Neuroscience of Learning and Memory
Thomas H. Brown, Ph.D. Stanford 1977

Selected Publications:

2005-Present| 2000-2004 | 1995-1999 | 1990-1994 | 1985-1989 | 1980-1984

2005 – Present

• Tankhiwale, A. A., and Brown, T. H. Temporal lobe and object recognition. Thompson, R.F, Shors, T. J. (eds.) Encyclopedia of Behavioral Neuroscience. Oxford: Elsevier. in press.

• Bang, S. J. and Brown, T. H. Perirhinal cortex supports acquired fear of auditory objects. Neurobiol Learn Mem, doi:10.1016/j.nlm.2009.01.002, 2009

• Bang, S.J. and Brown, T. H. Muscarinic receptors in perirhinal cortex control trace fear conditioning. J. Neuroscience 29(14): 4346-4350, 2009

• Kholodar-Smith, D.B., Boguszewski, P. and B Brown, T.H. Auditory Trace Fear Conditioning Requires Perirhinal Cortex. Neurobiology of Learning and Memory, 90(3), pp. 537-543, 2008.

• Kholodar-Smith, D.B., Allen, T.A. and Brown, T.H. Fear Conditioning to Discontinuous Auditory Cues Requires Perirhinal Cortical Function. Behavioral Neuroscience, 122(5), pp. 1178-1185, 2008.

• Allen, T.A., Narayanan, N.S., Kholodar-Smith, D.B., Zhao, Y., Laubach, M. and Brown, T.H. Imaging the Spread of Reversible Brain Inactivations using Fluorescent Muscimol. The Journal of Neuroscience Methods, 171(1), pp. 30-38, 2008.

• Bang, S.J., Allen, T.A., Jones, L.K., Boguszewski, P. and Brown, T.H. Asymmetrical Stimulus Generalization Following Differential Fear Conditioning. Neurobiology of Learning and Memory, 90(1), pp. 200-216, 2008.

• Furtak, S.C., Allen, T.A. and Brown, T.H. Single-Unit Single-Unit Firing in Rat Perirhinal Cortex Caused by Fear Conditioning to Arbitrary and Ecological Stimuli. The Journal of Neuroscience, 27(45), pp. 12277-12291, 2007.

• Furtak, S.C., Moyer, J.R., Jr., and Brown, T.H. Morphology and Ontogeny of Rat Perirhinal Cortical Neurons. Journal of Comparative Neurology, 505, pp. 493-510, 2007.

• Moyer, J.R., Jr., and Brown, T.H. Visually-Guided Patch-Clamp Recordings in Brain Slices. In: Walz W, editor. 3rd Ed. Advanced Techniques for Patch-Clamp Analysis. 2007.

• Allen, T.A., Furtak, S.C., and Brown, T.H. Single-Unit Responses to 22 kHz Ultrasonic Vocalizations in Rat Perirhinal Cortex. Behavioral Brain Research, 182(2), pp. 327-336, 2007.

• Moyer, J.R., Jr., and Brown, T.H. Impaired Trace and Contextual Fear Conditioning in Aged Rats. Behavioral Neuroscience, 120(3), pp. 612-624, 2006.

• Padlubnaya, D.B., Parekh, N.H., and Brown, T.H. Neurophysiological Theory of Kamin Blocking in Fear Conditioning. Behavioral Neuroscience, 120(2), pp. 337-352, 2006.

2000 – 2004

• Lindquist, D.H., and Brown, T.H. Perirhinal Cortex Supports Delay Fear Conditioning to Rat Ultrasonic Social Signals. The Journal of Neuroscience, 24(14), pp. 3610-17, 2004.

• Lindquist, D.H., and Brown, T.H. Temporal encoding in Fear Conditioning Revealed through Associative Reflex Facilitation. Behavioral Neuroscience, (118)2:, 2004.

• Lindquist, D.H., and Brown, T.H. Amygdalar NMDA Receptors Control the Expression of Associative Reflex Facilitation and Three other Conditional Responses. Behavioral Neuroscience, (118)1:, 2004.

• Brown, T.H. Furtak, S.C. and Lindquist, D.H. Hebbian Synapses. In Encyclopedia of Neuroscience (3rd ed.) eds: Adelman, G. and Smith, B.H. (Eds.), New York, NY : Elsevier Science, 2004.

