnold, Y. K. Reshetnyak, F. Zhang
Lecturers C. A. Bascom-Slack (Molecular, Cellular, and Developmental Biology), L. Boulanger, R. J. Brown (Pediatrics), R. I. Herzog (Medicine), A. B. Pawashe, C. A. Tormey (Laboratory Medicine), S. H. Wrzesinski (Medicine)
MB&B 500a/MCDB 500a, Biochemistry An introduction to the biochemistry of animals, plants, and microorganisms, emphasizing the relations of chemical principles and structure to the evolution and regulation of living systems. L. N. Ornston, R. Breaker, D. Engelman
MB&B 517a2/ENAS 517a2, Methods and Logic in Interdisciplinary Research This half-semester IGPPEB class is intended to introduce students to integrated approaches to research. Each session is led by faculty with complementary expertise and discusses papers that use different approaches to the same topic (for example, physical and biological or experiment and theory). E. Dufresne, P. Forscher, E. Rhoades, C. O’Hern, L. Regan, S. Mochrie, C. Wilson, T. Emonet, C. Jacobs-Wagner, M. Levene, E. De La Cruz
MB&B 520a1, Boot Camp Biology An intensive introduction to biological nomenclature, systems, processes, and techniques for graduate students with previous backgrounds in non-biological fields including physics, engineering, and computer science who wish to perform graduate research in the biological sciences. L. Regan, M. Hochstrasser, A. Koleske, T. Pollard
MB&B 523a, Biological Physics An introduction to the physics of several important biological phenomena, including molecular motors, protein folding, bacterial locomotion, and allostery. The material and approach are positioned at the interface of the physical and biological sciences. S. Mochrie
MB&B 545b, Methods and Logic in Molecular Biology An examination of fundamental concepts in molecular biology through analysis of landmark papers. Development of skills in reading the primary scientific literature and in critical thinking. Open only to MB&B students pursuing the B.S./M.S. degree. A. Koleske, N. Grindley, M. Hochstrasser, D. Söll
MB&B 550a, Molecular Foundations of Medicine This course is part of the Molecules to Systems course, which is open only to first-year medical students. An introduction to the major concepts of biochemistry and molecular biology, with emphasis on the human body. Special attention is devoted to how recent advances in basic science contribute to our understanding and treatment of human disease. S. Baserga, M. Solomon, D. Engelman. Conference leaders: A. Belperron, R.J. Brown, R. Herzog, M. Strout, E. Thrower, C. Tormey, S. Wrezsinski
MB&B 591b/ENAS 991b, Integrated Workshop This required course for students in IGPPEB involves hands-on laboratory modules with students working in pairs. S. Mochrie
MB&B 600a, Principles of Biochemistry I Discussion of the physical, structural, and functional properties of proteins, lipids, and carbohydrates, three major classes of molecules in living organisms. Energy metabolism, hormone signaling, and muscle contraction as examples of complex biological processes whose underlying mechanisms can be understood by identifying and analyzing the molecules responsible for these phenomena. M. Koelle, T. Biederer
MB&B 601b, Principles of Biochemistry II A continuation of MB&B 600a that considers the chemistry and metabolism of nucleic acids, the mechanism and regulation of protein and nucleic acid synthesis, and selected topics in macromolecular biochemistry. S. Strobel, P. Sung
MB&B 602a/CBIO 602a/MCDB 602a, Molecular Cell Biology A comprehensive introduction to the molecular and mechanistic aspects of cell biology for graduate students in all programs. Emphasizes fundamental issues of cellular organization, regulation, biogenesis, and function at the molecular level. S. Wolin, T. Pollard, C. Crews, and faculty
MB&B 625a/GENE 625a/MCDB 625a, Basic Concepts of Genetic Analysis The universal principles of genetic analysis in eukaryotes are discussed in lectures. Students also read a small selection of primary papers illustrating the very best of genetic analysis and dissect them in detail in the discussion sections. While other Yale graduate molecular genetics courses emphasize molecular biology, this course focuses on the concepts and logic underlying modern genetic analysis. T. Xu, A. Giraldez, T.-H. Kim, M. Koelle, R. Lifton, S. Roeder
MB&B 630b/MCDB 630b, Biochemical and Biophysical Approaches in Molecular and Cellular Biology This graduate course introduces the theory and application of biochemical and biophysical methods to study the structure and function of biological macromolecules. The course considers the basic physical chemistry required in cellular and molecular biology but does not require a previous course in physical chemistry. One class per week is a lecture introducing a topic. The second class is a discussion of one or two research papers utilizing those methods. Does not count for graduate course credit for MB&B graduate students. T. Pollard, E. De La Cruz, and staff
MB&B 635a1, Mathematical Methods in Biophysics Applied mathematical methods relevant to analysis and interpretation of biophysical and biochemical data are covered. Students apply these methods (statistics and error analysis, differential equations, linear algebra, and Fourier transforms) to analyze data from research groups in MB&B. Prerequisites: Math 120 (or equivalent) and MB&B 600a (or equivalent) or permission of instructors. E. Rhoades, Y. Xiong, C. O’Hern
[MB&B 642a/EMD 642a/GENE 642a/MBIO 642a/MCDB 642a, Roles of Microorganisms in the Living World]
MB&B 650, Laboratory Rotation for First-Year Students Required for all MB&B first-year graduate students. Credit for full year only. M. Solomon
MB&B 676b, Responsible Conduct of Research Designed for students who are beginning to do scientific research. The course seeks to describe some of the basic features of life in contemporary research and some of the personal and professional issues that researchers encounter in their work. Approximately six sessions, run in a seminar/discussion format. Required for all first-year MB&B graduate students. T. Biederer and staff
MB&B 705aU/GENE 705a/MCDB 505au, Molecular Genetics of Prokaryotes Molecular aspects of the storage, replication, evolution, and expression of genetic material in prokaryotes. Prerequisites: previous or concurrent introductory courses in genetics and biochemistry. N. Grindley
MB&B 710b4/C&MP 710b, Electron Cryo-Microscopy for Protein Structure Determination Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. The course is an introduction to the concepts and applications of high-resolution electron cryo-microscopy. This rapidly emerging new technique is the only method that allows biological macromolecules to be studied at all levels of resolution from cellular organization to near atomic detail. Counts as 0.5 credit toward MB&B graduate course requirements. F. Sigworth, H. Wang
MB&B 720a, Macromolecular Structure and Biophysical Analysis An in-depth analysis of macromolecular structure and its elucidation using modern methods of structural biology and biochemistry. Topics include architectural arrangements of proteins, RNA, and DNA; practical methods in structural analysis; and an introduction to diffraction and NMR. Prerequisites: physical chemistry (may be taken concurrently) and biochemistry. A. Miranker, A. Pyle, Y. Xiong
MB&B 721b, Macromolecular Interactions and Dynamic Properties This course examines dynamic properties of macromolecules, their interactions, catalytic activities, and methods for analyzing their behavior. Topics include macromolecular folding, binding interfaces, ligand interactions, and the properties of membrane proteins, enzymes, ribozymes, and molecular motors. These areas are presented together with modern methods for analysis of macromolecular associations and dynamic properties. Prerequisites: biochemistry, physical chemistry, and MB&B 720a or permission of the instructor. A. Pyle, D. Engelman, E. Rhoades, H. Wang
MB&B 730a, Methods and Logic in Molecular Biology This course examines fundamental concepts in molecular biology through intense critical analysis of the primary literature. The objective is to develop primary literature reading and critical thinking skills. Required of and open only to first-year graduate students in MB&B. M. Solomon, A. Koleske, L. Regan
[MB&B 734a/MBIO 734a/GENE 734a, Molecular Biology of Animal Viruses]
MB&B 743b/GENE 743b/MCDB 743b, Advanced Eukaryotic Molecular Biology Selected topics in transcriptional control, regulation of chromatin structure, mRNA processing, mRNA stability, RNA interference, translation, protein degradation, DNA replication, DNA repair, site-specific DNA recombination, somatic hypermutation. Prerequisite: biochemistry or permission of the instructor. M. Hochstrasser, A. Koleske, P. Sung
MB&B 749a/GENE 749a, Medical Impact of Basic Science Consideration of examples of recent discoveries in basic science that have elucidated the molecular origins of disease or that have suggested new therapies for disease. Emphasis is placed on the fundamental principles on which these advances rely. Reading is from the primary scientific and medical literature, with emphasis on developing the ability to read this literature critically. Aimed primarily at undergraduates. Prerequisite: biochemistry or permission of the instructor. May not be taken by MB&B B.S./M.S. students for graduate course credit. J. Steitz, M. Hochstrasser, I. G. Miller, L. Regan, D. Schatz
MB&B 750a, Biological Membranes Biological membranes and their resident proteins are essential for cellular function; yet comparatively little is known about their structure and dynamics. This class provides an introduction to the biochemistry and biophysics of lipids, lipid bilayers, and lipid-derived second messengers. In addition, structural as well as functional aspects of the different classes of membrane proteins are discussed along with an outline of experimental approaches used to achieve an understanding of membrane protein structure and function at a molecular level. Counts as 0.5 credit toward MB&B graduate course requirements. Prerequisite: biochemistry. T. Biederer, D. Engelman
MB&B 752b/CB&B 752b/CPSC 752b/MCDB 752b, Bioinformatics and Applied Data Mining Genomics describes the determination of the nucleotide sequence and many further analyses to discover functional and structural information on all the genes of an organism. Topics include the methods and results of functional and structural gene analysis on a genome-wide scale as well as a discussion of the implications of this research. Bioinformatics describes the computational analysis of genomes and macromolecular structures on a large scale. Topics include sequence alignment, biological database design, comparative genomics, geometric analysis of protein structure, and macromolecular simulation. Prerequisite: EEB 122b and MATH 115, or permission of the instructor. M. Gerstein
MB&B 760b3, Principles of Macromolecular Crystallography Rigorous introduction to the principles of macromolecular crystallography, aimed at students who are planning to carry out structural studies involving X-ray crystallography or who want to obtain in-depth knowledge for critical analysis of published crystal structures. Counts as 0.5 credit toward MB&B graduate course requirements. Prerequisites: physical chemistry and biochemistry. Y. Modis, Y. Xiong, and staff
[MB&B 761b4, X-Ray Crystallography Workshop]
[MB&B 765b, Enzyme Mechanisms]
MB&B 800a, Advanced Topics in Molecular Medicine This seminar, which covers topics in the molecular mechanisms of disease, illustrates timely issues in areas such as protein chemistry and enzymology, intermediary metabolism, nucleic acid biochemistry, gene expression, and virology. M.D. and M.D./Ph.D. students only. Prerequisite: biochemistry (may be taken concurrently). S. J. Baserga, W. Konigsberg, and staff
MB&B 900a or 901b, Reading Course in Biophysics Directed reading course in biophysics. Term paper required. By arrangement with faculty. Open only to graduate students in MB&B. M. Solomon
MB&B 902a or 903b, Reading Course in Molecular Genetics Directed reading course in molecular genetics. Term paper required. By arrangement with faculty. Open only to graduate students in MB&B. M. Solomon
MB&B 904a or 905b, Reading Course in Biochemistry Directed reading course in biochemistry. Term paper required. By arrangement with faculty. Open only to graduate students in MB&B. M. Solomon
Neurobiology
Office: SHM C303, 785.4323
Professors A. F. Arnsten, B. S. Bunney (Psychiatry), N. Daw (Ophthalmology and Visual Science), P. De Camilli (Cell Biology), N. C. deLanerolle (Neurosurgery), J. E. Gelernter (Psychiatry), C. A. Greer (Neurosurgery), T. L. Horvath (Comparative Medicine), J. D. Kocsis (Neurology), R. H. LaMotte (Anesthesiology), C. Leranth (Obstetrics, Gynecology, and Reproductive Sciences), P. J. Lombroso (Child Study Center), D. A. McCormick, G. D. Pearlson (Psychiatry), M. Picciotto (Psychiatry), P. Rakic (Chair), J. Santos-Sacchi (Surgery), I. R. Schwartz (Surgery), G. M. Shepherd, S. M. Strittmatter (Neurology), C. H. van Dyck (Psychiatry), X. Wang, S. G. Waxman (Neurology)
Associate Professors M. Alreja (Psychiatry), H. Blumenfeld (Neurology), H. Blumenfeld (Neurology), C. J. Bruce, M. C. Crair, S. Diano (Obstetrics, Gynecology, and Reproductive Sciences), M. Gunel (Neurosurgery), A. J. Koleske (Molecular Biophysics and Biochemistry), M. Laubach, D. Lee, V. A. Pieribone (Cellular and Molecular Physiology), M. L. Schwartz, N. Sestan, F. M. Vaccarino (Child Study Center), M. F. Yeckel
Assistant Professors S. A. Castner (Psychiatry), E. A. Jonas (Medicine), C. Li (Psychiatry), A. Louvi (Neurosurgery), J. A. Mazer, D. S. Navaratnam (Neurology), J. V. Verhagen, G. V. Williams (Psychiatry)
Senior Research Scientist N. Carnevale
Research Scientist L. D. Selemon
Associate Research Scientists M. Cano-Vinas, A. Duque, K. Hashimoto-Torii, X. Liu, Y. Morozov, T. M. Morse, M. Rasin, R. N. Sachdev, H. Seo, M. Torii, M. Wang, D. C. Willhite, H. Xu
Research Affiliates W. R. Chen, C. Draeger
NBIO 500b/NSCI 510b, Structural and Functional Organization of the Human Nervous System An integrative overview of the structure and function of the human brain as it pertains to major neurological and psychiatric disorders. Neuroanatomy, neurophysiology, and clinical correlations are interrelated to provide essential background in the neurosciences. Lectures in neurocytology and neuroanatomy survey neuronal organization in the human brain, with emphasis on long fiber tracts related to clinical neurology. Weekly three-hour laboratory sessions devoted to neuroanatomy in which students dissect the human brain and examine histological sections in close collaboration with faculty members. Lectures in neurophysiology cover various aspects of neural function at the cellular level, with a strong emphasis on the mammalian nervous system. Clinical correlations consist of five sessions given by one or two faculty members representing both basic and clinical sciences. These sessions relate neurological symptoms to cellular processes in various diseases of the brain. Variable class schedule; contact course instructors. M. Schwartz, P. Rakic, and staff
NBIO 501a/NSCI 501a, Principles of Neuroscience General neuroscience seminar: lectures, readings, and discussion of selected topics in neuroscience. Emphasis is on how approaches at the molecular, cellular, physiological, and organismal levels can lead to understanding of neuronal and brain function. M. Picciotto, M. Yeckel
NBIO 502a, Structure and Function of Neocortex This course covers anatomical, biochemical, and physiological organization of selected sensory, motor, and association regions of cortex. Sample topics discussed include development, evolution of multiple representations, columnar organization, and plasticity of neocortex. Hours arranged with individual instructors.
