The HIV Genome

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HIV Structure
The HIV genome consists of numerous proteins specific to HIV, shown in pinks and purples, as well as elements common to many retroviruses. In our exploration of HIV, we will explore the evolution of the HIV genome as a whole and how individual proteins evolve within the genome. Our primary focus will be on gag, pol, and env, which encode the nucleocapsid, polymerase, and envelope proteins, repectively. Below is a map and legend to the HIV genome.

 

Legend:

LTR-long terminal repeats; repetitive sequence of bases
gag-group specific antigen gene, encodes viral nucleopcapsid proteins: p24, a nucleoid shell protein, MW=24000; several internal proteins, p7, p15, p17 and p55.
pol-polymerase gene; encodes the viral enzyme, protease (p10), reverse transcriptase (p66/55; alpha and beta subunits) and integrase (p32).
env-envelope gene; encodes the viral envelope glyocproteins gp120 (extracellular glycoprotein, MW=120 000) and gp41 (transmembrane glycoprotein, MW=41000).
tat: encodes transactivator protein
rev: encodes a regulator of expression of viral protein
vif: associated with viral infectivity
vpu: encodes viral protein U
vpr: encode viral protein R
nef: encodes a 'so-called' negative regulator protein

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EEB Home Page

HIV Structure
EEB Web Site 1998/HIV Lab--Site Maintained by Jeff Huckaby, Yale University.