• Brown, T.H., and Lindquist, D.H. Long-term Potentiation: Amygdala. In Learning and Memory, 2nd Ed.), ed: Byrne, J.H., Farmington Hills, MI: Macmillan Reference, pp. 342-46, 2003.

• Brown, T.H., Byrne, J.H, Labar, K., LeDoux, J., Lindquist, D.H., Thompson, R.F., and Teyler, T.J. Learning and memory: Basic mechanisms. In Cellular and Molecular Neuroscience. eds: Byrne, J.H. and Roberts, J.L. San Diego, CA: Academic Press, pp. 499-574, 2003.

• Choi, J -S., and Brown, T.H. Central amygdala lesions block ultrasonic vocalization and freezing as conditional but not unconditional responses. J. of Neuroscience, 23(25): 8713-8721, 2003.

• Moyer, J.R., Jr. and Brown, T.H. Patch-clamp techniques applied to brain slices. In: Advanced Techniques for Patch-Clamp Analysis, eds: W. Walz, A.A. Boulton, & G.B. Baker, Totowa, NJ: Humana Press, pp. 135-194, 2002.

• Moyer, J.R., McNay, E.C. and Brown, T.H. Three classes of pyramidal neurons in layer V of rat perirhinal cortex. Hippocampus, 12: 218-234, 2002.

• Choi, J-S., Lindquist, D.H., and Brown, T.H. Amygdala lesions block conditioned enhancement of the early component of the rat eyeblink reflex. Behavioral Neuroscience, 115 (4): 764-775, 2001.

• Lee, H.J., Choi, J-S., Brown, T.H., and Kim, J.J. Amygdalar N-Methyl-D-Aspartate (NMDA) receptors are critical for the expression of multiple conditioned fear responses. J. Neuroscience, 21(11): 4116-4124, 2001.

• McGann, J.P., Moyer, J.R., Jr., and Brown, T.H. Predominance of late-spiking neurons in layer VI of rat perirhinal cortex. J. Neuroscience,21(14): 4969- 4976, 2001.

• McGann, J.P. and Brown, T.H. Fear conditioning model predicts key temporal aspects of conditioned response production. Psychobiology, 28 (3): 303-313, 2000.

• Beggs, J.M., Moyer, J.R., McGann, J.P., Brown, T.H. Prolonged synaptic integration in perirhinal cortical neurons. J Neurophysiol, 83: 3294-3298, 2000.

1995 - 1999

• Beggs, J. M., Brown, T. H., Byrne, J. H., Crow, T., LeDoux, J. E., LeBar, K., and Thompson, R. F. Learning and memory: Basic mechanisms and systems. In: Fundamentals of Neuroscience, M. J. Zigmond, F. E. Bloom, S. C. Landis, J. L. Roberts, L. S. Squire (eds.), Academic Press, San Diego, CA. pp. 1411-1454, 1999.

• Faulkner, B. and Brown, T. H. Morphology and physiology of neurons in the rat perirhinal-lateral amygdala area. J. Comp. Neurol., 411: 613-642, 1999.

• Brown, T. H. and Faulkner, B. Hebbian synapses. In: Encyclopedia of Neuroscience, G. Adelman and B. Smith, (eds.), on CD-ROM, 1999. 865-868, Amsterham, Netherlands, 1999.

• Greenwood, A. C., Landaw, E. M., and Brown, T. H. Testing the fit of a quantal model of neurotransmission. Biophys. J., 76: 1847-1855, 1999.

• Tieu, K. H., Keidel, A. L., McGann, J. P., Faulkner, B., and Brown, T. H. Perirhinal-amygdala circuit-level computational model of temporal encoding in fear conditioning. Psychobiology, 27: 1-25, 1999.

• Moyer, J. R. and Brown, T. H. Methods for whole-cell recording from visually preselected neurons of perirhinal cortex in brain slices from young and aging rats. J. Neurosci. Meth., 86 (1): 35-54, 1998. abstract

• Xiang, Z. and Brown, T. H. Complex synaptic current waveforms evoked in hippocampal pyramidal neurons by extracellular stimulation of dentate gyrus. J. Neurophysiol., 79: 2475-2484, 1998.

• Faulkner, B., Brown, T. H., and Evinger, C. Identification and characterization of rat orbicularis oculi motoneurons using confocal laser scanning microscopy. Exp. Brain Res., 116: 10-19, 1997.

• Faulkner, B., Tieu, K. H., and Brown, T. H. Mechanism for temporal encoding in fear conditioning: delay lines in perirhinal cortex and lateral amygdala. Computational Neuroscience, J. Bower (ed.), Plenum Publishing Corp., New York, NY. pp. 641-645, 1997.