NBIO 507b/NSCI 507b, Cellular and Molecular Mechanisms of Neurologic Disease Focuses on those diseases (Alzheimer’s, Parkinson’s, ALS, and other neurodegenerative diseases, Triplet Repeat induced diseases, multiple sclerosis, epilepsy, etc.) in which modern neuroscience has advanced mechanistic explanations for clinical conditions. The course highlights recent molecular, electrophysiological, and imaging experiments in parsing disease mechanisms. The application of pathophysiologic understanding to therapeutics is considered. Web casts of the lectures and Internet-based interactive tutorials are also available. The course extends a twelve-lecture course, Neurobiologic Mechanisms of Disease, offered in the spring of 2009. The course can be taken for credit or audited. Those wishing credit will be graded on a 30-minute Internet-based final exam and a term paper. D. Navaratnam, S. Strittmatter, S. Waxman
NBIO 509b/NSCI 539b, Synaptic Organization of the Nervous System An integrative introduction to the principles underlying the organization of neural systems. The focus is on the best-understood systems, including spinal cord, olfactory bulb, retina, cerebellum, thalamus, basal ganglia, and cerebral cortex. Students integrate experimental findings from anatomy, electrophysiology, and neuropharmacology with computational models at the cellular and circuit level to understand the neural basis of behavior. G. Shepherd, A. Williamson, M. Hines
NBIO 510a, Introduction to Methods in Cellular and Molecular Neurobiology Firsthand insight into various techniques and approaches used in neuroscience. Light microscopic techniques include various metallic impregnation methods, autoradiography, anterograde and retrograde axonal transport methods, hybridoma and recombined DNA technology, deoxyglucose metabolic method, fluorescent and immunocytochemical methods. Electron microscopy encompasses transmission, electronmicroscopic autoradiography, and immuno-peroxidase methodology. Choice of techniques and hours to be arranged with individual faculty or staff members of the Department of Neurobiology.
NBIO 511, Introduction to Techniques Used in Electrophysiological Analysis at the Cellular Level Includes practical training in in vivo and in vitro nervous system preparations, extracellular and intracellular recordings, sensory stimulation, dye injections, and selected neuropharmacological procedures. Choice of techniques and hours to be arranged with individual faculty of the Department of Neurobiology. Neurobiology faculty
NBIO 524b/NSCI 514b, Neurodevelopment and Neuropsychiatric Disorders This course discusses basic concepts concerning the development of the central nervous system. We focus on the mechanisms that regulate progenitor cell proliferation, the acquisition of regional and cellular identity, neuronal migration, axon guidance, cell death, and activity-dependent mechanisms of neural circuit formation. Information drawn from these basic developmental mechanisms is used to discuss the newest emerging ideas about the pathogenesis of neuropsychiatric disorders such as autism, Tourette’s syndrome, depression, and other affective disorders. F. Vaccarino, M. Crair
[NBIO 535b/NSCI 535b, History of Modern Neuroscience]
[NBIO 570a/NSCI 570a, Cellular and Network Dynamics of Sensory and Motor Functions]
[NBIO 590a/NSCI 590a, Sensory Neuroethology: Bats and Owls, Electric Fish and Beyond]
[NBIO 595a/NSCI 595a, Seminar in Visuomotor Neurophysiology]
NBIO 602, Topics in Cortical Development and Evolution This advanced tutorial course involves extensive reading, discussion, and pilot experiments on the topic. P. Rakic
NBIO 610b, Fundamentals in Neurophysiology This course is designed for students who wish to gain a theoretical and practical knowledge of modern neurophysiology. Graduate students specializing in neurophysiology and non-neurophysiology are encouraged to attend, as the course begins at a very basic level and progresses to more complicated topics. Topics include properties of ion channels, firing properties of neurons, synaptic transmission, and neurophysiology methodology. V. Pieribone, F. Sigworth
NBIO 720a/MCDB 720a/NSCI 720a, Neurobiology Examination of the excitability of the nerve cell membrane provides a starting point for the study of molecular, cellular, and intracellular mechanisms underlying the generation and control of behavior. H. Keshishian, P. Forscher
Neurology
Office: LCI 708, 785.5947
Professors T. Allison (Emeritus), J. Booss (Emeritus), M. B. Bracken (Epidemiology), G. H. Glaser (Emeritus), B. Jabbari, R. D. Kerns (Psychiatry), J. D. Kocsis, R. H. Mattson (Emeritus), L. R. Ment (Pediatrics), G. Miller (Pediatrics), J. W. Prichard (Emeritus), P. Rakic (Neurobiology), G. B. Richerson, B. A. Shaywitz (Pediatrics), S. M. Strittmatter, S. G. Waxman (Chair)
Associate Professors J. M. Baehring (Neurosurgery), H. Blumenfeld, R. B. Duckrow, J. M. Goldstein, J. W. Pan (Neurosurgery), H. S. Patwa, O. A. Petroff
Assistant Professors S. S. Chandra, S. Novella, J. Preiningerova, J. Schindler, H. Tokuno
Instructors O. Avitzur, G. Buchanan, J. S. Chang, N. Y. Harel, M. Phipps, D. Richardson, D. C. Volpe
Senior Research Scientist R. H. Mattson
Research Scientists J. A. Black, S. D. Dib-Hajj, D. S. Navaratnam
Associate Research Scientists E. J. Arroyo, J. Bai, X. Bai, J. S. Choi, N. R. Driesen (Psychiatry), M. Estacion, A. R. Ferguson, T. Z. Fischer, E. C. Gunther, M. R. Hodges, K. Lankford, M. Sasaki, A. M. Szekely (Genetics), X. Wang, Y. Wu, H. P. Zaveri, P. Zhao
Clinical Professors R. L. Lesser (Ophthalmology and Visual Science), K. Marek, F. M. Testa (Pediatrics), T. J. Walsh
Associate Clinical Professors R. C. Delaney, J. C. McVeety, K. N. Sena, N. S. Werdiger, R. S. Young (Pediatrics)
Assistant Clinical Professors S. L. Bridgers, J. B. Butler, D. J. Coskun, E. J. Fertig, J. B. Guarnaccia, M. Hasbani, A. Katz, J. H. Mashman, D. S. Russell (Psychiatry), M. J. Stransky
Clinical Instructors L. J. Cretella, C. H. Gottschalk, M. J. Hasbani, A. S. Mednick, H. Sami, J. Yim
Lecturers L. Bangalore, M. Carrithers, J. L. Gross, S. Kadimi, P. J. McAllister, A. Quan Hong, K. C. Siegel, D. M. Zagar
Neurology 102, Clinical Neuroscience Core Clerkship The primary goal of this four-week clinical clerkship is to provide students with a fundamental approach to the nervous system. Specifically, this means the history, examination, diagnostic imaging, and treatment in the context of specific patients. Additionally, there is a series of lectures covering the broad range of conditions students are likely to encounter, such as trauma, stroke, infections, tumors, dementias, and seizures. Students take call with neurology residents once a week at Yale-New Haven Hospital; students assigned to neurosurgery take call with the residents on that service. After having given input on their preferences, students are placed on one of the following services for their clerkships: adult inpatient neurology, adult neurology consultation service, pediatric neurology, neurosurgery. All rotations are done at YNHH, the VA Connecticut Healthcare System, West Haven, or St. Raphael’s Hospital. H. Patwa, L. Ment, C. Duncan, H. Blumenfeld
Neurology 103, Clinical Neurology Elective Assignments for the clinical neurology elective are to the YNHH neurology consultation service, a rotation consisting of all outpatient clinics; or to the YNHH Inpatient Neurology Service. Four-week blocks coinciding with clerkship dates are preferred, but scheduling of electives is somewhat flexible. Students are able to request a choice, but assignment is made to assure that there is a balanced distribution between students in the required Neuroscience Clerkship and those doing electives, in order to allow an optimal learning experience for all students. Students work directly with attending faculty, chief residents, and junior residents as well as other medical students, rotators, and support staff. In addition to in-hospital patient evaluation and care, students on a consultation service are assigned to outpatient clinics. The students participate in departmental conferences and seminars. In addition, participation in most of the activities of the required Neuroscience Clerkship (e.g., didactic lectures) is encouraged (see Neurology 102 for description of clerkship details). The department is receptive to other specially tailored programs in areas such as epilepsy, stroke, movement disorders, neuroimmunology, etc., as well as clinical neurophysiology and research methods. H. Patwa and associates
Neurology 104, Clinical Neurology Subinternship Under appropriate supervision, students directly examine, diagnose, and manage patients on the neurology services at Yale-New Haven Hospital and attend daily teaching rounds and conferences. Hours to be arranged. Four-week rotations are recommended; alternative services are possible. Limited to two students each period. H. Patwa and associates
Neurology 106b, Clinical Neurophysiology Seminars and demonstrations in clinical applications of neurophysiology: electromyography and electroencephalography. Basic electronics are taught along with standard practice of recording and interpreting neurophysiology studies. J. M. Goldstein, H. Patwa, S. P. Novella
Neurology 108b/NSCI 507b, Cellular and Molecular Mechanisms of Neurological Disease Focuses on those diseases (Alzheimer’s, Parkinson’s, ALS and other neurodegenerative diseases, triplet repeat induced diseases, multiple sclerosis, epilepsy, etc.) in which modern neuroscience has advanced mechanistic explanations for clinical conditions. The course highlights recent molecular, electrophysiological, and imaging experiments in parsing disease mechanisms. The application of pathophysiologic understanding to therapeutics is considered. D. Navaratnam, S. Strittmatter, S. Waxman
Neurology 112b, Neuro-Oncology Neurological complications occur in approximately 20 percent of hospitalized oncology patients. The neurological complications of systemic cancer, as well as of primary CNS tumors, are discussed in depth. Issues regarding diagnosis and management of metastatic disease involving the nervous system as well as treatment-related complications are reviewed. In addition, metabolic and vascular disturbances and infections unique to the oncology patient that involve the nervous system are discussed. Specific cases are presented and arrangements are made to see specific patients during the elective period. This course is offered every three weeks with two lectures each week and is limited to three or four students per session. J. Baehring
Neurology 114b, Physiology of the Mammalian Nervous System The overall objective of this laboratory course is to introduce the student by hands-on experience to a variety of cellular electrophysiological techniques used in the study of the mammalian nervous system. Students set up a small electrophysiology laboratory and carry out experiments with the supervision of faculty. Laboratories include sucrose gap in whole nerve, single microelectrode current and voltage clamp recording of sensory neurons, field potential studies in rat hippocampal slice, and patch clamp analysis of cultured neurons. This course is limited to six to eight students. Permission of instructor is required for enrollment, 203.937.3802. J. D. Kocsis
Neurosurgery
Office: TMP 4, 785.2805
Professors R. A. Bronen (Diagnostic Radiology), W. F. Collins (Emeritus), R. T. Constable (Diagnostic Radiology), N. C. deLanerolle, C. A. Greer, M. Gunel, H. P. Hetherington, C. C. LaMotte, J. A. Persing (Surgery), J. M. Piepmeier, D. E. Redmond Jr. (Psychiatry), K. J. Ruskin (Anesthesiology), D. D. Spencer (Chair), A. N. Van den Pol
Associate Professors J. M. Baehring, H. Blumenfeld (Neurology), A. Bordey, R. B. Duckrow (Neurology), M. H. Johnson (Diagnostic Radiology), J. T. King, J. W. Pan, K. P. Vives, A. Williamson
Assistant Professors K. M. Abbed, K. R. Bulsara, I. Cavus (Psychiatry), V. L. Chiang, E. J. Fertig (Neurology), D. J. Gaal (Anesthesiology), A. Louvi, J. Schindler (Neurology), M. N. Spann, H. B. Treloar, F. S. Winstanley
Instructors E. Alam, L. Balsamo
Associate Research Scientists N. Avdievich, K. Bilguvar, T. Eid (Laboratory Medicine), L. Fu, P. K. Ghosh, H. Huang, G. Wollmann, K. Wu, Y. Xu, K. Yasuno
Clinical Professor L. M. Davey
Associate Clinical Professors I. Goodrich, D. E. Nijensohn
Assistant Clinical Professors A. P. Amar, T. J. Arkins, F. C. Brown, P. S. Dickey, K. S. Firlik, Z. Ghogawala, J. K. Sabshin, J. G. Strugar, M. Westerveld
Clinical Instructor E. W. Akeyson
Lecturer E. M. Lydon
Neurosurgery 101, Neurological Surgery This is an externship in which the student is involved in inpatient evaluation, outpatient visits, supervised emergency, and inpatient consultations. The student attends the operating room, follows patients, and is expected to correlate the clinical experience with basic neuroscience. K. M. Abbed, J. Baehring, K. R. Bulsara, V. Chiang, R. B. Duckrow, C. C. Duncan, M. Gunel, J. King, J. M. Piepmeier, D. D. Spencer, K. P. Vives
Neurosurgery 102, Investigational Neuroscience Typically taken during completion of the thesis requirement. Specific projects are by agreement with faculty members. Ongoing laboratory research includes the molecular neuroanatomical assessment of the epileptic focus (N. C. deLanerolle); ultrastructural assessment of organization and plasticity in local synaptic networks (C. A. Greer); the distribution and specificity of membrane-bound proteins directing neuronal growth (A. Van den Pol); glial cell function at synapses; intercellular communication promoting neurogenesis (A. Bordey); human and animal slice electrophysiology (A. Williamson, A. Bordey); human and animal intracerebral microdialysis (D. Spencer, I. Cavus, T. Eid); image-guided neurosurgical robotics and biophysical studies of brain imaging (D. Spencer, J. Duncan, K. Vives); stimulation of the brain for chronic neurological diseases (K. Vives, R. B. Duckrow, D. Spencer); molecular genetics of neurological disease (M. Gunel); angiogenesis and neurogenesis, skull base anatomy, bypass techniques, and endovascular technology development (K. Bulsara); characterization of ensheathing cells in promoting axonal elongation (C. A. Greer). Clinical research includes neurotrauma (V. Chiang), neuropsychological studies (F. Brown, M. Spann, S. Winstanley), spine disease and clinical trials (K. Abbed, Z. Ghogawala), epilepsy surgery (D. Spencer, K. Vives), pediatric neurosurgery outcomes (C. Duncan), neurooncology (J. Piepmeier, J. Baehring), basic mechanisms in CNS lymphoma (J. Baehring), and stereotactic radiosurgery (V. Chiang, K. Vives). Available throughout the year. Arrangements made with C. A. Greer