• Jaffe, D. B. and Brown, T. H. Calcium dynamics in thorny excrescences of CA3 pyramidal neurons. J. Neurophysiol., 78: 10-18, 1997.

• Carnevale, N. T., Tsai, K. Y., Claiborne, B. J., and Brown, T. H. Comparative electrotonic analysis of three classes of rat hippocampal neurons. J. Neurophysiol., 78: 703-720, 1997.

• Lam, Y.-W., Wong, A., Canli, T., and Brown, T. H. Conditioned enhancement of the early component of the rat eyeblink reflex. Neurobiol. Learn. Mem ., 66: 212-220, 1996.

• Mainen, Z. F., Carnevale, N. T., Zador, A. M., Claiborne, B. J., and Brown, T. H. Electrotonic architecture of hippocampal CA1 pyramidal neurons based on three-dimensional reconstructions. J. Neurophysiol., 76 (3): 1904-23, 1996. abstract

• Canli, T. and Brown, T. H. Amygdala stimulation enhances the rat eyeblink reflex through a short latency mechanism. Behav. Neurosci., 110 (1): 51-9, 1996.

• O'Boyle, M. P., Carnevale, N. T., Claiborne, B. J., and Brown, T. H. A new graphical approach for visualizing the relationship between anatomical and electrotonic structure. In: Computational Neuroscience, J. Bower (ed.), pp. 423-28, Academic Press, San Diego, CA, 1996.

• Carnevale, N. T., Tsai, K. Y., Claiborne, B. J., and Brown, T. H. Qualitative electrotonic comparison of three classes of hippocampal neurons in the rat. In: The Neurobiology of Computation, J. Bower (ed.), pp. 67-72, Kluwer, Boston, MA, 1995.

• Carnevale, N. T., Tsai, K. Y., Claiborne, B. J., and Brown, T. H. The electrotonic transformation: a tool for relating neuronal form to function. In: Advances in Neural Information Processing Systems 7, G. Tesauro, D. S. Touretzky, and J. Alspector, (eds.), pp. 69-76, Morgan Kaufmann , San Mateo, CA, 1995.

• Brown, T. H. and Chattarji, S. Hebbian plasticity. In: The Handbook of Brain Theory and Neural Networks, M. A. Arbib (ed.), pp. 454-459, MIT Press, 1995.

1990 - 1994

• Brown, T. H. and Jaffe, D. B. Calcium imaging in hippocampal neurons using confocal microscopy. Annl. N.Y. Acad. Sci., 747:313-324, 1994.

• Jaffe, D. B. and Brown, T. H. Confocal imaging of dendritic Ca2+ transients in hippocampal brain slices during simultaneous current- and voltage-clamp recordings. J. Microscopy Res. Tech., 29:279-289, 1994.

• Jaffe, D. B. and Brown, T. H. Metabotropic glutamate receptor activation induces calcium waves within dendrites of hippocampal neurons. J. Neurophysiol., 72:471-474, 1994.

• Jaffe, D. B., Fisher, S. A., and Brown, T. H. Confocal laser scanning microscopy reveals voltage-gated calcium signals within hippocampal dendritic spines. J. Neurobiol., 25(3):220-233, 1994.

• Tsai, K. Y., Carnevale, N. T. and Brown, T. H. Efficient mapping from neuroanatomical to electrotonic space. Network: Computation in Neural Systems, 5:21-46, 1994.

• Xiang, Z, Greenwood, A. C., Kairiss, E. W., and Brown, T. H. Quantal mechanisms of long-term potentiation in hippocampal mossy-fiber synapses. J. Neurophysiol. 71:2552-2556, 1994.

• Tsai, K. Y., Carnevale, N. T., and Brown, T. H. Hebbian learning is jointly controlled by electrotonic and input structure. Network: Computation in Neural Systems, 5:1-19, 1994.

• Brown, T. H. and Chattarji, S. Hebbian synaptic plasticity: evolution of the contemporary concept. Models of Neural Networks II , E. Domany, J. L. Van Hemmen, and K. Schulten (eds.), pp. 287-314, Springer-Verlag, New York, 1994.

• Yu, T.-P. and Brown, T. H. Three-dimensional quantification of mossy-fiber presynaptic boutons in living hippocampal slices using confocal microscopy. Synapse, 18:190-197, 1994.

• Claiborne, B. J., Xiang, Z., and Brown, T. H. Hippocampal circuitry complicates analysis of long-term potentiation in mossy fiber synapses. Hippocampus, 3:115-122, 1993.

• Claiborne, B. J., Zador, A. M., Mainen, Z. F., and Brown, T. H. Computational models of hippocampal neurons. In: Single Neuron Computation, T. McKenna, J. Davis, and S. F. Zornetzer (eds.), pp. 61-79, Academic Press, 1992.

• Koch, C., Zador, A. M., and Brown, T. H. Dendritic spines: Convergence of theory and experiment, Science, 256: 973-4, 1992.

• Zador, A. M., Claiborne, B. J., and Brown, T. H. Nonlinear pattern separation in single hippocampal neurons with active dendritic membrane. In: Advances in Neural Information Processing Systems 4, J. E. Moody, S. J. Hanson, and R. P. Lippmann (eds.), pp. 51-58, Morgan Kaufmann, 1992.

• Brown, T. H., Zador, A. M., Mainen, Z. F., and Claiborne, B. J. Self-organization of Hebbian synapses in hippocampal neurons. In: Advances in Neural Information Processing Systems 3, R. Lippmann, J. Moody, D. Touretzky (eds.), pp. 39-45, Morgan Kaufmann Publishers, 1991.

• Brown, T. H. and Zador, A. M. The hippocampus. In: Synaptic Organization of the Brain, G. Shepherd (ed.), pp. 346-388, Oxford, 1990.

• Brown, T. H., Kairiss, E. W., and Keenan, C. L. Hebbian synapses–biophysical mechanisms and algorithms. Ann. Rev. Neurosci., 13:475-511, 1990.

• Chapman, P. F., Kairiss, E. W., Keenan, C. L., and Brown, T. H. Long-term synaptic potentiation in the amygdala. Synapse, 6: 271-278, 1990. abstract

• Zador, A. M., Koch, C., and Brown, T. H. Biophysical model of a Hebbian synapse, Proc. Natl. Acad. Sci., 87: 6718-6722, 1990. full text

• Kairiss, E. W., Mainen, Z. F., Claiborne, B. J., and Brown, T. H. Dendritic control of Hebbian computations. In: Analysis and Modeling of Neural Systems, F. Beckman (ed.), pp. 69-83, Kluwer Academic Publishers, 1991. full text

• Brown, T. H., Zador, A. M., Mainen, Z. F., and Claiborne, B. J. Hebbian computations in hippocampal dendrites and spines. In: Single Neuron Computation, T. McKenna, J. Davis, and S. F. Zornetzer (eds.), pp. 81-116, Academic Press, 1992. full text

• Brown, T. H., Zador, A. M., Mainen, Z. F., and Claiborne, B. J. Hebbian modifications in hippocampal neurons. In: Long-Term Potentiation: A Debate of Current Issues, J. Davis and M. Baudry (eds.), pp. 357-389, MIT Press, 1991.

• Chapman, P. F., Kairiss, E. W., Keenan, C. L., and Brown, T. H. Long-term synaptic potentiation in the amygdala. Synapse, 6: 271-278, 1990.

1985 - 1989

• Brown, T. H., Ganong, A. H., Kairiss, E. W., Keenan, C. L., and Kelso, S. R. Long-term potentiation in two synaptic systems of the hippocampal brain slice. In: Neural Models of Plasticity, J. H. Byrne and W. O. Berry (eds.), pp. 266-306, Academic Press, 1989.

• Brown, T. H., Chang, V. C., Ganong, A. H., Keenan, C. L., and Kelso, S. R. Biophysical properties of dendrites and spines that may control the induction and expression of long-term synaptic potentiation. In: Long-Term Potentiation: From Biophysics to Behavior, P.W. Landfield and S. Deadwyler (eds.), pp. 201-264, Alan R. Liss, 1988.