Obstetrics, Gynecology, and Reproductive Sciences
Office: FMB 307, 785.4212, Jill Aulenti, Manager of Medical Education
Professors A. M. Arici, M. B. Bracken (Epidemiology), F. R. Braveman (Anesthesiology), G. N. Burrow (Medicine), J. A. Copel, R. A. Ehrenkranz (Pediatrics), I. Gross (Pediatrics), J. P. Hayslett (Medicine), M. Hickey (Adjunct), R. B. Hochberg, T. L. Horvath (Comparative Medicine), E. I. Kohorn (Emeritus), C. Leranth, C. J. Lockwood (Chair), M. J. Mahoney (Genetics), N. J. Maihle, S. M. McCarthy (Diagnostic Radiology), E. R. Norwitz, P. Patrizio, A. D. Santin, P. M. Sarrel (Emeritus), P. E. Schwartz, F. A. Tavassoli (Pathology), H. S. Taylor
Associate Professors M. Azodi, I. Buhimschi, C. Bulletti (Adjunct), S. Diano, A. J. Duleba (Adjunct), C. N. Epperson (Psychiatry), S. J. Fortunato (Adjunct), E. F. Funai, F. Galerneau, J. B. Henrich (Medicine), M. Lee (Adjunct), U. Magriples, G. G. Mor, M. J. Paidas, T. J. Rutherford, D. Sakkas (Adjunct), N. S. Stachenfeld (Epidemiology), K. A. Yonkers (Psychiatry)
Assistant Professors V. M. Abrahams, M. O. Bahtiyar, R. S. Bercik, C. S. Buhimschi, K. A. Connell, X. Gao, M. K. Guess, Y. Huang, J. L. Illuzzi, J. Johnson, P. H. Kodaman, M. D. Lalioti, R. Menon (Adjunct), L. Pal, C. M. Pettker, B. W. Rackow, J. L. Reiter, E. U. Seli, A. K. Sfakianaki, D. Silasi, C. O. Stocco, S. F. Thung
Instructors J. G. Bromer, M. Cackovic, H. W. Chen, A. T. Dulay, K. Elsahwi, C. S. Han, E. J. Hodgson, J. L. Kulp, S. Y. Lee, A. L. Leiser, G. Luo, J. Martin, E. Ratner, M. Wehrum, E. F. Werner
Senior Research Scientist G. B. Huszar
Research Scientists S. M. Guller, Z. Hu, H. J. Kliman, G. Krikun, F. Schatz
Associate Research Scientists A. Alvero, S. Bellone, E. Borok, H. Du, T. Hajszan, S. J. Huang, U. A. Kayisli, M. Maduro, H. Qian
Research Affiliate Y. Y. Ma
Clinical Professors M. R. Berman, D. Greenfeld, S. R. Lavietes, V. A. Lynch, M. Minkin, J. S. Silidker, S. S. Spangler, L. J. Wartel, K. P. Williams
Associate Clinical Professors R. D. Auerbach, R. A. Cwik, T. M. Hanson, R. B. Kaump, W. A. Lieber, N. A. Ravski, H. J. Sauer, H. Simon, R. J. Stiller, R. A. Vidone, L. H. Zamore
Assistant Clinical Professors N. Achong Dorvilus, P. C. Brines, S. E. Casper, A. R. Chelouche, R. Chosak, I. M. Cohen, P. J. Coppola, E. A. Fine, S. M. Flaherty, S. J. Fleischman, W. P. Fleming, K. C. Fletcher, D. P. Fox, G. J. Foye, M. E. Gillette, L. C. Hanlon, C. L. Kandall, E. D. Karlovsky, B. D. Karsif, G. E. Kleinman, J. M. Knudson, T. Kumarasamy, S. A. Laifer, P. M. Lamastra, D. M. Lima, E. Luchansky, I. Marcovici, S. Mark (Medicine), B. McDowell, R. D. Moscarelli, S. Pace, L. Plisic, B. F. Rigney, S. D. Rosenman, D. M. Roth, D. J. Russell, J. A. Shaw, L. A. Starace-Colabella, A. Strong, H. I. Suesserman, E. A. Topran, O. J. Vincent, T. Zreik
Clinical Instructors N. Adsuar, M. A. Anderson (Student Affairs), A. Asis, M. C. Asis, K. R. Aversa, E. A. Berry, U. Bhuvanesh, S. P. Bowers, F. L. Cohn, J. Cron, M. Dick, M. Dube, A. Y. Edusa, J. T. Grosso, C. R. Huttler, J. C. Kaczmarek, N. R. Kellett (Student Affairs), D. R. Kopel, A. B. Landry, B. L. Maloy, J. J. McGrade, M. Mitchell, C. Negron, H. J. Nusbaum, E. Palluotto, A. T. Petruzzelli, R. Pringle, K. M. Rath, J. A. Reinshagen (Student Affairs), M. C. Rhee, A. M. Ross, T. M. Santos (Student Affairs), M. L. Speranza, A. L. Tirado, D. Tonzola, M. M. Tse, S. R. Vaz, J. D. Vulte (Student Affairs), M. J. Wise
Lecturers J. A. Cuteri, R. C. Deal, K. Despot, D. Gottschall, M. A. Haney (Student Affairs), F. P. Haseltine, G. M. Johnson (Student Affairs), E. Kuczynski, M. R. Laser, A. E. Moss (Student Affairs), M. Reault (Student Affairs)
Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship This core clerkship is a six-week rotation in which students serve as clinical clerks on the following services: obstetrics (two weeks), gynecology (two weeks), and ambulatory/antenatal (two weeks). Yale-New Haven Hospital and Bridgeport Hospital serve as the main clinical sites for this rotation. During the first week of the six-week clerkship, all students attend an in-depth evening teaching session with the Gynecologic Teaching Associates (GTA). At this session, they are carefully taught pelvic and breast examination techniques, and practice these techniques with the GTA. These practice sessions prepare students to adeptly handle actual patient examinations, review techniques and instruments, as well as understand how to manage patient encounters. During the Obstetrics portion of the rotation (one week Day Float and one week Night Float), the clinical clerk is assigned to the Labor and Delivery Unit and is expected to actively participate in patient care commensurate with his or her experience. Students are expected to work up and follow patients during the labor and delivery process, write notes during the intrapartum period, participate in vaginal deliveries, scrub in and assist in cesarean deliveries, and participate in the patient’s postpartum care. Students on the Gynecology services become familiar with the common disorders encountered in gynecological practice. They scrub for both major and minor surgeries, including those performed for gynecologic malignancy. The rotation offers an opportunity for the student to learn preoperative and postoperative management of gynecologic patients and to review pelvic and abdominal anatomy. The students spend two weeks in the ambulatory OB/GYN setting where they actively participate in antenatal care of pregnant patients as well as preventative and urgent healthcare visits for non-pregnant women. Students are supervised by attendings, physician associates, midwives, and residents as they learn to take histories, perform pelvic and breast exams, and gain experience in conducting normal obstetrical visits and routine gynecological care. The student is expected to gain experience in topics such as contraceptive counseling, family planning, menopause management, and other common patient complaints. Throughout the rotation, a didactic curriculum is delivered to cover the core topics in Obstetrics and Gynecology, which includes seminars, lectures, clinical reasoning workshops, and student presentations. Evaluation of the student is based on clinical performance and knowledge, professionalism and attendance, participation at rounds and didactics, student presentations, and submitted write-ups for the student portfolio. The recommended text for this elective is Obstetrics and Gynecology at a Glance by Errol Norwitz and John Schorge. Clerkship director: J. Illuzzi
Obstetrics, Gynecology, and Reproductive Sciences 107, Perinatal Elective The Maternal Fetal Medicine Division of the Department of Obstetrics, Gynecology, and Reproductive Sciences offers a four-week High-Risk Obstetrics elective for fourth-year medical students. The student functions as a Sub-Intern and team member in the care of high-risk obstetrical patients at Yale-New Haven Hospital. In addition to inpatient duties, the student attends the outpatient clinic once a week. Students also participate in prenatal ultrasound sessions as well as labor and delivery activities. Numerous didactic conferences are held during the rotation. It is recommended that students use the text Williams Obstetrics (Cunningham) to prepare for this experience and for research during the rotation. Evaluation of the student is based on clinical performance, participation at rounds, and the student’s presentation of one evidence-based case review to members of the MFM Division. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. Faculty coordinator: F. Galerneau
Obstetrics, Gynecology, and Reproductive Sciences 108, Reproductive Endocrinology and Infertility Elective The Reproductive Endocrine and Infertility division offers a four-week sub-internship to students. In addition to gaining knowledge of human reproductive endocrine function, students are introduced to disruptions in physiology and function leading to endocrinological and infertility problems. Typical clinical scenarios include androgen excess syndromes, hyperprolactinemia, anovulatory syndromes, endometriosis, and genetic abnormalities associated with menstrual anomalies and/or infertility. Exposure to Advanced Reproductive Technologies (ART) is integrated into this elective. In addition to the outpatient clinic/surgery and the in-patient service, students have the opportunity to attend division-specific conferences. Evaluation of the student is based on clinical performance, participation at rounds, and presentation of a case-based review of the literature. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. It should be noted that it is necessary to travel to the Long Wharf Medical Center, 150 Sargent Drive, New Haven, for this sub-internship program. There is no Night Call on this elective. Faculty coordinator: B. Rackow
Obstetrics, Gynecology, and Reproductive Sciences 109, GYN-Oncology Elective The Gynecology Oncology Division offers a four-week oncology elective to enhance the student’s knowledge of the diagnosis and management of women’s gynecologic malignancies. The student is exposed to all modalities of treatment for gynecologic malignancies including radical gynecological surgery, chemotherapy, and radiation therapy. The student is expected to be an integral part of the team in the management of the patients admitted to the service. The student admits patients and takes part in their care throughout the elective period. In addition to operating room exposure, extensive experience is gained in the postoperative management of these patients. On a weekly basis, students also attend outpatient clinics, divisional teaching sessions, as well as the multidisciplinary tumor conference. There is no Night Call on this elective. The recommended text is Clinical Gynecologic Oncology (DiSaia). Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. Faculty coordinator: A. Santin
Obstetrics, Gynecology, and Reproductive Sciences 110, Gallup Indian Medical Center (New Mexico) Elective The general OB/GYN department of the Gallup Indian Medical Center (GIMC) in New Mexico offers a subinternship in Obstetrics and Gynecology to fourth-year Yale medical students. This center provides OB/GYN health care to a growing underserved population. There are no residents at GIMC and, therefore, the student gains first-assistant experience during this rotation. The center has 20,000 outpatient visits, 750 deliveries, and 400 surgical cases per year. Bedside rounds, hands-on teaching, formal and informal lectures, and weekly conferences (High-Risk OB, GYN M&M, C-Section review) are integrated into this extramural elective. Students also experience an immersion in the Navajo culture. Evaluation of students is based on clinical performance, participation at rounds, and a final case-based presentation. Night Call is approximately every 4–5 nights. The recommended text for this elective is Danforth’s Obstetrics and Gynecology. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. Students are responsible for the cost of travel, lodging, and miscellaneous expenses. Faculty coordinator: G. Lynch (on site at GIMC, New Mexico)
Obstetrics, Gynecology, and Reproductive Sciences 111, Ambulatory Care OB/GYN Elective The goal of this four-week elective is to provide a broad exposure to outpatient gynecologic issues, such as contraception, family planning, menstrual abnormalities, pelvic pain, sexually transmitted disease, infertility, disorders of urinary continence, screening for gynecologic malignancies, and management of menopausal symptoms that are commonly encountered in the ambulatory setting. The student also has the opportunity to participate in the prenatal care of pregnant women, in order to gain a deeper understanding of the changes in maternal physiology throughout gestation, prenatal diagnosis, genetic counseling, and the outpatient management of the pregnant woman and her fetus. This elective gives the student opportunities to work in the Yale-New Haven Hospital Women’s Center, the Yale Urogynecology practice, the Yale Gynecologic Oncology Clinic, the Yale Maternal-Fetal Medicine practice, and the private community office setting. The recommended text for this elective is Obstetrics and Gynecology at a Glance by Errol Norwitz and John Schorge. Prerequisite: Obstetrics, Gynecology, and Reproductive Sciences 103, Core Clerkship or equivalent. It should be noted that it is necessary to travel to the Long Wharf Medical Center, 150 Sargent Drive, New Haven, and other private community offices for this elective. There is no Night Call on this elective. Faculty coordinator: J. Illuzzi
Ophthalmology and Visual Science
Office: BB 110, 785.2020
Professors M. Coca-Prados, N. Daw (Emeritus), C. Gonzalez (Emeritus), W. H. Miller (Emeritus), M. L. Sears (Adjunct), M. L. Sears (Emeritus), M. Shields, J. H. Sinard (Pathology), J. C. Tsai (Chair), Z. Zhou
Associate Professors R. A. Adelman, C. R. Bernardino, M. C. Crair (Neurobiology), J. J. Hoh (Epidemiology), L. J. Rizzolo (Surgery), K. M. Stoessel, C. J. Zeiss (Comparative Medicine)
Assistant Professors J. J. Huang, J. K. Lee, M. A. Materin, P. C. Palmisano, D. J. Salchow, D. Zenisek (Cellular and Molecular Physiology)
Instructors M. G. Bodman, J. E. Kempton
Associate Research Scientists S. Ghosh, J. Lin, X. Xu
Research Affiliates J. Y. Choi, C. Hsiao
Clinical Professors I. Abrahams, R. L. Lesser, P. E. Liggett, D. E. Silverstone, T. J. Walsh
Associate Clinical Professors B. M. DeBroff, S. H. Forster, P. H. Haffner, A. J. Levada, M. S. Milner, J. J. Olson, D. W. Parke, A. D. Rose, G. Shafranov, C. A. Sklar, K. M. Stoessel, R. A. Wiznia
Assistant Clinical Professors D. A. Bacal, P. J. Branden, G. A. Bullwinkel, N. Chaudhry, A. J. Daccache, V. P. de Luise, L. Doctor, P. A. Ecker, J. S. Elman, G. T. Emerick, P. M. Falcone, A. J. Fezza, P. Gaudio, J. Geffin, S. B. Hersh, W. I. Larrison, E. S. Lim, J. F. Martone, H. R. Mayer, A. W. Mead, A. Musto, A. D. Pearlstone, E. A. Petrelli, R. L. Petrelli, A. Romania, A. Shayegani, C. A. Sierra, J. Sokol, S. M. Soloway, D. Tom, J. M. Weisz, M. L. Weitzman, B. D. Zuckerman
Clinical Instructors E. J. Anderson, J. Q. Brooks, S. B. Castracane, A. H. Guerrero, P. C. Guida, M. A. Howard, Y. Kostina-O’Neil, P. E. Masi, S. W. Meskin, J. J. Pasternack, M. R. Shapiro, D. P. Shore, J. E. Silbert, V. A. Tarud, S. C. Thornquist
Ophthalmology and Visual Science 120, Elective in Clinical Ophthalmology This intensive two-to-four-week elective consists of twenty half-day or forty half-day sessions during which the students observe in subspecialty clinics, evaluate patients in general ophthalmology clinics, observe ophthalmic surgery, participate in department conferences, and review independent study material provided by the department. A short presentation on a specific topic provides an opportunity to explore one aspect of ophthalmology in depth. Subspecialty experiences include corneal and external eye diseases, glaucoma, neuro-ophthalmology, oculoplastics, and retinal diseases. Each two-week elective is limited to two fourth-year students. Offered all year. S. Forster, faculty, and resident staff
Ophthalmology and Visual Science 126, Preceptorial in Ophthalmology In this elective the student has intensive exposure to one ophthalmic subspecialty under the direct supervision of one or two faculty members. Generally, the experience includes observing in a subspecialty clinic and the operating room, and may include completion of a minor research project. Prior to starting this elective, the student must have outlined a plan of study and obtained the approval of the supervising faculty members. Faculty members in corneal and external diseases, glaucoma, oculoplastics, and retina participate. A list is available from the director of medical studies. Limited to fourth-year students. One to four weeks. Offered all year. Faculty
Orthopaedics and Rehabilitation
Office: YPB 133, 785.2579
Professors M. R. Baumgaertner, T. O. Carpenter (Pediatrics), G. E. Friedlaender (Chair), C. M. Gundberg, M. C. Horowitz, P. Jokl, L. D. Katz (Diagnostic Radiology), K. J. Keggi, M. M. Panjabi (Emeritus), R. R. Pelker, T. S. Renshaw (Emeritus), W. O. Southwick (Emeritus)
Associate Professors J. N. Grauer, J. F. Slade, B. G. Smith, A. M. Vignery, J. J. Yue
Assistant Professors S. D. Dodds, V. P. Eswarakumar, A. H. Haims (Diagnostic Radiology), P. C. Ivancic, D. M. Lindskog, M. J. Medvecky, J. S. Reach, C. R. Swigart, P. G. Whang
Instructors V. L. Bruegel Sanchez, C. H. Dushey, B. Lawrence, L. E. Rubin
Research Scientist L. Li
Clinical Professors J. K. Lynch, U. H. Weil
Associate Clinical Professors H. B. Bradburn, R. N. Margolis, E. J. Sella
Assistant Clinical Professors M. P. Altman, J. M. Aversa, A. L. Axtmayer, R. A. Bernstein, P. A. Blume, D. S. Caminear, M. P. Connair, J. P. Daigneault, P. A. DeLuca, D. H. Gibson, G. A. Gorecki, J. F. Irving, J. D. Kelley, K. M. Kramer, J. V. Lieponis, M. A. Luchini, P. P. Luchini, J. S. Marsh, R. B. Mayor, J. D. McCallum, T. Moran, M. J. Murphy, D. C. Novicki, M. M. Pressman, J. F. Raycroft, A. M. Reznik, D. S. Rosenblum, J. J. Shine, A. B. Sicklick, M. D. Silver, J. M. Sumner, S. L. Tomak, S. Vyce, L. D. Weis, L. D. Weis, J. Wu, R. A. Zell
Clinical Instructors D. F. Bindelglass, D. A. Brittis, C. A. Callahan, M. R. Clain, R. V. Dawe, R. Diana, A. H. Feldman, R. B. Feldman, P. D. Fragner, R. P. Hendrikson, H. I. Hermele, M. J. Kaplan, N. R. Kaplan, J. J. Key, J. V. Mangieri, P. Minotti, M. A. Morrison, J. M. Perlman, A. Rice, D. P. Sakalkale, R. A. Stanton, P. B. Stovell, K. M. Sutton, P. G. Whang, V. J. Williams
Lecturers L. R. Brenner, G. A. Gorecki, M. J. Parisi, R. E. Stevenson, B. T. Zazulak
Orthopaedics and Rehabilitation 102, Surgical Clerkship Twelve weeks total. Students in the first clinical year spend six weeks on the general surgical service of one of the following: Yale-New Haven Hospital, VA Connecticut Healthcare System, West Haven, or Hospital of St. Raphael. Each student is integrated into the clinical team and assigned to specific patients. Responsibilities include taking histories and performing physical examinations on their patients, participating in the evaluation and management of these patients, following patients’ progress, and participating as assistants in the surgical operations performed upon their assigned cases. In addition, the students are expected to participate in the evaluation and care of the critically ill patient in the intensive care unit and the injured patient in the emergency room. Emphasis is placed on involving students in the process of clinical problem solving with the guidance of the residents and the attending preceptors. Conferences, case study groups, and rounds are held emphasizing this problem-oriented approach. Staff
The remaining six-week period is spent as a clinical clerk in the surgical specialties. Seven specialties are offered: cardiothoracic, otolaryngology, neurosurgery, orthopaedics, pediatric, plastic and reconstructive, and urology. Each student elects three of these specialties and spends two weeks on each. While on the specialty of choice, the student is assigned patients in rotation and carries out complete histories, physical examinations, and certain procedures on these patients. While on the orthopaedic service, the student is assigned to one of the subspecialty teams, which include pediatric orthopaedics, spine, joint reconstruction, trauma, oncology, foot and ankle, hand, and sports medicine. The student is expected to participate, whenever possible, in the operative procedures performed on these patients and in their postoperative care. The student is also invited to attend the outpatient clinics in his or her assigned specialty. A series of one-hour lectures, rounds, or demonstrations is given each afternoon by the surgical specialties so that the student has the opportunity of gaining knowledge of the wide field of specialties even though he or she does not participate in every specialty as a clinical clerk. Directed by individual surgical specialty chiefs
Orthopaedics and Rehabilitation 104, Subinternship Limited to third- and fourth-clinical years, with prior clerkship rotation. The student is an active member of one of the orthopaedic teaching teams (pediatric orthopaedics, spine, joint reconstruction, trauma, oncology, foot and ankle, hand, and sports medicine). Inpatient, outpatient, and operating room experience is supplemented by regular conferences. Limited to four students, preferably for one-month rotations, throughout the year. Arrangements must be made with K. Umlauf
Orthopaedics and Rehabilitation 108, Subinternship, Adult Reconstructive and Rehabilitative Orthopaedics, VA Connecticut Healthcare System, West Haven The student functions as the intern on a large adult orthopaedic service. He or she attends conferences at the Veterans Affairs Connecticut Healthcare System, West Haven, and at Yale-New Haven Hospital. (YNHH conferences include an ongoing seminar on basic sciences as related to the musculoskeletal diseases.) The student is a full participant in the outpatient department and in the work of the operating room. This subinternship offers an intensive clinical experience with a variety of complex orthopaedic reconstructive problems. Rotations are usually for one month. By arrangement with K. Umlauf
Orthopaedics and Rehabilitation 110, Biomechanics Terminology Presentation and explanation of some basic biochemical terms used to describe body tissues, structures, and functions. More than one hundred basic engineering terms are introduced. The format of presentation for each term is (1) a precise definition followed by units of measurement in the new S.I. system, (2) a detailed explanation, and (3) examples of its use in the everyday experience as well as in the medical field. Mathematical formations are presented whenever necessary. Eight weeks, by arrangement. P. Ivancic
Orthopaedics and Rehabilitation 116, Basics of (Fracture) Diagnosis and Treatment A six-week seminar in the basic elements of diagnosis and treatment of a spectrum of musculoskeletal trauma. M. Baumgaertner
Orthopaedics and Rehabilitation 118, Musculoskeletal Anatomy The basics of musculoskeletal anatomy from a functional anatomic and surgical perspective. The material is presented using prosected specimens. Knowledge of Anatomy 100a or its equivalent is assumed. M. Baumgaertner
Orthopaedics and Rehabilitation 120, Rehabilitation Medicine at Gaylord Hospital A four-week elective rotation designed to provide a comprehensive view of rehabilitation. The elective is composed of didactic sessions and clinical experiences in both the inpatient and outpatient setting. Areas of primary focus include spinal cord injury, head trauma, multiple trauma, amputations, pain management, occupational rehabilitation, stroke, and other neurologic rehabilitation. Specific problems, such as gait deviation, heterotropic ossification, and spasticity are addressed. Therapeutic modalities—bracing and other durable medical equipment—are covered. The roles of allied health professionals, including physical, occupational, and speech therapies, and neuropsychology are demonstrated. Available throughout the year by arrangement with A. Sicklick and D. Rosenblum
Pathology
Office: LH 108, 785.2759
Professors R. Bucala (Medicine), J. Chen (Therapeutic Radiology), D. Chhieng, Y. Choi, J. Costa, S. E. Downing (Emeritus), G. E. Friedlaender (Orthopaedics and Rehabilitation), E. J. Glusac, N. J. Holbrook (Medicine), M. Kashgarian (Emeritus), J. H. Kim (Emeritus), D. S. Krause (Laboratory Medicine), P. M. Lizardi, J. A. Madri, N. J. Maihle (Obstetrics, Gynecology, and Reproductive Sciences), V. T. Marchesi, J. M. McNiff (Dermatology), J. S. Morrow (Chair), J. S. Pober (Immunobiology), D. L. Rimm, M. E. Robert, J. K. Rose, G. S. Shadel, J. H. Sinard, J. L. Sklar, D. F. Stern, F. A. Tavassoli, A. West, R. Yesner (Emeritus)
Associate Professors M. W. Bosenberg (Dermatology), J. L. Brandsma (Comparative Medicine), S. E. Cowper (Dermatology), G. Haines, L. Hao, R. J. Homer, P. Hui, D. Jain, D. Kowalski, G. Kupfer (Pediatrics), R. Lazova (Dermatology), W. Min, G. Moeckel, V. Parkash, A. O. Vortmeyer
Assistant Professors A. Adeniran, V. Bossuyt, D. Braddock, G. Cai, P. Cohen, A. Galan (Dermatology), M. Harigopal, A. J. Huttner, S. Khelifa, S. H. Kleinstein, C. J. Ko (Dermatology), M. O. Krauthammer, T. Kyriakides, R. Means, K. A. Mitchell, M. M. Pinto, M. Robek, O. Saglam, A. Subtil (Dermatology), C. Theoharis, D. P. Tuck, Z. Walther, Q. Yan, E. V. Zambrano
Instructor A. Levi
Senior Research Scientists M. Kashgarian, J. H. Kim, R. Yesner
Research Scientists C. L. Howe, J. Li
Associate Research Scientists S. Agarwal, R. A. Albright, Y. Bai, R. L. Camp, A. Chattopadhyay, D. Chen, C. D. Cianci, J. K. Czyzyk, S. Dai, P. Gershkovich, M. A. Gilmore-Hebert, Y. He, U. Hershberg, Q. Huang, S. Lang, H. Li, Q. Li, Z. Liu, X. Ma, N. F. Rose, J. A. Schwartz, M. C. Stankewich, A. Stortchevoi, H. Zhang
Research Affiliate A. Dimou
Clinical Professors G. L. Davis, D. M. Lowell
Associate Clinical Professors P. N. Fiedler, D. F. Miller
Assistant Clinical Professors W. Carver, T. E. Ciesielski, N. A. Gelfman, G. M. Golenwsky, R. N. Kranwinkel
Clinical Instructors W. G. Frederick, A. Katsnelson, S. L. Wain
Pathology 600, Pathological Basis of Human Disease Fundamental principles underlying the pathological alterations in function and structure that constitute the reaction of the organism to injury. Pathology of diseases involving special organs and systems. Correlation of the clinical and anatomical manifestations is emphasized. For YSPH graduate students and MSTP students who are required to take PATH 100 for graduate credit. D. Rimm and staff
Pathology 616, Autopsy Pathology Participation in the autopsy service with members of the house staff in pathology. Participation in autopsies and the presentation and review of the clinical and anatomical findings of postmortem examinations with senior members of the department. Opportunities exist for correlation studies with previous biopsies, and clinical investigative and cell biologic techniques in relation to necropsy material. Six weeks minimum, full time. Enrollment limited to two students. J. Sinard and staff
Pathology 617, Anatomic Pathology The department offers an elective to medical students in the third and fourth years which provides a broad experience in general diagnostic techniques. Students have opportunities to participate in surgical pathology, cytology (including fine-needle aspiration), and autopsy. A daily conference is scheduled for both residents and students. In addition to direct responsibilities in the handling of the cases, the student has the opportunity to apply the special techniques of electron microscopy, immunohistochemistry, flow cytometry, and molecular diagnostics. A minimum of four weeks is suggested for this elective. Five students are accommodated every four to six weeks. B. West and staff
Pathology 618b, Clinical and Pathologic Correlates in Renal Disease A series of clinical pathologic conferences designed to illustrate clinicopathologic correlates in renal disease. At each session, one student acts as clinician and another as pathologist in the evaluation and discussion of case material from autopsies or renal biopsies. Discussions are informal, but require preparation in advance and all participants are expected to contribute in each session. One two-hour session per week for six weeks. Given once in spring term. Limited to twelve students. M. Kashgarian
Pathology 620a and b, Laboratory Rotations in Experimental Pathology Laboratory rotations for first-year graduate students. G. Shadel
Pathology 630b, Biomaterial-Tissue Interactions An in-depth survey of the interactions between tissues and biomaterials, with an emphasis on the molecular- and cellular-level events that influence the performance and longevity of clinically relevant devices. Background in chemistry and cell biology is assumed. Open to advanced undergraduates with permission of the organizer. T. Kyriakides
Pathology 650b, Cellular and Molecular Biology of Cancer A comprehensive survey of cancer research from the cellular to the clinical level. The relation of cancer to intracellular and intercellular regulation of cell proliferation is emphasized, as are animal models for cancer research. Background in molecular genetics and cell biology is assumed. D. F. Stern, R. Means