• Brown, T. H., Chapman, P. F., Kairiss, E. W., and Keenan, C. L. Long-term synaptic potentiation. Science, 242: 724-728, 1988. abstract

• Keenan, C. L., Chapman, P. F., Chang, V. C., and Brown, T. H. Videomicroscopy of acute brain slices from hippocampus and amygdala. Brain Res. Bull., 21: 373-383, 1988. abstract

• Johnston, D. and Brown, T. H. Control theory applied to neural networks illuminates synaptic basis of interictal epileptiform activity. In: Advances in Neurology, Vol. 44. Basic Mechanisms of Epilepsies. Molecular and Cellular Approaches, A. B. Delgado-Escueta, A. A. Ward, D. M. Woodbury and R. J. Porter (eds.), pp. 263-274, Raven Press, 1986. abstract

• Barrionuevo, G., Kelso, S., Johnston, D., and Brown, T. H. Conductance mechanism responsible for long-term potentiation in monosynaptic and isolated excitatory synaptic inputs to hippocampus. J. Neurophysiol., 55:540-550, 1986. abstract

• Griffith, W. H., Brown, T. H., and Johnston, D. Voltage-clamp analysis of synaptic inhibition during long-term potentiation in hippocampus. J. Neurophysiol., 55:767-775, 1986. abstact

• Kelso, S. and Brown, T. H. Differential conditioning of associative synaptic enhancement in hippocampal brain slices. Science, 232:85-87, 1986. abstract

• Kelso, S., Ganong, A., and Brown, T. H. Hebbian synapses in hippocampus. Proc. Natl. Acad. Sci., 83:5326-5330, 1986. full text

• Baxter, D., Bittner, G. D., and Brown, T. H. Quantal mechanism of long-term synaptic potentiation. Proc. Natl. Acad. Sci., 82:5978-5982, 1985.

• Briggs, C. A., Brown, T. H., and McAfee, D. A. Neurophysiology and pharmacology of long-term potentiation in the rat sympathetic ganglion. J. Physiol. 359:503-52l, l985.

1980 - 1984

• Johnston, D. and Brown, T. H. The synaptic nature of the paroxysmal depolarizing shift in hippocampal neurons. Annals of Neurology, 16(S1):S65-S71, 1984.

• Johnston, D. and Brown, T. H. Mechanisms of neuronal burst generation. In: Electrophysiology of Epilepsy, P. A. Schwarzkroin and H. V. Wheal (eds.), pp. 277-301. Academic Press, 1984.

• Johnston, D. and Brown, T. H. Biophysics and microphysiology of synaptic transmission in hippocampus. In: Brain Slices, R. Dingledine (ed.), pp. 51-86, Plenum Press, 1984.

• Johnston, D. and Brown, T. H. Interpretation of voltage-clamp measurements of hippocampal neurons. J. Neurophysiol., 50:464-486, 1983.

• Barrionuevo, G. and Brown, T. H. Associative long-term synaptic potentiation in hippocampal slices. Proc. Natl. Acad. Sci., 80:7347-7351, 1983. full text

• Brown, T. H. and Johnston, D. Voltage-clamp analysis of mossy-fiber synaptic input to hippocampal neurons. J. Neurophysiol., 50:487-507, 1983.

• Brown, T. H. and McAfee, D. Long-term synaptic potentiation in superior cervical ganglion. Science, 215:1411-1413, 1982. abstract

• Johnston, D. and Brown, T. H. Giant synaptic potential hypothesis for epileptiform activity. Science, 211:294-297, 1981. abstract

• Brown, T. H., Perkel, D. H., Norris, J. C., and Peacock, J. H. Electrotonic structure and specific membrane properties of mouse dorsal-root ganglion neurons. J. Neurophysiol., 45:1-15, 1981.

• Brown, T. H., Fricke, R. A., and Perkel, D. H. Passive electrical constants in three classes of hippocampal neurons. J. Neurophysiol., 46:812-827, 1981.

• Brown, T. H. and Newby, N. A. Quantal nature of neuromuscular transmission in crayfish phasic abdominal flexors. J. Comp. Physiol., 136:89-101, 1980.

1975 - 1979

• Noble, M. D., Brown, T. H., and Peacock, J. H. Direct effects of neostigmine on aneural myotube cultures. Neurosci. Lett., 11:149-154, 1979.

• Brown, T. H., Wong, R. K. S., and Prince, D. A. Spontaneous miniature synaptic potentials in hippocampal neurons. Brain Res., 177:194-199, 1979.

• Noble, M. D., Brown, T. H., and Peacock, J. H. Regulation of acetylcholine receptors levels by cholinergic agonist in mouse muscle cell cultures. Proc. Natl. Acad. Sci., 75:3488-3492, 1978.

• Brown, T. H., Perkel, D. H., and Feldman, M. W. Evoked neurotransmitter release: Statistical effects of nonuniformity and nonstationarity. Proc. Natl. Acad. Sci., 73:2913-2917, 1976.


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