Pathology 670b, Biological Mechanisms of Reaction to Injury An introduction to human biology and disease as a manifestation of reaction to injury. Topics include organ structure and function, cell injury, circulatory and inflammatory responses, disordered physiology, and neoplasia. M. Kashgarian and staff
Pathology 680a, Seminar in Pharmacology and Molecular Medicine Readings and discussion in topics relevant to cell biology, signal transduction, immunology, and molecular medicine. The overall theme of the papers discussed is pathogenesis of human infectious disease. The class emphasizes analysis of primary research literature and development of presentation skills. TBA
Pathology 690a, Molecular Mechanisms of Disease This course covers aspects of the fundamental molecular and cellular mechanisms underlying various human diseases. Many of the disorders discussed represent major forms of infectious, degenerative, vascular, neoplastic, and inflammatory disease. Additionally, certain rarer diseases that illustrate good models for investigation and/or application of basic biologic principles are covered in the course. The objective is to highlight advances in experimental and molecular medicine as they relate to understanding the pathogenesis of disease and the formulation of therapies. M. Robek
Pediatrics
Office: LMP 4085, 785.4638
Professors W. A. Andiman, W. R. Anyan (Emeritus), R. S. Baltimore, G. P. Beardsley, M. Cappello, S. Caprio, T. O. Carpenter, J. A. Copel (Obstetrics, Gynecology, and Reproductive Sciences), R. A. Ehrenkranz, S. H. Emre (Surgery), R. L. Fisher (Medicine), B. W. Forsyth, A. H. Friedman, P. G. Gallagher, M. Genel (Emeritus), I. Gross, A. L. Horwich (Genetics), M. K. Hostetter (Chair), Z. Kain (Child Study Center), D. M. Komp (Emeritus), J. F. Leckman (Child Study Center), J. M. Leventhal, M. J. Mahoney (Genetics), L. C. Mayes (Child Study Center), P. L. McCarthy, L. R. Ment, G. Miller, I. Miller, P. K. Mistry, R. Moss (Surgery), H. A. Pearson (Emeritus), S. A. Rivkees, S. A. Rooney (Emeritus), D. J. Schonfeld (Adjunct), M. R. Seashore (Genetics), E. D. Shapiro, S. E. Shaywitz, B. A. Shaywitz, R. N. Shiffman, N. S. Talner (Emeritus), W. V. Tamborlane, R. J. Touloukian (Surgery), F. R. Volkmar (Child Study Center), J. Woolston (Child Study Center)
Associate Professors R. J. Antaya (Dermatology), C. R. Baum, A. Bazzy-Asaad, D. Beardsley, K. A. Bechtel, V. Bhandari, C. W. Bogue, M. Brueckner, R. L. Chapman, E. R. Colson, D. F. Donnelly, M. E. Egan, J. T. Fahey, J. N. Grauer (Orthopaedics and Rehabilitation), J. R. Gruen, G. Kupfer, J. M. McNamara, M. R. Mercurio, D. S. Pashankar, K. Pugh, L. E. Rosenfeld (Medicine), S. A. Ryan, K. Santucci, T. Shinoka (Surgery), A. Tufro, S. A. Weinzimer, C. C. Weitzman, M. Westerveld (Neurosurgery), Y. Xia
Assistant Professors N. A. Ameen, L. D. Arnold, A. G. Asnes, J. D. Asnes, S. Bhaduri-McIntosh, S. Bhargava, M. J. Bizzarro, C. K. Breuer (Surgery), T. S. Burgert, L. Chen, K. Y. Ching, M. X. Cicero, K. Dhodapkar, B. R. Doolittle (Medicine), K. B. Dorsey, A. M. Fenick, E. J. Fertig (Neurology), M. R. Grossman, D. C. Hersh, A. B. Hittelman (Surgery), A. L. Hsiao, S. Z. Husain, P. T. Jubinsky, N. Kadan-Lottick, M. K. Khokha, M. Langhan, F. M. Lobo (Medicine), R. A. Martinello (Medicine), M. E. McCabe, M. A. McKee (Surgery), E. Michaelides (Surgery), E. Paintsil, F. D. Pashankar, R. A. Rosencrantz, D. J. Salchow (Ophthalmology and Visual Science), S. N. Sudikoff, M. Vazquez, B. P. Weeks, P. G. Weiss
Instructors K. E. D’Aco, H. Kocinsky, M. A. Monaco, V. M. Pierce, D. M. Walker
Senior Research Scientist M. Genel
Research Scientists J. D. Dziura (Medicine), J. M. McGrath (Comparative Medicine), K. C. Schneider
Associate Research Scientists A. Ali, L. Ardeshirpour, A. L. Benin, E. M. Bruscia, E. Cengiz, D. Chao, X. Chen, C. A. Dinauer, A. E. Esquibies, J. E. Goodwin, A. R. Gupta, J. Liu, K. E. Marchione, T. S. Murray, E. Pinter, M. S. Rosenthal, V. Schulz, D. D. Veron, C. C. Wendler, H. Z. Zhang (Genetics)
Research Affiliates A. Cali, N. Cope
Clinical Professors R. Angoff, H. D. Fink, P. Goldstein, H. Jacobs, T. L. Kennedy, R. G. LaCamera, S. R. Levy, B. M. McDonald, A. C. Mermann, C. Randolph, M. W. Sklaire, S. Z. Spiesel, F. M. Testa, J. H. Zelson
Associate Clinical Professors F. P. Anderson, M. Apkon, K. M. Berkwits, R. M. Biondi, H. D. Bornstein, C. Canny, R. D. Chessin, H. D. Fink, J. S. Fong, R. M. Freedman, M. W. Galal, G. S. Germain, C. W. Goff, F. L. Gruskay, J. Hen, R. A. Herzlinger, M. P. Hommel, C. F. Mann, S. K. Nallainathan, S. M. Peterec, R. L. Shelling, E. L. Stone, S. C. Updegrove, C. C. Wood, R. S. Young
Assistant Clinical Professors R. J. Anderson, A. J. Avni-Singer, J. W. Blanton, S. Boulware, J. Burger, C. G. Butler, J. G. Calderon, A. Cameron, D. P. Cheromcha, J. T. Combs, N. Condulis, N. Czarkowski, M. E. Dilorenzo, C. L. Dorfman, D. H. Dreyfus, A. Driggers, D. P. Durante, S. I. Escalera, T. Etkin, K. A. Fearn, C. A. Fischbein, M. B. Flaherty-Hewitt, M. Gaeta, B. Gardner, E. H. Gleich, A. Golioto, D. L. Griffin, J. A. Gruskay, R. B. Halperin, R. J. Hobbie, D. L. Idelson, M. K. Ikeda, D. E. Karas (Surgery), S. J. Lavietes, M. A. Lee, A. Liebling, J. L. Morgan, C. L. Morrison, H. J. Pierce, P. T. Pitlick, U. P. Puranik, M. F. Robert, M. F. Robert, M. A. Sanyal, M. Seli, L. Semeraro, L. B. Shader, R. J. Shea, M. Siev, E. C. Springhorn, J. M. Stein, C. P. Summers, J. Talwalkar, S. Tsalbins, A. Vaezy, G. R. Wanerka, P. P. Wang, S. A. Weiner, N. Weinstein, P. J. Whang, R. F. Whelan, E. Wiesner, R. D. Windom, J. Wynne
Clinical Instructors P. M. Alvino, J. M. Ambrosino, L. Berlin, S. Bogursky, R. J. Brown, K. R. Burke, M. F. Canarie, R. E. Carroll, M. C. Caserta, J. Cersonsky, B. V. Citarella, B. V. Citarella, A. M. Coughlin, M. R. Dillaway, R. G. Dorr, M. Ellison, S. B. Fishberger, B. G. Freeman, K. Y. Goldberg, A. Gork, L. E. Gray, M. E. Groth, J. E. Harwin, K. L. Hodges, A. M. Hoefer, M. S. Hogan, F. C. Holmes, D. L. Idelson, L. R. Jayanthi, H. Kipperman, J. T. Lau, I. Lazar, D. A. Listman, R. Lockhart, E. A. Lomotan, A. J. Maley, A. Matczuk, L. M. McGrimley, C. Menzies, C. L. Miliaresis, J. M. Miller, B. C. Natt, C. Nicolosi, R. Nolfo, R. R. Ongjoco, C. L. Patterson, M. Pouliot, R. F. Ramos (Medicine), C. B. Rosen-Carole, L. K. Rudich, R. L. Sawyer, S. K. Simon, D. J. Springer, J. H. Stein, S. M. Storeygard, G. Streeter, D. C. Torres, V. P. Tsuei, L. Visscher, L. A. Waldman, S. A. Walsh, J. L. Young, R. A. Zlotoff (Medicine)
Lecturers C. D. Cook, J. C. Samuel, S. J. Santacroce (Nursing)
Pediatrics 103, Third-Year Clerkship The Pediatric Third Clerkship is an eight-week required rotation based on a national curriculum developed specifically for students beginning their clinical rotations. The students spend four weeks in the inpatient setting and four weeks in the outpatient setting. During the outpatient rotation, students are exposed to primary care as well as specialty care in the ambulatory setting. The inpatient portion of the rotation takes place at Yale-New Haven Hospital or Bridgeport Hospital. The objectives of the eight-week clerkship include improvement in knowledge as well as clinical skills such as history taking, physical examination skills, and problem solving. During the rotation, students are observed performing these skills by designated supervisors. They have the opportunity to supplement and complement their clinical experiences by doing self-directed reading, completing computer-based cases, working with a simulated model, and interviewing standardized adolescent patients. Attention is paid to optimizing exposure to all pediatric age groups. The clinical experience is enhanced by a weekly interactive teaching session run by pediatric faculty members specifically for the third-year students. E. Colson, M. Bizzarro
Pediatrics 128, Hematology–Oncology A survey of the normal and abnormal hematology and the common malignancies of infancy and childhood. Students make initial rounds with the attending and the ward team at 7.30 a.m. The mornings are then spent in clinic seeing outpatients who come for therapy or follow-up. More extended bedside rounds, including time allotted for family discussions, take place in the afternoon. Students are expected to prepare a brief presentation for the team. One student, full time for two weeks, throughout the academic year. G. Kupfer and staff
Pediatrics 139, Pediatric Neurology Students participate in the pediatric neurology clinic and see neurology patients on the pediatric wards. Up to two students, full time, for three weeks, throughout the academic year. L. R. Ment, G. Miller, B. Shaywitz, S. Shaywitz
Pediatrics 143b/Surgery 136b, Pediatric Surgery A general survey of pediatric surgical problems based on illustrated case summaries and subject presentation by students, with selected readings from the literature. Limited to six students, first and last six weeks of spring term. Once weekly, time to be arranged. C. K. Breuer, R. J. Touloukian, M. A. McKee, R. L. Moss
Pediatrics 144, Clinical Clerkship in Pediatric Cardiology Developmental aspects of cardiovascular function as applied to infants and children in a clinical setting. Students are assigned to various members of the pediatric cardiology staff. Emphasis on physical diagnosis, use of noninvasive methods, and clinical physiologic correlates. Observation of catherization and operative procedures. One student every four weeks throughout the year. J. Asnes, M. Brueckner, J. Fahey, A. H. Friedman, G. Porter, B. Weeks
Pediatrics 146, Clinical Pediatric Infectious Diseases Students participate in daily consultation rounds, Pediatric HIV/ AIDS Clinic, and weekly Pediatric Infectious Diseases Clinic. Students also participate in weekly pediatric infectious disease rounds by presenting the case studies of one or more inpatients whom they have examined to a group of faculty and fellows. Rounds last approximately two hours (Thursday afternoon) and monthly rounds with U.Conn occur the fourth Wednesday in the morning. Emphasis is placed on correlation of the clinical problem and its practical management with principles of infectious disease epidemiology and clinical microbiology (bacteriology, virology, and parasitology). Limited to two students per three- to six-week period throughout the academic year. W. Andiman, R. Baltimore, S. Bhaduri-McIntosh, M. Cappello, M. Hostetter, G. Miller, T. Murray, E. Paintsil, G. Shapiro, M. Vazquez
Pediatrics 148, Pediatric Endocrinology and Metabolism An extensive exposure to clinical pediatric endocrinology, in particular problems of growth, sexual development, thyroid disorders, adrenal diseases, obesity, type 1 and 2 diabetes mellitus, and other disorders of carbohydrate metabolism. A full six-week elective includes daily clinics in general endocrinology, diabetes, and hyper lipidemia/obesity, and the inpatient service. One student, full-time, six weeks, throughout the academic year. S. Boulware, T. Burgert, S. Caprio, T. Carpenter, E. Cengiz, M. Genel, S. Rivkees, W. V. Tamborlane, S. Weinzimer
Pediatrics 152, Subinternship Senior students serve four weeks on either the Infant/Toddler or School Age/Adolescent Unit at Yale-New Haven Hospital. Students are considered intern equivalents and therefore take on the same roles and responsibilities as the interns. Work is supervised by senior residents and attending physicians. D. Hersh
Pediatrics 153, Pediatric Gastroenterology/Hepatology A general survey of clinical pediatric gastroenterology and hepatology with particular emphasis on inflammatory bowel disease, malabsorption, diarrheal disorders, nutrition, and liver disease. The elective includes daily inpatient rounds including rounds with pediatric liver transplant service, three weekly GI clinics, inherited metabolic liver disease clinic, and several weekly clinicopathologic conferences, as well as observation of endoscopic procedures. One student, full-time, two-week rotation. N. Ameen, S. Husain, P. Mistry, D. Pashankar, R. Rosencrantz
Pediatrics 154, Pediatric Respiratory Medicine Students participate in the daily activities of the service in both the inpatient rounds and outpatient clinics. These include the evaluation of respiratory function in a variety of diseases including asthma, cystic fibrosis, bronchopulmonary dysplasia, pneumonia, aspiration syndromes, obstructive sleep disorders, and care of technology-dependent infants and children. Emphasis is on physical diagnosis. Rotations through the pulmonary function laboratory and the Children’s Sleep Center are available. Laboratory experience can be arranged. Participation in seminars and journal club are expected. One student, every two weeks, throughout the academic year. A. Bazzy-Asaad, S. Bhargava, M. Egan, A. Esquibies, P. Weiss
Pediatrics 155, Pediatric Emergency Medicine Senior students have the opportunity to evaluate and help manage a broad range of acute pediatric illnesses and injuries. Students are supervised by a Pediatric Emergency Medicine specialist. Clinical duties are scheduled by the program director. One student, full time, every four weeks throughout the year. L. D. Arnold and staff
Pharmacology
Office: SHM B204, 785.4372
Professors G. K. Aghajanian (Psychiatry), K. S. Anderson, B. S. Bunney (Psychiatry), E. S. Canellakis (Emeritus), Y. Cheng, E. Chu (Medicine), J. R. Cooper (Emeritus), C. M. Crews (Molecular, Cellular, and Developmental Biology), P. S. Dannies, R. S. Duman (Psychiatry), B. E. Ehrlich, R. E. Handschumacher (Emeritus), J. R. Howe, D. K. Jorkasky (Adjunct), L. K. Kaczmarek, N. J. Maihle (Obstetrics, Gynecology, and Reproductive Sciences), A. C. Nairn (Psychiatry), M. Picciotto (Psychiatry), W. H. Prusoff (Emeritus), S. Rockwell (Therapeutic Radiology), R. H. Roth (Psychiatry), G. Rudnick, A. C. Sartorelli, J. Schlessinger (Chair), W. C. Sessa, S. G. Waxman (Neurology), D. Wu
Associate Professors A. M. Bennett, M. P. DiGiovanna (Medicine), Y. Ha, R. Heimer (Epidemiology), M. E. Hodsdon (Laboratory Medicine), I. Lax, E. Lolis
Assistant Professors T. Boggon, D. A. Calderwood, V. P. Eswarakumar (Orthopaedics and Rehabilitation), S. Jordt, E. Paintsil (Pediatrics), B. E. Turk
Senior Research Scientists J. R. Cooper, W. H. Prusoff
Associate Research Scientists R. P. Baumann, S. C. Bussom, G. V. Crichlow, C. Fernandez-Hernando, V. Gazula, R. Hu, K. Ishiguro, W. Lam, Z. Lin, J. W. Murphy, P. G. Penketh, A. D. Pivazyan, H. Qin, H. A. Seow, K. Shyam, U. Sung, X. Wang, C. Wang, Y. Yang, C. Ying, J. Yu, Y. Zhang, W. Zhang, Y. Zhang, Y. Zhu
Research Affiliate Y. Opatowsky
Lecturer R. J. Levine (Medicine)
PHAR 502a and b, Seminar in Pharmacology A seminar given by a department faculty member on his or her area of interest to teach students how to critically evaluate papers and to improve the ability of students to give oral presentations. D. Wu
PHAR 504a, Pharmacology I: Interfering Selectively Lectures covering pharmacokinetics and drug toxicity, modern approaches to drug discovery and development, and mechanisms of drug action in the following areas: antibiotics and anti-viral therapy, immunosuppression and anti-inflammation, anti-asthmatic and anti-allergic therapy, cancer chemotherapy and medical uses of radiation, and pain. E. Lolis and staff
PHAR 504b, Pharmacology II: Maintaining and Restoring Homeostasis The course covers the general principles of pharmacology, which include areas of drug-receptor interactions, control of second messenger systems and ion-gated channels, and the regulation of physiological systems. These concepts are integrated with examples of how drugs are used when normal physiological controls fail. Discussion groups are directed toward current and emerging topics of signaling mechanisms that may yield novel pharmacological targets for future clinical therapies. A. Bennett
PHAR 506a and b, Methods in Pharmacological Research (Rotations) Students work in laboratories of faculty of their choice. The period spent in each laboratory is one term. E. Lolis
PHAR 508b, Neuropharmacology An intensive examination of current understanding of the sites and mechanisms involved in drug action on single nerve cells and on the brain. Emphasis on basic functions and illustrative examples of their disturbance by drugs. J. Howe
PHAR 518b, Current Topics in Cancer and Viral Therapy This course discusses current and evolving topics in cancer and viral mechanisms of disease and potential treatments. Each session is two hours in length. The lecturers present a general overview of the field as well as some of their research activities. Students are required to discuss papers on the particular topic of the day. Y. Cheng, B. Turk
PHAR 521a/NSCI 521a, Neuroimaging in Neuropsychiatry I: Imaging Methods Neuroimaging methodologies including Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Magnetic Resonance Imaging (MRI), functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy (MRS), and gene array imaging (GAI) are rapidly evolving tools used to study the living human brain. Neuroimaging has unprecedented implications for routine clinical diagnosis, for assessment of drug efficacy, for determination of psychotropic drug occupancy, and for the study of pathophysiological mechanisms underlying neurologic and psychiatric disorders. This course is designed to provide an overview of the theory and current state of development of the different neuroimaging modalities. A second course, offered in the spring, focuses on applications. J. Staley, K. Cosgrove
PHAR 521b/NSCI 521b, Neuroimaging in Neuropsychiatry II: Clinical Applications Neuroimaging methodologies including Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), structural Magnetic Resonance Imaging (sMRI), functional Magnetic Resonance Imaging (fMRI), Diffusion Tensor Imaging (DTI), and Magnetic Resonance Spectroscopy (MRS) are rapidly evolving tools used to study the living human brain. Neuroimaging has unprecedented implications for assessment of drug efficacy, for determination of psychotropic drug occupancy and for the study of pathophysiological mechanisms underlying neuropsychiatric disorders. This course is designed to provide an overview of the application of state-of-the-art neuroimaging methods to research in neuropsychiatric disorders. It is recommended for PGY I-VI, Child Psychiatry Fellows, Interdepartmental Neuroscience students, and trainees in pharmacology, neurology, neurosurgery, psychiatry, psychology, and radiology. H. Blumberg, K. Cosgrove, J. Staley
Psychiatry
Office: 300 George Street, Suite 901, 785.2117
Professors G. K. Aghajanian, S. A. Ball, M. D. Bell, S. J. Blatt, B. S. Bunney (Emeritus), K. M. Carroll, J. P. Comer (Child Study Center), L. Davidson, R. S. Duman, M. H. Ebert, P. L. Errera (Emeritus), J. Ford (Adjunct), J. E. Gelernter, E. H. Griffith, C. M. Grilo, G. Heninger (Emeritus), R. E. Hoffman, M. A. Hoge, S. C. Jacobs (Emeritus), H. G. Jarecki (Adjunct), P. I. Jatlow (Laboratory Medicine), R. D. Kerns, R. A. King (Child Study Center), J. H. Krystal, J. F. Leckman (Child Study Center), P. J. Lombroso (Child Study Center), A. S. Martin (Child Study Center), J. W. Mason (Emeritus), C. Mazure, T. H. McGlashan, D. F. Musto (Child Study Center), A. C. Nairn, S. S. O’Malley, G. D. Pearlson, M. Picciotto, S. M. Powsner, D. M. Quinlan, D. E. Redmond Jr., R. Rosenheck, R. H. Roth, B. J. Rounsaville, R. S. Schottenfeld, M. J. Sernyak, M. H. Sheard (Emeritus), R. Sinha, W. H. Sledge (Acting Chair), D. L. Snow, S. M. Southwick, J. S. Strauss (Emeritus), J. R. Taylor, C. H. van Dyck, F. R. Volkmar (Child Study Center), B. E. Wexler, S. W. Woods, H. V. Zonana
Associate Professors M. Alreja, L. M. Anez, M. Baranoski, K. L. Behar, R. Belitsky, H. Blumberg, A. Buchanan, V. D. Calhoun (Adjunct), N. L. Cooney, D. C. D’Souza, R. A. Desai, E. Diaz, R. J. DiLeone, C. J. Easton, C. N. Epperson, E. L. Giller (Adjunct), D. C. Glahn, L. S. Godleski, K. A. Hawkins, J. S. Kaufman, J. Kaufman, P. D. Kirwin, S. Krishnan-Sarin, R. T. Malison, S. Marans (Child Study Center), S. Martino, G. F. Mason (Diagnostic Radiology), D. H. Mathalon (Adjunct), S. McKee, T. J. McMahon, A. Neumeister, M. A. Norko, D. A. Oren (Adjunct), I. L. Petrakis, M. N. Potenza, R. M. Rohrbaugh, M. I. Rosen, G. Sanacora, D. Small, M. Sofuoglu, J. K. Staley-Gottschalk, J. L. Steiner, T. H. Styron, N. E. Suchman, G. D. Tamagnan (Adjunct), J. K. Tebes, D. F. Tolin (Adjunct), K. A. Yonkers
Assistant Professors W. Abi-Saab (Adjunct), D. Aikins, R. C. Andres-Hyman, A. Annamalai, M. Assaf (Adjunct), R. S. Astur (Adjunct), S. R. Axelrod, J. E. Beauvais, L. E. Bedregal, R. D. Beech, Z. Bhagwagar, M. O. Bonarrigo, J. A. Brewer, D. Brunner (Adjunct), G. J. Bryson, S. A. Castner, I. Cavus (Adjunct), M. C. Chawarski, L. G. Chepenik, L. Chwastiak, C. Connell, J. M. Cook, K. P. Cosgrove, C. A. Crusto, I. E. Dearaujo, M. E. Delphin, P. H. Desan, G. J. Diefenbach (Adjunct), C. G. Edelen, M. S. Farkas, D. C. Fehon, J. M. Fiszdon, E. H. Flanagan, L. M. Frantsve, H. E. Goff, N. Hansen, I. Harpaz-Rotem, M. G. Hunt, M. Jean-Baptiste, A. Kaffman, S. Kendell (Adjunct), A. S. Klee, S. D. Kruger, D. M. LaPaglia, C. Li, S. Lim, X. Luo, S. Madonick (Adjunct), R. Masheb, R. S. McWilliam (Child Study Center), P. T. Morgan, P. M. Morrissey (Adjunct), M. Paris, C. Pittenger, A. N. Ponce, M. L. Randall, S. G. Resnick, P. Ridgway, K. A. Sanders, C. Sanislow, S. N. Sathyanesan, J. J. Sellinger, D. J. Sells, A. A. Simen, P. Skudlarski (Adjunct), V. H. Srihari, H. R. Steinberg, S. Steinberg (Adjunct), T. P. Sullivan, C. Tek, E. S. Tek, B. A. Toll, P. Van Wattum (Child Study Center), D. Vojvoda, N. Ward, A. H. Weinberger, M. A. White, G. V. Williams, W. A. Williams, B. Yang, R. J. Yun, P. Zimbrean, L. D. Zimmerman (Child Study Center), Z. Zimolo
Instructor R. Kapoor
Senior Research Scientists J. D. Elsworth, G. Heninger, S. C. Jacobs
Research Scientists J. Olausson, J. Poling, E. Ralevski
Associate Research Scientists E. Ansell, M. Banasr, D. Barry, K. T. Bergquist, F. Bois, D. A. Cavallo, T. Chaplin, I. E. Cottrill, J. A. Cramer, N. R. Driesen, C. H. Duman, C. T. Dyer, H. M. Fichtenholtz, H. Fox, D. J. Guarnieri, A. A. Heapy, A. Herman, S. M. Hyman, J. S. Jane, J. H. Kalmar, W. J. Kasprow, C. J. Kendall, R. F. Leeman, D. Li, R. Liu, D. J. Martin, R. A. Miller, Y. S. Mineur, M. S. Neale, E. E. O’Brien, R. H. Pietrzak, P. H. Rosenberger, J. R. Saksa, E. Santa Ana, T. J. Schmutte, A. D. Schweinsburg, M. A. Silva, G. W. Valentine, J. J. Vanderploeg, F. Wang, M. Wu, P. Wupperman, J. Xu, H. Zhang, W. Zito, L. Zuo
Research Affiliate X. Wang
Clinical Professors D. N. Berg, D. A. Carlson, G. H. Flamm, D. G. Greenfeld, D. Laub, D. O. Lewis, E. Prelinger, K. D. Pruett, L. W. Reiser, C. E. Riordan, H. L. Ruben, L. D. Siggins, J. L. Young
Associate Clinical Professors J. Allison, V. A. Altshul, R. M. Balsam, D. S. Bialos, S. Boltax-Stern (Child Study Center), E. A. Brett, C. Chiles, J. J. Ciarcia, V. Coric, J. De Figueiredo, L. Deutsch (Child Study Center), A. Evans, L. B. Fierman, J. Geller, R. L. Goettsche, K. Grady, L. L. Harkness, O. F. Hills, R. J. Hoffnung, D. Johnson, D. Koenigsberg (Child Study Center), C. C. Kovel, K. Liebmann, K. M. Long, J. S. Lustman, B. McKee, S. Mohamed, C. A. Morgan, M. S. Okasha, R. B. Ostroff, H. R. Pearsall, E. A. Perlswig (Child Study Center), R. Peters, J. Phillips, S. H. Phillips, S. G. Possick, M. Rowe, M. Rubenstein, E. R. Ryan, S. J. Schreiber, A. P. Siegal, E. W. Snyder, R. Stern, T. D. Stewart, T. D. Stewart, R. R. Tampi, A. P. Thies (Child Study Center), G. J. Watstein, E. C. Wolff (Child Study Center), T. Zanker (Child Study Center)
Assistant Clinical Professors A. C. Adis, A. M. Almai, J. A. Amatruda, P. T. Amble, M. M. Amer, B. Arnaout, S. R. Atkins, J. P. Azcona, R. Aziz, C. B. Baker, J. Ballew, A. L. Balter, L. C. Barr, M. V. Barrios, L. A. Bayer, B. R. Becker, E. Becker-Dunn, R. S. Behrends, M. Beitel, C. D. Bellamy, C. C. Bemis, S. Bender, D. E. Bendor, E. H. Berger, R. L. Bergeron, T. Bergherr, S. Bers, H. C. Blue, D. Boltas, K. F. Bonese, M. F. Bower, D. M. Brandt, D. Brockett, T. E. Brown, A. Buonopane, L. V. Calabrese, A. Cappiello, R. Casey, L. I. Chaikovsky, J. Charney, J. R. Check, A. S. Cheng, D. E. Ciancimino, J. C. Cline, S. J. Cohen, J. T. Collins (Child Study Center), M. L. Conroy, L. W. Cross, E. Cumberbatch, W. F. Dailey, C. Dike, C. Doebrick, N. Donegan (Psychology), V. M. Dreisbach, L. K. Driscoll, J. J. Erdos, R. D. Fallot, M. S. Farkas, D. C. Fehon, S. Feuerstein, J. F. Fickes, P. L. Filip, S. Finkelstein, D. A. Fisk, F. G. Fortunati, P. A. Fountain, P. Fox, E. R. Frazer, T. A. Freeman, R. Freeman, D. Fried, T. George, T. Glinberg, C. T. Goldberg, L. I. Goldstein, G. Gonzalez-Haddad, D. M. Gordon, T. C. Greig, M. C. Groner, E. G. Grottole, C. S. Grove, L. B. Grunebaum, H. Gunduz-Bruce, J. C. Harland, D. D. Hawkins, D. M. Higgins, S. R. Hill, W. Hill, M. Hillbrand, K. Holtzman, S. J. Houlding, D. D. Jacobson, C. Jean, A. Kaner, M. Kang, K. G. Kennedy, K. E. Kerfoot, S. Khan, S. Kidd, B. Klink, B. E. Knox, F. E. Koerner, R. E. Kravitz, J. Kremer, J. Kurt, M. M. Kurtz, A. Lamba, H. M. Lankenau, D. Laub, K. M. Lazzarini, B. Lee, N. E. Legow, L. N. Levenson, L. N. Levenson, R. C. Lewis, S. V. Lewis, H. J. Lin, E. B. Littman, H. G. Lizcano, D. B. London, C. Lozano, H. Lubin, L. M. Maccarelli, M. Mandelkern, B. F. Marcus, C. A. Markle, R. Masheb, R. W. McCleary, B. B. McConnell, B. Meandzija, A. W. Meisler, N. C. Mellos, D. M. Mender, R. M. Meyer, S. J. Migdole, E. S. Millman, R. M. Milstein, C. R. Miner, B. A. Moore, V. R. Morrow, F. C. Mueller, P. V. Mulinski, J. Myer, E. D. Nasper, M. P. Nespoli, J. Nields, F. J. Ninivaggi (Child Study Center), D. O. Nudel, K. F. Nuro, N. D. Olson, C. A. Opsahl, A. G. Oren, S. Ottenheimer, S. Ottenheimer, R. M. Ownbey, M. V. Pantalon, N. Panza, A. Papsun, A. Papsun, H. L. Paxton, H. V. Phan, D. Pilkey, J. F. Poll (Child Study Center), M. L. Prevey, G. R. Racusin, J. Rakfeldt, M. Ranganathan, I. S. Rathbone, D. R. Rau, A. Resnick, G. Richardson, J. P. Robbins, L. Robinson, J. E. Robinson, V. C. Rosen, B. S. Rothschild, N. Roy, M. P. Roy, R. Rubin, S. Rubin, D. S. Russell, D. S. Russell, J. A. Sabbatino, N. Sahay, D. K. Sakheim, K. M. Salisbury, D. Salomy, C. Sanders, L. C. Sanfilippo, A. P. Sawyer, J. O. Schechter, R. R. Schreibman, J. S. Schwartz, B. Schweinsburg, J. L. Scott, J. P. Seibyl (Diagnostic Radiology), K. A. Sevarino, C. Shankar, J. K. Shepard, D. E. Sholomskas, S. H. Silverstein, M. F. Sperrazza, A. D. Spivack, S. Sreenivasan, D. A. Stayner, M. C. Stevens, W. A. Stewart, M. Stitelman, G. E. Sturges, D. C. Tate, E. J. Tello-Silva, A. N. Tessler, S. E. Thomas, B. Tobin, J. L. Tondora, L. A. Trevisan, K. V. Trueblood, M. Tupper, D. J. Wallington, J. M. Wexler, R. S. White, J. Wolf, C. M. Young, J. R. Zigun
Clinical Instructors M. Bailey, V. V. Carvalho, J. F. Chapman, V. Coggshall, L. M. Edwards, D. J. Flanigan, D. J. Flanigan, C. Grazia, M. C. Grenough, J. O. Hannestad, J. O. Hannestad, C. M. Hunnicutt, L. C. Hyman, W. Levy, N. M. Lustman, M. McCarthy, M. McCarthy, B. C. Moore, S. S. Mubbashar, J. Nields, R. Plant (Child Study Center), J. N. Rascati, S. J. Rathi, S. H. Rodrigues, R. A. Sewell, D. J. Suscovich, M. B. Vollmar, E. Weiss
Lecturers J. D. Alvaro, C. Atkins, C. M. Barber, F. Begum, R. M. Berman, D. A. Berv, A. Brownlow, J. L. Callahan, R. A. Cole, C. Conrad, H. F. Crabbe, G. H. Davis, A. R. Demac, C. E. Desmond, P. J. Dileo, P. A. Dillon, L. K. Frisman, L. R. Gonzalez, S. G. Goodson, J. B. Gordon, G. Greenberg, F. Grossman, M. A. Kalacznik, A. Kalafa, R. H. Klein, B. C. Klein, J. Klugman, A. L. Labruzza, L. Lager, R. B. Lenoci, L. M. Lothstein, L. M. Madden, R. B. Makover, K. Marcus, A. Margolin, J. H. Meyer, M. L. Mitchell, D. C. Moore, I. Moses, R. L. Munich, C. S. Naungayan, M. Nicholas, A. Oberkirch, M. J. Orlosky, R. T. Phillips, J. M. Pisciotta, M. K. Pruett, M. D. Rego, W. N. Reich, E. B. Rubin, S. L. Satel, M. N. Savage, J. M. Schnitt, A. J. Sholomskas, G. H. Sirkin, P. F. Thomas, R. K. Westheimer
The Department of Psychiatry teaches in both preclinical and clinical years. The pre-clinical course is a study of medical behavioral science, rather than an introduction to clinical psychiatry. Specific clinical skills, such as interviewing and the recognition and management of psychiatric syndromes, are taught later in the curriculum and especially during the required clinical clerkship in Psychiatry. Electives are available for students with special interest in selected areas. All advanced clinical electives are numbered in the 200s. The required core clinical clerkship (Psychiatry 106) is a prerequisite for enrollment in any of these advanced clinical electives; an advanced clinical elective may not be taken instead of the required core clinical clerkship. Please note: All students signing up for a seminar elective must also register with the Medical Student Education Office, Department of Psychiatry, 785.2089 (pending approval of the instructor).
Psychiatry 101a, Patient-Centered Interviewing: The Patient’s Story This segment of the Pre-Clinical Clerkship focuses on the experience of illness—how people react to and cope with illness. The various psychosocial factors and psychological defenses which impact on the experience of illness, such as age, gender, social supports, socioeconomic status, and coping style, are examined. There is an emphasis on the patient interview and techniques for eliciting the patient’s story in an empathic and effective manner. The format includes lectures, demonstration interviews, and practice with standardized patients. R. Belitsky and Departments of Psychiatry and Medicine faculty
Psychiatry 101b, Biological Basis of Behavior Lectures are integrated with the Neurology course, and include principles and neural mechanisms of learning and memory; neural systems involved in fear and anxiety; neural systems involved in reward and drug addiction; neural systems involved in stress; and neural systems involved in attention. Following each lecture, a psychiatrist interviews patients diagnosed with obsessive-compulsive disorder, panic disorder, cocaine abuse, post-traumatic stress disorder, and schizophrenia. These 1.5-hour clinical presentations, which include time for questions, link psychiatric symptoms to the neural mechanisms discussed in the lecture on that day. 2.5 hours per week. Department of Psychiatry faculty
Psychiatry 106, Clinical Clerkship Skills and knowledge needed for the general practice of medicine are acquired in a clinical psychiatric setting. There is a “Patients in Crisis” component that emphasizes: conducting a competent screening interview in order to identify symptoms of a psychiatric or substance abuse disorder; performing a complete mental status examination of a patient who is emotionally disturbed or mentally ill; making a differential diagnosis, and planning for further evaluation and tests that would be useful in deciding among various diagnostic possibilities; making recommendations for biological, psychosocial, and/or social treatment interventions; assessing whether or not dangers to or from a patient exist; and understanding indications and procedures for lawful involuntary commitment of a patient to a mental hospital for treatment. There is also a “Psychiatry at the Interface with Medicine” component designed to provide students with an understanding of the presentation of psychiatric illness in patients with co-morbid medical disorders. Emphasis is placed on screening interviews, including mental status examination; identification of symptoms; and differential diagnosis and initial treatment recommendations of patients with co-morbid medical and psychiatric illness. Special emphasis is placed on evaluation of psychiatric emergencies and competency to make informed medical decisions. Additionally, students have the opportunity to learn and develop clinical skills through carefully designed outpatient experiences. R. Rohrbaugh and Department of Psychiatry faculty
Psychiatry 203, Subinternship in Hospital Psychiatry, Inpatient Division, Connecticut Mental Health Center Intensive work with inpatients who suffer from major psychiatric disorders with or without substance abuse. Emphasis is on assessment, acute treatment, and arrangement of continuing care in the community. The clerk functions as an integral member of a multidisciplinary treatment team. Clinical research participation is encouraged. Opportunities available to explore special areas of interest (e.g., forensics, psychopharmacology, administrative) with Connecticut Mental Health Center faculty. The elective is given on the inpatient service, CMHC. Scheduled throughout the year during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 106. Maximum registration: two students. S. Jacobs, M. Jean-Baptiste, and staff. To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 205, Subinternship in Medical Psychiatry (Consultation Psychiatry), Yale-New Haven Hospital, 2039 Clinic Building This is an advanced clinical elective for third- and fourth-year students who have a particular interest in the psychiatric disorders that can occur in medical-surgical patients. The staff has special interests in differential diagnosis of medical vs. psychiatric illness, in psychopharmacology, and in computer applications in psychiatry. Each student works up patients in parallel with advanced residents in inpatient and emergency department settings. Teaching occurs on daily walk rounds. Scheduled throughout the year during regular clerkship rotations (except July and August) for a minimum of four weeks. (Note: Fourth-year students will be given preference.) Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. P. Desan, T. Stewart, W. H. Sledge, A. Papsun, and staff. To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 206, Advanced Clinical Elective in Law and Psychiatry This clerkship program affords opportunities for fourth-year medical students to observe and participate in “competency to stand trial” evaluations with a clinical team that makes these assessments at the New Haven Correctional Center. In addition, they may attend Law School classes with students who represent psychiatric patients, observe civil commitment procedures, attend probate court hearings, as well as the criminal proceedings in local New Haven Superior Courts. Students attend work seminars where case evaluations and write-ups are discussed and prepared, and read appropriate legal cases and psychiatric literature. Students may be able to participate in parts of evaluations of insanity defense, custody determination, and other forensic issues. They attend the Law and Psychiatry Seminar during their rotation. Scheduled throughout the year (except August) during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 106. Maximum registration: two students. H. Zonana and staff. To enroll in this advanced clinical elective, please contact R. Rohrbaugh
Psychiatry 208, Subinternship in Consultation-Liaison Psychiatry at the VA Connecticut Healthcare System (VACHS), West Haven, Connecticut The Consultation-Liaison Service at the VACHS West Haven provides consultation to acute medical and surgical units, specialized rehabilitation units, and outpatient primary care clinics. Students participate in the management of patients with close supervision from attending staff. The goals of the rotation are (1) to increase skill in conducting a psychiatric interview which maximizes the collection of pertinent clinical data; (2) to use the data collected in formulating and implementing treatment plans emphasizing the interplay of biological and psychological factors in the patients’ presentation; (3) to experience the satisfaction of caring for patients with complex medical and psychiatric illness. Scheduled throughout the year for a minimum of four weeks. Open to third- and fourth-year medical students. Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. C. Chiles and staff. To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 209, Substance Abuse Elective An elective clinical training experience in substance abuse for interested third- and fourth-year students. The primary training site is the Outpatient Service at the VA Connecticut Healthcare System (VACHS) in West Haven. The substance abuse elective is scheduled for four weeks. This experience is an intensive one in which students work closely with addicted patients with chronic mental illness. Students interested in learning about medical detoxification from alcohol and/or opiates may participate in an intensive two-week elective in the Ambulatory School of Medicine Detoxification Clinic at the VACHS. Students learn about the evaluation and treatment of alcohol withdrawal and detoxification. Patients with benzodiazepine and opiate dependence are also treated in this clinic. Prerequisite: Psychiatry 106. Maximum registration: two students. VACHS Faculty: L. Trevisan, I. Petrakis. Contact person (for VACHS): I. Petrakis, Psychiatry. To enroll in this advanced clinical elective, please contact R. Rohrbaugh
Psychiatry 210, Subinternship in Hospital Psychiatry, Inpatient Division, Yale-New Haven Psychiatric Hospital Intensive work with patients who suffer from major psychiatric disorders and range in age from college students to middle age. Emphasis is on assessment, acute treatment, and arrangement of post-discharge follow-up care in the community. The subintern is an advanced clerk functioning as a member of the multidisciplinary treatment team, taking on primary clinician and psychiatric/medical responsibilities for patients under the supervision of senior clinicians. The elective is given on the inpatient service at Y-NHPH; clinical research and outpatient involvement may be options. This subinternship is available throughout the year, during regular clerkship rotations for a minimum of four weeks. Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. R. M. Milstein, M. Bowers, R. Hoffman, R. Tampi, and staff. To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 211, Subinternship in Clinical Neuroscience, Clinical Neuroscience Research Unit Inpatient Division This clerkship offers senior medical students the opportunity to work closely with a variety of patients who are hospitalized during their participation and treatment in research protocols. The Clinical Neuroscience Research Unit (CNRU) is a thirteen-bed inpatient ward with associated outpatient clinics and basic science laboratories on the third floor of the Connecticut Mental Health Center (CMHC). Supervised implementation of novel psychopharmacology, exposure to multiple aspects of clinical and basic science research, and in-depth experience with individual and group psychotherapies are educational aspects of this elective. Patients’ diagnostic categories include depression, obsessive-compulsive disorder, schizophrenia, cocaine abuse, and substance abuse. Scheduled throughout the year for a minimum of four weeks. Prerequisites: Psychiatry 101 and 106. Maximum registration: one student per rotation. R. Malison, G. Heninger, V. Coric, Z. Bhagwagar, and staff. To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 214, Subinternship in Psychotic Disorders at G8W and the Schizophrenia Research Clinic at the VA Connecticut Healthcare System (VACHS) in West Haven, the Clinical Neuroscience Research Unit and the Psychopharmacology Intervention Program at the Connecticut Mental Health Center, the Community Care Center in West Haven This subinternship is designed to provide an integrative exposure to the interface of psychopharmacology and psychosocial treatments for chronic psychotic disorders. Each individual requesting a subinternship is asked to outline his or her interest in psychotic disorders. Based on this information, a faculty mentor is assigned and a clinical program prepared that provides greater depth in the relevant areas. An effort is made to provide exposure to both hospital- and community-based treatments as well as clinical neuroscience advances. Within all treatment settings, subinterns have closely supervised direct clinical contact with patients. Subinterns are invited to attend academic conferences within the Department of Psychiatry focused on clinical and neuroscience issues relevant to psychosis. The goals of the rotation are (1) to expose the subintern to established and experimental medication treatments for psychotic disorders, particularly schizophrenia; (2) to expose the subintern to rehabilitative approaches to schizophrenia; (3) to expose the subintern to community-based treatments for chronic mental illness. Scheduled throughout the year for a period of six to eight weeks. Prerequisite: Psychiatry 106. Maximum registration: one student per rotation. C. D’Souza, M. Bell, J. Cubells, L. Davidson, L. Harkness, S. Kruger, J. Krystal, and staff. To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 238, Subinternship in Early Psychosis: STEP Clinic STEP (Specialized Treatment Early in Psychosis) is a multidisciplinary team-based treatment for individuals presenting early in the course of a psychotic illness. This clinic offers unique opportunities in the assessment and treatment of a population that is difficult to access in other clinical settings. Trainees have the opportunity to observe structured research assessments and interpretation of these scales in light of careful clinical follow-up. Given the diagnostic and prognostic heterogeneity of illnesses presenting with psychosis, this experience provides the opportunity to develop clinical expertise in diagnosis and management of a range of mental health issues. The enriched treatment includes cognitive-behavioral group therapy, family psycho-education groups, and cognitive remediation in addition to vocational support with a focus on rapidly reintegrating patients back to age-appropriate social, educational, and employment goals. Students have the opportunity to observe or participate in any of these treatments. The multidisciplinary and pluralistic nature of the intervention presents a rich opportunity to participate in collaborative care with other mental health disciplines. Trainees can also participate in regular seminars sponsored by the STEP and PRIME (Prevention through Risk Identification, Management, and Education) clinics. The latter is a research clinic focused on prodromal psychosis. Positions: 1-2. Site: Connecticut Mental Health Center (CMHC).
Scholarship: STEP is designed as a service delivery model with a built-in observational cohort and experimental pragmatic randomized controlled trial. Trainees are invited to take an active role in the various domains of scholarship including community and clinician education efforts, publication, and learning about clinical research design. V. Srihari (clinic director), J. Pollard (project director and family interventions coordinator, STEP clinic), C. Tek, (program director, Psychosis Team), L. Hyman (team leader, Psychosis Team), S. Woods (director, PRIME Clinic), J. Saksa (CBT coordinator, STEP Clinic), B. Walsh (clinical coordinator, PRIME Clinic). To enroll in this subinternship, please contact R. Rohrbaugh
Psychiatry 325/CHLD 325, Child Psychiatry Elective, Yale Child Study Center The aim of this elective is to provide the student with an intensive experience in infant, child, and adolescent psychiatry. The curriculum includes assessments of normal development and psychopathology in childhood, treatment methods, and research in major disorders of childhood. The elective takes advantage of the wide range of ongoing seminars, conferences, and clinical services in place at the Child Study Center. Teaching methods include seminars, conferences, field observations, ward rounds, and School of Medicine practica selected by the student following consultation with the director of medical studies, Child Study Center. Open to fourth-year students throughout the year. A. Martin, D. Stubbe, J. Woolston, and staff. To enroll in this advanced clinical elective, please contact A. Martin directly at 688.6016 or 785.3370
Surgery
Office: FMB 102, 785.2697
Professors J. J. Abrahams (Diagnostic Radiology), L. M. Bartoshuk (Emeritus), M. Centrella, G. D’Onofrio, F. C. Detterbeck, S. J. Dudrick, J. A. Elefteriades, S. H. Emre, H. E. Foster, J. P. Geibel, B. G. Green, R. J. Gusberg, G. L. Hammond (Emeritus), B. Kinder (Emeritus), J. A. Kirchner (Emeritus), G. S. Kopf, D. R. Lannin, G. L. Larkin, S. B. Leder, D. J. Leffell (Dermatology), D. J. Leffell (Dermatology), A. Lofqvist (Adjunct), W. E. Longo, B. Lytton (Emeritus), L. M. Manuelidis, I. M. Modlin, R. Moss, J. A. Persing, J. Pollak (Diagnostic Radiology), S. M. Powsner (Psychiatry), S. H. Rosenbaum (Anesthesiology), W. Rosenblatt (Anesthesiology), R. R. Salem, J. Santos-Sacchi, C. T. Sasaki, I. R. Schwartz (Emeritus), J. H. Seashore (Emeritus), Y. H. Son (Therapeutic Radiology), B. Sumpio, G. Tellides, R. J. Touloukian, R. Udelsman (Chair), R. M. Weiss
Associate Professors J. E. Aruny (Diagnostic Radiology), S. L. Bernstein, M. S. Bogucki, S. Bokhari (Diagnostic Radiology), J. W. Colberg, D. C. Cone, A. Dardik, K. A. Davis, L. C. Degutis, R. N. Formica (Medicine), B. J. Grube, S. Hashim, G. M. Israel (Diagnostic Radiology), M. H. Johnson (Diagnostic Radiology), L. J. Kaplan, W. K. Kelly (Medicine), T. L. McCarthy, D. Narayan, L. A. Post, L. J. Rizzolo, R. A. Rosenthal, T. Shinoka, J. A. Sosa, W. B. Stewart, J. G. Thomson
Assistant Professors A. Arvelakis, R. L. Bell, D. J. Boffa, L. Bontempo, D. M. Botta, C. K. Breuer, C. H. Cha, C. H. Cha, H. A. Deshpande (Medicine), D. C. Duffey, A. Duffy, L. V. Evans, L. V. Evans, A. R. French, M. M. Fuenfer, A. Geirsson, J. M. Hammel, A. B. Hittelman, J. Indes, D. C. Johnson, K. J. Jubanyik, R. W. Kim, B. M. Kirrane, D. Kowalski (Pathology), P. E. Krochmal, S. Kulkarni, R. Kulkarni, S. M. Luczycki (Anesthesiology), S. M. Luczycki (Anesthesiology), S. M. Luczycki (Anesthesiology), S. M. Luczycki (Anesthesiology), F. Y. Lui, L. L. Maerz, M. Matthew, A. Maung, M. A. McKee, E. Michaelides, E. P. Monico, C. Moore, H. C. Moscovitz, B. E. Muhs, M. R. Osborne, V. Parwani, M. F. Perkal, K. E. Roberts, S. A. Roman, B. Safdar, J. E. Sather, K. M. Schuster, I. Schwartz, D. Singh, J. A. Sosa, H. E. Tantawy (Anesthesiology), A. F. Tarabar, A. Tomassoni, E. M. Uchio, C. M. Van Gelder, C. N. Walker, C. R. Wira, N. Young
Instructors C. Christy, A. J. Rousou, B. B. Whang
Associate Research Scientists S. Bian, W. Gao, M. S. Kidd, Y. Kondo, S. Peng, L. Song, S. Yang, J. Zhou, S. Zhou
Research Affiliates S. S. De Cabanyes Candela, I. S. Jovin, Y. T. Tran
Clinical Professors S. Ariyan, M. Arons, J. E. Fenn, J. F. Kveton, S. B. Nuland, R. S. Stahl, E. Yanagisawa
Associate Clinical Professors N. A. Atweh, Z. N. Chicarilli, J. M. Dowaliby, R. C. Fazio, A. J. Graham, H. L. Horton, J. P. Kelly, K. Koral, K. Lee, R. A. Lowlicht, J. Maisel, J. T. Schultz, J. M. Serling, S. A. Stein, B. S. Weisbart
Assistant Clinical Professors D. I. Astrachan, P. A. Barcewicz, H. Cedarbaum, B. Y. Cha, W. Cholewczynski, P. F. Corso, R. J. Dean, R. H. Delfini, R. W. DeNatale, M. L. Dewar, A. T. Dioguardi, T. G. Duplinsky, P. E. Fidler, S. V. Flagg, S. I. Friedman, R. Garvey, R. T. Golia, N. A. Gordon, J. Henley, R. H. Hirokawa, G. E. Horblitt, N. R. Horowitz, R. B. Kaplan, D. E. Karas, D. B. Keck, J. C. Kirchner, P. A. Kraus, S. B. Levine, M. Margolies, S. Mitra, D. J. Muller, S. Natkin, M. K. O’Brien, G. Opin, G. Opin, P. M. Opin, P. M. Opin, M. F. Perkal, G. J. Price, C. Rambus, D. D. Roberts, J. C. Salomon, R. F. Schlessel, M. J. Schpero, S. Shah, R. K. Shaw, L. W. Skope, R. E. Steller, R. F. Stroup, T. F. Sweeney, J. L. Tanenbaum, A. F. Tarabar, S. C. Thornton, R. Tross, D. Wasson, A. C. Weihl, M. H. Weinstein, M. J. Werdmann, A. E. Wilk, J. M. Willett, K. Yanagisawa, K. Zuckerman
Clinical Instructors J. A. Arons, S. Baker, P. W. Barrett, E. Baum, C. B. Beckman, M. S. Bianchi, J. S. Bomann, W. R. Butler, S. A. Chekijian, S. A. Chekijian, A. Coppola, E. M. Cozzi, P. Demir, T. Fabian, P. L. Fortgang, D. Isenberg, J. Joseph, T. A. Kelly, A. S. Kenler, J. R. Klenoff, S. Kotlyar, T. H. Lesnik, A. A. McKelvey, V. Parwani, D. B. Pearlstone, M. T. Pronovost, H. F. Reilly, M. J. Rest, P. E. Rubin, J. F. Schmidt, J. J. Tagliarini, T. Takoudes, A. Terk, E. Tham, N. Vasan, E. M. Vining, M. N. Waltzman, E. S. Weinstein, D. Wohl
Lecturers L. Acton, A. Albero, K. Baker, R. Bonner, L. M. Bow, H. C. Briggs, E. Browne, K. J. Burns, R. E. Chen, T. E. Cohen, N. Collins, C. Dill, G. M. Faherty, B. C. Fichandler, D. Garland, S. Ghofrany, A. L. Glick, A. Hirschman, J. Hopper, W. Huggins, S. Jolie, S. E. Kapadia, H. M. Keiser-Pedersen, E. W. Kelleher, T. Kimberly, E. B. Larned, V. Lee, L. Long, D. S. MacMillan, A. McGrath, A. Meiman, J. Mendes, T. G. Michalewski, T. A. Morris, M. C. Persinger, P. P. Possenti, C. Powell, E. A. Roessler, E. A. Roessler, P. G. Sasaki, M. T. Strong, D. E. Tichy, C. D. Walker, H. L. Warner, H. B. White
Surgery 103, Surgical Clerkship This is a twelve-week block that includes a four-week core experience on one of the general surgery services at either Yale-New Haven Hospital or the West Haven VA Hospital (Gastroenterology, Oncology, Trauma, and VAMC), a four-week rotation that is divided into two weeks on Anesthesia and two weeks on Emergency Medicine, and an additional four-week subspecialty rotation on which students may select two 2-week subspecialty services, which are completed at Yale-New Haven Hospital (Cardiac, Endocrine, Orthopedics, Otolaryngology, Pediatrics, Peripheral Vascular, Plastic Surgery, Thoracic, Transplant, and Urology).
During all of the rotations on the Surgery services, the students can expect to be integrated into the clinical teams, working up patients to which they are assigned and participating in the evaluation and management of these patients (in both the inpatient and outpatient settings). In addition to knowledge acquisition, emphasis is placed on the development of basic clinical skills as well surgical problem-solving skills.
Throughout the twelve-week block, each student is assigned to a surgical mentor, who is responsible for monitoring progress, reinforcing core concepts, and facilitating skill development. In addition, there is a core curriculum, including a series of problem-oriented, interactive sessions focused on fundamental surgical problems, a twelve-week simulation course designed to facilitate clinical skill development, and a weekly case-based seminar, focused on decision making and doctor/patient interactions.
At the outset of the clerkship, the students receive an outline of learning objectives (for both knowledge and skills) and take a self-assessment examination. At the conclusion of the clerkship there is an exit interview and a final self-assessment examination.
Surgery 122, Subinternship, Plastic Surgery Clinical experience as an intern on a large clinical ward. The student has experience in the management of craniofacial anomalies, burns, trauma, hand surgery, head and neck surgery, reconstructive surgery of the head and neck and extremities, microsurgery, as well as surgery of the congenital anomalies and cosmetic surgery. Limited to one fourth-year student per month with a minimum of one-month rotations. Arrangements must be made with J. A. Persing
Surgery 123b, Biochemical and Metabolic Foundations of Plastic and Reconstructive Surgery A course designed to provide in-depth understanding of the molecular events underlying the diverse clinical phenomena encountered in plastic surgery. Topics include fluid electrolyte metabolism in the burn patient, biochemistry and metabolism of collagen and its relation to scarring and connective tissue disorders, normal wound healing, and disorders of the same. Offered for four weeks during the spring term, two hours per week by arrangement. Limited to two fourth-year students. J. A. Persing
Surgery 129, Cardiopulmonary Transplantation Intensive exposure to laboratory and clinical aspects of cardiac, cardiopulmonary, and pulmonary transplantation. Special emphasis on the relation between ongoing laboratory studies and clinical practice in this field. Clinical involvement in preoperative assessment of prospective transplant candidates, donor procurement, intraoperative management, and postoperative immunosuppression. Limited to one student by arrangement with J. Elefteriades
Surgery 130, Subinternship, Cardiothoracic Intensive exposure to preoperative and postoperative management of adult and pediatric cardiothoracic surgical patients and to intraoperative conduct of surgical procedures, with active participation in the operating room and in regular conferences. Students attend regular seminars covering major areas of cardiothoracic surgery with members of the faculty, and may be required to present a seminar on a subject in cardiothoracic surgery to faculty and resident staff. Limited to two students in the second clinical year. Three or six weeks by arrangement with J. Elefteriades
Surgery 131, Subinternship, General Thoracic Intensive exposure to preoperative and postoperative management of general thoracic surgical patients and to the intraoperative conduct of surgical procedures involving the lung, the chest wall, the thymus, and the esophagus. Included is an organized lecture series covering the entire field of general thoracic surgery. Students are expected to present a seminar at the conclusion of the subinternship, focusing on a specialized topic in general thoracic surgery. Six weeks by arrangement with J. Elefteriades
Surgery 141, Outpatient Otolaryngology This is an opportunity for those students who have not had exposure in otolaryngology to spend time with a full-time attending otolaryngologist seeing outpatients in an office setting. Timing is quite flexible and a student may spend one to three mornings or afternoons each week for one to four weeks. By arrangement with C. T. Sasaki and the full-time otolaryngology staff
Surgery 142, Emergency Medicine The student participates in the evaluation and treatment of adult emergency patients, learning appropriate work-up and therapy. Students are expected to attend morning conferences four mornings per week and to work four twelve-hour shifts that may include nights and weekends. Prerequisite: Surgery 103
Surgery 143, Care of the Intensive Care Unit Patient Didactic and clinical sessions in the Yale-New Haven Hospital SICU prepare the student to provide treatment for the critically ill patient. Topics include cardiopulmonary resuscitation, airway and ventilator management, assessment of the multiple trauma patient, and management of sepsis. Prerequisite: Surgery 103. Three to four weeks, by arrangement. K. Davis, L. Kaplan
Surgery 144, Trauma Surgery The student functions as an extern and participates actively in trauma service rounds, teaching conferences, trauma resuscitation, and operative management of trauma cases. Students are expected to attend conferences and take inhouse call with the chief resident of the trauma service. Prerequisite: Surgery 103. K. Davis
Surgery 150, Plastic and Reconstructive Surgery Evaluation and reconstructive surgery of deformities of congenital, traumatic, and neoplastic origin. Includes inpatient, outpatient, and operating room experience, supplemented by regular conferences. Limited to two students; available throughout the year. J. A. Persing
Surgery 151, Subinternship, General Surgery (Four weeks) Offered throughout the academic year at both Yale-New Haven Hospital and VA Connecticut Healthcare System, West Haven. Limited to second clinical year, one or two students per month. Arrangements must be made with W. Longo
Surgery 152, Advanced Senior Seminar, General Surgery This is a weekly evening seminar series covering advanced and controversial topics in general surgery. Three one-hour sessions include dinner at faculty homes and run from October through February. Reprints of pertinent articles provided prior to each seminar. Staff
Surgery 153, Subinternship, Otolaryngology This clinical experience is independent of the third-year Surgery/Otolaryngology rotation, and takes place on an individual basis. It includes operating room experience, ward responsibilities, and involvement in outpatient ENT. Yale-New Haven Hospital, the Hospital of St. Raphael, and the VA Connecticut Healthcare System, West Haven, are available for the rotation. Minimum rotation of four weeks; limited to one student. C. T. Sasaki
Surgery 158, Surgery at Waterbury Hospital A well-supervised fourth-year clerkship including teaching rounds, operating room experience, outpatient clinical experience, and conferences in radiology, pathology, oncology, vascular surgery, and general surgery. Daily ICU rounds are conducted with an attending physician. Six weeks, for one or two students, with room and meals provided. E. Kwasnik and staff
Surgery 159, Subinternship, Urology This clinical experience is independent of the standard third-fourth year Urology rotation and takes place on an individual basis. It includes operating room experience, inpatient responsibilities, and involvement in the outpatient clinics at Yale-New Haven Hospital and West Haven VA Hospital. Subintern participates in scheduled conferences. Limited to one or two students for a three- or four-week rotation. Starting dates of the rotations are negotiable. R. Weiss
Surgery 160, Surgery at St. Mary’s Hospital, Waterbury Six-week subinternship in an affiliated community hospital of 400 beds, consisting of ward and operative experience, teaching rounds, and conferences. An independent general surgical residency exists at St. Mary’s. S. Dudrick and staff
Surgery 165, Surgery at Bridgeport Hospital For a student contemplating a career in clinical surgery, an opportunity to function as a team member with residents and attending staff in a large community hospital. General surgery with fundamental pre- and postoperative care, appropriate operating room activity, basic bedside diagnostic and therapeutic hands-on experience, emphasis on intensive care unit, trauma, and burns. Each student is expected to present a twenty-minute research or clinical topic of choice at completion of the course. Room and board available on duty. Limited to one or two students for six- to eight-week rotations in the fourth year. Staff
Surgery 171, Subinternship, Peripheral Vascular Surgery A practical experience in the diagnosis and management of vascular disease, including pre- and postoperative care. The scope of the experience includes orientation to the noninvasive vascular diagnostic laboratory, outpatient care in the Yale Vascular Center, and inpatient management (including patients in the OR, ICU, and the vascular surgery unit). Four weeks, by arrangement with B. Sumpio and staff
Surgery 172, Subinternship, Transplantation Surgery This intensive clinical experience emphasizes the preoperative assessment, intraoperative care, and postoperative management of patients suffering end-stage organ system failure who are cared for by transplantation. Emphasis also includes the management of immunosuppressive medication regimens and the care of post-transplant problems. Available throughout the year, one or two students, for one month. Arrangements with S. Emre and staff
Surgery 173, Experimental Transplantation Surgery and Immunobiology Clinical and laboratory studies into problems relevant to the field of organ transplantation. Students work under the tutelage of a member of the faculty in the Division of Organ Transplantation. Original projects must be mutually agreed upon, and may include studies into the immunology of allograft rejection, the mechanism of immunosuppressive drug action, immunological monitoring of patients following transplantation, or biochemical markers to potentially identify early rejection of renal, hepatic, pancreatic, or small bowel allografts. Available throughout the year, one or two students, time commitment by arrangement. S. Emre and staff
Surgery 174, Subinternship in Surgical Oncology Intensive exposure to surgical aspects of the treatment of cancer in clinic, hospital, and operating room. The interaction between surgery, medical oncology, and radiation therapy is experienced by following patients receiving multiple forms of therapy. Available throughout the year, one or two students, preferably for one-month rotations. Arrangements with R. R. Salem
Surgery 175, Pediatric Cardiac Surgery Intensive exposure to pediatric cardiac surgery with emphasis on preoperative evaluation and postoperative management. The student observes the changes in pre- and postoperative physiology and spends much of the time following postoperative patients. The student is exposed to the use of ventilators in the pediatric patient, inotropic and vaso-dilating agents, evaluation and treatment of low cardiac output state, and the use of pacemakers. Weekly conferences include surgical conferences, preoperative conferences, catheterization conference, pre- and postoperative clinics, as well as weekly sessions with the attending staff. Some technical experience and instruction are provided in the operating room according to the student’s interest. Limited to two students per month. T. Shinoka, G. S. Kopf, and R. Kim. Arrangements to be made with the pediatric cardiac surgery office
Surgery 176, Subinternship in Pediatric Surgery In-depth exposure to the broad spectrum of pediatric surgical problems of the abdomen, chest, head and neck, and pelvis. The student obtains experience with correction of congenital anomalies, management of trauma, care of the critically ill child, and management of solid tumors. The subintern is an integral part of the pediatric surgical team and is expected to take in-house night call every third night. Contact L. Moss
Therapeutic Radiology
Office: HRT 140, 785.2956
Professors S. J. Baserga (Molecular Biophysics and Biochemistry), D. E. Brash, J. Chen, D. C. DiMaio (Genetics), J. J. Fischer, P. M. Glazer (Chair), B. G. Haffty (Adjunct), R. Nath, R. E. Peschel, S. Rockwell, W. Rupp, R. J. Schulz (Emeritus), Y. H. Son, W. C. Summers, P. Sung (Molecular Biophysics and Biochemistry), J. B. Sweasy, L. D. Wilson
Professor (Adjunct) of Research K. Low
Associate Professors Z. Chen, J. Deng, S. A. Higgins, J. P. Knisely, K. B. Roberts
Assistant Professors D. J. Carlson, B. W. Chang, R. Decker, F. Guo, Y. S. Liu, S. Mani, M. S. Moran, A. A. Patel, F. A. Rogers, J. B. Weidhaas, Z. Yun
Associate Research Scientists A. K. Chikova, S. Dalal, Q. Lin, Y. Wu
Research Affiliate X. Cong
Associate Clinical Professors P. M. Pathare
Assistant Clinical Professors M. Ahmad, J. Albanese, J. E. Bond, A. Chu, Y. Fan
Lecturer R. Vera
Therapeutic Radiology 101, Clinical Clerkship in Radiation Therapy A flexible program designed to introduce the medical student to radiation therapy. The biological and physical bases of radiation therapy, together with clinical practice and ongoing research. Clinical exposure to patients with malignant disease, with between seventy and one hundred treated daily in the department. The student takes part in departmental conferences, clinics, lectures, and individual teaching sessions. Limited to two students at any time. L. D. Wilson and staff
Therapeutic Radiology 102, Clinical Radiobiology This course is designed to provide residents in radiation oncology with a comprehensive review of clinical radiobiology as it applies to the practice of radiation therapy. The course is open to residents and fellows in other disciplines interested in radiobiology as it applies to clinical oncology. The course participant attends approximately twenty lectures in clinical radiobiology, which are delivered throughout the academic year between September and June. Scheduling by arrangement with L. D. Wilson
Therapeutic Radiology 201b, A Survey of Radiobiology A review of the interaction of radiation on living organisms, progressing from DNA damage to complex mammalian systems. Modern concepts in molecular biology and cell kinetics are emphasized in understanding the sequelae of this interaction and the mechanism by which the organism responds to the injury produced. Fourteen sessions. By arrangement with Radiobiology staff
Therapeutic Radiology 305, Principles and Methods of Radiation Dosimetry A graduate-level course for physics students or medical students with a strong physics background who want to learn about radiation dosimetry as it applies to medical practice. Topics include X-ray spectra, ionization chambers, X-ray exposure and the roentgen, mass energy-absorption coefficients, the Bragg-Gray principle, stopping power and linear energy transfer, chemical dosimeters, instrumentation, and physical aspects of radiology. Approximately twenty hours of tutorial sessions. Scheduling by arrangement with instructor. R. Nath
Therapeutic Radiology 306, Laboratory Projects in Radiation Dosimetry Students are given problems that relate to and supplement long-term, ongoing radiation dosimetry projects within the department. Prerequisite: Therapeutic Radiology 305, or its equivalent. Scheduling by arrangement with instructor. R. Nath
